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Dr. Abdeleziz Tlili Academic RankAssociate Professor

Research Interests:

  • 1. Identification of genes responsible for mendelian human diseases 2. Characterization and study of human mutations 3. Development of molecular therapy pathways

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Ph.D. Human Molecular Genetics/Biology Engineering, National School of Engineers of Sfax, TUNISIA, 2007. M.Sc. Biology Engineering, National School of Engineers of Sfax, TUNISIA, 2003. B.Sc. Natural Sciences, Faculty of Sciences of Sfax, TUNISIA. 2000.
2003-2008: Teaching Assistant /Faculty of Sciences of Sfax, TUNISIA 2009 - 2011 : Post-doctoral Fellowship at Pasteur institute - Paris - France 2008-2012: Assistant Professor at /Faculty of Sciences of Sfax, TUNISIA.. 2012-Present: Assistant Professor at Applied Biology, College of Sciences, University of Sharjah, Sharjah, UAE.
Teaching Research Undergraduate Advising
1. Study of two splice site variants detected in two UAE families with hearing loss
1-Al Mutery A, Mahfood M, Chouchen J, Tlili A. Genetic etiology of hereditary hearing loss in the Gulf Cooperation Council countries. Hum Genet. 2021 Aug 2. doi: 10.1007/s00439-021-02323-x. 2-M Mahfood, J Chouchen, WKEA Mohamed, A Al Mutery, R Harati, A Tlili. Whole exome sequencing, in silico and functional studies confirm theassociation of theGJB2mutation p.Cys169Tyr with deafness and suggesta role for theTMEM59gene in the hearing process. Saudi Journal of Biological Sciences. 2021 Aug;28(8):4421-4429. doi: 10.1016/j.sjbs.2021.04.036. Souissi, M. Ben Said, I. Ben Ayed et al., Novel pathogenic mutations and further evidence for clinical relevance of genes and variants causing hearing impairment in Tunisian population, Journal of Advanced Research, https://doi.org/10.1016/j.jare.2021.01.005 3-Harati R, Mohammad MG, Tlili A, El-Awady RA, Hamoudi R. Loss of miR-101-3p Promotes Transmigration of Metastatic Breast Cancer Cells through the Brain Endothelium by Inducing COX-2/MMP1 Signaling. Pharmaceuticals (Basel). 2020 Jul 7;13(7):144. 4-Mohamed WKE, Arnoux M, Cardoso THS, Almutery A, Tlili A. Mitochondrial mutations in non-syndromic hearing loss at UAE. Int J Pediatr Otorhinolaryngol. 2020 Aug 7;138:110286. Harati R, Hafezi S, Mabondzo A, Tlili A. Silencing miR-202-3p increases MMP-1 and promotes a brain invasive phenotype in metastatic breast cancer cells. PLoS One. 2020 Oct 1;15(10):e0239292 5-M. Gaidi, K. Daoudi, A. Tlili, S. Columbus, J. Leblanc-Lavoie, K. Ramachandran, B. Suleiman, A.N. Alhazaa, M.A. El Khakani. Fast, highly sensitive and label free detection of small genetic sequence difference of DNA using novel Surface-Enhanced Raman Spectroscopy nanostructured sensor, Sensing and Bio-Sensing Research. https://doi.org/10.1016/j.sbsr.2021.100406. 6-Chouchen J, Mahfood M, Alobathani M, Eldin Mohamed WK, Tlili A. Clinical heterogeneity of the SLC26A4 gene in UAE patients with hearing loss and bioinformatics investigation of DFNB4/Pendred syndrome missense mutations. Int J Pediatr Otorhinolaryngol. 2020 Nov 9:110467.
Biology has the well-earned reputation for being a hard subject. My goal is to make Biology understandable, relevant, and fascinating. Student comments and my course evaluations indicate that many students love my courses and that my teaching approaches were key to their learning. My teaching approaches include: • Making my learning goals for the students clear in the syllabus and on the first day of class and reminding students of those goals throughout the semester. • Preparing outlines for each class session: organize the material for that day, provide some illustrations, pose questions, include problems that we will work on in class, and leave lots of room for note taking. • Using a variety of presentation tools during class: work problems, PowerPoint slides, online movies.
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