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Prof.Mohammad Harb Semreen Chairman of the Medicinal Chemistry Department Academic RankProfessor

Specialization:

  • Pharmaceutical Chemistry

Research Interests:

  • 1- Cancer Biomarkers-early diagnosis and treatment follow up, using Mass-Spectroscopy 2- Biomarkers of Infectious diseases (Covid-19 and Candida) 3- Metabolomics and proteomic studies. 4- Design and synthesis of novel anti-cancer drug leads. 5- Drug stability studies. 6- Enantioselective separation. 7- Bioanalysis and drug metabolism.

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Ph.D. in Pharmaceutical Sciences (Pharmaceutical chemistry), Messina- Italy. B. Sc. in Pharmacy, Messina University, Messina-Italy.
•Professor of Pharmaceutical Chemistry Jan. 2021 - Present, University of Sharjah (UOS), Sharjah, United Arab Emirates. •Chair of the Medicinal chemistry department, college of pharmacy, University of Sharjah, September 2016 to present. •Associate professor of Pharmaceutical Chemistry Feb. 2014, University of Sharjah (UOS), Sharjah, United Arab Emirates. •Assistant professor of Medicinal Chemistry: January 2007, University of Sharjah (UOS), Sharjah, United Arab Emirates. •Visiting assistant professor, department of pharmaceutical sciences, college of pharmacy, Uuniversity of Kentucky, USA, July 2011 •Visiting assistant professor, medicinal chemistry department, college of pharmacy, University of Messina, Italy, July, 2009 •Assistant professor of Pharmaceutical Chemistry: September 2002- January 2007, Al-Israa University, Amman, Jordan •Pharmaceutical Chemistry Department chair, Israa University, Amman, Jordan, September 2004- September 2006 •Acting dean, College of Pharmacy, Israa University, Amman , Jordan , Summer courses, 2004, 2005, 2006, Amman, Jordan •Lab. Coordinator ,College of Pharmacy, Israa University, Amman, Jordan, 2003-2007 •Quality Control Manager , Ram Pharmaceutical company (RAM), Amman , Jordan: May 2001- September 2002 •Consultant for pharmaceutical industries: Ram Pharmaceutical, Pharma international, Amman , Jordan, adjunct to full time employment at Al-Israa University: Jan 2004-Jan 2007 •Researcher in Jordanian Pharmaceutical company (J.P.M), Amman, Jordan, Jun. 1997-Dicember1997.
• Arab Health Pharma and Drug Discovery Conference, June 2021 • International Conference on Toxicology and Applied Pharmacology, April 2020 • Emirates international forensic conference and exhibition” 2016-2021 • International conference of personalized medicine and targeted therapy in cancer, Sharjah Institute for medical research, University of Sharjah-UAE, 2013 • Think Science Competition (Judge- Scientific Committee)), Emirates Foundation, Abu Dhabi, UAE, 2016-Present.
•Member of the International Forensic Scientific Council – IFSC, 2017-present, Dubai, UAE. •Scientific Committee Member “ Emirates international forensic conference and exhibition” 2016 •Scientific Committee Member: International Conference on pharmaceutical Drugs, May 15-17, 2017, Dubai, UAE. •Editorial board member of International Journal of Chromatography & Separation Techniques. •Editorial board member of the journal Natural Products Chemistry & Research. •Editorial board member of the journal of Medicinal Chemistry. •Editorial board member of the journal of current Medicinal Chemistry. •Drug registration and pricing higher technical committee Ministry of Health (MOH)-UAE, 2009 to present. •Member of the ACS (American Chemical Society), Medicinal Chemistry Division, 2010 to present. •Member of the ACS (American Chemical Society), Analytical Chemistry Division, 2010 to present.
1- Computational models applied to multi-omics data for the early diagnostics biomarkers of breast cancer in Arab and Russian population 2- A modern test for the timely personalized diagnosis of lung cancer onset and the disease progression based quantitative multiplexed determination of the proteome/metabolome profile of blood and exhaled breath condensate 3- The Discovery of novel salivary biomarkers for early detection of oral cancer with background of smokeless tobacco using targeted and untargeted quantitative proteomic & Transcriptomic approaches 4- Development of sensitive and selective analytical methods for the investigation and detection of pharmaceutical products and xenobiotics contaminants in UAE wastewater and its remediation 5- Synthesis and biophysical characterization of DNA binding ligands as potential antibacterial and anticancer agents.
1- Rawan M. Sbenati, Mohammad H. Semreen, Ahlam M. Semreen, Mahmoud K. Shehata, Fai M. Alsaghir, and Mohammed I. El-Gamal, Evaluation of imidazothiazole-based anticancer agents in one decade (2011-2020): Current status and future prospects, Bioorganic & Medicinal Chemistry, 29, 1, 2021,115897. 2- Abdallah Shanableh; Sourjya Bhattacharjee; Sama Alani; Noora Darwish; Mohamed Abdallah; Muath Mousa; Mohammad Semreen, Assessment of sulfamethoxazole removal by nanoscale zerovalent iron, Science of the Total Environment, 761, 20, 2021, 143307. 3- Sameh S. M. Soliman, Tasneem Al Hamidi, Shifaa Abdin, Ahmed M. Almehdi, Mohammad H. Semreen, Razan Al Hamidi, Sarra B. Shakartalla, Mohamed Haider, Mohamed I. Husseiny, Hany A. Omar, Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites, PLOS ONE, 27, 2020, 3390-3396. 4- Muhammad Nasir Khan Khattak, Abdallah Shanableh, Muhammad Iftikhar HussainAmir Ali Khan, Muhammad Abdulwahab, Wameed Radeef, Mohammad H. Semreen, Anticancer activities of selected Emirati Date (Phoenix dactylifera L.) variet-ies pits in human triple negative breast cancer MDA-MB-231 cells, Saudi Journal of Biological Sciences, 2020. 5- Mohammad H. Semreen, Hasan Alniss, Stefano Cacciatore, Rafat El-Awady, Muath Mousa, Ahmed M. Almehdi, Waseem El-Huneidi, Luiz Zerbini, Nelson C. Soares, GC-MS based comparative metabolomic analysis of MCF-7 and MDA-MB-231 cancer cells treated with Tamoxifen and/or Paclitaxel, In press, J. of Proteomics, 2020, 225, 103875. 6- Mohammed I. El-Gamal , Hany A. Omar, Mohammad H. Semreen, Israa A. Younes, Youmna Y. Zaghloul, Ayat E. Abbas, Iman G. Moussa, Fatima Hersi, and Chang-Hyun Oh, Antiproliferative activity of cycloalkanecarboxamide derivatives possessing sulfonate or sulfamate moiety, accepted article, Bioorganic Chemistry, 2020, 97,103677. 7- Hussain MI, Mohammad H. Semreen, Shanableh A, Khattak MNK, Saadoun, Ahmady IM, Mousa M, Darwish N, Radeef W, Soliman SSM, Phenolic Composition and Antimicrobial Activity of Different Emirati Date (Phoenix dactylifera L.) Pits: A Comparative Study, Plants, 2019 12; 8(11) 498. 8- Alniss HY, Witzel, Mohammad H. Semreen, Panda PK, Mishra YK, Ahuja R,. Investigation of the Factors That Dictate the Preferred Orientation of Lexitropsins in the Minor Groove of DNA. J Med Chem. 2019, 62(22):10423-10440. 9- Mohammad H. Semreen, Hasan Y. Alniss, Stefan Grgic, Rafaat El-Awady, Ahmed Almehdi, Muath K. Mousa, Rifat Hamoudi. GC-MS based comparative metabolomics of MCF-7 breast cancer cells using different extraction solvents assessed by mass spectroscopy, scientific reports, 2019, 9(1):13126. 10- Mohammad H. Semreen, Mohammed I. El-Gamal, Saif Ullah, Saquib Jalil , Sumera Zaib, Chang-Hyun Oh, Joanna Lecka, Jean Sévigny, and Jamshed Iqbal, Synthesis, biological evaluation, and molecular docking study of sulfonate derivatives as nucleotide pyrophosphatase (NPPs), Bioorganic and Medicinal Chemistry, 2019, 27, (13), 2741-2752. 11- Mohammad H. Semreen, Hasan Y. Alniss,Muath K. Mousa and Hassan Y. Aboul-Enein, Quick and Sensitive UPLC-ESI-MS/MS Method for Simultaneous Estimation of Sofosbuvir and Its Metabolite in Human Plasma, Molecules, 2019, 24 (7), 1302. 12- Mohammad H. Semreen, Abdallah Shanableh, Lucy Semerjian, Hasan Alniss, Mouath Khairi, Xuelian Bai and Kumud Acharya, Simultaneous determination of pharmaceuticals in by solid-phase extraction and liquid chromatography–tandem mass spectrometry: a case study from Sharjah sewage treatment plant, Molecules, 2019, 24(3), 633. 13- Mohammad H. Semreen, Sameh S. M. Soliman, Balsam Q. Saeed , Abdullah Alqarihi, Priya Uppuluri and Ashraf S. Ibrahim, Metabolic Profiling of Candida auris, a Newly-Emerging Multi-Drug Resistant Candida Species, by GC-MS, Molecules, 2019, 24 (3), 399.
• Metabolomics of breast cancer cells with different hormonal status treated with Tamoxifen and/or Trastuzumab assessed by Mass spectroscopy • Cell metabolomics and proteomics as an approach to identify the molecular targets of anti-lung cancer agents UHPLC-Q/TOF-MS and multivariate data analysis • Metabolomics and proteomics based comparative study of hepatocellular carcinoma (HCC) cell lines with multi drug resistant hepatocellular carcinoma (MDR- HCC) cell lines assessed by (TIMS-QTOF) mass spectroscopy. • Metabolomics of plasma and saliva for COVID-19 biomarkers identification and disease monitoring • Removal of Selected Pharmaceutical Compounds from Water Using Nanomaterials. • GC-MS based comparative metabolomic analysis of MCF7 and MDA-MB-231 cancer cells treated with Tamoxifen and/or Taxol
•Incentive award for distinguished faculty, teaching track, 2017, UOS. •Sharjah Islamic Bank award 2014, for distinguished, research article. •Associate professor rank promotion, 2014, Sharjah University, UAE. •Best research article award 2012, University of Sharjah, UAE. •Best research group award 2012, University of Sharjah,
• Merit award for distinction in teaching, University of Sharjah, 2017 & 2021 • Full professor rank promotion, University of Sharjah, 2021, UAE. • Sharjah Islamic Bank award, for distinguished research article, University of Sharjah, 2014. • Associate professor rank promotion, University of Sharjah, 2014, UAE. • Best research article award, University of Sharjah, UAE, 2012. • Best research group award, University of Sharjah, UAE, 2012. • Assistant professor, Isra University, Jordan, 2003. • Scholarship for Ph.D. In Pharmaceutical Sciences from the Italian government, 1998. • Scholarship for B.SC. In Pharmacy, from the Italian government, 1990.
- Member, Health Insurance Committee (2012-2015) - Member, Faculty Affairs Committee (2012-2014) - Chair, Exams Committee (2012- Present) - Chair, Purchasing Committee (2012-Present) - Member, College Council (2012-Present) - Chair, Faculty Development, (2010-present) - Member, Internal Technical Review Committee –Central lab. (2009-2012) - Chair, Purchasing and Laboratories Committee (2007, 2008, 2009, 2010 )
I believe that faculty member must be a role model for his/her students. He/she must be self-motivated and disciplined to meet the performance expectations of peers within the institution. Medicinal chemistry is considered by the most of the students as a difficult subject and hard to be understood, I think this is the primary challenge for me. Therefore, the goal of the course are evaluated regularly, as this will help me see where the class is going. I believe that university professors are ethically obligated to prepare and present material and conduct themselves in relation to their students in a specific way. As a university instructor, it’s my responsibility to enter each class fully prepared and to provide my students with clear explanations and policies in the syllabus. I am strongly convinced that successful teachers are those who possess the ability to explain, express their ideas effectively, respond to students’ questions and be available during office hours.
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