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Prof.Hany A. Omar Chair Academic RankProfessor
Hany A. Omar

Specialization:

  • Molecular Pharmacology and Therapeutics

Research Interests:

  • Molecular mechanisms of anticancer drugs, Treatment of hepatocellular carcinoma, Molecular pharmacology as a basis for cardiovascular drugs development, Oxidative stress and antioxidants implication in the pathophysiology of clinical disorders

Contact

- Ph.D (Molecular Pharmacology) Ohio State University, Columbus, Ohio, USA 2010. - M.Sc (Pharmacology and Toxicology) Faculty of Pharmacy, Cairo University, Egypt 2005 - Bachelor of Science (Pharmacy) Faculty of Pharmacy, Cairo University, Egypt 2005
- 2013-Current College of Pharmacy, University of Sharjah, Sharjah, UAE - 2012-2013 College of Pharmacy, Taif University, Taif, KSA - 2010-2012 Faculty of Pharmacy, Beni-Suef University, Egypt. - 2006-2010 College of Pharmacy, Ohio State University, Ohio, USA - 1999- 2005 Faculty of Pharmacy, Cairo University, Beni-Suef campus, Egypt.
- Member of editorial boards and program committees of many international journals - Member of the Research Ethics Committee Of the University of Sharjah - Member of the College of Pharmacy University of Sharjah Scientific Committee.
- American Association for Cancer Research (AACR) - European Association for Cancer Research (EACR). - The American Association of Pharmaceutical Scientists. - American Society Clinical Pharmacology Therapeutics. - American Society for Biochemistry and Molecular Biology.
• 2020: The winner of 80,000 AED grant as a PI for a research proposal from University of Sharjah (#2001110341). Title: "Combinatorial therapeutic approach to synergize the antitumor activity of sorafenib in hepatocellular carcinoma via the inhibition of RhoA/ROCK pathway", November 2020 • 2019: The winner of 40,000 AED grant as a PI for a graduate student (Dana Zaher) research grant from University of Sharjah. Title: "The role of metabolic reprogramming in the sensitivity of breast cancer to chemo- and immunotherapy", October 2019. • 2018: The winner of 300,000 AED grant as a PI for a research proposal from Al-Jalila Foundation (#AJF2018050). Title: "Metabolic Reprogramming as a Novel Approach to Sensitize Cancer Cells to Immunotherapy", October 2018 Link (Page 30) • 2018: The winner of 1,200,000 USD grant as a Co-PI for a research proposal from Islamic Development Bank, Jeddah, Saudi Arabia. Title: "Discovery of first-In-Class lead drug candidates for the treatment of multidrug-resistant bacteria", October 2018 •2018: The winner of 80,000 AED grant as a PI for a research proposal from University of Sharjah (#15011103001-P). Title: "Counteracting the multidrug resistance in breast cancer cells via interfering nuclear factor (NF)-kB signaling", September 2018 • 2018: The winner of 200,000 AED grant as a Co-PI for a research proposal from University of Sharjah. Title: "Exploring mechanisms of 5FU-resistance in colorectal cancer cells with DNA mismatch repair", September 2018 • 2018: The winner of 600,000 AED grant as a Co-PI for a research proposal from The American University of Sharjah, Biosciences and Bioengineering Research Institute (BBRI). Title: "Design and Synthesis of first-in-class Nature-Inspired Compounds: Targeting Mitochondrial Metabolism as Novel Anti-cancer Treatment", September 2018 • 2018: The winner of 200,000 AED grant as a Co-PI for a research proposal from University of Sharjah. Title: "Design and development, Proteomics analysis and In vivo studies of novel anticancer lead drug candidates", May 2018 • 2018: The winner of 80,000 AED grant as a Co-PI for a research proposal from University of Sharjah. Title: "Design, Synthesis, and Biological Evaluation of Sulfonate and Sulfamate Derivatives of Raloxifene as Potential Anticancer Agents", May 2018 •2016: The winner of 273,000 AED grant as a PI for a research proposal from Al-Jalila Foundation (#AJF201610). Title: "Energy Restriction as a Novel Approach Targeting Cancer Stem Cells Multi-Drug Resistance", October 2016 • 2015: The winner of 266,000 AED grant as a Co-PI for a research proposal from Al-Jalila Foundation (#AJF201531). Title: "Targeting Breast and Prostate Cancer: Design and Synthesis of Novel and Privileged polycyclic pyrido[1,2-a] quinolinones, Benzopyranes and Benzoxepines Motifs", October 2015 • 2015: The winner of 150,000 AED grant as a PI for a research proposal from University of Sharjah (#15011103001-P). Title: "Anti-tumor activity of novel metformin and glitazone-derived energy restriction mimetic agents", June 2015 • 2015: The winner of 110,300 AED grant as a Co-PI for a research proposal from University of Sharjah (#1501090206-P). Title: "Prevalence of statin-induced myopathy SLCO 1B1 gene polymorphism in Emirati population", June 2015 • 2014: The winner of 245,000 AED grant as a PI for a research proposal from Al-Jalila Foundation (#AJF201424). Title: "OSU-2S Combinatorial Approach, the Next Level in Tackling Cancer Cell Survival", August 2014. link (Page 23) • 2014: The winner of 34,000 AED grant as a PI for a student graduation project proposal from Boehringer Ingelheim pharmaceutical company. Title: "Pre-clinical investigation of novel metformin derivatives as energy restriction mimetic anticancer agents" • 2013: The winner of 107,000 SR grant as a PI for a research proposal from Taif University Vice-Presidency for Graduate Studies and Research (#1-434-2863). Title: "The Ability of Novel Energy Restriction Mimetic Agents to target Colorectal Cancer", March 2013. • 2013: The winner of 86,000 SR grant as a Co-PI for a research proposal from Taif University Vice-Presidency for Graduate Studies and Research (#1-434-2773). Title: "Design, Synthesis and Biological Evaluation of Novel Cyclooxygenase-II Inhibitors for the Treatment of Colorectal Cancer", March 2013.
1- Shifaa M. Abdina, Mai F. Tolba, Dana M. Zaher, Hany A. Omar*. Nuclear factor-κB signaling inhibitors revert multidrug-resistance in breast cancer cells  Chemico-Biological Interactions, 2021 May 1: 340: 109450; https://doi.org/10.1016/j.cbi.2021.109450 2- Dana MZ, Wafaa S. Ramadan, Raafat El-Awady, Hany A. Omar, Fatema Hersi, Vunnam Srinivasulu, Ibrahim YH, Farah Al -Marzooq, Cijo GV, Salim Merali, Carmen Merali, Nelson C. Soares, Paul Schilf, Saleh M. Ibrahim, Taleb H. Al-Tel. A Novel benzopyrane derivative targeting cancer cell metabolic and survival pathways. 2021 Cancers 2021, 13, 2840 https://doi.org/10.3390/cancers13112840 3-Noura Khaiwa, Noor R. Maarouf, Mhd H. Darwish, Dima W.M. Alhamad, Anusha Sebastian, Mohamad Hamad, Hany A. Omar, GorkaOrive, Taleb H.Al-Tel Camptothecin's Journey from Discovery to WHO Essential Medicine: Fifty Years of Promise. European Journal of Medicinal Chemistry, 2021, Nov 5;223: 113639 https://doi.org/10.1016/j.ejmech.2021.113639 4- Khuloud Bajbouj, Rakhee Ramakrishnan, Maha Saber-Ayad, Hany A. Omar, Narjes Sharif-Askari, Jasmin Shafarin, Adel Elmoselhi, Ahmed Ihmaid, Suhib Al Haj Ali, Abdulla Alalool, Reem Abdullah, Qutayba Hamid. PRMT5 Selective Inhibitor Enhances Therapeutic Efficacy of Cisplatin in Lung Cancer Cells. International Journal of Molecular Sciences, 2021, 22, 6131. https://doi.org/10.3390/ijms22116131 5- Jui-Hsiang Hung, Han-Yi Cheng, Yung-Chieh Tsai; Hsien-An Pan; Hany A. Omar, Chien-Chih Chiu; Yin-Mei Su; Yung-Ming Lin, Yen-Ni Teng. LRWD1 expression is regulated through DNA methylation in human testicular embryonal carcinoma cells. Basic and Clinical Andrology, 2021 May 20;31(1):12 https://doi.org/10.1186/s12610-021-00130-y 6- Leen M Eldohaji, Bahgat Fayed, Alshaimaa M Hamoda, Mai Ershaid, Shifaa Abdin, Tasneem B Alhamidi, Mohammad G Mohammad, Hany A. Omar, Sameh S M Soliman. Potential targeting of Hep3B liver cancer cells by lupeol isolated from Avicennia marina. Arch Pharm (Weinheim) . 2021 Jun 4;e2100120. https://doi.org/10.1002/ardp.202100120 7- Shaden A. M. Khalifa, Mohamed H. Elashal, Nermeen Yosri, Ming Du, Syed G. Musharraf, Lutfun Nahar, Satyajit D. Sarker, Zhiming Guo,Wei Cao, Xiaobo Zou, Aida A. Abd El-Wahed, Jianbo Xiao, Hany A. Omar, Mohamed-Elamir F. Hegazy and Hesham R. El-Seedi. Bee Pollen: Current Status and Therapeutic Potential.Nutrients 2021, 13(6), 1876; https://doi.org/10.3390/nu13061876 8-Samir A. Salama, and Hany A. Omar. Modulating NF-κB, MAPK, and PI3K/AKT signaling by ergothioneine attenuates iron overload-induced hepatocellular injury in rats. Journal of Biochemical and Molecular Toxicology 2021 Feb 13:e22729; https://doi.org/10.1002/jbt.22729 9- Bushra Mdkhana, Dana M. Zaher, Shifaa M. Abdin, and Hany A. Omar*. Tangeretin boosts the anticancer activity of metformin in breast cancer cells via curbing the energy production. Phytomedicine 2021, Jan; 83: 153470. https://doi.org/10.1016/j.phymed.2021.153470 10- Dima W. Alhamad, Sara M. Elgendy, Taleb H. Altel, Hany A. Omar*. Tangeretin as an adjuvant and chemotherapeutic sensitizer against various types of cancers, a comparative overview. Journal of Pharmacy and Pharmacology 2021, Mar 27;73(5):601-610 https://doi.org/10.1093/jpp/rgab013 11- Shatha K. Alyammahi, Shifaa M. Abdin, Dima W. Alhamad, Sara M. Elgendy, Amani T. Altell, Hany A. Omar*. The dynamic association between COVID-19 and chronic disorders: An updated insight into prevalence mechanism and therapeutic modalitie. Infection, Genetics and Evolution 2021, Jan; 87: 104647. https://doi.org/10.1016/j.meegid.2020.104647 12-RM Sbenati , SO Zaraei, MI El-Gamal, HS Anbar, H Tarazi, MM Zoghbor, NA Mohamood, MM Khakpour, DM Zaher, Hany A. Omar, NN Alach, MK Shehata, and R El-Gamal. Design, synthesis, biological evaluation, and modeling studies of novel conformationally-restricted analogues of sorafenib as selective kinase-inhibitory antiproliferative agents against hepatocellular carcinoma cells. European Journal of Medicinal Chemistry 2021, Jan 15;210:113081. https://doi.org/10.1016/j.ejmech.2020.113081 13- Schilf P, Srinivasulu V, Bolognesi ML, Ibrahim S, Majdalawieh A, Abu-Yousef IA, Omar, HA, ElAwady R, Al-Tel TH. Design and synthesis of nature-inspired, chromenopyrroles as potential modulators of mitochondrial metabolism. Medicinal Chemistry Research, 2021, Nov 30, 635–646 https://doi.org/10.1007/s00044-020-02669-3 14- PS Chen , HP Hsu , NN Phan , MC Yen , FW Chen , YW Liu , FP Lin , SY Feng , TL Cheng , PH Yeh, Hany A. Omar , Z Sun , J Jiang , YS Chan , MD Lai , JH Hung. CCDC167 as a potential therapeutic target and regulator of cell cycle-related networks in breast cancer. Aging 2020; doi.org/10.18632/aging.202382 https://doi.org/10.18632/aging.202382 15- Soliman S, Alhamidi T, Abdin S, Almehdi A, Semreen M, Alhumaidi R, Shakartalla S, Haider M, Husseiny M, Omar H. Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites. PloS ONE, 2020 Oct 6;15(10):e0240156 https://doi.org/10.1371/journal.pone.0240156 16- Sara M. Elgendy, Shatha K. Alyammahi, Dima W. Alhamad, Shifaa M. Abdin, Hany A. Omar*. Ferroptosis: An emerging approach for targeting cancer stem cells and drug resistance. Critical Reviews in Oncology/Hematology, 2020, Nov; 155: 103095 https://doi.org/10.1016/j.critrevonc.2020.103095 17- Shifaa M. Abdina, Sara M. Elgendy, Shatha K. Alyammahi, Dima W. Alhamad, Hany A. Omar*. Tackling the cytokine storm in COVID-19, challenges, and hopes. Life Sciences, 2020, Jul 11;257:118054 https://doi.org/10.1016/j.lfs.2020.118054 18- El-Shaimaa A. Arafa, Wafaa R. Mohamed, Dana M. Zaher, Hany A. Omar*. Gliclazide attenuates acetic acid-induced colitis via the modulation of PPARγ, NF-κB and MAPK signaling pathways. Toxicology and Applied Pharmacology, 2020, Feb, 391, 114919 https://doi.org/10.1016/j.taap.2020.114919 19- Fatema Hersi, Hany A. Omar*, Raed A. Al-Qawasmeh, Zainab Ahmad, Areej M. Jaber, Dana M. Zaher, Taleb H. Al-Tel. Design and synthesis of new energy restriction mimetic agents: Potent anti-tumor activities of hybrid motifs of aminothiazoles and coumarins. Scientific Reports, 2020, Feb 19;10(1):2893. https://doi.org/10.1038/s41598-020-59685-x 20- Ahmed H. Abdelazeem, Alaa M. Alqahtani, Hany A. Omar, Syed Nasir Abbas Bukhari, Ahmed M.Gouda. Synthesis, biological evaluation and kinase profiling of novel S-benzo[4,5]thiazolo[2,3-c][1,2,4]triazole derivatives as cytotoxic agents with apoptosis-inducing activity. Journal of Molecular Structure, 2020, Nov, 1219, 128567 https://doi.org/10.1016/j.molstruc.2020.128567 21- Shahira El-Menshawe, Heba Abou Taleb, Mina Saweris, Dana Zaher, Hany A. Omar*. The Use of New Quinazolinone Derivative and Doxorubicin Loaded Solid Lipid Nanoparticles: An Investigation into the Influence of Lipids and Surfactant in Controlling the Criteria of Developed Vesicles and Reversal of Drug Resistance. Journal of Drug Delivery Science and Technology, 2020, Feb, 56; 101569. https://doi.org/10.1016/j.jddst.2020.101569 22- Dana M. Zaher, Mohammed I. El-Gamal, Hany A. Omar *, Sarah N. Aljareh , Salma A. Al-Shamma, Aya J. Ali, Sumera Zaib, and Jamshed Iqbal, Recent advances of alkaline phosphatase isoenzymes and their inhibitors. Archiv der Pharmazie, 2020 https://doi.org/10.1002/ardp.202000011 . 23- Mohammed I.El-Gamal, Hany A. Omar*, Mohammad H. Semreen, Israa A.Younes, Youmna Y.Zaghloul, Ayat E.Abbas, Iman G.Moussa, Fatima Hersi, Chang-Hyun Ohe, Antiproliferative activity of cycloalkanecarboxamide derivatives possessing sulfonate or sulfamate moiety. Bioorganic Chemistry, February 2020, 97; 103677. https://doi.org/10.1016/j.bioorg.2020.103677 24- Nour Moussa-Pacha, Shifaa Abdin, Hany A. Omar, Hasan Alniss, Taleb H. Al-Tel. BACE1 Inhibitors: Current status and future directions in treating Alzheimer's disease. Medicinal Research Reviews, 2020, Jan;40(1):339-384. https://doi.org/10.1002/med.21622 25- Srinivasulu, V; Khanfar, A.; Omar, Hany; ElAwady, R; Sieburth, S; Sebastian, A; Zaher, D; Al Marzooq, F; Hersi, F; Al-Tel, T. Sequencing [4+1]-Cycloaddition and Aza-Michael Addition Reactions: A Diastereoselective Cascade for the Rapid Access of Pyrido[2',1':2,3]/Thiazolo[2',3':2,3]imidazo[1,5-a]quinolone Scaffolds as Potential Antibacterial and Anticancer Motifs. Journal of Organic Chemistry 2019 Nov 15;84(22):14476-14486 https://doi.org/10.1021/acs.joc.9b01919 26- Hany A. Omar*, Ahmed T. El-Serafi, Fatema Hersi, El-Shaimaa A. Arafa, Dana M. Zaher, Mohamed Madkour, Hany H. Arab and Mai F. Tolba. Immune-Modulatory MicroRNAs and Cancer Immune Evasion. The FEBS Journal, 2019, Jul 15. ; 286 (18): 3540–3557 https://doi.org/10.1111/febs.15000 27- El-Gamal MI, Ullah S, Zaraei SO, Jalil S, Zaib S, Zaher DM, Omar HA, Anbar HS, Pelletier J, Sévigny J, Iqbal J. Biological evaluation and docking studies of new raloxifene sulfonate or sulfamate derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase. European Journal of Medicinal Chemistry, 2019, Nov 1;181:111560 https://doi.org/10.1016/j.ejmech.2019.07.063 28- Khaled R.A. Abdellatif, Wael A.A. Fadaly, Yaser A. Mostafa, Dana M. Zaher, Hany A. Omar. Thiohydantoin derivatives incorporating a pyrazole core: Design, synthesis and biological evaluation as dual inhibitors of topoisomerase-I and cycloxygenase-2 with anti-cancer and anti-inflammatory activities. Bioorganic Chemistry, 2019, Jul 19;91:103132 https://doi.org/10.1016/j.bioorg.2019.103132 29- Mai F. Tolba, Hany A. Omar*, Fatima Hersi, Ane C. F. Nunes, Ayman M. Noreddin. The impact of Catechol-O-methyl transferase knockdown on the cell proliferation of hormone-responsive cancers. Molecular and Cellular Endocrinology, 2019 May; 488: 79-88 https://doi.org/10.1016/j.mce.2019.03.007 30- Hany A. Omar*, Mai F. Tolba. Tackling molecular targets beyond PD-1/PD-L1: Novel approaches to boost patients' response to cancer immunotherapy. Critical Reviews in Oncology/Hematology, 2019, Mar;135:21-92 https://doi.org/10.1016/j.critrevonc.2019.01.009 31- Pao-Lin Kuo, Jie-Yun Tseng, Hau-Ing Chen, Chia-Yun Wu, Hany A Omar, Chia-Yih Wang, Han-Yi Cheng, Chao-Chin Hsu, Tzu-Fun Fu, Yen Ni Teng. Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells. Biochimie, 2019 Mar;158:1-9 https://doi.org/10.1016/j.biochi.2018.11.018 32- Srinivasulu V, Schilf P, Ibrahim S, Khanfar MA, Sieburth SM, Omar Hany, Sebastian A, AlQawasmeh RA, O'Connor MJ, Al-Tel TH. Multidirectional Desymmetrization of Pluripotent Building Block en Route to Diastereoselective Synthesis of Complex Nature-Inspired Scaffolds. Nature Communication 2018, Nov 26;9(1):4989. https://doi.org/10.1038/s41467-018-07521-2 33- Wei-De Wu, Pin-Shern Chen, Hany A. Omar, El-Shaimaa Arafa, Hung-Wei, Pan, Jing-Yueh Jeng, Jui-Hsiang Hung. Antrodia cinnamomea boosts the anti-tumor activity of sorafenib in xenograft models of human hepatocellular carcinoma. Scientific Reports 2018, Aug 27;8(1):12914 https://doi.org/10.1038/s41598-018-31209-8 34- Rasha M. Hussein, Wafaa R. Mohamed, Hany A. Omar. A neuroprotective role of kaempferol against chlorpyrifos-induced oxidative stress and memory deficits in rats via GSK3β-Nrf2 signaling pathway. Pesticide Biochemistry and Physiology 2018 Nov;152:29-37 https://doi.org/10.1016/j.pestbp.2018.08.008 35- San-Yuan Chen, Ying-Ray Lee, Ming-Chia Hsieh, Hany A. Omar, Yen-Ni Teng, Ching-Yen Lin, Jui-Hsiang Hung. Enhancing the anticancer activity of Antrodia cinnamomea in hepatocellular carcinoma. Frontiers in Pharmacology 2018 Jul; 9: 780 https://doi.org/10.3389/fphar.2018.00780 36- Hany A. Omar* and Mai F. Tolba. Caffeic acid phenethyl ester guards against benign prostate hypertrophy in rats: Role of IGF-1R/ Protein Kinase-B (Akt)/ β-catenin signaling. IUBMB Life2018 Mar; 70(6):519-528 https://doi.org/10.1002/iub.1743 37- J.H. Hung, S.K Wee, H.A. Omar, C.H Su, P.S. Chen, C.C. Chiu, M.S. Wu, Y.N. Teng. Nuclear factor erythroid-2-related factor regulates LRWD1 expression and cellular adaptation to oxidative stress in human embryonal carcinoma cells. Biochimie, 2018 May;148:99-106 https://doi.org/10.1016/j.biochi.2018.03.001 38- S.A. Abdelatef, M.T. El-Saadi, N.H. Amin, A.H. Abdelazeem, Hany A. Omar, K.R.A. Abdellatif. Design, Synthesis and Anticancer Evaluation of Novel Spirobenzo[h]chromene and Spirochromane Derivatives with Dual EGFR and B-RAF Inhibitory activities. European Journal of Medicinal Chemistry, 2018 May;150:567-578 https://doi.org/10.1016/j.ejmech.2018.03.001 39- Salama SA, Arab HH, Omar HA, Gad HS, Abd-Allah GM, Maghrabi IA, Al Robaian MM. L-carnitine mitigates UVA-induced skin tissue injury in rats through downregulation of oxidative stress, p38/c-Fos signaling, and the proinflammatory cytokines. Chemico-Biological Interactions, 2018, Apr;285:40-47 https://doi.org/10.1016/j.cbi.2018.02.034 40- Soliman S, Mohammad MG, El-Keblawy AA, Omar HA, Abouleish M, Madkour M, Elnaggar A, Hosni RM. Mechanical and phytochemical protection mechanisms of Calligonum comosum in arid deserts. PloS ONE, 2018 Feb 7;13(2): e0192576. https://doi.org/10.1371/journal.pone.0192576 41- Shifaa M. Abdin, Dana M. Zaher, El-Shaimaa A. Arafa and Hany A. Omar*. Tackling the cancer resistance by immunotherapy: Updated clinical impact and safety of PD-1/PD-L1 inhibitors. Cancers, 2018, Jan 10(2), 32; https://doi.org/10.3390/cancers10020032 42- Mai F. Tolba and Hany A. Omar*, Immunotherapy, an evolving approach for the management of triple negative breast cancer: converting non-responders to responders. Critical Reviews in Oncology/Hematology, 2018, Feb;122:202-207 https://doi.org/10.1016/j.critrevonc.2018.01.005 43- Abdel-Nasser El-Shorbagi, Mohamed El-Naggar, Hamadeh Tarazi, Sachin Chaudhary, Hajjaj Abdu-Allah, Fatema Hersi, Hany A. Omar. Bis-(5-substituted-2-thiono-1,3,5-thiadiazinan-3-yl) butane as a scaffold of anti-proliferative activity, blended by a multicomponent process. Medicinal Chemistry Research, 2018, Apr;27: 1103–1110 https://doi.org/10.1016/S0223-5234(97)89645-6 44- Hany A. Omar*, Dana M. Zaher, Vunnam Srinivasulu, Fatema Hersi, Hamadeh Tarazi, Taleb H. Al-Tel. Design, synthesis and biological evaluation of new pyrrolidine carboxamide analogues as potential chemotherapeutic agents for hepatocellular carcinoma. European Journal of Medicinal Chemistry, 2017 Oct 20; 139:804-814. https://doi.org/10.1016/j.ejmech.2017.08.054 45- Ahmed M. Gouda, Ahmed H. Abdelazeem, Hany A. Omar, Ashraf N. Abdalla, Mohammed A.S. Abourehab, Hamed I. Ali. Pyrrolizines: design, synthesis, anticancer evaluation and investigation of the potential mechanism of action. Bioorganic & Medicinal Chemistry2017 Oct 15;25(20):5637-5651 https://doi.org/10.1016/j.bmc.2017.08.039 46- Hany H. Arab, Samir A. Salama, Tamer M. Abdelghany, Hany A. Omar, El-Shaimaa A. Arafa, El- Ibrahim A. Maghrabi. Camel milk attenuates rheumatoid arthritis via inhibition of mitogen activated protein kinase pathway. Cellular Physiology and Biochemistry, 2017 Sep 20;43(2):540-552. https://doi.org/10.1159/000480527 47- Ahmed H. Abdelazeem, Mohammed T. El-Saadi, Eman G. Said, Bahaa G.M. Youssif, Hany A. Omar, Samir M. El-Moghazy. Novel Diphenylthiazole Derivatives with Multi-Target Mechanism: Synthesis, Docking study, Anticancer and Anti-Inflammatory Activities. Bioorganic Chemistry, 2017 Sep 12;75:127-138. https://doi.org/10.1016/j.bioorg.2017.09.009 48- Mohamed A. Abdelgawad, Rania B. Bakr, Hany A. Omar. Design, synthesis and biological evaluation of some novel benzothiazole/ benzoxazole and/ or benzimidazole derivatives incorporating a pyrazole scaffold as antiproliferative agents. Bioorganic Chemistry, 2017 Jul 15;74:82-90. https://doi.org/10.1016/j.bioorg.2017.07.007 49- Mai F. Tolba, Ahmed T. El-Serafi, Hany A. Omar*. Caffeic acid phenethyl ester protects against glucocorticoid-induced osteoporosis in vivo: Impact on oxidative stress and RANKL/OPG signals. Toxicology and Applied Pharmacology, June 2017 324: 26-35 https://doi.org/10.1016/j.taap.2017.03.021 50- Khaled R. A. Abdellatif, Eman K. A. Abdelall, Mohamed A. Abdelgawad, Dina M. E. Amin, Hany A. Omar. Design, synthesis and biological evaluation of new 4-(4-substituted-anilino) quinoline derivatives as anticancer agents. Medicinal Chemistry Research, May 2017 26 (5): 929-939 https://doi.org/10.1007/s00044-017-1798-9 51- Ahmed H. Abdelazeema, Mohammed T. El-Saadi, Asmaa G. Safi El-Din, Hany A. Omar and Samir M. El-Moghazy. Design, Synthesis and Analgesic/Anti-inflammatory Evaluation of Novel Diarylthiazole and Diarylimidazole Derivatives Towards Selective COX-1 Inhibitors with Better Gastric Profile. Bioorganic & Medicinal Chemistry 2017 Jan 15;25(2):665-676. https://doi.org/10.1016/j.bmc.2016.11.037 52- Jui-Hsiang Hung, Chia-Yun Chen, Hany A. Omar, Kuo-Yuan Huang, Che-Chia Tsao, Chien-Chih, Chiu, Yi-Ling Chen, Po-Han Chen, Yen-Ni Teng. Reactive oxygen species mediate terbufos-induced apoptosis in mouse testicular cell lines via the modulation of cell cycle and pro-apoptotic proteins. Environmental Toxicology, 2016 Dec;31(12):1888-1898 https://doi.org/10.1002/tox.22190 53- Hany A. Omar*, Mai F. Tolba, Jui-Hsiang Hung, Taleb H. AlTel. OSU-2S/sorafenib synergistic antitumor combination against hepatocellular carcinoma: The role of PKCδ/p53. Frontiers in Pharmacology 2016 Nov 30;7:463 https://doi.org/10.3389/fphar.2016.00463 54- Mai F.Tolba, Hany A. Omar, Samar S. Azab, Amani E. Khalifa, Ashraf B. Abdel-Naim, Sherif Z. Abdel-Rahman. Caffeic acid phenethyl ester: A review of its antioxidant, antimicrobial activities, protective effects against ischemia reperfusion injury and drug adverse reactions. Critical Reviews in Food Science and Nutrition,2016 Oct 2;56(13):2183-90. https://doi.org/10.1080/10408398.2013.821967 55- Ahmed Abdelazeem, Yasser Mohamed, Ahmed Gouda, Hany Omar, Majed Al Robaian. Novel Thymohydroquinone Derivatives as Potential Anticancer Agents: Design, Synthesis and Biological Screening. Australian Journal of Chemistry, 2016 Jun, 69, 1277–1284 https://doi.org/10.1071/CH16102 56- Khaled R. Abdellatif, Phoebe F. Lamie, Hany A. Omar. 3-Methyl-2-phenyl-1-substituted-indole derivatives as indomethacin analogs: design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents. Journal of Enzyme Inhibition and Medicinal Chemistry, 2016 Apr;31(2):318-24. https://doi.org/10.3109/14756360903357585 57- Hany A. Omar, Wafaa R. Mohamed, Hany H. Arab, El-Shaimaa A. Arafa. Tangeretin alleviates cisplatin-induced acute hepatic injury in rats: Targeting MAPKs and apoptosis. PLoS ONE, 2016 Mar 31;11(3):e0151649 https://doi.org/10.1371/journal.pone.0151649 58- Hany A. Omar, Wafaa R. Mohamed, El-Shaimaa A. Arafa, Basim A. Shehata, Gamal A. El Sherbiny, Hany H. Arab, Abdel Nasser. A. M. Elgendy. Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its antitumor activity. Pharmacological Reports, 2015. Sep;68(2):349–56 https://doi.org/10.1016/j.pharep.2015.09.007 59- Samir A. Salama, Mohammad S. Al-Harbi, Mohamed S. Abdel-Bakky, Hany A. Omar. Glutamyl cysteine dipeptide suppresses ferritin expression and alleviates liver injury in iron-overload rat model. Biochimie, June 2015. 115, 203-211. https://doi.org/10.1016/j.biochi.2015.06.006 60- Kuan-Han Lee*, Hany A. Omar*, Shu-Jing Wu, Pin-Shern Chen, Yu-Chung Chen, Yen-Ni Teng, Hung-Chang Huang, Clay C. C. Wang and Jui-Hsiang Hung. The effect of reactive oxygen species produced by 6-shogaol on cell cycle progression and cell death-associated signaling pathways in human hepatoma cells. European Journal of Pharmacology, June 2015, 762(5) 449–458. https://doi.org/10.1016/j.ejphar.2015.06.032 (*Equal contribution) 61- Hany H. Arab, Samir A. Salama, Hany A. Omar, El-Shaimaa A. Arafa and Ibrahim A. Maghrabi. Diosmin protects against ethanol-induced gastric injury in rats: Novel anti-ulcer actions. PLoS ONE, March, 2015, 30;10(3):e0122417. https://doi.org/10.1371/journal.pone.0122417 62- Khaled R. A. Abdellatif, Heba A. H. Elshemy, Samir A. Salama, and Hany A. Omar. Synthesis, characterization and biological evaluation of novel 4’-fluoro-2’-hydroxy-chalcone derivatives as antioxidant, anti-inflammatory and analgesic agents. Journal of Enzyme Inhibition and Medicinal Chemistry, June 2015; 30(3):484-91. https://doi.org/10.3109/14756366.2014.949255 63- Ahmed H. Abdelazeem, Ahmed M. Gouda, Hany A. Omar, Mai F. Tolba. Design, Synthesis and Biological Evaluation of Novel Diphenylthiazole-Based Cyclooxygenase Inhibitors as Potential Anticancer Agents. Bioorganic Chemistry,Dec 2014, 57, 132–141.https://doi.org/10.1016/j.bioorg.2014.10.001 64- Hany A. Omar, Mai F. Tolba and Maha M. Saber-Ayad. Potential Targets of Energy Restriction Mimetic Agents in Cancer Cells. Future Oncology, 2014 Dec;10(16): 2547-2550. https://doi.org/10.2217/fon.14.191 65- Ahmed H. Abdelazeem, Shaimaa A. Abdelatef, Mohammed T. El-Saadi, Hany A. Omar, Shabana I. Khan, Christopher R. McCurdy and Samir M. El-Moghazy. Novel Pyrazolopyrimidine Derivatives Targeting COXs and iNOS enzymes; Design, Synthesis and Biological Evaluation as Potential Anti-inflammatory Agents. European Journal of Pharmaceutical Sciences, Oct 2014, 62, 197–211. https://doi.org/10.1016/j.ejps.2014.05.025 66- Hany H. Arab, Samir A. Salama, Ahmed H. Eid, Hany A. Omar, El-Shaimaa A. Arafa and Ibrahim A. Maghrabi. Camel's milk ameliorates TNBS-induced colitis in rats via down-regulation of inflammatory cytokines and oxidative stress. Food and Chemical Toxicology, April, 2014, 69C:294-302. https://doi.org/10.1016/j.fct.2014.04.032 67- Hany A. Omar, El-Shaimaa A. Arafa, A. Maghrabi and Jing-Ru Weng. Sensitization of Hepatocellular Carcinoma Cells to Apo2L/TRAIL by a Novel Akt/NF-kB Signaling Inhibitor. Basic & Clinical Pharmacology & Toxicology, 2014 Jun;114(6):464-71. https://doi.org/10.1111/bcpt.12190 68- Kuan-Han Lee, Wen-Yueh Ho, Shu-Jing Wu, Hany A. Omar, Po-Jui Huang, Clay C. C. Wang and Jui-Hsiang Hung. Modulation of cyclins, p53 and MAPK signaling in breast cancer cell lines by 4-(3,4,5-trimethoxyphenoxy)benzoic acid. International Journal of Molecular Sciences, 2014, 15(1), 743-757. https://doi.org/10.3390/ijms15010743 69- Samir A. Salama, Hany A. Omar, Ibrahim A. Maghrabi, Mohammed S. AlSaeed and Adel E. EL-Tarras. Iron supplementation at high altitude causes oxidative injury and inflammation in lung tissues of rats. Toxicology and Applied Pharmacology, 2014 Jan 1;274(1):1-6. https://doi.org/10.1016/j.taap.2013.10.034 70- El-Shaimaa A. Arafa, Ahmed H. Abdelazeem, Hany H. Arab and Hany A. Omar. OSU-CG5, a Novel Energy Restriction Mimetic Agent Inhibits Colorectal Cancer Cells. Acta Pharmacologica Sinica, 2014 Mar; 35(3):394-400. https://doi.org/10.1038/aps.2013.183 71- Samir A. Salama, Hany H. Arab, Hany A. Omar and Robert M. Snapka. Nicotine mediates hypochlorous Acid-induced nuclear protein damage in Mammalian cells. Inflammation, 2014 Jun;37(3):785-92. https://doi.org/10.1007/s10753-013-9797-6 72- Hany A. Omar, El-Shaimaa A. Arafa, Samir A. Salama and Jing-Ru Weng. OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting Akt-NF-κB and MAPK signaling pathways. Toxicology and Applied Pharmacology, 2013 Nov 1;272(3):616-24. https://doi.org/10.1016/j.taap.2013.07.014 73- Khaled R. A. Abdellatif a, Amany Belal, Hany A. Omar. Design, synthesis and biological evaluation of novel triaryl (Z)-olefins as tamoxifen analogues. Bioorganic & Medicinal Chemistry Letters, 2013 Sep 1;23(17):4960-4963 https://doi.org/10.1016/j.bmcl.2013.06.056 74- Mohamed A. Abdelgawad, Amany Belal, Hany A. Omar, Lamees Hegazy and Mostafa E. Rateb. Synthesis, Anti-Breast Cancer Activity and Molecular Modeling of Some Benzothiazole and Benzoxazole Derivatives. Archiv der Pharmazie Chemistry in Life Sci.2013, 346(7), 534–541. https://doi.org/10.1002/ardp.201300044 75- Hany A. Omar, Samir A. Salama, El-Shaimaa A. Arafa and Jing-Ru Weng. Antitumor Effects of Energy Restriction-Mimetic Agents: Thiazolidinediones. Biological Chemistry, 2013; 394(7): 865–870. https://doi.org/10.1515/hsz-2013-0139 76- Ahmed O.H. El-Nezhawy, Ayman R. Biuomy, Fatma S. Hassan, Ayman K. Ismaiel and Hany A. Omar. Design, synthesis and pharmacological evaluation of omeprazole-like agents with anti-inflammatory activity. Bioorganic & Medicinal Chemistry, 2013 Apr 1;21(7):1661-1670.https://doi.org/10.1016/j.bmc.2013.01.070 77- Hany A. Omar, Lisa Berman-Booty and Weng JR. Energy restriction: stepping stones towards cancer therapy. Future Oncology, 2012 Dec;8(12):1503-1506. https://doi.org/10.2217/fon.10.130 78- Hany A. Omar, Yihui Ma, Jui-Hsiang Hung, Chih-Chien Chou, Lisa D. Berman-Booty, Dasheng Wang, Takayuki Kogure, Tushar Patel, Natarajan Muthusamy, John C. Byrd, Samuel K. Kulp and Ching-Shih Chen. Antitumor Effects of OSU-2S, a Non-immunosuppressive Analogue of FTY720, in Hepatocellular Carcinoma. Hepatology, 2011 Jun;53(6):1943-58. https://doi.org/10.1002/hep.24293 79- Hany A. Omar, Lisa Berman-Booty, Samuel K. Kulp, and Ching-Shih Chen. Energy Restriction as an Antitumor Target. Future Oncology, 2010 Nov; 6(11), 1675–1679. https://doi.org/10.2217/fon.10.130 80- Jing-Ru Weng, Hany A. Omar, Samuel K. Kulp, and Ching-Shih Chen. Pharmacological Exploitation of Indole-3-Carbinol to Develop Potent Antitumor Agents. Mini-Reviews in Medicinal Chemistry, 2010 May;10(5):398-404.https://doi.org/10.2174/138955710791330945 81- Li-Yuan Bai, Hany A. Omar, Chang-Fang Chiu, Zeng-Pang Chi, Jing-Ru Weng. Antitumor effects of (S)-HDAC42, a phenylbutyrate-derived histone deacetylase inhibitor, in multiple myeloma cells. Cancer Chemotherapy and Pharmacology, 2010 Aug;68(2):489-96. https://doi.org/10.1007/s00280-010-1501-z 82- Jing-Ru Weng, Li-Yuan Bai, Hany A. Omar, Aaron Sargeant , Ching-Tung Yeh, Yuan-Yin Chen, Ming-Hsui Tsai, Chang-Fang Chiu. A novel indole-3-carbinol derivative inhibits growth of human oral squamous cell carcinoma in vitro. Oral Oncology, 2010 Oct; 46(10): 748-754. https://doi.org/10.1016/j.oraloncology.2010.08.005 83- Jing-Ru Weng, Chen-Hsun Tsai, Hany A. Omar, Aaron M. Sargeant, Dasheng Wang, Samuel K. Kulp, Charles L. Shapiro, and Ching-Shih Chen. OSU-A9, a Potent Indole-3-Carbinol Derivative, Suppresses Breast Tumor Growth by Targeting the Akt-NF-κB Pathway and Stress Response Signaling. Carcinogenesis, 2009 Oct;30(10):1702-9. https://doi.org/10.1093/carcin/bgp202 84- Hany A. Omar, Aaron M. Sargeant, Jing-Ru Weng, Dasheng Wang, Samuel K. Kulp, Tushar Patel, and Ching-Shih Chen. Targeting of the Akt-NF-кB Signaling Network by OSU-A9, a Novel Indole-3-Carbinol Derivative, in a Mouse Model of Hepatocellular Carcinoma. Molecular Pharmacology, 2009 Nov;76(5):957-68. https://doi.org/10.1124/mol.109.058180
- Ph.D: Candidate: Amany Abd-Elkhalek A. Azouz; Title: “Novel strategy for cytoprotection of transplanted kidneys”. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Egypt - M.Sc: Candidate: Mustafa Ahmed Abdel-Raheim; Title: “Pharmacological study of the possible interactions between antidiabetic drugs and some angiotensin inhibitors in streptozotocin-induced diabetic rats”. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Egypt - M.Sc: Candidate: Sayed Mizar Metwally Mizar. Title: “Pharmacological study of the possible protective effect of B-blockers and Statins in experimentally-induced liver injury”. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Egypt
•2021: The winner of the “Emirates Award” 2020, 3rd session for Best Resident University Doctor in UAE (Formerly called the Founder Leader Award). The award evaluates academics through several criteria: Academic competence, quality of research, and community service. (January, 2021) https://www.instagram.com/p/CMAV5xcpB2u/ •2020: The winner of the University of Sharjah Annual Incentive Award for Distinguished Faculty Member in Teaching (December, 2020) •2020: According to a Stanford University study, I was listed among the World's Top 2% Scientists https://dx.doi.org/10.17632/btchxktzyw article link. •2020: The winner of the best oral presentation award as a supervisor (Ph.D candidate: Dana Zaher) in the 8th Pan Arab Human Genetics Conference, Title: Metabolic Reprogramming as a Promising Approach for Everting Breast Cancer Multi-Drug Resistance, Dubai, United Arab Emirates (19 - 20 January, 2020). link •2019: The winner of the University of Sharjah Annual Incentive Award for Distinguished Faculty Member in Scientific Research (April, 2019) •2019: The winner of the 2nd Best Innovative Graduate Student Project Award as a supervisor (M.Sc. candidate: Shifaa Abdin). Title: "NF-kB inhibition as a Novel Maneuver to Re-sensitize Multi-Drug Resistant Breast cancer". 13th University of Sharjah Annual Scientific Research Forum. University of Sharjah, (April 29th, 2019). •2019: The winner of the 3rd Best Innovative Graduate Student Project Award as a supervisor. Title: "Pharmacological Study of the Anti-angiogenic Activity of the Novel SIMR1389 Compound as a Potential Anticancer Mechanism". 13th University of Sharjah Annual Scientific Research Forum. University of Sharjah, (April 29th, 2019). •2019: The winner of the 3rd best Pharmacy Student Poster Presentation Award as a supervisor. Title: Repositioning of 5-fluorouracil as an Anti-scarring Agent. Dubai International Pharmaceuticals and Technologies Conference and Exhibition (DUPHAT, February 26-28, 2019). •2018: The winner of the best poster award as a supervisor in the 6th Emirati-German Congress in Medicine & 2nd International Conference on Pharmacy and Medicine, 18-21 November 2018 •2018: The winner of the best paper award as a supervisor in the UAE-GSRC 2018 (UAE Graduate Student Research Conference) in the Clinical and Health category, (April 21st, 2018). link •2018: The winner of the 2nd Best Innovative Graduate Student Project Award as a supervisor. Title: "Energy Restriction as a Novel Approach Targeting Breast Cancer Stem Cells Multi-Drug Resistance". 12th University of Sharjah Annual Scientific Research Forum. University of Sharjah, (May 13th, 2018). •2018: The Winners of the Sharjah Islamic Bank Award for Distinguished Research 2017-2018 (29 April 2018) as a supervisor for the best student research article (student name: Shifaa Abdin, article: Shifaa M. Abdin, Dana M. Zaher, El-Shaimaa A. Arafa and Hany A. Omar*. Tackling the cancer resistance by immunotherapy: Updated clinical impact and safety of PD-1/PD-L1 inhibitors. Cancers, 2018, 10(2), 32). •2018: The winner of the 3rd Best Pharmacy Student Poster Presentation Award as a supervisor. Title: Human Organs on Chips. Dubai International Pharmaceuticals and Technologies Conference and Exhibition (DUPHAT, February 27 - March 1, 2018). •2018: The winner of the 5th Best Pharmacy Student Thematic Poster Award as a supervisor. Dubai International Pharmaceuticals and Technologies Conference and Exhibition (DUPHAT, February 27 - March 1, 2018). •2017: The winner of the Best Innovative Graduate Student Project Award as a supervisor. Title: "Novel OSU-2S-derived Small-Molecule Targeted Chemotherapeutic Agents for Hepatocellular Carcinoma". 11th University of Sharjah Annual Scientific Research Forum. University of Sharjah, (15 May 2017). •2017: The winner of the 4th Best Pharmacy Student Innovative Poster Award as a supervisor. Dubai International Pharmaceuticals and Technologies Conference and Exhibition (DUPHAT, 7-9 March 2017). •2016: The winner of the University of Sharjah Annual Incentive Award for Distinguished Faculty Member in Scientific Research (May, 2016) •2016: The winner of the 2nd Best Pharmacy Student Innovative Poster Award as a supervisor. Dubai International Pharmaceuticals and Technologies Conference and Exhibition (DUPHAT, 15-17 March 2016). •2015: The winner of Beni-Suef University Excellence Award for the best research and academic achievement in the last five years, March 2015 •2014: Featured scientific article by Global Medical Discovery •2012: The winner of 31,000 LE Scientific Publication Award for the best published research article with an impact factor of 11.981 (Hepatology, 2011) from Misr El Kheir Foundation •2011: The winner of 35,000 LE grant for a research proposal from Beni-Suef University Research Centre, Projects Funding and Support Unit, October 2011. •2011: The best Ph.D thesis, Beni-Suef University, Egypt, April 2011 link •2011: Egyptian Students Association in North America (ESANA) Best Research Award. ESANA-GA annual meeting, January 2011 in Washington, D.C., USA. •2010: The National Institutes of Health (NIH) travel award to the fifth annual NIH National Graduate Student Research Festival, October 25-26, 2010 in Bethesda, Maryland, USA. •2009: American Association of Cancer Research (AACR) award to support professional development as an early-career investigator-in-training waiving Associate membership dues for two years, 2010-2011.
Bringing exercises and simulations into the classroom is essential since, for most students, what they learn only comes to life when they start using it In the field of pharmacology; students enjoy applying what they learn in real life by integrating the class knowledge to the hospital or pharmacy training. I used to guide my students how to use the available resources to discover new medications by gathering existing knowledge from comprehensive sources, prioritizing it, designing set of experiments and eventually publishing work and seeking the best applications.
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