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Dr.Sameh Soliman Academic RankAssociate Professor

Specialization:

  • Pharmacognosy & Natural Products (Systems Biology and Biotechnology)

Research Interests:

  • 1)Discovery of novel pharmaceutical products that can be developed to novel drugs in particular anticancer and antimicrobial. 2) Elucidating the natural products biosynthetic pathways for either understanding their importance in its original host or using its backbone for developing effective medicines. 3) Chemical and biomolecular engineering of semi-natural products including vaccines and antibodies.

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2011 – 2014: Post-Doctorate education (Chemical and Biomolecular engineering of natural products) 2007 – 2010: PhD (Pharmacognosy; Chemical Ecology and Systems Biology) 2001 – 2004: M.Sc. (Pharmacognosy; Natural Products biotechnology) 1994 - 1999: B.Sc. (Pharmacy)
 Currently: Faculty Member at Department of Medicinal Chemistry, College of Pharmacy. 2013-2015: PostDoc research and teaching fellow at the Chemical and Biomolecular Engineering Department 2012-2018: Assistant Professor, Pharmacognosy, and natural products Biotechnology 2011-2019: Faculty Research Scientist, mycotoxins biotransformation, molecular biology, genomics, and proteomics. 2010-2011: Research associate, molecular biology, OAC 2007-2010: Research assistant, Chemical Evolution, and Biochemistry, OAC 2006-2007: Instructor, Biochemistry Department, Faculty of Forestry and Environmental biology 2003-2006: Instructor, pharmacognosy, and phytochemistry 1999-2003: Teaching Assistant, Pharmacognosy and Natural Products Biotechnology Department, Faculty of Pharmacy
Member of the American Chemical Society. Member of American Society of Microbiology. Editor at Journal of Enzymology and Metabolism. Member of the faculty development committee at University of Sharjah. Member of the Faculty Affairs Committee at University of Sharjah. Member in Education Quality Assurance and Accreditation to reform undergraduate education, Egypt (2005-2006). Developing pilot program for undergraduate career mentoring, University of Zagazig, Faculty of Pharmacy, Egypt.
•Member of the American Chemical Society •Member of American Society of Microbiology •Editor at Journal of Enzymology and Metabolism •Member of the faculty development committee at University of Sharjah •Member of the Faculty Affairs Committee at University of Sharjah •Member in Education Quality Assurance and Accreditation to reform undergraduate education, Egypt (2005-2006). •Developing pilot program for undergraduate career mentoring, University of Zagazig, Faculty of Pharmacy, Egypt
Discovery of novel antimicrobial and anticancer drugs and their underlined biosynthetic pathways Discovery of natural virulence factors prior to normalization by developing vaccines and/ or antibodies Design and develop peptides and/ or small molecules inhibitors in purpose of treatment and diagnosis
1.Soliman, S, Tsao, R., Raizada, M. (2011) Chemical inhibitors suggest endophytic fungal Paclitaxel is derived from both mevalonate and non-mevalonate-like pathways. Journal of Natural Products. 74: 2497−2504. 2.Soliman, S, Raizada, M. (2013) Interactions between co-habitating fungi elicit synthesis of Taxol from an endophytic fungus in host Taxus plants. Frontier Microbiology. 4:1-14 3.Soliman S., Trobacher C., Tsao R., John Greenwood J. and Raizada M. (2013) A Fungal Endophyte Induces Transcription of Genes Encoding a Redundant Fungicide Pathway in its Host Plant. BMC Plant Biology. 13:93-103 4.Soliman, S., Greenwood, J., Bombarely, A., Mueller, L., Tsao, R., Mosser, D., Raizada, M. (2015) An endophyte constructs fungicide-containing extracellular barriers for its host plant. Current Biology. 25 (19):2570-2576 5.Michael T., Soliman S., Raizada M. (2012) Bacterial whole-cell biosensor for glutamine with applications for quantifying and visualizing glutamine in plants. Applied Environmental Microbiology. 78(2):604. 6.Gaudin A, McClymont S, Soliman S, Raizada M. (2014) The effect of altered dosage of a mutant allele of teosinte branched 1 (tb1-ref) on the root system of modern maize. BMC Genetics.15:23 7.Soliman S, Tang Y. (2015) natural and engineering production of taxadiene with taxadiene synthase. Biotechnology and Bioengineering 112 (2), 229-235. 8.Soliman S, Sjaarda D, Li X-Z, Svircev A, Zhou T. (2015) Potential mycotoxin contamination risks of apple products associated with fungal flora of apple core. Food Control 47, 585–591. 9.Wang W, Soliman S, Li X._Z, Zhu H._h, Lin Y, Yin Y._L, and Zhou T. (2015) Transformation of trichothecene acetyldeoxynivalenol to deoxynivalenol by bacterial acetyltransferase. In: Medicine Science and Bioengeneering. Wang (Ed.), CRC Press. PP, 775-781. (Book Chapter) 10.Chibucos, M. C., Soliman, S., Gebremariam, T., Lee, H., Daugherty, S., Orvis, J., ... & Kumari, P. (2016). An integrated genomic and transcriptomic survey of mucormycosis-causing fungi. Nature Commun., 7. 11.Soliman, S., Mohammad H. Semreen, Ali A. El-Keblawy, Arbab Abdullah, Priya Uppuluri and Ashraf S. Ibrahim. (2017). Assessment of herbal drugs for promising anti- Candida activity. BMC Complementary and Alternative Medicine. 17:257. 12.Soliman, S., Alnajdy, D., El-Keblawy, A.A., Khoder, G., Noreddin, A.M. (2017). Plants' natural products as alternative promising anti-Candida drugs. Pharmacognosy Reviews. 11(22), pp. 104-122 13.Soliman, S. , Mosa, K.A., El-Keblawy, A.A., Husseiny, M.I. (2017) Exogenous and endogenous increase in fungal GGPP increased fungal Taxol production. Applied Microbiology and Biotechnology. 101(20): 7523-7533 http://www.ncbi.nlm.nih.gov/sites/myncbi/1X_1elrDIGd5G/bibliography/48968026/public/?sort=date&direction=ascending
1.PhD students at the Science and Technology centre, Canada: Major; bacterial biotransformation of natural toxins. 2.Summer students in Chemical and biomolecular engineering, USA: teaching synthetic biology techniques. 3.Master students at UCLA, USA: currently to investigate novel antimicrobial drugs. 4.Master student at UCLA, USA: Currently to investigate mechanisms of toxin-based pathogenesis and their minimization.
1.US Patent Application No. US 61/499286 (filed June 20, 2012). “Screening for Nitrogen Fixation” (Inventors: Manish Raizada, Michael Tessaro, Sameh Soliman and Hanan Shehata). 2.U.S. Provisional Patent Application Serial No. 62/260,054 (November 25, 2015) “NOVEL FUNGAL TOXINS AND METHODS RELATED TO THE SAME” November 25, 2015 (Inventors: Sameh Soliman and Ashraf S. Ibrahim).
8. NIH research fund for junior investigator, 2014 7. Fungal secondary metabolites discovery, detection and modification (NSERC) proposal grant ($50000.00/year for three years), 2013 6. Natural Sciences and Engineering Research Council of Canada (NSERC) award ($46000.00/year for two years), 2011-2013 5. Faculty Dean`s award, Canada 2010 ($2000.00) 4. Mrs. Fred Ball scholarship, Canada 2007 ($5000.00) 3. Egyptian Higher education scholarship (2006) 2. Best undergrad student at Faculty of Pharmacy (1996) 1. Best High school student, Egypt (1993)
Special research designer for undergrad pharmaceutical and natural products chemistry courses, faculty of pharmacy, Egypt (2005-2006). Assist in designing and writing practical notes for Fifth year students, Department of Pharmacognosy and Natural Products Biotechnology, Faculty of Pharmacy, Egypt (2004-2006). Assist in writing and reviewing Chromatography, Spectroscopy and medicines of natural products Textbooks for 5th Year undergrad students at the Pharmacognosy and Natural Products Biotechnology Department, Faculty of Pharmacy, Zagazig, Egypt (2004-2006).
My teaching philosophy is a two-way interactive teaching between me as the instructor and the students. Having a continuous feedback from the students regarding the course materials and the teaching strategy will help to improve the general teaching outcomes and empower the students, making them more confident and strong. Also I believe in that to deliver most of the teaching benefits to students, students should be more in contact and familiar with the markets needs by first designing a course linking the basic sciences to the applications required in our real lives. Second, by involving the students in real market problems and teaching them ways to solve these problems or ask their opinions for better solutions. Third, by introducing famous names to the students and how they make big differences and enrich our lives will help the students not only to develop their mentality but also help them to find more opportunities. Finally, I depend in my teaching philosophy in conducting the materials in ways that can help the students to develop their own carriers and establish their own business.
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