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Dr.Sameh Soliman Academic RankAssociate Professor

Specialization:

  • Pharmacognosy & Natural Products (Systems Biology and Biotechnology)

Research Interests:

  • 1)Discovery of novel pharmaceutical products that can be developed to novel drugs in particular anticancer and antimicrobial. 2) Elucidating the natural products biosynthetic pathways for either understanding their importance in its original host or using its backbone for developing effective medicines. 3) Chemical and biomolecular engineering of semi-natural products including vaccines and antibodies.

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2011 – 2014: Post-Doctorate education (Chemical and Biomolecular engineering of natural products) 2007 – 2011: Ph.D. (Pharmacognosy; Chemical Ecology and Systems Biology) 2001 – 2004: M.Sc. (Pharmacognosy; Natural Products biotechnology) 1994 - 1999: B.Sc. (Pharmacy)
•06-2020 - Present, Associate Professor at the Department of Medicinal Chemistry (Pharmacognosy and natural products), College of Pharmacy, University of Sharjah, Sharjah, UAE. •009-2015 to 6-2020 Assistant Professor at the Department of Medicinal Chemistry (Pharmacognosy and natural products), College of Pharmacy, University of Sharjah, Sharjah, UAE. •10 -2014 to 09-2015 Postdoc at School of medicine (fungal pathogenesis by natural toxins and relevant treatment) University of California, Los Angeles (UCLA), USA •2013-2015: Postdoc research and teaching fellow at the Chemical and Biomolecular Engineering Department. •06 -2013 to 10-2014 Postdoc research and teaching fellow at the Chemical and Biomolecular Engineering of natural products University of California, Los Angeles (UCLA), USA. •2012-2018: Assistant Professor, Pharmacognosy, and natural products Biotechnology •2011-2019: Faculty Research Scientist, mycotoxins biotransformation, molecular biology, genomics, and proteomics. •2010-2011: Research associate, molecular biology, OAC •2007-2010: Research assistant, Chemical Evolution, and Biochemistry, OAC •2006-2007: Instructor, Biochemistry Department, Faculty of Forestry and Environmental biology •2003-2006: Instructor, Pharmacognosy, and Phytochemistry •1999-2003: Teaching Assistant, Pharmacognosy and Natural Products Biotechnology Department, Faculty of Pharmacy
•Member of the American Chemical Society •Member of American Society of Microbiology •Editor at Journal of Enzymology and Metabolism •Member of the faculty development committee at University of Sharjah •Member of the Faculty Affairs Committee at University of Sharjah •Member in Education Quality Assurance and Accreditation to reform undergraduate education, Egypt (2005-2006). •Developing pilot program for undergraduate career mentoring, University of Zagazig, Faculty of Pharmacy, Egypt
Discovery of novel antimicrobial and anticancer drugs and their underlined biosynthetic pathways Discovery of natural virulence factors prior to normalization by developing vaccines and/ or antibodies Design and develop peptides and/ or small molecules inhibitors in purpose of treatment and diagnosis
1. Soliman SSM, Baldin C, Gu Y, et al. Mucoricin is a Ricin-Like Toxin that is Critical for the Pathogenesis of Mucormycosis. Nature Microbiology 2021. 2. Abdullah Alqarihi, Teclegiorgis Gebremariam, Yiyou Gu, Marc Swidergall, Sondus Alkhazraji, Sameh SM Soliman, Vincent M Bruno, John E Edwards, Scott G Filler, Priya Uppuluri, Ashraf S Ibrahim. (2020) GRP78 and Integrins Play Different Roles in Host Cell Invasion During Mucormycosis. Mbio 11 (3) 3. Teclegiorgis Gebremariam, Sondus Alkhazraji, Sameh S. M. Soliman, Yiyou Gu, Heewon H. Jeon, Lina Zhang, Samuel W. French, David A. Stevens, John E. Edwards Jr., Scott G. Filler, Priya Uppuluri, Ashraf S. Ibrahim. (2019). Anti-CotH3 antibodies protect mice from mucormycosis by prevention of invasion and augmenting opsonophagocytosis. Science Advances. 5: eaaw1327 4. Angeliki M Andrianaki, Irene Kyrmizi, Kalliopi Thanopoulou, Clara Baldin, Elias Drakos, Sameh SM Soliman, Amol C Shetty, Carrie McCracken, Tonia Akoumianaki, Kostas Stylianou, Petros Ioannou, Charalampos Pontikoglou, Helen A Papadaki, Maria Tzardi, Valerie Belle, Emilien Ettiene, Anne Beauvais, George Samonis, Dimitrios P Kontoyiannis, Evangelos Andreakos, Vincent M Bruno, Ashraf S Ibrahim, Georgios Chamilos. (2018). Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species. Nature Communication. 9 (1), 3333 5. Soliman, S., Mosa, K.A., El-Keblawy, A.A., Husseiny, M.I. (2017). Exogenous and endogenous increase in fungal GGPP increased fungal Taxol production. Applied Microbiology and Biotechnology. 101(20): 7523-7533. 6. Chibucos, M. C., Soliman S., Gebremariam, T., Lee, H., Daugherty, S., Orvis, J., ...& Kumari, P. (2016). An integrated genomic and transcriptomic survey of mucormycosis-causing fungi. Nature Communication.7: 12218. 7. Soliman, S., Greenwood, J., Bombarely, A., Mueller, L., Tsao, R., Mosser, D., Raizada, M. (2015). An endophyte constructs fungicide-containing extracellular barrier for its host plant. Current Biology. 25 (19):2570-2576. 8. Gaudin A, McClymont S, Soliman S., Raizada M. (2014). The effect of altered dosage of a mutant allele of teosinte branched 1 (tb1-ref) on the root system of modern maize. BMC Genetics.15:23. 9. Soliman, S., Raizada, M. (2013). Interactions between co-habitating fungi elicit synthesis of Taxol from an endophytic fungus in host Taxus plants. Frontier in Microbiology. 4:1-14. 10. Soliman, S., Tsao, R., Raizada, M. (2011). Chemical inhibitors suggest endophytic fungal Paclitaxel is derived from both mevalonate and non-mevalonate-like pathways. Journal of Natural Products.74: 2497−2504.
1.PhD students at the Science and Technology centre, Canada: Major; bacterial biotransformation of natural toxins. 2.Summer students in Chemical and biomolecular engineering, USA: teaching synthetic biology techniques. 3.Master students at UCLA, USA: currently to investigate novel antimicrobial drugs. 4.Master student at UCLA, USA: Currently to investigate mechanisms of toxin-based pathogenesis and their minimization.
1. UoS patent (June 2021) “Novel Anti-SARS-CoV-2 drugs with dual targeting activity. (Inventors: Sameh Soliman, Bahgat Fayed, Rania Hamdy, Ahmed Elmehdi) 2. U.S. Provisional patent (December 12th, 2019) “Novel Candida inhibitors” (Inventors: Sameh Soliman, Rania Hamdy and Ashraf Ibrahim). 3. U.S. Provisional Patent Application Serial No. 62/260,054 (November 25, 2015) “Novel Fungal Toxins And Methods Related To The Same” November 25, 2015 (Inventors: Sameh Soliman and Ashraf S. Ibrahim). 4. US Patent Application No. US 61/499286 (filed June 20, 2012). “Screening for Nitrogen Fixation” (Inventors: Manish Raizada, Michael Tessaro, Sameh Soliman, and Hanan Shehata).
1. Incentive Research Award, UOS, September 2021 2. Rashid bin Humaid Award, November 17th, 2021 3. First Place Winner in AlOwais national research competition award- June 2019 4. Incentive Teaching Award, UOS, April 2019 5. First place winner in the 13th University of Sharjah Research Competition (Pi), April 2019 6. First place winner in the 7th UAE Undergraduate Research GCC Competition (Pi), April 2019 7. First place winner in Think sciences national competition (Pi), April 2019 8. Appreciation letter by the University Chancellor to my role in the University research, September 2018 9. First place winner in the 6th UAE Undergraduate Research Competition (Co-Pi), April 2018 10. Sharjah Islamic Bank Student Research Award (Co-Pi), April 2018 11. Incentive Research Award, UOS, April 2018 12. First place winner in the 5th UAE Undergraduate Research Competition (Pi), May 2017 13. Seventh best undergraduate oral presentation in Duphat 2017 (Pi) 14. Natural Sciences and Engineering Research Council of Canada (NSERC) award ($46000.00/year for two years), 2011-2013 15. Faculty Dean`s award, Canada 2010 ($2000.00) 16. Mrs. Fred Ball scholarship, Canada 2007 ($5000.00) 17. Best undergrad student at Faculty of Pharmacy (1996)
Special research designer for undergrad pharmaceutical and natural products chemistry courses, faculty of pharmacy, Egypt (2005-2006). Assist in designing and writing practical notes for Fifth year students, Department of Pharmacognosy and Natural Products Biotechnology, Faculty of Pharmacy, Egypt (2004-2006). Assist in writing and reviewing Chromatography, Spectroscopy and medicines of natural products Textbooks for 5th Year undergrad students at the Pharmacognosy and Natural Products Biotechnology Department, Faculty of Pharmacy, Zagazig, Egypt (2004-2006).
My teaching philosophy is a two-way interactive teaching between me as the instructor and the students. Having a continuous feedback from the students regarding the course materials and the teaching strategy will help to improve the general teaching outcomes and empower the students, making them more confident and strong. Also I believe in that to deliver most of the teaching benefits to students, students should be more in contact and familiar with the markets needs by first designing a course linking the basic sciences to the applications required in our real lives. Second, by involving the students in real market problems and teaching them ways to solve these problems or ask their opinions for better solutions. Third, by introducing famous names to the students and how they make big differences and enrich our lives will help the students not only to develop their mentality but also help them to find more opportunities. Finally, I depend in my teaching philosophy in conducting the materials in ways that can help the students to develop their own carriers and establish their own business.
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