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Dr.Rania Harati Academic RankAssistant Professor

Specialization:

  • Experimental & Clinical Pharmacology.

Research Interests:

  • Impact of inflammation on the blood-brain barrier, Maturation of the blood-brain barrier, Regulation of drug influx/efflux transporters, Development of three-dimensional in vitro cell culture models, Optimizing the Sorafenib treatment of hepatocellular carcinoma.

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Ph.D. Experimental & Clinical Pharmacology, Paris-Sud University, Paris, France (2012). M.Sc. Pharmacology, Faculty of Pharmacy, University of Strasbourg I, Strasbourg, France (2008).
2014 - 2015: Post-Doctoral Researcher / Instructor (Sorbonne Universities, Pierre & Marie Curie University (Paris VI), Faculty of Medicine, INSERM, Saint-Antoine Research Center, Paris, France). Research Project: «Evaluating the Anti-Tumor Properties of Metformin for the Treatment of Hepatocellular Carcinoma». 2013 - 2014: Post-Doctoral Researcher French National Institute for Industrial Environment and Risks (INERIS), Paris area, France. Research Project: «Development of an Improved Three-Dimensional in vitro Blood-Testis Barrier Model». 2009 - 2012: Ph.D. French Alternative and Atomic Energies Commission (CEA), Saclay, Paris area, France. Research Project: «Blood-Brain Barrier and Neuro-inflammation during Brain Maturation».
Member of the International Brain Barriers Society (IBBS).
2014 – 2015: «Evaluating the Anti-Tumor Properties of Metformin for the Treatment of Hepatocellular Carcinoma» (INSERM, Saint-Antoine Research Center, Paris, France). 2013 – 2014: «Development of an Improved Three-Dimensional in vitro Blood-Testis Barrier Model» (French National Institute for Industrial Environment and Risks (INERIS), Paris area, France). 2009 – 2012: «Blood-Brain Barrier and Neuro-inflammation during Brain Maturation» (French Alternative and Atomic Energies Commission (CEA), Saclay, Paris area, France). 2008: «Role of the Low-density lipoprotein Receptor-related Protein-1 (LRP1) in Regulation of Chondrocyte Differentiation» (French National Center for Scientific Research (CNRS), Strasbourg, France).
1- R. Harati, H. Benech, A.S. Villegier and A. Mabondzo. P-glycoprotein, Breast cancer resistance protein, Organic anion transporter 3 and transporting peptide 1a4 during Blood-Brain Barrier Maturation: Involvement of Wnt/β-Catenin and Endothelin-1 Signaling. Molecular Pharmaceutics - American Chemical Society publications. 2013 May 6;10(5):1566-80. Epub 2012 Oct 12. 2- R. Harati, A.S. Villegier, W.A. Banks and A. Mabondzo. Susceptibility of Juvenile and Adult Blood-Brain Barrier to Endothelin-1: Regulation of BCRP and P-glycoprotein Expression and Transport activity. Journal of Neuroinflammation. 2012 Dec 19;9:273.
Supervision of a Master II Thesis: «Optimizing the Sorafenib Treatment of Hepatocellular Carcinoma» - A. Maury, 2015 (Sorbonne Universities, Pierre & Marie Curie University (Paris VI), Faculty of Science, Paris, France).
1- A Three-year PhD Fellowship from the French National Agency for Research on AIDS (ANRS) (2009- 2012): «Blood-Brain Barrier and Neuro-inflammation during Brain Maturation». 2- An Eighteen-month Postdoctoral Fellowship from the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) (2013-2014): «Development of an Improved Three-Dimensional in vitro Blood-Testis Barrier Model».
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