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Dr.Amir Ali Khan Academic RankAssistant Professor

Specialization:

  • Stem cells

Research Interests:

  • The roles of microRNAs and differential genes regulation in the differentiation of Mesenchymal stem cells into Adipocytes and Neural lineages.

Contact

Ph.D in human stem cells proteomics from University of Leeds, UK. B.Sc (honour) in human Genetics from University of Leeds, UK.
1st September 2013-To date: Assistant Professor at the Department of Applied Biology, University of Sharjah, UAE. April 2012-April 2013: Post-doctoral research fellow in Stem cells Biology, Department of Neuroscience, University of Sains Malaysia. 2010-2012 : Assistant Professor in Stem Cells Biology, Quaid-i-Azam University, Islamabad, Pakistan. Oct 2008-March 2009: Post PhD work in Stem cell Biology in the School of Medicine University of Leeds (UK).
Member of the University of Leeds Alumina.
2004-2008: Medical research Council (UK) studentship for PhD in stem cells at University of Leeds. 2010-2011: Gained an initial grant from Higher Education Commission (HEC) in Pakistan to initiate the human embryonic stem cells research at Quaid-i-Azam University, Islamabad. 2013-2015: Quantitative methylation of CG in the imprinting genes in the human mesenchymal stem cells at different passages, Seed grant (20,000 AED), University of Sharjah, UAE.
1): Huntriss, J., Hinkins, M., Khan, A.A., Picton, H.M. Microarray Analysis of Imprinted Gene Expression in Human Embryonic Stem Cells: Imprinted Genes as Biomarkers for Assessing Epigenetic poster presentation at EuroEpiStem: European Epigenomics & Stem Cells-2009 Meeting. Conference presentation 2): Huntriss J, Woodfine K, Huddleston J, Murrell A, Rutherford A, Elder K, Khan A.A, Hemmings K, Picton H.M: Quantitative Analysis of DNA Methylation of Multiple Imprinted Genes in Single Human Blastocysts by Pyrosequencing. Fertility and sterility. Volume 95, Issue 8, 30 June 2011, Pages 2564-2567. 3): Syeda Anum Zahra. Syed Raheel Muzavir, Humaira Zafar, Amir Ali Khan and Aftab Ahmad Khan: Stem cells therapy for spinal cord injury. The health 2012; 3 (1): 19-23. 4): Tee Jong Huat, Amir Ali Khan, Soumya Pati, Zulkifli Mustafa, Jafri Malin Abdullah, Hasnan Jaafar: IGF-1 enhances early differentiation of Bone Marrow Mesenchymal Stem Cell into Neural lineage. BMC Neuroscience, BMC Neurosci. 2014 Jul 22;15(1):91. doi: 10.1186/1471-2202-15-91. 5): Tee Jong Huat, Amir Ali Khan, Jafri Malin Abdullah, Fauziah Mohamad Idris and Hasnan Jaafar: MicroRNA expression profile of neural progenitor-like cells derived from mesenchymal stem cells under the influence of IGF-1, bFGF and EGF. Stem cell research. Int. J. Mol. Sci. 2015, 16(5), 9693-9718. 6): Tee Jong Huat, Amir Ali Khan, Jafri Malin Abdullah, Fauziah Mohamad Idris and Hasnan Jaafar: MicroRNA expression Profile of Bone Marrow Mesenchymal Stem Cells-derived Neural Progenitor Cells by microarray under the influence of EGF, bFGF and IGF-1. Genomics Data. Volume 5, September 2015, Pages 201–205. 7): Tee Jong Huat, Amir Ali Khan, Jafri Malin Abdullah & Hasnan Jaafar. MicroRNA profiling of the enhanced differentiation of mesenchymal stem cells into neural-like progenitor cells due to IGF-1 reveal specific miRNA signature. 19th National Conference of Medical and Health Sciences, page 28. Universiti Sains Malaysia, 8th - 9th September 2014. 8): Tee Jong Huat, Amir Ali Khan, Jafri Malin Abdullah, Fauziah Mohamad Idris & Hasnan Jaafar. MicroRNA expression profiling and functional network analysis upon enhanced neurogenic differentiation of mesenchymal stem cells suggest miR-22 as important regulator. International Conference on the Advancement in Science and Technology. International Islamic University Malaysia, 10th – 12th August 2015. 9): Tee Jong Huat, Putri Nur Hidayah Al-Zikri, Amir Ali Khan, Mohamed Faruque Reza, Jafri Malin Abdullah, Fauziah Mohamad Idris & Hasnan Jaafar. IGF-1, bFGF and EGF Induced Neural Progenitor-like Cells derived from MSCs Exhibit the Characteristics of Functional Pyramidal Neurons in 3-D Hydrogel Culture: A Preliminary Study. National Colloquium on Stem Cell Research. Universiti Sains Malaysia, 7th – 8th March 2015.
Tee Hunt (2013-Present): Micro profile of differentiation of mesenchymal stem cells into neural lineage, M.Sc Thesis, Department of neurosciences, Universiti Sains Malaysia. Mehtab Khan (2012): Analysis of SOX2 gene promoter in Leukemia patients. M. Phil thesis, Quaid-i-Azam University Islamabad, Pakistan. Humaira (2012): Analysis of SOX2 gene expression and determination of epigenetic modification in the gene promoter in leukemia patients. M. Phil Thesis, M. Phil thesis, Quaid-i-Azam University Islamabad, Pakistan. Syda Anum Zahra (2012): methylation analysis of upstream sequence of SOX2 gene in leukemia patients. M. Phil thesis, Quaid-i-Azam University Islamabad, Pakistan. Uzma Malik (2012): Analysis of OCT4 gene expression and determination of epigenetic modification in the gene promoter in leukemia patients. M.Phil Thesis, M. Phil thesis, Quaid-i-Azam University Islamabad, Pakistan. Mahira Arrooj (2012): NANOG gene expression and determination of epigenetic modification in the gene promoter in leukemia patients. M.Phil Thesis, M. Phil thesis, Quaid-i-Azam University Islamabad, Pakistan. Urooj Zahra (2011): Analysis of upstream promoter of OCT4 in general population. M. Phil thesis, Quaid-i-Azam University Islamabad, Pakistan. Rehman Khan (2011): Analysis of upstream promoter of SOX2 in general population. M. phil thesis, Quaid-i-Azam University Islamabad, Pakistan.
2004-2008 Medical research Council (UK) studentship for PhD in stem cells at University of Leeds
I am member of the following committees in the department of Applied Biology: Curriculum and accreditation committee: Recruitment committee Laboratory and safety committee Scientific committee Student advising and training committee
I have been Involved in the University teaching since 2010 and I have enjoyed it ever since. I have extensive teaching experience to both post-graduate and undergraduate students. Since September 2013, I have been teaching different courses to undergraduate as well as to master students in the department of applied Biology at University of Sharjah. To achieve excellence in teaching, good teachers should prepare themselves and deliver lecture materials in enjoyable and friendly manner. I prepare myself before every lecture to deliver good knowledge to students. To prepare myself, I read the latest materials in the relevant books and in the recent relevant journals. Good teachers should always encourage questions from their students and also encourage students to read widely about the subject. Furthermore, personal contact with students is essential to my approach as many students need encouragement to talk to their teachers, so I emphasize my availability for informal discussion and my willingness to help them to solve any problems they may have with their courses during the office hours. My experience as a teacher has greatly enriched by this contact with students. Apart from effective teaching, students should also be advised about the choice of their courses. Effective teachers should advise students on how to prepare their schedules and how to upgrade their accumulative averages. Apart from the encouraging and positive teaching environment, a good teacher should challenge students to different levels of learning. The learning experience can be effective to students if teachers encompass, during teaching, Bloom’s cognitive taxonomy which consists of six different dimensions (evaluation, synthesis, analysis, application, comprehension, and knowledge). I believe, using these different cognitive dimensions, teachers will equip students to acquire, understand, and comprehend subject matter that can be easily recalled in the future. Students’ evaluations and feedbacks should be taken as indicator of the teacher’s performance. Good teachers should alter teaching methodologies to take into account the comments of the students.
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