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Prof.Taleb H. AlTel Director of the Institute for Medical & Health Sciences Research Academic RankProfessor

Specialization:

  • Organic medicinal chemistry

Research Interests:

  • Drug design and discovery, privileged DOS

Contact

- 1995 - Ph.D. (Suma Cum Laude) Tuebingen-University, Germany Research advisor: Prof. h.c. Wolfang Voelter, Dissertation: "Regio- and Stereoselective Strategies for the Synthesis of Polyfunctionalized Chiral Oxa-ring Systems for Medicinal Purposes" - 1990 - M.Sc. University of Jordan Amman, Jordan And Pennsylvania State University, Pennsylvania, State college, USA. Research advisors: Prof..Musa Abu Zarga, & Prof. Salim Sabri, Prof. Maurice Shamma. Dissertation: "Chemical Constituents of the Medicinal Plants of Jordan (VI): Isolation, identification and biological studies of the Constituents of Colchicum ritchii and Leontice Leontopetalum" - 1987 - B.Sc. in Chemistry and Chemical Technology College of Science and Technology (now Al-Qudus University), Jerusalem/ West -Bank. Postgraduate Training: - 4/1995-4/1996 Postdoctoral Research Associate: Supervisor: Prof. Dr. Scott McN. Sieburth, State University of New York at Stony Brook, USA. Research Theme: [4+4] Photocycloaddition reactions of tethered 2-pyridones: Toward the total synthesis of 5-8-5-tricyclic antiviral natural products. - 8/2003-7/2004 Visiting Professor at the Chemistry department, Duke University, Durham, North Carolina, USA. Supervisor: Prof. Stephen L. Craig Project: Self-Healing Reversible Polymers - 7/2004-7/2007 Principal Scientist and team leader of drug design and discovery groups (cancer and Alzheimers), Transtech Pharma, High Point, North Carolina, USA.
9/2009-present - Chairman of the Medicinal Chemistry Department, College of Pharmacy, University of Sharjah-UAE. - 10/2014-present Acting Director, Sharjah Institute for Medical Research-UAE - 1/2013-present - Professor of organic medicinal chemistry, college of pharmacy, university of sharjah, sharjah, UAE. - 8/2007-12/2012 Associate Professor of organic medicinal chemistry, college of pharmacy, university of sharjah, sharjah, UAE. - 9/1999-8/2002 - Director of Studies & Research Unit at An-Najah Natioal University, West-Bank. - 9/1996 to 2/2001 - Assistant and then Associate Professor of organic Chemistry An-Najah National University, West-Bank, via Israel.
Currently Active Research Competitive Grants 1. Terry Fox Foundation Grant: Drug Design of HDACs Inhibitors as Cancer Drug Targets, 2013 to present. (AlTel-PI) 2. Terry Fox Foundation Grant: Drug Design of HKII Inhibitors as Cancer Drug Targets, 2013 to present. (AlTel-Co-PI) 3. Boehringer Ingelheim Pharmaceutical Company Research grant: Drug Design and Discovery Targeting CDKs, 2013 to present. (AlTel-PI) 4. National Research Foundation Grant-UAE: Targeting BACE1: Design and synthesis of Alzheimer’s Drug Leads-2011 to present. (AlTel-PI) 5. KEF Holding Charity Foundation Grant: Targeting Caspases for the design and synthesis of cancer drug leads, 2012-present. (AlTel-PI) 6. National Research Foundation-UAE grant for: Targeting Cancer and Alzheimers Diseases through the synthesis of Novel Schaffolds, 2011-2014. (AlTel-PI)
- Member of the ACS American Chemical Society, Organic Chemistry Division, 2003 to present. - Member of the ACS American Chemical Society, Medicinal Chemistry Division, 2003 to present. - Member of AAAS (American Association for the Advancement of Science (2003-to-2008). - Affiliated member of IUPAC, International Union of Pure and Applied Chemistry (2003 to present).
1. Design and Synthesis of TRAIL protein drug activators through targeting the kinome signaling as cancer drug target. 2. Design and Synthesis of Selective HDACs inhibitors as validated targets for diabetes and cancer 3. Design and Synthesis of Hexo kinase II inhbitors as cancer drug target 4. Design and synthesis of BACE1 inhibitors 5. Design and synthesis of privileged structures through DOS and Phenotypic screening thereof.
- Nitrogen-containing heterocycle derivatives, pharmaceutical compositions, and methods of use thereof as antiviral agents, US-patent-20070219239, 2008. 1. M. T. Ardah, K. E. Paleologou, u. Lv, S. B. Abul Khair, A. S. Kazim, S. T. Minhas, Taleb H. Al-Tel, A. Al-Hayani, M. E. Haque, D. Eliezer and O. M. A. El-Agnaf; “Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicity”; Front. Aging Neurosci., 05 August 2014 | doi: 10.3389/fnagi.2014.00197. 2. A. El-Dahshan, S. I. Al-Gharabli, S. Radetzki, Taleb H. Al-Tel, P. Kumar, J. Rademann; “Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity”, Bioorganic & Medicinal Chemistry, July 2014 DOI: 10.1016/j.bmc.2014.07.024 3. Subash Chandra Sahoo, Naba Kamal Nath, Lidong Zhang, Mohamad H. Semreen, Taleb H. Al–Tel, Panče Naumov; “Actuation Based on Thermo/Photosalient Effect: Biogenic Smart Hybrid Driven by Light and Heat", Royal Society Advances, 2014, DOI: 10.1039/C3RA46688D. 4. Raed Al-Qawasmeh, Monther A. Khanfar, Mohamad H. Semreen, Raed Abu Odeh, and Taleb H. Al-Tel; “Design and Synthesis of New Hybrid Triazine-Indole Derivatives as Potential Antimicrobial Agents against Hospital Resistant Strains”, Heterocycles, 2013, 87, 2013, pp.2385-2394. 5. Taleb H. Al-Tel, Mohammad H. Semreen, Raafat El-Awady, Raed Abu-Odeh, Maha Saber, Raed A. Al-Qawasmeh, Salem Chouaib “Tandem Multicomponent Reactions Toward the Design and Synthesis of Novel Antibacterial and Cytotoxic Motifs” Curr. Med. Chem. 2013, 20, 1445-1459. 6. Taleb H. Al-Tel, Mohamad H. Semreen, Raed A. Al-Qawasmeh, Marco F. Schmidt, Raafat El-Awadi, Mustafa Ardah, Rania Zaarour, and Shashidhar N. Rao,Omar El-Agnaf “Design, Synthesis and Qualitative Structure Activity Evaluations of Novel -Secretase Inhibitors as Potential Alzheimer’s Drug Leads” J. Med. Chem. 2011, Publication Date: November 1, 2011 (Article); DOI: 10.1021/jm201181f. 7. Taleb H. Al-Tel ,Raed A. Al-Qawasmeh and Rania Zaarour, “Design, Synthesis and in vitro Antimicrobial Evaluation of Novel Imidazo[1,2-a]pyridine and Imidazo[2,1-b][1,3]benzothiazol Motifs”, Eur. J. Med. Chem., 2011, 46, 1874-1881. 8. Taleb H. Al-Tel, Raed A. Al-Qawasmeh, Wolfgang Voelter, “Rapid Assembly of Polyfunctional Structures Using a One-Pot Five- and Six-Component Sequential Groebke–Blackburn/Ugi/Passerini Process” European Journal of Organic Chemistry, (2010), 5586–5593. 9. Taleb H. Al-Tel, “Design, synthesis and qualitative structure–activity evaluations of novel hexahydropyrano[3,2-c][1,2]diazepin-3(4H)-one and tetrahydropyrano[3,2-b]pyrrol-2(1H)-one derivatives as anticancer agents Eur. J. Med. Chem., 2010, 45, 4615-4621. 10. Taleb H. Al-Tel, Raed A. Al-Qawasmeh, “Post Groebke-Blackburn Multicomponent Protocol: Synthesis of New Polyfunctional Imidazo[1,2-a]pyridine and Imidazo[1,2-a]pyrimidine Derivatives as Potential Antimicrobial Agents”, European Journal of Medicinal Chemistry, (2010), 45, DOI:10.1016/j.ejmech.2010.09.049. 11. Taleb H. Al-Tel, “Design and Synthesis of Novel Tetrahydro-2H-Pyrano[3,2-c]Pyridazin-3(6H)-One Derivatives as Potential Anticancer Agents”, Eur. J. Med. Chem., 2010, 45, DOI:10.1016/j.ejmech.2010.09.029. 12. Taleb H. Al-Tel, M. H. Semreen and Wolfgang Voelter, “Tandem Achmatowicz-Knoevenagel protocol: diastereoselective synthesis and anticancer evaluation of cyclopenta[b]pyrane derivatives” Org. Biomol. Chem., (2010), DOI:10.1039/c0ob00289e. 13. Anas Rasras, Taleb H. Al-Tel, Raed Al-Qawasmeh and Amal El-Aboudi, Synthesis and Antimicrobial Activities of Cholic Acid Derivatives, Eur. J. Med. Chem., 2010, 45, 2307–2313. 14. Mohammad H. Semreen, Abdel-Nasser El-Shorbagi, Taleb H. Al-Tel and Izzeddin M.M. Alsalahat, ” Targeting gamma-Aminobutyric Acid (GABA) Carriers to the Brain: Potential Relevance as Antiepileptic Pro-Drugs”, Medicinal Chemistry, (2010), 6, 144-149. 15. Taleb H. Al-Tel, Raed A. Al-Qawasmeh, Marco F. Schmidt, Amal Al-Aboudi, Shashidhar N. Rao, Salim S. Sabri, and Wolfgang Voelter “Rational Design and Synthesis of Potent Dibenzazepine Motifs as β-Secretase Inhibitors”, Journal of Medicinal Chemistry, 2009, 52, 6484. 16. Taleb H. AlTel, Raed Al-Qawasmeh and Wolfgang Voelter, “Differential Use of Anhydropyranosides for Enantiopure Routes to Bis-γ-butyrolactones: A New Approach to the Frameworks of Antibiotic and Anticancer Agents Isoavenaciolide and Ethisolide”, Journal of Organic Chemistry, 2009, 74 (13), pp 4690–4696. 17. Armando M. De Palma, Hendrik Jan Thibaut, Kjerstin Lanke, Ward Heggermont, Stephen Ireland, Robert Andrews, Murty Arimilli3, Taleb H. Al-Tel, Erik De Clercq, Frank van Kuppeveld and Johan Neyts; Antimicrobial Agents and Chemotherapy (AAC), 2009, 53, 1850-1857. 18. Hala I. Al-Jaber, Mustafa M. El-Abadelah, Salim S. Sabri, Taleb H. Al-Tel, And Wolfgang Voelter, Thienopyridone Antibacterials V[1]. Synthesis of Some N(7)-azacyclohexyl-4-oxotheino[2,3-b]pyridine-5-carboxylic Acids and Related Congeners,, Z. Naturforsch. 2009, 64b, 1625 – 1632. 19. Taleb H. Al-Tel, Raed Al-Qawasmeh and Wolfgang Voelter, Diversity oriented organic Synthesis:Discovery of small molecules as drug candidates, 2009, ACS-abstract, oral resentation, medicinal chemistry section, Utah-USA. 20. Raed A. Al-Qawasmeh, Taleb H. Al-Tel, Khalid M. Khan, Shahnaz Perveen and Wolfgang Voelter, Archive of organic Chemistry, 310, 2007. 21. H. S. Hilal, M. Shtayeh, Taleb H. AlTel, W. Voelter and R. Arafat, European Journal of Medicinal Chemistry, 2006, 41, 1017.
- 6/2003-8/2004 Fulbright-USA award for lecturing and research at Duke university, 2003/2004, USA - 6/2003-8/2004 IDB (Islamic Development Bank) award for lecturing and research at Duke Chemistry Department, USA, 2003/2004 - 1999 Abdel-hammeed Shomman International Prize for the YOUNG Arab RESEACHER. - 4/1991-4/1995 - DAAD award (Germany) for my Ph.D. Studies. - 9/1987-6/199 - Scholarship from college of science and Technology (Jerusalem) for my M.Sc. studies. - 1990 - ISESCO Exchange-Research Award-Student at H.E.J. Research Institute of Chemistry, isolation and identification of naturally occurring alkaloids, Prof. Dr.Atta-Ur- Rahaman, Karachi-Pakistan. - 4/1989-11/1989 - NSF-USA-Exchange-Research-Student Award at Pennsylvania State University, USA, isolation and identification of naturally occurring alkaloids in the lab of Dr. Maurice Shamma. - 1/1984-6/1987 - President Award for B.Sc studies, college of science and Technology-Jerusalem. - 2013 University of Sharjah Incentive Award for Excellence in research. - 2011 - University of Sharjah Research Incentive Award-Sharjah Islamic Bank - 2010 - University of Sharjah Incentive Award for Excellence in research
First and foremost, I am an advocate of the passionate, curious mind. All humans, and many animals, are innately equipped to be endlessly exploratory, to ask questions, and to be fascinated by the world and other minds around them. My ultimate goal is to foster students' passions and curiosity. I have found that the best way for me to encourage such curiosity and enthusiasm is to root my classroom in inquiry-based learning. Students tend to learn fundamental concepts better when they know they will soon be asked to apply them to problems they find important and relevant. I structure my courses with challenging and interesting questions right from the beginning of the semester, and try to infuse my students with a desire to know more, to realize that one answered question leads to many others, and with the analytical tools they need to satisfy their curiosity. My role in the inquiry classroom resembles my experience as an outdoor education leader: a facilitator and guide in a challenging adventure designed to foster collaboration, discourse, and discovery. Achieving these objectives requires making the students active participants as much as possible. On a Simple level, this involves developing inquiry-based activities to stimulate their curiosity while guiding them through the scientific process. Active participation in my classroom is not limited to inquiry-based activities but can be applied to facts customarily learned by rote. Teaching through inquiry and active participation is a tall order. Many students emerge from high school lulled by studying just facts and quizzed through multiple choice testing. Some come to college with expectations that a neat career path will be laid out for them, and that they must only connect the dots in order to graduate and start their chosen career. But, I want my students to be independent thinkers and pioneers when they graduate. By emphasizing both the importance and the pleasure of asking--then striving to answer --scientific questions, I hope to foster a thirst for knowledge that extends beyond the classroom. If I can help a student who has always hated science classes to find rewards in asking questions and in acquiring the analytical tools to answer those questions, then I have met my goals. Ideally, I hope to awaken a passion for lifelong learning in my students. “Learning from students is more important than learning from books, though it’s a reciprocal process of education”
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