Department of Pharmacy Practice and Pharmacotherapeutics Our People Detail

Education

2012 PhD in Experimental & Clinical Pharmacology Paris-Sud (XI) University (University of Paris-Saclay) Graduate Doctoral School ED425 «Therapeutic innovation», Paris, France. Distinction: Very Honorable 2008 Master II in Pharmacology Louis Pasteur University (University of Strasbourg), Faculty of Pharmacy, Strasbourg, France 2007 Master I in Biochemistry Lebanese University, Faculty of Sciences (I), Beirut, Lebanon

Employment History

2022-present Associate Professor, Department of Pharmacy Practice & Pharmacotherapeutics, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates 2015-2022 Assistant Professor, Department of Pharmacy Practice & Pharmacotherapeutics, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates 2014-2015 Post-Doctoral Fellow, Saint-Antoine Research Center, The National Institute of Health & Medical Research (INSERM), Pierre & Marie Curie (Paris VI) University, Sorbonne Universities, Paris, France 2013-2014 Post-Doctoral Fellow, Unit of Experimental Toxicology Unit, The French National Institute for Industrial Environment & Risks (INERIS), Vernueil-en-Halatte, France 2009-2012 PhD in Experimental & Clinical Pharmacology, The Drug Metabolism Research Laboratory (LEMM), Service of Pharmacology and Immunoanalysis (SPI), Institute of Biology and Technology Saclay (iBiTec-S), The French Alternative Energies & Atomic Energy Commission (CEA), Saclay, France 2008-2008 Master II Training in Pharmacology, The French National Centre for Scientific Research (CNRS), Faculty of Pharmacy, University of Strasbourg, Strasbourg, France

Professional Activities

2018 – 2020: Coordinator of the Pharmacology Unit, Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah.

Professional Memberships

Member of the International Brain Barriers Society (IBBS) Member of the International Brain Barriers Society (IBBS) Member of the European Association for Cancer Research (AACR)

Selected Research Projects

• R Harati (Principal investigator): Restoring MicroRNA-101 and MicroRNA-26b Expression to Suppress Breast Cancer Brain Metastasis. The Terry Fox Foundation (300000 AED). • R Harati (Principal investigator): Targeting the microRNA-30 and microRNA-200 families to prevent brain metastasis of breast cancer cells. University of Sharjah Competitive Research Grant (80000 AED). • R Harati (Principal investigator): Evaluating the therapeutic potential of microRNAs in restoring normal function and immunoquiescence of the Blood-Brain Barrier in multiple sclerosis. University of Sharjah Competitive Research Grant (80000 AED). • M Ghaleb (Principal investigator), R Harati (co-investigator): Dendritic cells and immunoregulation in central nervous system in mice model of multiple sclerosis. University of Sharjah Targeted Research Grant (193000 AED).

Selected Publications

2024 Broca-Brisson L, Disdier C, Harati R, Hamoudi R, Mabondzo A. Epigenetic alterations in creatine transporter deficiency: a new marker for dodecyl creatine ester therapeutic efficacy monitoring. Front Neurosci. 2024 Apr 17;18:1362497. doi: 10.3389/fnins.2024.1362497. eCollection 2024. 2023 Banerjee SM, Acedo P, El Sheikh S, Harati R, Meecham A, Williams NR, Gerard G, Keshtgar MRS, MacRobert AJ, Hamoudi R. Combination of verteporfin-photodynamic therapy with 5-aza-2'-deoxycytidine enhances the anti-tumour immune response in triple negative breast cancer. Front Immunol. 2023 Nov 7;14:1188087. doi: 10.3389/fimmu. 2023. 1188087. eCollection 2023. 2023 Broca-Brisson L, Harati R, Disdier C, Mozner O, Gaston-Breton R, Maïza A, Costa N, Guyot AC, Sarkadi B, Apati A, Skelton MR, Madrange L, Yates F, Armengaud J, Hamoudi R, Mabondzo A. Deciphering neuronal deficit and protein profile changes in human brain organoids from patients with creatine transporter deficiency. Elife. 2023 Oct 13;12:RP88459. doi: 10.7554/eLife.88459. 2023 AlJayoush A, Hassan H, Asiri H, Jafar M, Saeed R, Harati R, Haider M. Niosomes for nose-to-brain delivery: A non-invasive versatile carrier system for drug delivery in neurodegenerative diseases. J Drug Deliv Sci Technol. Volume 89, November 2023, 105007. 2023 Osaid Z, Haider M, Hamoudi R, Harati R*. Exosomes Interactions with the Blood-Brain Barrier: Implications for Cerebral Disorders and Therapeutics. Int J Mol Sci. 2023 Oct 26;24(21):15635. doi: 10.3390/ijms242115635. 2023 Alsabbagh R, Ahmed M, Alqudah MAY, Hamoudi R, Harati R*. Insights into the Molecular Mechanisms Mediating Extravasation in Brain Metastasis of Breast Cancer, Melanoma, and Lung Cancer. Cancers (Basel). 2023 Apr 12;15(8):2258. doi: 10.3390/cancers15082258.PMID: 37190188. 2023 Alnaqbi N, Mohammad MG, Hamoudi R, Mabondzo A, Harati R*. Molecular Heterogeneity of the Brain Endothelium. Curr Issues Mol Biol. 2023 Apr 16;45(4):3462-3478. doi: 10.3390/cimb45040227.PMID: 37185751. 2023 Abdelsalam M, Ahmed M, Osaid Z, Hamoudi R, Harati R*. Insights into Exosome Transport through the Blood-Brain Barrier and the Potential Therapeutical Applications in Brain Diseases. Pharmaceuticals (Basel). 2023 Apr 10;16(4):571. doi: 10.3390/ph16040571.PMID: 37111328. 2023 Mabondzo A, Harati R, Broca-Brisson L, Guyot AC, Costa N, Cacciante F, Putignano E, Baroncelli L, Skelton MR, Saab C, Martini E, Benech H, Joudinaud T, Gaillard JC, Armengaud J, Hamoudi R. Dodecyl creatine ester improves cognitive function and identifies key protein drivers including KIF1A and PLCB1 in a mouse model of creatine transporter deficiency. Front Mol Neurosci. 2023 Mar 24;16:1118707. doi: 10.3389/fnmol.2023.1118707. eCollection 2023.PMID: 37063368. 2022 Hammash D, Mahfood M, Khoder G, Ahmed M, Tlili A, Hamoudi R, Harati R*. miR-623 Targets Metalloproteinase-1 and Attenuates Extravasation of Brain Metastatic Triple-Negative Breast Cancer Cells. Breast Cancer (Dove Med Press). 2022 Aug 1;14:187-198. doi: 10.2147/BCTT.S372083. eCollection 2022. PMID: 35936987. 2022 Harati R*, Hammad S, A Tlili, M Mahfood, Mabondzo A, Hamoudi R. MiR-27a-3p regulates expression of intercellular junctions at the brain endothelium and controls the endothelial barrier permeability. PLoS One. 2022 Jan 13;17(1):e0262152. doi: 10.1371/journal.pone.0262152. eCollection 2022. PMID: 35025943.

Theses and Projects Supervision

• Supervision of Master Thesis in Pharmacology: “Enhancing anti-epileptic drug delivery to the brain: miR-27a as a potential therapeutic target to modulate P-glycoprotein expression at the blood-brain barrier”. M.Sc. candidate Saba Hammad. September 2020. Masters in Pharmaceutical Sciences (Pharmacology), College of Pharmacy, University of Sharjah. • Supervision of Master Thesis in Pharmacology: “Evaluating the therapeutic potential of miR-623 to suppress extravasation of brain metastatic breast cancer cells”. M.Sc. candidate Duaa Hammash. September 2020. Masters in Pharmaceutical Sciences (Pharmacology), College of Pharmacy, University of Sharjah. • Supervision of Master Thesis in Pharmacology: “Role of miR-let-7c in brain metastasis of triple negative breast cancer”. M.Sc. candidate Rama Al-Sabbagh. November 2020. Masters in Pharmaceutical Sciences (Pharmacology), College of Pharmacy, University of Sharjah. • Supervision of Master Thesis in Pharmacology: “Role of exosomes in extravasation of brain metastatic triple negative breast cancer cells”. M.Sc. candidate Manal AbdelSalam. February 2020. Masters in Pharmaceutical Sciences (Pharmacology), College of Pharmacy, University of Sharjah. • Co-Supervision of Master thesis: «Optimizing the Sorafenib treatment of hepatocellular carcinoma». M.Sc. candidate Amélie Maury. September 2014. Sorbonne Universities, Pierre & Marie Curie Faculty of Medicine, Paris, France

Awards Recognitions

• Winner of the University of Sharjah Annual Incentive Award for Distinguished Faculty Member in Teaching, 2021 • Winner of the 5th best Pharmacy Student Poster Presentation Award as a supervisor (Students Munazza Ahmed and Grace Daoud). Title: CRISPR-Cas9 as a potential therapeutic platform for breast cancer. Dubai International Pharmaceuticals and Technologies Conference and Exhibition (DUPHAT), 2021

Services

• Reviewer: Frontiers in Immunology • Reviewer: Frontiers in Pharmacology • Reviewer: UAE Graduate Students Research Conference

Teaching Philosophy

My ultimate teaching philosophy as an educator is to help my students succeed. My teaching concepts consist on1) Creating an environment that enables students to be critical thinkers, and 2) Employing various learning methods that ensure an effective communication of the knowledge and an active participation of the students, as well as students’ interaction. In my teaching practice, I apply a student-driven learning approach where students are active participants in the process, enhanced with an evidence-based approach such as cutting-edge research and clinically relevant cases to make the message as applicable as possible. I believe that using a variety of instructional methods greatly benefit the students as not all students learn in the same manner or in the same environment. However, most importantly, I always make sure I stop and listen to my students’ needs, determine their strengths, and make appropriate decisions based on what will benefit them the most.

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