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Dr.Mohammed Ibrahim El-Gamal Academic RankAssociate Professor

Research Interests:

  • Medicinal Chemistry; Organic Chemistry; Drug Design and Synthesis; Pharmacokinetics and Pharmacodynamics.

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Ph.D. degree in Medicinal Chemistry. Korea Institute of Science and Technology, Seoul, Republic of Korea
Star Postdoc Fellow at Korea Institute of Science and Technology, Seoul, Republic of Korea (Sept. 2012 ~ Aug. 2014). Assistant Professor of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Egypt (Sept. 2013 till now).
Teaching and research in the field of medicinal chemistry.
Membership of the Asian Council of Science Editors (ACSE).
Design and synthesis of pyrazoles as anticancer agents; Design and synthesis of sulfonate and sulfamate derivatives as steroid sulfatase inhibitors.
Mahmoud M. Gamal El-Din, Mohammed I. El-Gamal, Mohammed S. Abdel-Maksoud, Kyung Ho Yoo, and Chang-Hyun Oh; "Design, synthesis, broad-spectrum antiproliferative activity, and kinase inhibitory effect of triarylpyrazole derivatives possessing arylamides or arylureas moieties". Eur. J. Med. Chem. 2016, 119, 122-131. 2) Mohammed I. El-Gamal (Corresponding author), Mohammad H. Semreen, Paul A. Foster (Co-corresponding author, University of Birmingham, UK), and Barry V.L. Potter (University of Oxford, UK); "Design, synthesis, and biological evaluation of new arylamide derivatives possessing sulfonate or sulfamate moieties as steroid sulfatase enzyme inhibitors". Bioorg. Med. Chem. 2016, in press. http://www.sciencedirect.com/science/article/pii/S0968089616302838 3) Mohammed I. El-Gamal, and Chang-Hyun Oh; "Synthesis, in vitro antiproliferative activity, and in silico studies of fused tricyclic coumarin sulfonate derivatives". Eur. J. Med. Chem. 2014, 84, 68-76. 4) Mohammed I. El-Gamal, Mohammad Ashrafuddin Khan, Mohammed S. Abdel-Maksoud, Mahmoud M. Gamal El-Din, and Chang-Hyun Oh; "A new series of diarylamides possessing quinoline nucleus: Synthesis, in vitro anticancer activities, and kinase inhibitory effect". Eur. J. Med. Chem. 2014, 87, 484-492. 5) Mohammed I. El-Gamal, Hong Seok Choi, Kyung Ho Yoo, Daejin Baek, and Chang-Hyun Oh; “Antiproliferative diarylpyrazole derivatives as dual inhibitors of the ERK pathway and COX-2”. Chem. Biol. Drug Des. 2013, 82(3), 336-347. 6) Mohammed I. El-Gamal, Yi Seul Park, Dae Yoon Chi, Kyung Ho Yoo, and Chang-Hyun Oh; “New triarylpyrazoles as broad- spectrum anticancer agents: Design, synthesis, and biological evaluation”. Eur. J. Med. Chem. 2013, 65, 315-322. 7) Mohammed I. El-Gamal, Hanan S. Anbar, Hye Jin Chung, Hyun-Il Kim, Young-Jin Cho, Bong Sang Lee, Sun Ahe Lee, Ji Yun Moon, Dong Jin Lee, Dow Kwon, Won-jai Choi, Hong-Ryeol Jeon, and Chang-Hyun Oh; “Discovery of olmesartan hexetil: A new potential prodrug of olmesartan”. Bioorg. Med. Chem. Lett. 2013, 23(5), 1347-1350.This compound has been marketed in The Republic of Korea. 8) Mohammed I. El-Gamal, Seong Jong Kim, and Chang-Hyun Oh; “Synthesis and in vitro antibacterial activity of new meropenem analogs”. J. Antibiot. [Nature Publishing Group (NPG)] 2011, 64, 687-688. 9) Mohammed I. El-Gamal, Myung-Ho Jung, and Chang-Hyun Oh; “Discovery of a new potent bisamide FMS kinase inhibitor”. Bioorg. Med. Chem. Lett. 2010, 20(11), 3216-3218. 10) Mohammed I. El-Gamal, Said M. Bayomi, Saadia M. El-Ashry, Shehta A. Said, Alaa A.-M. Abdel-Aziz, and Naglaa I. Abdel-Aziz,; “Synthesis and antiinflammatory activity of novel (substituted)benzylidene acetone oxime ether derivatives: molecular modeling study”. Eur. J. Med. Chem. 2010, 45(4), 1403-1414.
Design and synthesis of novel sulfonate or sulfamate derivatives as steroid sulfatase inhibitors for treatment of hormone-dependent cancers.
KR 2012040980 A; 2013010514 A.
International R&D Academy (IRDA) Excellence Award: for my research achievements in 2011. [Korea Institute of Science and Technology (KIST), Feb. 10th, 2012, on the occasion of KIST’s 46th anniversary commemorative ceremony]. Academic Excellence Award: for my research achievements over the Ph.D. course. [Korea Institute of Science and Technology (KIST), Aug. 8th, 2012, at the commencement ceremony]. Excellence Award: for my research achievements over the Ph.D. course. [University of Science and Technology (UST), Aug. 17th, 2012, at the commencement ceremony]. 2012 UST Research Paper Award - Best Award of Paper Field: for my papers published in 2011. [University of Science and Technology (UST), Aug. 29th, 2012]. Publication of our review article in Medicinal Research Reviews has been reported on the official website of Biological Research Information Center (BRIC) in the Republic of Korea. http://bric.postech.ac.kr/myboard/read.php?id=32725&Page=1&Board=hbs_treatise&FindIt=&FindText=&skin=hbs_treatise&idauthorid=22349
Chairperson of the Examination & Timetable Committee at the College of Pharmacy, University of Sharjah, during the academic year 2015/2016. This committee is responsible for management of the mid-term and final exams, as well as preparation of the teaching schedules.
Teaching medicinal chemistry depends mainly on correlation between the drug's structure and its activity, mechanism of action, pharmacokinetics, and toxicity.
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