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Prof.Taleb H. AlTel Director of the Institute for Medical & Health Sciences Research Academic RankProfessor

Specialization:

  • Organic medicinal chemistry

Research Interests:

  • Drug design and discovery, privileged DOS

Contact

•1995 - Ph.D. (Suma Cum Laude) Tuebingen-University, Germany Research advisor: Prof. h.c. Wolfang Voelter, Dissertation: "Regio- and Stereoselective Strategies for the Synthesis of Polyfunctionalized Chiral Oxa-ring Systems for Medicinal Purposes" • 1990 - M.Sc. University of Jordan Amman, Jordan and Pennsylvania State University, Pennsylvania, State college, USA. Research advisors: Prof..Musa Abu Zarga, & Prof. Salim Sabri, Prof. Maurice Shamma. Dissertation: "Chemical Constituents of the Medicinal Plants of Jordan (VI): Isolation, identification and biological studies of the Constituents of Colchicum ritchii and Leontice Leontopetalum" • 1987 - B.Sc. in Chemistry and Chemical Technology College of Science and Technology (now Al-Qudus University), Jerusalem/ West -Bank. Postgraduate Training: • 4/1995-4/1996 Postdoctoral Research Associate: Supervisor: Prof. Dr. Scott McN. Sieburth, State University of New York at Stony Brook, USA. Research Theme: [4+4] Photocycloaddition reactions of tethered 2-pyridones: Toward the total synthesis of 5-8-5-tricyclic antiviral natural products. • 8/2003-7/2004 Visiting Professor at the Chemistry department, Duke University, Durham, North Carolina, USA. Supervisor: Prof. Stephen L. Craig Project: Self-Healing Reversible Polymers • 7/2004-7/2007 Principal Scientist and team leader of drug design and discovery groups (cancer and Alzheimers), Transtech Pharma, High Point, North Carolina, USA.
• Director, Research Institute of Medical and Health Sciences University of Sharjah, Sharjah-UAE, 2014 - present • Chairman of the Medicinal Chemistry Department College of Pharmacy, University of Sharjah, Sharjah-UAE, 9/2009 - 9/2015. • Professor of Organic Medicinal Chemistry College of Pharmacy, University of Sharjah, Sharjah-UAE, 2013 - present • Associate Professor of Organic Medicinal Chemistry College of Pharmacy, University of Sharjah, Sharjah-UAE, 8/2007 - 12/2012 • Principal Scientist and team leader of drug design and discovery research groups (cancer, obesity, viral and Alzheimers diseases), Transtech Pharma, High Point, North Carolina, USA, 7/2004 - 7/2007 • Visiting Professor, Department of Chemistry, Duke University Taleb H. Al-Tel CV page 2 Durham, North Carolina, USA. Project: Self-Healing Reversible Polymers, 8/2003 - 7/2004 • Director of Studies & Research Unit, An-Najah National University Nablus, West-Bank, 9/1999 - 8/2002 • Assistant and then Associate Professor of Organic Chemistry An-Najah National University, Nablus, West-Bank, 9/1996 - 6/2003 • Teaching and Research Assistant University of Jordan, Amman, Jordan, 6/1990 - 4/1991
Currently Active Research Competitive Grants 1. Terry Fox Foundation Grant: Drug Design of HDACs Inhibitors as Cancer Drug Targets, 2013 to present. (AlTel-PI) 2. Terry Fox Foundation Grant: Drug Design of HKII Inhibitors as Cancer Drug Targets, 2013 to present. (AlTel-Co-PI) 3. Boehringer Ingelheim Pharmaceutical Company Research grant: Drug Design and Discovery Targeting CDKs, 2013 to present. (AlTel-PI) 4. National Research Foundation Grant-UAE: Targeting BACE1: Design and synthesis of Alzheimer’s Drug Leads-2011 to present. (AlTel-PI) 5. KEF Holding Charity Foundation Grant: Targeting Caspases for the design and synthesis of cancer drug leads, 2012-present. (AlTel-PI) 6. National Research Foundation-UAE grant for: Targeting Cancer and Alzheimers Diseases through the synthesis of Novel Schaffolds, 2011-2014. (AlTel-PI) 7.Director, Research Institute of Medical and Health Sciences University of Sharjah, Sharjah-UAE, 2014 - present 8. Chairman of the Medicinal Chemistry Department College of Pharmacy, University of Sharjah, Sharjah-UAE, 9/2009 - 9/2015.
• American Chemical Society (ACS) member-UAE Chapter, 2016 to present, • Vice Chair ACS Organic Division, 2003 to present • ACS Medicinal Chemistry Division, 2003 to present • American Association for the Advancement of Science (AAAS), 2003 to present • International Union of Pure and Applied Chemistry (IUPAC), Affiliate, 2003 to present • Central German-DAAD Committee for Palestine (selection of Ph.D. & M.Sc candidates to study in Germany, 1997 to 2003)
• Discovery of Novel lead drug candidates targeting COVID19, AlJalila Foundation, 2015 - present • Selective Targeting of Thyrodoxin Reductase and Glutathione Reductase, Terry Fox Foundation Grant: 2019 to 2021 • Discovery of First in Class Lead Drug Candidates for the treatment of Superbugs. 2019-2021 • Targeting Breast and Prostate Cancer: Design and Synthesis of Novel and Privileged polycyclic pyrido[1,2-a]quinolinones, Benzopyranes and Benzoxepines Motifs (AlJalila Foundation), 2015 - present (AlTel-PI) • Design and Synthesis of Small Molecules for the Potential Modulation of the Tumor Suppressor TRAIL Protein-UOS, 2015 to present • Design of Novel and Privileged Structures: Forward Chemical Genetics for Phenotypic Screening of Chemical Probes Toward Dissecting the Gap of Biological Space – UOS, to present
• Manandhar, A.; Srinivasulu,V.; Hamad, M.; Tarazi, H.; Omar, H.; Colussi, D.; Gordon, J.; Childers, W.; Klein, M. L.; Al-Tel, T. H.; Abou-Gharbia, M.; Elokely, K. “Discovery of Novel Small-Molecule Inhibitors of SARS-CoV-2 Main Protease as Potential Leads for COVID-19 Treatment”, J. Chem. Inf. Model., 2021. https://doi.org/10.1021/acs.jcim.1c00684. • Srinivasulu, V.; Sieburth, S. McN.; Khanfar, M. A.; Abu-Yousef, I. A.; Majdalawieh, A.; Ramanathan, M.; Sebastian, A.; Al-Tel, T. H. “Stereoselective Late-Stage Transformations of Taleb H. Al-Tel CV page 9 Indolo[2,3-a]quinolizines Skeleta to Nature-Inspired Scaffolds”. J. Org. Chem. 2021, DOI: https://doi.org/10.1021/acs.joc.1c01523. • El-Awady, R., Saleh, E., Hamoudi, R., Ramadan, W.S., Mazitschek, R., Nael, M.A., Elokely, K.M., Abou-Gharbia, M., Childers, W.E., Srinivasulu, V., Aloum, L., Menon, V., Al-Tel, T.H. Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents, Bioorganic and Medicinal Chemistry, 2021, 42, art. no. 116251. DOI: 10.1016/j.bmc.2021.116251. • Srinivasulu, V., Al-Marzooq, F., Hamad, M., Khanfar, M.A., Ramanathan, M., Soares, N.C., Al-Tel, T.H. Sequencing Groebke-Blackburn-Bienaymé and Aza-Michael Addition Reactions: A Modular Strategy for Accessing a Diverse Collection of Constrained Benzoxazepine and Imidazopyrazine Systems. Synthesis, 2021, 53 (11), pp. 1911-1922. DOI: 10.1055/s-0040- 1706006. • Zaher, D.M., Ramadan, W.S., El-Awady, R., Omar, H.A., Hersi, F., Srinivasulu, V., Hachim, I.Y., Al-Marzooq, F.I., Vazhappilly, C.G., Merali, S., Merali, C., Soares, N.C., Schilf, P., Ibrahim, S.M., Al-Tel, T.H. A novel benzopyrane derivative targeting cancer cell metabolic and survival pathways. Cancers, 2021: DOI: 10.3390/cancers13112840. • Alhamad, D.W., Elgendy, S.M., Al-Tel, T.H., Omar, H.A. Tangeretin as an adjuvant and chemotherapeutic sensitizer against various types of cancers: a comparative overview. The Journal of pharmacy and pharmacology, 2021, 73 (5), pp. 601-610. DOI: 10.1093/jpp/rgab013. • Schilf, P., Srinivasulu, V., Bolognesi, M.L., Ibrahim, S., Majdalawieh, A.F., Abu-Yousef, I.A., Omar, H.A., ElAwady, R., Al-Tel, T.H. Design and synthesis of nature-inspired chromenopyrroles as potential modulators of mitochondrial metabolism. Medicinal Chemistry Research, 2021, 30 (3), pp. 635-646. DOI: 10.1007/s00044-020-02669-3. • Koippallil Gopalakrishnan Aghila Rani, a Mohamad A. Hamad, b Dana M. Zaher, c Scott McN Sieburth, d Navid Madani, e and Taleb H. Al-Telf; Drug development post COVID-19 pandemic: toward a better system to meet current and future global health challenges Expert Opin Drug Discov. 2021, doi: 10.1080/17460441.2021.1854221. • Schilf, P., Srinivasulu, V., Bolognesi, M.L. Taleb H. Al-Tel. Design and synthesis of natureinspired chromenopyrroles as potential modulators of mitochondrial metabolism. Med Chem Res (2020). https://doi.org/10.1007/s00044-020-02669-3. • Vunnam Srinivasulu, Paul Schilf, Saleh Ibrahim, Ihsan A. Shehadi, Omar G. Malik, Scott Sieburth, Monther A. Khanfar, Mohamad Hamad, Imad A. Abu-Yousef, Amin F. Majdalawieh, Taleb H. Al-Tel* Divergent Strategy for Diastereocontrolled Synthesis of Small- and Medium-Ring Architectures J. Org. Chem. 2020, 85, 10695−10708.
• Mentored more than 30 undergraduate students in various research projects. • Co-Supervised more than 5 M.Sc. students in the fields of organic and medicinal chemistry. • Co-Supervised more than 4 PhD students in the field of cancer biology, organic and medicinal chemistry. • Co-Supervised more than 6 post docs and research assistants.
• Altel, Taleb H.; Srinivasulu, Vunnam; Ibrahim, Saleh; Schilf, Paul “Discovery of novel first in class nature-inspired compounds targeting the mitochondrial function and pharmaceutical composition thereof”. PCT Int. Appl. (2020), WO 2020021489 A2 20200130. • Altel, Taleb H.; El-Awady, Raafat A.; Srinivasulu, Vunnam; Al-Marzooq, Taleb H. Al-Tel CV page 8 Farah Ibrahim. “Novel heterocyclic systems and pharmaceutical applications thereof”. PCT Int. Appl. (2019), WO 2019186387 A2 20191003. • Altel, Taleb H.; El-Awady, Raafat A.; Vunnam, Srinivasulu; Vazhappilly, Cijo George; Omar, Hany A. “Novel heterocyclic systems for treating diseases related to cell proliferation”. PCT Int. Appl. (2019), WO 2019186384 A2 20191003. • Altel, Taleb H.; El-Awady, Raafat A.; Vunnam, Srinivasulu; Vazhappilly, Cijo George; Omar, Hany A. “Novel heterocyclic systems and pharmaceutical compositions thereof “. U.S. Pat. Appl. Publ. (2019), US 20190292204 A1 20190926. • Altel, Taleb H.; El-Awady, Raafat A.; Vunnam, Srinivasulu; Al-Marzooq, Farah Ibrahim. “Novel heterocyclic systems and pharmaceutical applications thereof”. U.S. Pat. Appl. Publ. (2019), US 20190292202 A1 20190926. 6. Last Inventor on: Nitrogen-containing heterocycle derivatives, pharmaceutical compositions, and methods of use thereof as antiviral agents. US Patent 20070219239, 2008.
- 6/2003-8/2004 Fulbright-USA award for lecturing and research at Duke university, 2003/2004, USA - 6/2003-8/2004 IDB (Islamic Development Bank) award for lecturing and research at Duke Chemistry Department, USA, 2003/2004 - 1999 Abdel-hammeed Shomman International Prize for the YOUNG Arab RESEACHER. - 4/1991-4/1995 - DAAD award (Germany) for my Ph.D. Studies. - 9/1987-6/199 - Scholarship from college of science and Technology (Jerusalem) for my M.Sc. studies. - 1990 - ISESCO Exchange-Research Award-Student at H.E.J. Research Institute of Chemistry, isolation and identification of naturally occurring alkaloids, Prof. Dr.Atta-Ur- Rahaman, Karachi-Pakistan. - 4/1989-11/1989 - NSF-USA-Exchange-Research-Student Award at Pennsylvania State University, USA, isolation and identification of naturally occurring alkaloids in the lab of Dr. Maurice Shamma. - 1/1984-6/1987 - President Award for B.Sc studies, college of science and Technology-Jerusalem. - 2013 University of Sharjah Incentive Award for Excellence in research. - 2011 - University of Sharjah Research Incentive Award-Sharjah Islamic Bank - 2010 - University of Sharjah Incentive Award for Excellence in research
First and foremost, I am an advocate of the passionate, curious mind. All humans, and many animals, are innately equipped to be endlessly exploratory, to ask questions, and to be fascinated by the world and other minds around them. My ultimate goal is to foster students' passions and curiosity. I have found that the best way for me to encourage such curiosity and enthusiasm is to root my classroom in inquiry-based learning. Students tend to learn fundamental concepts better when they know they will soon be asked to apply them to problems they find important and relevant. I structure my courses with challenging and interesting questions right from the beginning of the semester, and try to infuse my students with a desire to know more, to realize that one answered question leads to many others, and with the analytical tools they need to satisfy their curiosity. My role in the inquiry classroom resembles my experience as an outdoor education leader: a facilitator and guide in a challenging adventure designed to foster collaboration, discourse, and discovery. Achieving these objectives requires making the students active participants as much as possible. On a Simple level, this involves developing inquiry-based activities to stimulate their curiosity while guiding them through the scientific process. Active participation in my classroom is not limited to inquiry-based activities but can be applied to facts customarily learned by rote. Teaching through inquiry and active participation is a tall order. Many students emerge from high school lulled by studying just facts and quizzed through multiple choice testing. Some come to college with expectations that a neat career path will be laid out for them, and that they must only connect the dots in order to graduate and start their chosen career. But, I want my students to be independent thinkers and pioneers when they graduate. By emphasizing both the importance and the pleasure of asking--then striving to answer --scientific questions, I hope to foster a thirst for knowledge that extends beyond the classroom. If I can help a student who has always hated science classes to find rewards in asking questions and in acquiring the analytical tools to answer those questions, then I have met my goals. Ideally, I hope to awaken a passion for lifelong learning in my students. “Learning from students is more important than learning from books, though it’s a reciprocal process of education”
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