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Dr.Khalid Bajou Academic RankAssistant Professor

Specialization:

  • Biochemistry and Cell biology

Research Interests:

  • Structure and function of Plasminogen activator Inhibitor-1. Cancer biology and tumor micro-environment . Tumor Angiogenesis and metastasis.

Contact

Ph.D. in Science, October 25, 2001, University of Liège, Liege, Belgium. Dissertation title: Role of Plasminogen Activator Inhibitor-1 in tumor invasion and angiogenesis. (Supervisor, Professor J.M. Foidart). Master in Molecular and Cellular Biology, June 1992, University of Liège, Liege, Belgium
Assistant Professor, the Interdisciplinary Cluster for applied Genoproteomics (GIGA) Research Center, Cancer Department, College of Biomedical Science, University of Liege, Liege, Belgium, since July 2007. Postdoctoral fellow with Prof. Yves A. DeClerck, Division of Hematology-Oncology, Department of Pediatrics, Children’s Hospital Los Angeles, University of Southern California, Los Angeles. November 2002 – Jun 2007. Postdoctoral fellow with Prof. Agnes Noel, Department of Tumor and Developmental Biology, University of Liège, Liege, Belgium. October 2001 – October 2002. Ph. D student with Prof. Jean Michel Foidart, Department of Tumor and Developmental Biology, University of Liège, Liege, Belgium. September 1995 – September 2001. Research Position with Prof. Jose Remacle, Department of Biochemistry and Cellular Biology, University of Namur, (Belgium). October 1992 – August 1995.
- American Association for Cancer Research (active member). - The International Society on Thrombosis and Haemostasis (regular member) - International Proteolysis Society (regular member) - Belgian Association for Cancer Research (regular member) - Belgian Society for Cell and Developmental Biology (regular member)
Research Grant, Role of Prolactin 16K in tumor metastasis. Principal Investigator, from The Belgian Federal Science Policy, Brussels, Belgium, (July 2007 – Jun 2009). 200,000 Euro. Research Grant for Career Development, Research Associate, Plasminogen Activator type PAI-1 in neuroblastoma tumor, awarded by the Children’s Hospital Los Angeles, Los Angeles, July 2003 – Jun 2005. 80,000 $.
Bajou,K., Herkenne,S., Thijssen,V.L., D'Amico,S., N.guyen,N.Q.N., Bouché,A., Tabruyn,S., Srahna,M., Carabin,J.V., Nivelles,O., Paques,C., Cornelissen,I., Lion,M., Noel,A., Gils,A., Vinckier,S., Declerck,P.J., Griffioen,A.W., Dewerchin,M., Martial,J.A., Carmeliet,P. and Struman,I. PAI-1 mediates the anti-angiogenic and pro- fibrinolytic effects of 16K prolactin. Nat.Med., 2014 jul, 20, 741-747. I.F. =24.302. Bajou,K., Peng,W., Laug,W.E., Maillard,C., Noel,A., Foidart,J.M., Martial,J.A., DeClerck,Y.A. Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis. Cancer Cell, 2008, 14, 324-334 I.F. =24.962. Bajou,K., Maillard,C., Jost,M., Lijnen,R.H., Gils,A., Declerck,P., Carmeliet,P., Foidart,J..M., Noel,A. Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth. Oncogene, 2004, 23, 6986-90. I.F. =6.318. Bajou,K., Masson,V., Gerard,R.D., Schmitt,P.M., Albert,V., Praus,M., Lund,L.R., Frandsen,T.L., Brunner,N., Dano,K., Fusenig,N.E., Weidle,U., Carmeliet,G., Loskutoff,D., Collen,D., Carmeliet,P., Foidart,J.M., Noel,A. The Plasminogen Activator Inhibitor PAI-1 Controls In Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin. Implications for antiangiogenic strategies. J. Cell. Biol., 2001, 152, 777-784. I.F. = 12.915. Bajou,K., Noel,A., Gerard,R.D., Masson,V., Brunner,N., Holst-Hansen,C., Skobe,M., Fusenig,N.E., Carmeliet,P., Collen,D., Foidart,J.M. Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization. Nat. Med., 1998, 4, 923-928. I.F. = 28.114.
A pharmaceutical composition for treatment of thrombosis-related diseases comprising a fragment of prolactin (PRL)-growth hormone(GH) - placental lactogen (PL)-family protein., EP 2356998 A1, US20130035289, 2010, Europe. Struman,I., Bajou,K., D’Amico,S., Martial,J. University of Liege.
Van Beirs Prize, Fonds Léon Fredericq, Liege, Belgium, 2002. Lions Club Prize, University of Liege, Liege, Belgium, 2002 Adolphe Wetrems Prize, by the Royal Academy of Science, Literature and Art of Belgium, Brussels, Belgium, 2001. Alvarenga de Piauhy Prize by the Royal Academy of Medicine of Belgium, Brussels, Belgium. 2001. Best Poster Prize by the American Association for Cancer Research (Travel Grant Award), Nyborg, Denmark, June 14-18, 1998. Travel Award by AACR-AstraZeneca, American Association for Cancer Research, 97th Annual Meeting, Washington DC: April 1-5, 2006. Travel Award by The Gorgon Research Conferences, Plasminogen Activation and Extracellular Proteolysis, Ventura, CA: February 8-13, 2004. Post-Doc Fellowship Award by Rose and Jean Hoguet Foundation, Brussels, Belgium, 2002-2003, 2003-2004. Post-Doc Fellowship Award by the “CENTRE ANTICANCEREUX” Liège, Belgium, 2002 Post-Doc Fellowship Award by the “KANKEROLOGISCHE STICHTING ST-MICHIEL V.Z.W.” Foundation, Brussels, Belgium, 2002. Post-Doc Fellowship Award by the Rotary International District 1630, Belgium, 2002. Post-Doc Fellowship Award by the “Mr et Mm F. Braconnier-Lamarche”, Liege, Belgium, 2002. Travel Fellowship Award by “Agathon De Potter Foundation”, the Royal Academy of Science, Literature and Art of Belgium, Brussels, Belgium, 2002. Ph.D Fellowship Award by the “Fonds National de la Recherche Scientifique” (FNRS), Belgium. October 1997 – September 2001: Ph.D Fellowship Award by the “Centre Anticancereux” Liège, Belgium. October 1996 – September 1997:
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