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Prof.Ihsan Ali Khlaif Al-Mahasenh Professor Academic Rank• Professor

Specialization:

  • Biotechnology & Genetic Engineering

Research Interests:

  • • Eukaryotic Genomics: DNA sequencing & human genotyping of the Arabian Tribal genealogy (covering the Arabian world) using the DNA Microsatellite platform for the STR genes of Y chromosome as per the Arabian geneographic landscape towards establishment of Gene Therapy platform • Prokaryotic Genomics: DNA sequencing of bacterial 16S rDNA gene for clinical & industrial strains, production of antibiotic actinorhodin (by Streptomyces coelicolor strain), citric acid (by Aspergillus niger), SCP & carotene (by Spirulina strain) & alginate from Nostoc strains, Rhodopsin (by Halobacterium Jordanicus) using fermentation technology

Contact

• Ph.D., Biotechnology & Genetic Engineering, University of Durham, England, U.K. 1988. • M.Sc. Microbiology, Yarmouk University, Jordan. 1984 • B.Sc. Biology, Yarmouk University, Jordan. 1984. • Higher Diploma in Medical Sciences, Medical Institute, Ministry of Health, Jordan. 1977
• Vice-President of Al al-Bayt University& Dean of Scienc College, Dean of Graduate Studies & Research (Mu’tah University) (1988-2011), • Dean of Community Colleges (5 campuses), Dean of College of Medicine, (University of Sharjah 2011-2016), • Professor (1988) & Distinguished Professor (2002). • 2011- Present, Professor of Biotechnology & Genetic Engineering, Department of Biotechnology, University of Sharjah, UAE. • 1994-20011 Professor (1998) and Associate of Biotechnology, Department of Biotechnology, AI al-Bayt University, Jordan (including 4 years 2001-2005 of Sabbatical leave in University of Qatar, Department of Biotechnology & Genetic Engineering. • 1993 Associate Professor, Department of Biological Sciences, Mu'tah University, Jordan. • 1988 Assistant Professor, Department of Biological Sciences, Mu'tah University, Jordan
• Distinctive International Research Contributor to the international Gene/Bank YHRD (Y-STR Haplotype Reference Database), University of Medicine, Berlin, Germany, since 2009. • Distinctive International Research Contributor to the international Gene/Banks of USA (NCBI), DNA Data Bank of Japan (DDBJ), Europe (EMBL), since 2011. • Colleague affiliation & member of Nobel-Prize Holders, New York Academy of Sciences, USA, 1997. • Colleague affiliation & Honorary Appointment to the Research Board of Advisors, American Biographical Institute, USA, 2002. • Honorary Appointment to the Research Board of Advisors, American Biographical Institute, USA, 2002. • Member of the British Society of Cell & Gene Therapy (BSCGT), 2013 • Member of the International Society of Genetic Genealogy (ISOGG), 2013 • Member of the Global Intellectual Society, 2013 • Member, Jordanian Biological Society, 1988 • Member, Arabian Biological Society, 1988 • Honorable Editor for International Journal of Molecular Biology 2016
• Chaired committees: more than 100 committee has been chaired. • Member of committees: more than 100 committee has been membered. • Member & Colleague of Nobel-Prize Holders, New York Academy of Sciences, USA, 1997. • Member (Honorary Appointment) of the Research Board of Advisors, American Biographical Institute, USA, 2002. • Member, Board of Trustees of Zytoona University, Jordan, 1998-2004 • Member, Research Board of Advisors , American Biographical Institute, USA, 2002. • Member, University Council, AL al-Bayt University 1994-2000 • Member, Deans Council, Mu’tah University, 1990-1994 • Member, Deans Council, Al al-Bayt University 1994-2010 • Member, Deans Council, University of Sharjah, 2011-2016 • Member, Governmental Interior Ministry Council of Jerash Province, Jordan, 1997-2000
My research is focusing on 2 parallel lines of DNA sequencing & genotyping models: • Sequencing of human DNA & genotyping: Genetic map analysis of the Arabian genome: a currently growing project since 1995 & contribution into the international Genographic project governed by the National Geographic Society Using the Genetic Analyzer ABI 310 & since 1995, which have established to developing of Arabian Genetic Map of Y-chromosome analysis for medical, forensic and genealogical applications. As a result of the scientific revolution on human genomics through the Human Genome Project (HGP), there have been a worldwide interest on the use of the analysis of the non-coding & non-recombined region of human Y chromosome known as the Short Tandem Repeats (Y-STRs) as a technological tool in human genotyping and identifications such as forensic human identification, social genetics, human populations and human geneography. This project has started since 1995 and we have been able to conduct analysis of Y-STRs analysis of (17 loci) for (2000) male sample which were collected from Arabian tribes and populations of (21) of Arab countries: (Egypt, Sudan, Morocco, Algeria, Tunisia, Libya, Somalia, Mauritania, Syria, Jordan, Palestine, Iraq, Lebanon, Yemen, Saudi Arabia, United Arab Emirates, Kuwait, Qatar, Bahrain, Oman). As yet, we have been able to provide a bioinformatics analysis of for such genomic platforms by accomplishment of Y-Haplogroup analysis as well as Haplotype analysis for a future atlas of the Arabian genomics encyclopedia. The Most Common Haplotypes was also constructed for each country, region and thus the Arab world as one population compared to other nations around the world. The data have been published in the International Haplotype Reference Database (YHRD) in the University of Medicine, Berlin, Germany and under the accession numbers of (YA003522) and (YA003523). • Sequencing of 16S rRNA gene of pathogenic bacteria & the antibiotic-producing Streptomyces coelicolor. Using the Genetic Analyzer ABI 310 for sequencing the 16S rRNA gene has led to establishment of new generation platforms of antibiotic against the multi-antibiotic-resistant pathogenic strains particularly the re-emerging Mycobacterium tuberculosis, a multi resistant strain as there are a worldwide problem of respiratory infections. Currently, there is a worldwide growing demand for production of a new generation of antibiotics particularly due to the increase of evolution of resistant pathogens and that the problem of multi-resistance is being progressively accelerated due to the misuse of the available antibiotics during several decays. Streptomycetes are being consider as one of medicine's most important microbes which produces most of the natural antibiotics in use today in addition to the production of natural anti-cancer and immune-suppressing compounds. Therefore, Sequencing of the 16S rRNA gene of the Streptomyces coelicolor will help our understanding and thus capabilities in genetic engineering of a future strain capable of production of a new generation of antibiotics against the Multi-resistant pathogens. This project has started since 2006 and we have been able to provide a conclusive sequence of the 16S rRNA gene of the novel wild type strain of Strepromyces coelicolor after had been isolated from the desert soil of Qatar. The Full gene sequence has been deposited in the International Gene/Banks/DDBJ/EMBL/NCBI and assigned an accession number of (AB588124). The data has been published in last 2011 (copy enclosed) and it does match the clone of Strepromyces coelicolor A3(2) as sequence by David A. Hopwood, of Johannes Centre in Norwich, and the Sanger Institute, U.K.
1. Mahasneh I. 2016. Human Biology ISBN: 978-994-813-992-5, PP288. University Book Shop, Sharjah, UAE. (www.universitybookshop.ae) . 2. Mahasneh I. 2015. Man & Environment. ISBN 978-994-818-459-1. PP 333. University Book Shop, Sharjah, UAE. (www.universitybookshop.ae) . 3. Mahasneh I.A. 2014. Genetic profiling of genealogical-cancers among Arabian population, 5th. National Conference, UAEGDA, 14-17-9-2014. 4. Mahasneh I.A. 2014. Bioinformatics analysis of the Arabian genomic landscape among Human Genetic Map of Y-chromosome. 3rd Annual Conference of Canadian Human & Statistical Genetics, 3-6/5. 5. Mahasneh I.A. 2013. Analysis of the STRs genes of Y-chromosome in the Arabian populations. UAE National Conference on Genetic Diseases. Proceedings: UAEGDA, p37. 6. Mahasneh I.A., R. F. Al-Thani, M. A. Abuannadi and M. A. Qandil. 2011. A Complete Sequence of The 16S rRNA Gene of A novel Streptomyces coelicolor (AB588124) (QU66C-2002) Isolated From The Soil Of Qatar . Biotechnology. Vol. 10 (2): 167-174. 7. Mahasneh I. 1994. Multi-antibiotic resistance pattern of 10 bacterial strains isolated from hospitalized patients of Prince Ali Hospital, Karak, Jordan. Biomedical Letters 50: 121-124. 8. Mahasneh I. 1992. Gastrointestinal pathogenic strains as fecal indicators of diarrhea in the urban and rural natural drinking water sources. Biomedical Letters 47: 347-354. 9. Mahasneh I. & Hello J. 1995. Antibiotic activity of natural products aginst multi-antibiotic-resistant bacteria (MRB) isolated fron Karak Hospital. Microbios 83: 23-36. 10. Al-Thani RF and Mahasneh I.A.2002. Atlas of the Pathogenic and non-pathogenic Strptomycetes in the soil of Qatar. pp.71. SARC, University of Qatar. 11. Mahasneh I.A.2002. Biodiversity of Qatar. pp.71. SARC, University of Qatar. 12. Mahasneh I., Al-Thani R.F. and Brown G. 2006. Profiling of the Sabkhat microbial contents in Qatar. Sabkha Ecosystem. Volume II: West and Central Asia, pp89-97. Springer. 13. Mahasneh I.A, Tiwari DN, Al-Thani RF and Qandeel M. 2004. Engineering of mutants of cyanobacterium Anabaena PCC 7120 constructed by DNA-plasmid transfer and UV-radiation resistant to Diuron. Biotechnologia Aplicada. Vol 1:13-15. 14. Mahasneh I. & Tiwari D.N. 1993. Transposon-induced mutants of the cyanobacterium Anabaena sp. PCC. 7120. Biotechnology letters 16 (8):765-770. 15. Mahasneh I. 1992. Biological Sciences-I (A University Text in Arabic/English version). 1st Ed. 211 p. Dar¬ Alshoroug Press, Amman, Jordan. 16. Mahasmeh I. 1992. Biological sciences-II. (A University Text in Arabic/English version). 1st Ed. 188p. Dar¬ Alshoroug Press, Amman, Jordan. 17. Mahasmeh I. 1997. Biological Sciences. (A University Text in Arabic/English version).P288 2nd Ed. Dar¬ Alshoroug Press, Amman, Jordan. 18. Mahasneh I. 1995. Biotechnology (Arabic version) 40p. Arab League, ALESCO, Tunnis. 19. Mahasneh I. & Babaker M 1998. Dictionary of Biotechnology. (Arabic-English version). 425p. Dar Ammar, Amman, Jordan. 20. تدرس عددا من كتبي المؤلفة بالعربية منذ بداية التسعينيات لطلبة السنة الاولى في الكليات الطبية والصحية والعلوم في العديد من الجامعات العربية في الاردن ودول الخليج العربي والسودان والشمال الافريقي. ولقد تم ترجمة بعضا منها الى الروسية والياباني والصينية نظرا لأهميتها.
• Thesis (48) • Graduation projects (14) • Links for Distinguished Contributions on International Research Platform: in Gene/Bank, International Journals, Books Publishers: 1. Honorable Editor of the International Journal of Molecular Biology (IJMBOA).(http://medcraveonline.com/IJMBOA/editorial-board), 2016 2. Genes Registration in the International DNA Gene Banks of the Nucleotide Sequence Database of GeneBanks of American National Center for Biotechnology Information (NCBI), DNA Data Bank of Japan (DDBJ), European Molecular Biology Laboratory (EMBL) and the. Gene Accession Numbers of AB588124 (www.ncbi.nlm.nih.gov), 2011. 3. Gene Registration in the International Haplotype Reference Database Gene/Bank of the Y-chromosome (YHRD) in the University of Medicine, Berlin, Germany. Gene Accession Numbers of (YA003522) and (YA003523) for The Arabian Genetic Map, 2009. (www.yhrd.org/search), 2009. 4. Human Biology ISBN: 978-994-813-992-5, PP288. University Book Shop, Sharjah, UAE. (www.universitybookshop.ae) , 2016. 5. Man & Environment. ISBN 978-994-818-459-1. PP 333. University Book Shop, Sharjah, UAE. (www.universitybookshop.ae) , 2015.
• Patency in Gene registration in International Gene Banks 1. Mahasneh I. 2011. Genes Registration in the International DNA Gene Banks of the Nucleotide Sequence Database of GeneBanks of American National Center for Biotechnology Information (NCBI), Japan (DDBJ), European Molecular Biology Laboratory (EMBL) and the. Gene Accession Numbers of AB588124 (www.ncbi.nlm.nih.gov). 2. Mahasneh I. 2009. Gene Registration in the International Haplotype Reference Database Gene/Bank of the Y-chromosome (YHRD) in the University of Medicine, Berlin, Germany. Gene Accession Numbers of (YA003522) and (YA003523) for The Arabian Genetic Map, 2009. (www.yhrd.org/search). DNA GeneBanks (NCBI/EMBL/DDBJ) www.ncbi.nlm.nih.gov -Genbank accession number:AB588124 -Genes(s)16r RNA gene - Genetic platform :Streptomyces coelicolor 2011 -GeneBanks: YHRD www.yhrd.org/Search -Genbank accession number :YA003522 -Gene(s):17 genes cluster -Genetic platform: Arabian Genetic Map of Y-chromosome, 2009 -YHRD www.yhrd.org/Search -Genbank accession number: YA003523 -Gene(s): 17 genes cluster -Genetic platform:Arabian Genetic Map of Y-chromosome, 2009
Awards and Recognitions: 1. Award of American Gold Medal of Honor for Distinguished Leadership, American Biographical Institute, USA, 2002. 2. Award Certificate for Distinguished Leadership, American Biographical Institute, USA, 2002. 3. Award Certificate of New York Academy of Sciences, USA for Outstanding Contribution in Research and Community Services, 1997. 4. Colleague affiliation of Nobel-Prize Holders, New York Academy of Sciences, USA, 1997. 5. Award Certificate of Research Board of Advisors , American Biographical Institute, USA, 2002. 6. Honorary Appointment to the Research Board of Advisors, American Biographical Institute, USA, 2002. 7. ORS Award (Overseas Research Award of British Universities), England, 1985. 8. ORS Award (Overseas Research Award of British Universities), England, 1986. 9. Award of Scientific Distinction, Yarmouk University), Jordan, 1984. 10. Award of Scientific Distinction of His Majesty King Hussein), Jordan, 1984. 11. Certificate of Recognition and Outstanding services in Mu'tah, Jordan. 1988-2000. 12. Certificate of Recognition and Outstanding services in Al-al-Bayt University, Jordan, 1994-2005. 13. Certificate of Distinction and Outstanding , University of Qatar, 2001-2005. 14. Certificate of Recognition and Outstanding services in Sharjah University 15. International Consultations in Biotechnology & Genetic Engineering: (UNESCO, UNDP, ALESCO, ESESCO, European Commission), 1990-present.
• Community Services organization & supervision: More than 500 events during the period of (2011-2016) in the (5) branches of the Community Colleges (Sharjah, Maleha, Khorfakan, Kalba, Dibba), University of Sharjah. • Public lecturing & international speaker: more than (100). • International & regional consultations: more than (50).
• To promote Self-learning approach based on practical, observations, analysis and discussion • To educate student how acquire skills of knowledge production rather than to intake information. Teaching: During the last 28 years, I have taught both Undergraduates (a total of (33courses) & (7 courses) for the Postgraduates: (Gene testing, Gene Therapy, Advanced Biotechnology , Advanced Genetic Engineering, Advanced Experiments in Biotechnology, Advanced Cell and Tissue Culture, Advanced Marine Biotechnology.
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