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Prof.Gianfranco Pintus Chairperson Academic RankProfessor

Specialization:

  • Biochemistry, Cell Biology

Research Interests:

  • Research interests of Prof. Pintus encompass multiple aspects of Vascular Biology including i) the impact of Naturally Occurring Antioxidants on Vascular cells ii) the molecular mechanisms that regulate vascular remodeling during both aging and chronic diseases iii) the Impact and signaling pathways targeted by antiangiogenic drugs. Prof. Pintus is involved in many research projects in collaboration with regional, national and international scientists and research groups

Contact

BSc (Sassari, Italy), PhD (Bologna, Italy)
2019-Present. Professor, Head of Department, University of Sharjah, UAE 2016-2019 - Associate Professor of Biomedical Sciences, Qatar University, Doha, Qatar. 2016–2017. Honorary Senior Research Fellow, University of Bristol, Bristol, UK. 2013 - Present. Visiting Professor, Hue University of Medicine and Pharmacy, Hue, Vietnam. 2006 - Present. Associate Professor of Biochemistry, Head of Laboratory, University of Sassari, Italy (on leave) 2004–2007 - Research Fellow, National Institute on Aging, National Institutes of Health, Baltimore, USA. 2001–2006 - Assistant Professor, University of Sassari, Sassari, Italy. 1999–2000 - Postdoctoral Fellowship INBB (National Institute for Biostructures and Biosystems), Rome, Italy.
Grant Panels Review: 2012-present. Università del Foro Italico (Intramural projects), Italy 2007–present. Ministry of Education, University and Research (FIRB Project), Italy. 2007-present Ministry of Education, University and Research (MIUR Projects), Italy 2017- present Cancer Research Wales, Wales, UK. Editorial Activity: Editorial Boards Memberships - PLOS ONE (Academic Editor), Journal of Infection in Developing Countries (Editorial Board), Frontiers in Cardiovascular Medicine - Cardiovascular Biologics and Regenerative Medicine (Associated Editor), Frontiers in Genetics - Genetic of Aging (Guest Associate Editor), Oxidative Medicine and Cellular Longevity (Guest Editor), EC Nutrition (Editorial Board), The Open Biochemistry Journal (Editorial Board) Ad hoc Reviewer - Archives of Biochemistry and Biophysics, Cancer Immunology Immunotherapy, Cardiovascular Research, Endocrine, Metabolic & Immune Disorders-Drug Targets, FASEB Journal, Food Chemistry, Food Research International, Frontiers in Bioscience, International Journal of Biological Sciences, International Journal of Molecular Sciences, Journal of Cellular and Molecular Medicine, Journal of Cellular Physiology, Journal of Functional Foods in Health and Disease, Journal of Infection in Developing Countries, Journal of Inorganic Biochemistry, Journal of Pharmacy and Pharmacology, Molecules, Oncogene, PloS ONE, Food and Chemical Toxicology, Molecular Biology Reports, Experimental Cells Research, Aging., Molecular Brain Research, Frontiers in Physiology, Cells, Biomolecules.
-Italian Society of Biochemistry and Molecular Biology (SIB), since 2000. -Federation of European Biochemical Societies (FEBS), since 2000. -European Atherosclerosis Society (EAS), since 2000. -European Society of Cardiology (ESC), WG on Atherosclerosis and Vascular -Biology, since 2009. -European Vascular Biology Organization (EVBO), since 2009. -Society for Free Radical Research Europe (SFRR), since 2017. -Middle East Molecular Biology Sources (MEMBS), since 2017. -Fellow of the Royal Society of Biology (FRSB), since 2019.
2018-2020 - Project Title: Investigating predictive biomarkers and cellular/molecular determinants of chronic respiratory diseases. Lead PI – Funded by the Qatar University - Grant, 244.000 USD - [QU IRCC281 2018-2019] 2019–2020 - Project Title: Effect of natural antioxidants on high glucose-induced endothelial-to-mesenchymal transition Funded by Qatar National Research Fund –. Lead PI. Grant, USD 30.000 - [UREP24-016-3-004] 2019-2021- Project Title: Development of a predictive biomarker fingerprint of disease exacerbations in subjects with obstructive and restrictive respiratory diseases. Funded by the Autonomous Region of Sardinia. PI- Grant, 110.000 EUR. – [# RAS SR 82005] 2018-2019 - Project Title: Effect of natural antioxidants on Diabetes-induced epigenetic modifications in human endothelial cells: An ex-vivo/in-vitro Approach”. Funded by Qatar University - Lead PI- Grant, 298.927 QR. – [QUCG-CHS-2018\2019-1] 2012- 2015 - Project Title: “Development of innovative nano-devices with site specific action for the prevention, diagnosis and therapy of prostate cancer”. Funded by the Autonomous Region of Sardinia. Unit Coordinator & PI. Grant, 125.500 EUR - [CRP-25920] 2017-2018 - Project Title: Role of oxidative stress in high glucose-induced endothelial-to-mesenchymal transition: Funded by by Qatar National Research Fund – UREP20-051-3-012. Lead PI. Grant, USD 30.000 2016-2019 - Project Title: Sustainability of the Olive-oil System: Funded by The Fondazione Cariplo Co-Pi. 40.000 EUR [# SOS] 2014-2015 - Project Title: Analysis of the epigenetic transmission in the cardiovascular diseases through the characterization of the changes induced by prenatal gestational diabetes in Sardinia”. Funded by the Bank of Sardinia Foundation. PI. Grant, Euro 20.000 2010-2012 - project Title: “Role of the Immune response in the genesis of scleroderma vascular disease: Molecular mechanisms and identification of early biochemical markers”. Funded by the Autonomous Region of Sardinia. Groups Coordinator & lead PI Grant, 75.500 EUR - [CP3-133] 2010-2012 - Project Title “Table olives and olive oil: influence of transformation, extraction, conservation and cooking processes on both anti-oxidant activity and vascular protection, in vitro and in vivo studies”. Funded by the Italian Ministry of Education, University and Research). Coordinator & Lead PI Grant, 190.888 EUR – [PRIN-08 #2008FEATER ] 2010-2012 - Project Title: Evaluation of vascular protective effects of alimentary antioxidant derived from table olives and olive oil: Molecular analysis on cultured endothelial and vascular smooth muscle cells. Funded by the Italian Ministry of Education, University and Research - Lead PI. Grant, 65.429 EUR [2008FEATER_001) 2005-2008 - Project Title: “Analytical characterization and "in vivo" determination of antioxidant activity of new formed antioxidants in fruit and vegetable derivatives”. Funded by the Italian Ministry of Education, University and Research. Scientific Responsible, Groups Coordinator & Lead PI Grant, 117.215 EUR total [PRIN-05 2005070480].
-Flavin Oxidase-Induced ROS Generation Modulates PKC Biphasic Effect of Resveratrol on Endothelial Cell Survival. Posadino AM, Giordo R, Cossu A, Nasrallah GK, Shaito A, Abou-Saleh H, Eid AH, Pintus G. Biomolecules. 2019 May 30;9(6) -Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene. Hussein EA, Zagho MM, Rizeq BR, Younes NN, Pintus G, Mahmoud KA, Nasrallah GK, Elzatahry AA. Int J Nanomedicine. 2019 Jun 20;14:4529-4539. -Ecotoxicological Assessment of Thermally- and Hydrogen-Reduced Graphene Oxide/TiO₂ Photocatalytic Nanocomposites Using the Zebrafish Embryo Model. Al-Kandari H, Younes N, Al-Jamal O, Zakaria ZZ, Najjar H, Alserr F, Pintus G, Al-Asmakh MA, Abdullah AM, Nasrallah GK. Nanomaterials (Basel). 2019 Mar 28;9(4). -Antioxidant Activity Mediates Pirfenidone Antifibrotic Effects in Human Pulmonary Vascular Smooth Muscle Cells Exposed to Sera of Idiopathic Pulmonary Fibrosis Patients. Fois AG, Posadino AM, Giordo R, Cossu A, Agouni A, Rizk NM, Pirina P, Carru C, Zinellu A, Pintus G. Oxid Med Cell Longev. 2018 Oct 21;2018:2639081. -Protective Effect of Cyclically Pressurized Solid⁻Liquid Extraction Polyphenols from Cagnulari Grape Pomace on Oxidative Endothelial Cell Death. Posadino AM, Biosa G, Zayed H, Abou-Saleh H, Cossu A, Nasrallah GK, Giordo R, Pagnozzi D, Porcu MC, Pretti L, Pintus G. Molecules. 2018 Aug 21;23(9). -Reduced vasorin enhances angiotensin II signaling within the aging arterial wall. Pintus G, Giordo R, Wang Y, Zhu W, Kim SH, Zhang L, Ni L, Zhang J, Telljohann R, McGraw KR, Monticone RE, Ferris C, Liu L, Wang M, Lakatta EG. Oncotarget. 2018 Jun 5;9(43):27117-27132. -Oxidative stress-induced Akt downregulation mediates green tea toxicity towards prostate cancer cells. Posadino AM, Phu HT, Cossu A, Giordo R, Fois M, Thuan DTB, Piga A, Sotgia S, Zinellu A, Carru C, Pintus G. Toxicol In Vitro. 2017 Aug;42:255-262 Activation of the Pro-Oxidant PKCβII-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Patients With Diabetes With Critical Limb Ischemia. -Vono R, Fuoco C, Testa S, Pirrò S, Maselli D, Ferland McCollough D, Sangalli E, Pintus G, Giordo R, Finzi G, Sessa F, Cardani R, Gotti A, Losa S, Cesareni G, Rizzi R, Bearzi C, Cannata S, Spinetti G, Gargioli C, Madeddu P. Diabetes. 2016 Dec;65(12):3691-3704 -Human Serum Albumin Increases the Stability of Green Tea Catechins in Aqueous Physiological Conditions. Zinellu A, Sotgia S, Scanu B, Forteschi M, Giordo R, Cossu A, Posadino AM, Carru C, Pintus G. PLoS One. 2015 Jul 31;10(7):e0134690. -Gestational diabetes mellitus impairs fetal endothelial cell functions through a mechanism involving microRNA-101 and histone methyltransferase enhancer of zester homolog-2. Floris I, Descamps B, Vardeu A, Mitić T, Posadino AM, Shantikumar S, Sala-Newby G, Capobianco G, Mangialardi G, Howard L, Dessole S, Urrutia R, Pintus G, Emanueli C. Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):664-74. -Resveratrol alters human endothelial cells redox state and causes mitochondrial-dependent cell death. Posadino AM, Cossu A, Giordo R, Zinellu A, Sotgia S, Vardeu A, Hoa PT, Nguyen le HV, Carru C, Pintus G. Food Chem Toxicol. 2015 Apr;78:10-6. -Evaluation of non-covalent interactions between serum albumin and green tea catechins by affinity capillary electrophoresis. Zinellu A, -Sotgia S, Scanu B, Pisanu E, Giordo R, Cossu A, Posadino AM, Carru C, Pintus G. J Chromatogr A. 2014 Nov 7;1367:167-71
More than 15 BSc students, 4 MSc Students, 15 PhD Students, and 4 post doc.
-Co-financial award by the University of Sassari in support of the research project PRIN2008. Euro 14.629 -Award by the University of Sassari in support of the research project PRIN2008. Euro 5.500 (high ranked national projects) -Award by the Sardinia Region in support of the research activity of prof. Pintus Euro 10.000 -Award by the University of Sassari in support of the research project PRIN2011. Euro 10.000 (high ranked national projects)
-2019–present. Head of Department, Medical Laboratory Sciences, University of Sharjah -2016–2019 - Member of the College of Health Sciences Promotion committee Qatar University -2016–2019 - Member of the -Department's Curriculum Committee, Department of Biomedical Sciences, Qatar University. -2016–2019 - Member of the Department's Research Committee, Department of Biomedical Sciences, Qatar University -2016–2019 - Member of the Department's Graduate Committee, Department of Biomedical Sciences, Qatar University -2017–2019 - Learning Program Objectives (LPO) coordinator for the Master Program in Biomedical Sciences, College of Health Sciences, Qatar University -2013–2015 - Member of the Big Instruments Committee of the University of Sassari -2015–2017 - Member of the Academic Senate University of Sassari -2015-2017 - Member of the Department's Research Committee, Department of Biomedical Sciences, University of Sassari -2013–2015 - Member of the Internationalization Committee of the University of Sassari -2013-present – member of the Academic and Scientific Board of the Joint International MSc Program in Medical Biotechnology (university of Sassari, Sassari, Italy – University of Hue College of Medicine and Pharmacy, Hue, Vietnam) -2003-present – member of the Academic and Scientific Board of the International PhD Program in Life Sciences and Biotechnologies (university of Sassari, Sassari, Italy)
You need to be a good researcher in order to be a good teacher.
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