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Prof.Raafat Abd El-Gawad El-Gharib El-Awady Academic RankProfessor


  • Pharmacology

Research Interests:

  • • Pharmacogenomics and individualized cancer therapy • Epigenetics and response of cancer cells to chemotherapy • Regulation of Cell cycle checkpoints and DNA repair • Induction and repair of DNA damage in mammalian cells • The regulation of homologous DNA recombination and non-homologous-end joining during the repair of DNA double-strand breaks


Bachelor of Pharmaceutical Sciences (Mai 1990) College of Pharmacy, Zagazig University, Egypt Master in Pharmaceutical Sciences/ Pharmacology (June 1996) Subject: “Chemosensitivity of certain tumour cell lines to topoisomerase inhibitors as determined by graded-field gel electrophoresis “ College of Pharmacy, Cairo University, Egypt PhD in Pharmacology (July 2000) Subject: “Concept of DNA double-strand breaks induction and repair for radiosensitivity of human tumour cells”. Cairo/Hamburg University (channel system)PhD
• Dean, College of Graduate Studies, University of Sharjah, UAE, 2017 till now • Acting Dean, College of Pharmacy, University of Sharjah, UAE - Sep 2016 – Feb 2017 and Sep 2020 – January 2021 • Professor of Pharmacology, College of Pharmacy, University of Sharjah, UAE – July 2016 to date • Professor of Pharmacology, National Cancer Institute, Cairo University, Egypt, 2013 • Associate Professor of Pharmacology, College of Pharmacy, Sharjah University, United Arab Emirates Aug 2006 – Aug 2008 • Associate Professor of Pharmacology, College of Pharmacy, King Khalid University, Kingdom Saudi Arabia October 2005 – July 2006 Sep 2002-Sep 2005 • Postdoc fellow, Experimental Oncology Department, School of Medicine, Hamburg University, Germany Jan 2000- Aug 2002 • Assistant Professor of Pharmacology and experimental Oncology, Cancer Biology Department, National Cancer Institute, Cairo University, Egypt Jun 1997-Oct. 1999 • Ph.D. fellow, Department of Experimental Oncology, School of Medicine, Hamburg University, Germany 1996-2000 • Lecturer of pharmacology, Cancer Biology Department, National Cancer Institute, Cairo University 1992-1996 • Demonstrator of pharmacology, Cairo University.
• Dean, College of Graduate Studies, University of Sharjah, UAE, 2017 till now • Acting Dean, College of Pharmacy, University of Sharjah, UAE - Sep 2016 – Feb 2017 and Sep 2020 – January 2021 • Chairman of the Department of Pharmacy Practice & Pharmacotherapeutics, College of Pharmacy, University of Sharjah, UAE 2012 – 2017 • Coordinator of Pharmacology and Clinical Drug Monitoring Unit, National Cancer Institute, Cairo University, Cairo, Egypt, 2005-2006 • Coordinator of the Drug Design & Discovery Research Group, College of Pharmacy, University of Sharjah: April 2015 – Sep 2017
- Member of the German DNA Repair Network. - Member in the Emirates Medical Association - International Scholarly research network Genetics Journal, Editor - International Journal of Medicine and medical sciences, Editor - Journal of costal life medicine, Editor - World Journal Surgical Oncology, reviewer - Carcinogenesis Journal, reviewer - International Journal of Oncology, reviewer - Saudi Medical Journal, reviewer
• Raafat El-Awady, Amr Amin, Aya Al-Azzawi and Hamadah Tarazi. Targeting Tyrosyl-DNA phosphodiesterase 1 enzyme with natural products as a potential method for improving efficacy of topoisomerase I inhibitors in cancer therapy. University of Sharjah, 2021 – 2023 • Raafat El-Awady, Timo Gemoll, Iman Talaat, Semrein Ahmed and Wafaa Ramadan. Investigating the role of the histone acetyltransferase CBP in orchestrating cellular response to genotoxic stress involved in breast tumorigenesis and response to chemotherapy. University of Sharjah, 2020 – 2022 • Raafat El-Awady, Iman Talaat, Riyad Bendardf, Wael Mansour and Abdel Hady A. Abdel Wahab. Histone Deacetylase 4& 6 as prognostic markers and therapeutic targets in Triple negative breast cancer. Collaborative research project University of Sharjah/Sharjah Research Academy. 2021 – 2023 • New inhibitors of protein tyrosine phosphatase (SHP2) as potential anti-cancer compounds. University of Sharjah, 2018 – 2020 • Discovery of first-In-Class lead drug candidates for the treatment of multidrug resistant bacteria. Islamic Development Bank, 2018 – 2020
• Mouffak S., Shubbar Q., Saleh E., El-Awady R. Recent advances in management of COVID-19: A review. Biomedicine and Pharmacotherapy Volume 143November 2021 Article number 112107. DOI 10.1016/j.biopha.2021.112107 • Ramadan WS, Talaat IM, Hachim MY, Lischka A, Gemoll T, El-Awady R. The impact of CBP expression in estrogen receptor-positive breast cancer. Clin Epigenetics. 2021 Apr 7;13(1):72. doi: 10.1186/s13148-021-01060-2.PMID: 33827682 • El-Awady, R., Saleh, E., Hamoudi, R., ...Menon, V., Al-Tel, T.H. Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents Bioorganic and Medicinal Chemistry, 2021, 42, 116251 • Zaher, D.M., Ramadan, W.S., El-Awady, R., ...Ibrahim, S.M., Al-Tel, T.H. A novel benzopyrane derivative targeting cancer cell metabolic and survival pathways Cancers, 2021, 13(11), 2840 5. Schilf, P., Srinivasulu, V., Bolognesi, M.L., ...El-Awady, R., Al-Tel, T.H. Design and synthesis of nature-inspired chromenopyrroles as potential modulators of mitochondrial metabolism Medicinal Chemistry Research, 2021, 30(3), pp. 635–646 • Menon, V., Elgharib, M., El-awady, R., Saleh, E. Ginger: From serving table to salient therapy. Food Bioscience, 2021, 41, 100934 • Vazhappilly CG, Hodeify R, Siddiqui SS, Laham AJ, Menon V, El-Awady R, Matar R, Merheb M, Marton J, Al Zouabi HAK, Radhakrishnan R. Natural compound catechol induces DNA damage, apoptosis, and G1 cell cycle arrest in breast cancer cells. Phytother Res. 2021 Apr;35(4):2185-2199. doi: 10.1002/ptr.6970. Epub 2020 Dec 7.PMID: 33289235 • Murali C, Mudgil P, Gan CY, Tarazi H, El-Awady R, Abdalla Y, Amin A, Maqsood S. Camel whey protein hydrolysates induced G2/M cellcycle arrest in human colorectal carcinoma. Sci Rep. 2021 Mar 29;11(1):7062. doi: 10.1038/s41598-021-86391-z.PMID: 33782460 • El-Gamal MI, Zaraei SO, Foster PA, Anbar HS, El-Gamal R, El-Awady R, Potter BVL. A new series of aryl sulfamate derivatives: Design, synthesis, and biological evaluation. Bioorg Med Chem. 2020 Apr 15;28(8):115406. doi: 10.1016/j.bmc.2020.115406. Epub 2020 Mar 3. PMID: 32173116 • Abdu-Allah HHM, Abdelmoez AAB, Tarazi H, El-Shorbagi AA, El-Awady R Conjugation of 4- aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids. Bioorg Chem. 2020 Jan;94:103378. doi: 10.1016/j.bioorg.2019.103378. Epub 2019 Oct 24.PMID: 31677858
• Supervision of 5 M.Sc thesis in pharmacology (Cairo, Ain Shams and El- Azhr Universities - Egypt) – 2000- 2002 and 2005 – 2008 • Supervision of 3 M.D thesis in school of medicine-Hamburg University (2002-2005) • Supervision of one PhD in Pharmacology, College of Pharmacy – Cairo University (2012 – 2017) • Supervision of different pharmacy students graduation projects (2008 – 2017) • Supervision of twelve master thesis, Molecular Medicine & Translational research program, College of Medicine, University of Sharjah, UAE (2012 – 2020) • Supervision of three Ph.D. thesis, Molecular Medicine & Translational research program, College of Medicine, University of Sharjah, UAE (2017 – current)
Annual Incentive Award of University of Sharjah for outstanding faculty in the field of research 2013/2014 Annual Incentive Award of University of Sharjah for outstanding faculty in the field of research 2010/2011 Sharjah Islamic Bank award for the best research paper 2009/2010 Post-doc scholarship in School of Medicine, Hamburg University 2002-2005 Cairo University Award for the best PhD thesis 2001 DAAD PhD scholarship (Hamburg University/Germany) 1996 - 1999
Over the past 20 years I have had the opportunity to construct, coordinate and sustain numerous basic and clinical pharmacology syllabi in different universities at both under- and postgraduate levels. It is from this history that I have drawn my own teaching philosophy. My teaching philosophy is that teaching is a two-way process. Both students and teacher should come to the classroom with high expectations of each other and put in their best efforts. This means that students should be engaged in the lecture and the teacher's role is to guide, providing access to information rather than acting as the primary source of information. I see the instructor, students, and the selected course material all playing pivotal roles in the success of any class. In all programs, I focus on three issues; communication, critical thinking and application of evidence-based pharmacotherapy. I facilitate oral communication through presentations, topic discussions, and pharmacotherapeutic care plan discussions- and written communication through journal clubs, and formal drug information questions. I model and ask learners to think about their thought processes regarding common occurrences in practice I always try to make my students to realize their full potential and expect a lot from themselves. This can be achieved through creating a stimulating atmosphere allowing the student's natural curiosity to direct their learning. Another side that I strongly believe in as a very important part of the teacher’s job is to promote the learner’s respect for all things and all people. To assist the learners keeping their passion and motivation at the top, I must keep my knowledge always updated, growing and developed. I always seek out educational and research opportunities that directly apply to my areas of practice: both educational and administrative Finally, I view research as an extension of my teaching. It serves to educate students and to reinforce my personal commitment to learning. Likewise, I am deeply dedicated to increasing my own understanding of the subject matter I teach. I design my research projects to have particular relevance to my courses, and I continually look for ways to push my own knowledge base, which is essential for teaching such an evolving discipline. I will absolutely continue my habit of gaining and incorporating research experience into my pharmacology courses, which I value equally to information acquired from published reports and scholarly articles.
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