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Dr.Mohammad Harb Semreen Chairman of the Medicinal Chemistry Department Academic RankAssociate Professor

Specialization:

  • Ph.D. in Pharmaceutical Chemistry.

Research Interests:

  • •Development and validation of analytical methods using techniques such as LC-MS/MS, HPLC, GC and their application in pharmacokinetics. •Pharmaceuticals and biopharmaceutical analysis. •Drug stability studies. •Enantioselective separation •Design and synthesis of novel anti-cancer drug leads.

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Ph.D. in Pharmaceutical Sciences (Pharmaceutical chemistry), Messina- Italy. B. Sc. in Pharmacy, Messina University, Messina-Italy.
•Chair of the Medicinal chemistry department, college of pharmacy, University of Sharjah, September 2016 to present. •Associate professor of Pharmaceutical Chemistry Feb. 2014, University of Sharjah (UOS), Sharjah, United Arab Emirates. •Assistant professor of Medicinal Chemistry: January 2007, University of Sharjah (UOS), Sharjah, United Arab Emirates. •Visiting assistant professor, department of pharmaceutical sciences, college of pharmacy, Uuniversity of Kentucky, USA, July 2011 •Visiting assistant professor, medicinal chemistry department, college of pharmacy, University of Messina, Italy, July, 2009 •Assistant professor of Pharmaceutical Chemistry: September 2002- January 2007, Al-Israa University, Amman, Jordan •Pharmaceutical Chemistry Department chair, Israa University, Amman, Jordan, September 2004- September 2006 •Acting dean, College of Pharmacy, Israa University, Amman , Jordan , Summer courses, 2004, 2005, 2006, Amman, Jordan •Lab. Coordinator ,College of Pharmacy, Israa University, Amman, Jordan, 2003-2007 •Quality Control Manager , Ram Pharmaceutical company (RAM), Amman , Jordan: May 2001- September 2002 •Consultant for pharmaceutical industries: Ram Pharmaceutical, Pharma international, Amman , Jordan, adjunct to full time employment at Al-Israa University: Jan 2004-Jan 2007 •Researcher in Jordanian Pharmaceutical company (J.P.M), Amman, Jordan, Jun. 1997-Dicember1997.
•Drug registration and pricing technical committee, Ministry of Health (MOH)-UAE, 2009 to present. •Drug registration and pricing higher technical committee, Ministry of Health (MOH)-UAE, 2009 to present. •Member of the International Forensic Scientific Council – IFSC, Dubai, UAE, 2017-present •Scientific Committee Member: International Conference on Pharmaceutical Drugs, May 15-17, 2017, Dubai, UAE.
•Member of the International Forensic Scientific Council – IFSC, 2017-present, Dubai, UAE. •Scientific Committee Member “ Emirates international forensic conference and exhibition” 2016 •Scientific Committee Member: International Conference on pharmaceutical Drugs, May 15-17, 2017, Dubai, UAE. •Editorial board member of International Journal of Chromatography & Separation Techniques. •Editorial board member of the journal Natural Products Chemistry & Research. •Editorial board member of the journal of Medicinal Chemistry. •Editorial board member of the journal of current Medicinal Chemistry. •Drug registration and pricing higher technical committee Ministry of Health (MOH)-UAE, 2009 to present. •Member of the ACS (American Chemical Society), Medicinal Chemistry Division, 2010 to present. •Member of the ACS (American Chemical Society), Analytical Chemistry Division, 2010 to present.
•Design, synthesis and biological evaluation of new sulfonate derivatives as potential anticancer agents, Boehringer ingelheim, 2017, •Emerging Contaminants in Wastewater Reuse in The Emirate of Sharjah, University of Sharjah. •Inhibition of Biogas production from sewage sludge Co-digested with date palm (Phoenix dactylifera L.) seeds and antibacterial and anticancer characteristics of date seeds, University of Sharjah, 2016. •Design, synthesis and biological evaluation of new sulfonate derivatives as potential anticancer agents, Boehringer ingelheim, 2017. •Design and synthesis of new sulfamate derivatives as potential inhibitors of steroid sulfatase enzyme for the treatment of hormone-dependent cancers, Boehringer ingelheim, 2016-present. •Design and synthesis of new sulfamate and sulfonate derivatives as steroid sulfatase inhibitors for the treatment of estrogen- and androgen-dependent cancers, Boehringer ingelheim, 2015. •Design, synthesis, and in vitro antiproliferative activity of new sulfonate derivatives possessing naphthyl moiety, Boehringer ingelheim, 2015.
•Soliman, S., Mohammad H. Semreen, Ali A. El-Keblawy, Arbab Abdullah, Priya Uppuluri and Ashraf S. Ibrahim. Assessment of herbal drugs for promising anti-Candida activity. BMC Complementary and Alternative Medicine, (2017) 17, (1): 257, DOI 10.1186/s12906-017-1760-x •Raed A. Al-Qawasmeh, Basil B. Huthaila, Mutasem . Sinnokrot, Mohammad H. Semreen, Raed A. Odeh, Musa H. Abu-Zarga, Hamadeh Tarazi, lmad A. Yousef and Taleb H AI-Tel, Design, Synthesis and Qualitative Structure Activity Relationship Evaluations of Quinoline-Based Bisarylimidazoles as Antibacterial Motifs. Medicinal chemistry, 2016, 11,563-573. •Mohammed I. El-Gamal, Mohammad H. Semreen, Paul A. Foster, and Barry V.L. Potter; "Design, synthesis, and biological evaluation of new arylamide derivatives possessing sulfonate or sulfamate moieties as steroid sulfatase enzyme inhibitors". Bioorganic & Medicinal Chemistry, 2016, 24(12), 2762-2767. •Raafat A. El-Awady, Mohammad H. Semreen, Maha M. Saber, Farhan Cyprian, Taleb Al-Tel, Modulation of DNA damage response and induction of apoptosis mediates synergism between doxorubicin and a new imidazopyridine derivative in breast and lung cancer cells, DNA-Repair, 2016, 37, 1-11. •Subash Chandra Sahoo, Naba K. Nath, Lidong Zhang, Mohammad H. Semreen, Taleb H. Al-Tel and Panče Naumov, Actuation based on thermo/photosalient effect: a biogenic smart hybrid driven by light and heat, RSC Adv., 2014,4, 7640-7647 •Raed A. Al-Qawasmeh, Monther A. Khanfar, Mohamad H. Semreen, Raed Abu Odeh, and Taleb H. Al-Tel, Design and synthesis of new hybrid triazine-indol derivatives as potential antimicrobial agents against hospital resistant strains, Heterocycles, 2013, 87, 11, 2385-2394. •Mohammad H. Semreen, Raafat El-Awady, Raed Abu-Odehb, Maha Saber-Ayada, Raed A. Al-Qawasmehe, Salem Chouaib, Wolfgang Voelterg and Taleb H. Al-Tel, Tandem Multicomponent Reactions Toward the Design and Synthesis of Novel Antibacterial and Cytotoxic Motifs, Current Medicinal Chemistry, 2013, 20, 1445-1459 •Taleb H. Al-Tel, Mohammad H. Semreen, Raed Al-Qawasmeh, Marco F. Schmidt, Rafat El-Awadi, Mustafa Ardah, Rania Zaarour, Shashidahar N. Rao, and Omar El-Agnaf, Design, Synthesis and qualitative structure- activityevaluation of novel β-secretase inhibitor as potential Alzheimer's drugleads, J. Med. Chem. 2011, 54, 8373-8385 •Mohammad H. Semreen, Hassan Y. Aboul-Eneien, Enantioselective separation and determination of citalopram enantiomers in pharmaceutical dosage forms and bulk drug using experimental design approach on chiralcel® OC as a chiral stationary phase. Acta chromatographica, 23, 2011, 3, 389-401 •Mohammad H. Semreen, Hassan y. Aboul-Enein , Determination of heavy metals contents in wild- Edible mushrooms from Jordan, Analytical letters, 2011 (44) 932–941. •Taleb H. Al-Tel , Mohammad H. Semreen and Wolfgang Voelter, Tandem Achmatowicz-Knoevenagel protocol: diastereoselective synthesis and anticancer evaluation of cyclopenta[b]pyrane derivatives, J. Org. & Biomolecular Chemistry, 2010, 8, 5375-5382 •Mohammad H. Semreen, Abdel-Nasser El-Shorbagi, Taleb H. Al-Tel, Izzeddin M. M. Alsalahat, Targeting γ-aminobutyric acid (GABA) carrier to the brain, potential relevance as antiepileptic drug, Medicinal chemistry, 2010, (6) 144-149. •Mohammad H. Semreen, Hassan Y. Aboul-Eneien, LC-UV method development, and validation for the non-steroidal antiinflamatory agent Tenoxicam. J. Liquid chromatography and related technologies, 2010, 33,720 -729. •Mohammad H. Semreen, Hassan y. Aboul-Enein , Experimental design strategies in LC method development and in robustness testing for reversible cholinesterase inhibitor rivastigmin in pharmaceutical formulation, J. Liquid chromatography and related technologies, 2010, 33, 191-201.
•Design, synthesis and biological evaluation of new sulfonate derivatives as potential anticancer agents. •Design and synthesis of new sulfamate derivatives as potential inhibitors of steroid sulfatase enzyme for treatment of hormone-dependent cancers •Simultaneous determination of pharmaceuticals in multiple urban wastewater by Solid-phase extraction and liquid chromatography–tandem mass spectrometry.
•Incentive award for distinguished faculty, teaching track, 2017, UOS. •Sharjah Islamic Bank award 2014, for distinguished, research article. •Associate professor rank promotion, 2014, Sharjah University, UAE. •Best research article award 2012, University of Sharjah, UAE. •Best research group award 2012, University of Sharjah,
- Sharjah Islamic Bank award 2014, for distinguished research article. - Associate professor rank promotion, 2014, Sharjah university, UAE - Best research article award 2012, university of sharjah,UAE - Best research group award 2012, university of sharjah,UAE - Assistant professor,2003, Israa University, Jordan - Scholarship for Ph.D. in pharmaceutical sciences from Italian government, 1998 - Scholarship for B.SC. in Pharmacy, from Italian government.1990
- Member, Health Insurance Committee (2012-2015) - Member, Faculty Affairs Committee (2012-2014) - Chair, Exams Committee (2012- Present) - Chair, Purchasing Committee (2012-Present) - Member, College Council (2012-Present) - Chair, Faculty Development, (2010-present) - Member, Internal Technical Review Committee –Central lab. (2009-2012) - Chair, Purchasing and Laboratories Committee (2007, 2008, 2009, 2010 )
I believe that faculty member must be a role model for his/her students. He/she must be self-motivated and disciplined to meet the performance expectations of peers within the institution. Medicinal chemistry is considered by the most of the students as a difficult subject and hard to be understood, I think this is the primary challenge for me. Therefore, the goal of the course are evaluated regularly, as this will help me see where the class is going. I believe that university professors are ethically obligated to prepare and present material and conduct themselves in relation to their students in a specific way. As a university instructor, it’s my responsibility to enter each class fully prepared and to provide my students with clear explanations and policies in the syllabus. I am strongly convinced that successful teachers are those who possess the ability to explain, express their ideas effectively, respond to students’ questions and be available during office hours.
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