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Prof.Mohammad Harb Semreen Academic RankProfessor
Mohammad Harb Semreen

Specialization:

  • Pharmaceutical Chemistry

Research Interests:

  • 1- Cancer Biomarkers-early diagnosis and treatment follow up, using Mass-Spectroscopy 2- Biomarkers of Infectious diseases (Covid-19 and Candida) 3- Metabolomics and proteomic studies. 4- Design and synthesis of novel anti-cancer drug leads. 5- Drug stability studies. 6- Enantioselective separation. 7- Bioanalysis and drug metabolism.

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Ph.D. in Pharmaceutical Sciences (Pharmaceutical chemistry), Messina- Italy. B. Sc. in Pharmacy, Messina University, Messina-Italy.
•Professor of Pharmaceutical Chemistry Jan. 2021 - Present, University of Sharjah (UOS), Sharjah, United Arab Emirates. •Chair of the Medicinal chemistry department, college of pharmacy, University of Sharjah, September 2016 to 2024. •Associate professor of Pharmaceutical Chemistry 2014 - 2021, University of Sharjah (UOS), Sharjah, United Arab Emirates. •Assistant professor of Medicinal Chemistry: January 2007, University of Sharjah (UOS), Sharjah, United Arab Emirates. •Visiting assistant professor, department of pharmaceutical sciences, college of pharmacy, Uuniversity of Kentucky, USA, July 2011 •Visiting assistant professor, medicinal chemistry department, college of pharmacy, University of Messina, Italy, July, 2009 •Assistant professor of Pharmaceutical Chemistry: September 2002- January 2007, Al-Israa University, Amman, Jordan •Pharmaceutical Chemistry Department chair, Israa University, Amman, Jordan, September 2004- September 2006 •Acting dean, College of Pharmacy, Israa University, Amman , Jordan , Summer courses, 2004, 2005, 2006, Amman, Jordan •Lab. Coordinator ,College of Pharmacy, Israa University, Amman, Jordan, 2003-2007 •Quality Control Manager , Ram Pharmaceutical company (RAM), Amman , Jordan: May 2001- September 2002 •Consultant for pharmaceutical industries: Ram Pharmaceutical, Pharma international, Amman , Jordan, adjunct to full time employment at Al-Israa University: Jan 2004-Jan 2007 •Researcher in Jordanian Pharmaceutical company (J.P.M), Amman, Jordan, Jun. 1997-Dicember1997.
• Arab Health Pharma and Drug Discovery Conference, June 2021 • International Conference on Toxicology and Applied Pharmacology, April 2020 • Emirates international forensic conference and exhibition” 2016-2021 • International conference of personalized medicine and targeted therapy in cancer, Sharjah Institute for medical research, University of Sharjah-UAE, 2013 • Think Science Competition (Judge- Scientific Committee)), Emirates Foundation, Abu Dhabi, UAE, 2016-Present.
Ph.D. program in pharmaceutical sciences. Chair UoS 2020 Present Master program in pharmaceutical sciences. Member UoS 2016 Present •Member of the International Forensic Scientific Council – IFSC, 2017-present, Dubai, UAE. •Scientific Committee Member “ Emirates international forensic conference and exhibition” 2016 •Scientific Committee Member: International Conference on pharmaceutical Drugs, May 15-17, 2017, Dubai, UAE. •Editorial board member of International Journal of Chromatography & Separation Techniques. •Editorial board member of the journal Natural Products Chemistry & Research. •Editorial board member of the journal of Medicinal Chemistry. •Editorial board member of the journal of current Medicinal Chemistry. •Drug registration and pricing higher technical committee Ministry of Health (MOH)-UAE, 2009 to present. •Member of the ACS (American Chemical Society), Medicinal Chemistry Division, 2010 to present. •Member of the ACS (American Chemical Society), Analytical Chemistry Division, 2010 to present.
1- Computational models applied to multi-omics data for the early diagnostics biomarkers of breast cancer in Arab and Russian population 2- A modern test for the timely personalized diagnosis of lung cancer onset and the disease progression based quantitative multiplexed determination of the proteome/metabolome profile of blood and exhaled breath condensate 3- The Discovery of novel salivary biomarkers for early detection of oral cancer with background of smokeless tobacco using targeted and untargeted quantitative proteomic & Transcriptomic approaches 4- Development of sensitive and selective analytical methods for the investigation and detection of pharmaceutical products and xenobiotics contaminants in UAE wastewater and its remediation 5- Synthesis and biophysical characterization of DNA binding ligands as potential antibacterial and anticancer agents.
2024 Abufares HI, Zenati RA, Soares NC, El-Huneidi W, Dahabiyeh LA, Al-Hroub HM, Alqudah MA, Abuhelwa AY, Alzoubi KH, Abu-Gharbieh E, Fararjeh MA, Abu-Irmaileh B, Bustanji Y, Mohammad H. Semreen*. A Non-Targeted Metabolomics Comparative Study on Plasma of Pfizer and Sinopharm COVID-19 Vaccinated individuals, Assessed by (TIMS-QTOF) Mass Spectrometry. Heliyon. 2024 Jul 30. 2024 Giddey AD, Hagyousif YA, Soares NC, Al-Hroub HM, Rani KA, Zaher DM, Omar H, Al Kawas S, Mohammad H. Semreen*, Al-Rawi N. Comparative Proteomic Analysis of Saliva from Chewing Tobacco Users and Oral Cancer Patients Reveals Shared Biomarkers: A case control observational study. Journal of Dentistry. 2024 Jul 30:105268. 2024 Bustanji Y, Taneera J, Bargooth A, Abuhelwa A, Issa A, El-Huneidi W, Abu-Gharbieh E, Alzoubi K, Alqudah MA, Alhusban A, Hamad I, Mohammad H. Semreen. Exploring the global landscape of self-medication among students: Trends, risks, and recommendations for safe and responsible practices. Pharmacy Practice. 2024 Mar 6;22(1):1-4. 2024 Fatima M. Al-Daffaie, Sara F. Al-Mudhafar, Aya Alhomsi , Hamadeh Tarazi, Ahmed M. Almehdi, Waseem El-Huneidi, Eman Abu-Gharbieh, Yasser Bustanji, Mohammad A. Y. Alqudah, Ahmad Y. Abuhelwa , Adnane Guella, Karem H. Alzoubi, and Mohammad H. Semreen*. Metabolomics and Proteomics in Prostate Cancer Research: Overview, Analytical Techniques, Data Analysis, and Recent Clinical Applications. Accepted for publication 2024, International Journal of Molecular sciences. 2024 Ahmed M, Semreen AM, Giddey AD, Ramadan WS, El-Awady R, Soares NC, El-Huneidi W, Bustanji Y, Alqudah MAY, Alzoubi KH, Mohammad H. Semreen*. Proteomic and metabolomic signatures of U87 glioblastoma cells treated with cisplatin and/or paclitaxel. Ann Med. 2023;55(2):2305308. doi: 10.1080/07853890.2024.2305308. Epub 2024 Jan 22. PMID: 38253025; PMCID: PMC10810643. 2024 Alshamsi MA, Mosa KA, Khan AA, Mousa M, Ali MA, Soliman SS, Mohammad H. Semreen. Biosynthesized Silver Nanoparticles from Cyperus conglomeratus Root Extract Inhibit Osteogenic Differentiation of Immortalized Mesenchymal Stromal Cells. Current Pharmaceutical Biotechnology. 2024 Aug 1;25(10):1333-47. 2024 Semerjian L, Wardah R, Almatrook K, Kamali L, Almadhani S, Mohammad H. Semreen Abass K. Quantification and Environmental Burden of Trace Metals in Disposable Facemasks Widely Used in UAE during COVID-19 Pandemic. 2024. 2024 Dakilah I, Harb A, Abu-Gharbieh E, El-Huneidi W, Taneera J, Hamoudi R, Semreen MH, Bustanji Y. Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicine. Frontiers in Pharmacology. 2024 Jan 19;15:1324001. 2023 Lina A. Dahabiyeh, Farah Hudaib, Wafa Hourani, Wesam Darwish, Bashaer Abu-Irmaileh, Pran Kishore Deb, Katharigatta N. Venugopala, Viresh Mohanlall, Sandeep Chandrashekharappa, Rana Abu-Dahab, Mohammad H. Semreen, and Yasser Bustanji. “Mass Spectrometry-Based Metabolomics Approach and in Vitro Assays Revealed Promising Role of 2,3-Dihydroquinazolin-4(1H)-One Derivatives Against Colorectal Cancer Cell Lines.” European Journal of Pharmaceutical Sciences 2023, 106378. doi: 10.1016/J.EJPS.2023.106378. 2023 Munazza Ahmed, Ahlam M. Semreen, Waseem El-Huneidi, Yasser Bustanji, Eman Abu-Gharbieh, Mohammad A. Y. Alqudah, Ahmed Alhusban, Mohd Shara, Ahmad Y. Abuhelwa, Nelson C. Soares, Mohammad H. Semreen*, and Karem H. Alzoubi. “Preclinical and Clinical Applications of Metabolomics and Proteomics in Glioblastoma Research.” International Journal of Molecular Sciences 2023, Vol. 24, Page 348 24(1):348. doi: 10.3390/IJMS24010348. 2023 Ruba A. Zenati, Alexander D. Giddey, Hamza M. Al-Hroub, Yousra A. Hagyousif, Waseem El-Huneidi, Yasser Bustanji, Eman Abu-Gharbieh, Mohammad A. Y. Alqudah, Mohd Shara, Ahmad Y. Abuhelwa, Nelson C. Soares, and Mohammad H. Semreen*. “Evaluation of Two Simultaneous Metabolomic and Proteomic Extraction Protocols Assessed by Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry.” International Journal of Molecular Sciences 2023, Vol. 24, Page 1354 24(2):1354. doi: 10.3390/IJMS24021354. 2022 Alsoud LO, Soares NC, Al-Hroub HM, Mousa M, Kasabri V, Bulatova N, Suyagh M, Alzoubi KH, El-Huneidi W, Abu-Irmaileh B, Bustanji Y, Mohammad H. Semreen*, Identification of Insulin Resistance Biomarkers in Metabolic Syndrome Detected by UHPLC-ESI-QTOF-MS, Metabolites, 2022, 1; 12 (6): 508. doi: 10.3390/metabo12060508. 2022 Sharaf BM, Giddey AD, Alniss H, Al-Hroub HM, El-Awady R, Mousa M, Almehdi A, Soares NC, Mohammad H. Semreen, Untargeted Metabolomics of Breast Cancer Cells MCF-7 and SkBr3 Treated With Tamoxifen/Trastuzumab, Cancer Genomics Proteomics, 2022;19 (1):79-93. doi: 10.21873/cgp.20305.
• Metabolomics of breast cancer cells with different hormonal status treated with Tamoxifen and/or Trastuzumab assessed by Mass spectroscopy • Cell metabolomics and proteomics as an approach to identify the molecular targets of anti-lung cancer agents UHPLC-Q/TOF-MS and multivariate data analysis • Metabolomics and proteomics based comparative study of hepatocellular carcinoma (HCC) cell lines with multi drug resistant hepatocellular carcinoma (MDR- HCC) cell lines assessed by (TIMS-QTOF) mass spectroscopy. • Metabolomics of plasma and saliva for COVID-19 biomarkers identification and disease monitoring • Removal of Selected Pharmaceutical Compounds from Water Using Nanomaterials. • GC-MS based comparative metabolomic analysis of MCF7 and MDA-MB-231 cancer cells treated with Tamoxifen and/or Taxol
•Incentive award for distinguished faculty, teaching track, 2017, UOS. •Sharjah Islamic Bank award 2014, for distinguished, research article. •Associate professor rank promotion, 2014, Sharjah University, UAE. •Best research article award 2012, University of Sharjah, UAE. •Best research group award 2012, University of Sharjah,
• Merit award for distinction in teaching, University of Sharjah, 2017 & 2021 • Full professor rank promotion, University of Sharjah, 2021, UAE. • Sharjah Islamic Bank award, for distinguished research article, University of Sharjah, 2014. • Associate professor rank promotion, University of Sharjah, 2014, UAE. • Best research article award, University of Sharjah, UAE, 2012. • Best research group award, University of Sharjah, UAE, 2012. • Assistant professor, Isra University, Jordan, 2003. • Scholarship for Ph.D. In Pharmaceutical Sciences from the Italian government, 1998. • Scholarship for B.SC. In Pharmacy, from the Italian government, 1990.
- Chair, Ph.D. program in pharmaceutical sciences. (2020-Present) - Member, Master program in pharmaceutical sciences. (2016-Present) - Member, Health Insurance Committee (2012-2015) - Member, Faculty Affairs Committee (2012-2014) - Chair, Exams Committee (2012- Present) - Chair, Purchasing Committee (2012-Present) - Member, College Council (2012-Present) - Chair, Faculty Development, (2010-present) - Member, Internal Technical Review Committee –Central lab. (2009-2012) - Chair, Purchasing and Laboratories Committee (2007, 2008, 2009, 2010 )
I believe that faculty member must be a role model for his/her students. He/she must be self-motivated and disciplined to meet the performance expectations of peers within the institution. Medicinal chemistry is considered by the most of the students as a difficult subject and hard to be understood, I think this is the primary challenge for me. Therefore, the goal of the course are evaluated regularly, as this will help me see where the class is going. I believe that university professors are ethically obligated to prepare and present material and conduct themselves in relation to their students in a specific way. As a university instructor, it’s my responsibility to enter each class fully prepared and to provide my students with clear explanations and policies in the syllabus. I am strongly convinced that successful teachers are those who possess the ability to explain, express their ideas effectively, respond to students’ questions and be available during office hours.
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