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Dr.Hasan Yaser Alniss Academic RankAssociate Professor

Specialization:

  • Ph.D. in Pharmacy and Biomedical Sciences (Medicinal Chemistry)

Research Interests:

  • • Cancer drug discovery • Synthesis of small molecules to regulate bioprocesses • Biophysical Characterization of nucleic acid structures and drug-nucleic acid complexes • Molecular modeling of biological systems

Contact

• Ph.D. in Pharmacy and Biomedical Sciences (Medicinal Chemistry), University of Strathclyde, United Kingdom, 2011 • M.Sc. Pharmaceutical Analysis, University of Strathclyde, United Kingdom, 2007 • B.Sc. Pharmacy, An-Najah National University, Palestine, 2001
• 01/2020- present Associate Professor, University of Sharjah, Sharjah, UAE. • 09/2015- 12/2019 Assistant Professor, University of Sharjah, Sharjah, UAE. • 07/2014- 8/2015 Assistant Professor, An-Najah National University, Nablus, Palestine. • 07/2013-06/2014 Visiting Professor, University of Toronto Toronto-Canada • 06/2011- 7/2013 Assistant Professor, An-Najah National University, Nablus, Palestine.
• Development of the pharmacy curriculum for several courses at the undergraduate level (e.g., Chemistry for Pharmacy, Pharmaceutical Analysis, Medicinal Chemistry). and postgraduate level (Instrumental Analysis, Advanced Pharmaceutical Analysis. • I participated in preparing the application for renewal of the pharmacy BSc. program accreditation and the application for the initial accreditation of the M.Sc. and PhD programs in Pharmaceutical Sciences.
• Member of Pharmaceutical Association - Jerusalem Centre • Member of the American Chemical Society • Member of the University Class schedule & Exam Committee • Member of the CoP Misconduct & Discipline Committee • Member of the CoP Scientific Affairs Committee • Member of UOS Library Committee
• Synthesis and characterization of DNA binding ligands as potential antibacterial and anticancer agents • Synthesis of DNA minor groove binders to selectively target the androgen response element sequence • Biophysics in Drug Discovery: Characterization of DNA Minor groove binders. • Thermodynamics of DNA minor groove binders
1- Alniss, H. Y.; Witzel, II; Semreen, M. H.; Panda, P. K.; Mishra, Y. K.; Ahuja, R.; Parkinson, J. A., Investigation of the Factors That Dictate the Preferred Orientation of Lexitropsins in the Minor Groove of DNA. J Med Chem 2019, 62 (22), 10423-10440. 2- Alniss, H. Y., Thermodynamics of DNA Minor Groove Binders. J Med Chem 2019, 62 (2), 385-402. 3- Alniss, H.; Zamiri, B.; Khalaj, M.; Pearson, C. E.; Macgregor, R. B., Jr., Thermodynamic and spectroscopic investigations of TMPyP4 association with guanine- and cytosine-rich DNA and RNA repeats of C9orf72. Biochem Biophys Res Commun 2018, 495 (4), 2410-2417. 4- Moussa-Pacha, N. M.; Abdin, S. M.; Omar, H. A.; Alniss, H.; Al-Tel, T. H., BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease. Med Res Rev 2020, 40 (1), 339-384. 5- Semreen, M. H.; Alniss, H.; Cacciatore, S.; El-Awady, R.; Mousa, M.; Almehdi, A. M.; El-Huneidi, W.; Zerbini, L.; Soares, N. C., GC-MS based comparative metabolomic analysis of MCF-7 and MDA-MB-231 cancer cells treated with Tamoxifen and/or Paclitaxel. J Proteomics 2020, 225, 103875. 6- Semreen, M. H.; Alniss, H. Y.; Grgic, S. R.; El-Awady, R. A.; Almehdi, A. H.; Mousa, M. K.; Hamoudi, R. A., Comparative metabolomics of MCF-7 breast cancer cells using different extraction solvents assessed by mass spectroscopy. Sci Rep 2019, 9 (1), 13126. 7- Semreen, M. H.; Alniss, H. Y.; Mousa, M. K.; Aboul-Enein, H. Y., Quick and Sensitive UPLC-ESI-MS/MS Method for Simultaneous Estimation of Sofosbuvir and Its Metabolite in Human Plasma. Molecules 2019, 24 (7). 8- Semreen, M. H.; Shanableh, A.; Semerjian, L.; Alniss, H.; Mousa, M.; Bai, X.; Acharya, K., Simultaneous Determination of Pharmaceuticals by Solid-phase Extraction and Liquid Chromatography-Tandem Mass Spectrometry: A Case Study from Sharjah Sewage Treatment Plant. Molecules 2019, 24 (3). 9- Alniss, H. Y.; Salvia, M. V.; Sadikov, M.; Golovchenko, I.; Anthony, N. G.; Khalaf, A. I.; MacKay, S. P.; Suckling, C. J.; Parkinson, J. A., Recognition of the DNA minor groove by thiazotropsin analogues. Chembiochem : a European journal of chemical biology 2014, 15 (13), 1978-90. 10- Alniss, H. Y.; Anthony, N. G.; Khalaf, A. I.; MacKay, S. P.; Suckling, C. J.; Waigh, R. D.; Wheate, N. J.; Parkinson, J. A., Rationalizing sequence selection by ligand assemblies in the DNA minor groove: the case for thiazotropsin A Chemical Science 2012, 3, 711-722.
• G-quadruplexes as novel therapeutic targets • An Overview of DNA Minor Groove Binders • Synthesis and characterization of distamycin analogues as potential antibacterial and anticancer agents • Synthesis of amide-linked minor groove binders (MGBs) to target the Androgen Response Element Sequence”. (Master thesis) Saber Abu Jabal. 2013. An-Najah National University, Nablus, Palestine. • Synthesis, characterization & biological activity of Isopropyl Thiazole derivatives of the natural products Distamycin & Proximicin. (Master thesis) Amjad Abdalrahman. 2017, An-Najah National University, Nablus, Palestine.
• Sharjah Islamic Bank Award for distinguished Research (2020) • First prize winner research project, UOS- Boehringer Ingelheim Partnership (2017). • First prize winner for the best poster, International Conference on Pharmaceutical Drugs, CrownPlaza, Dubai, UAE (2017) • Distinguished Research Award (Impact Factor)-An-najah National University (2014). • Distinguished Scholar Award-Arab Fund for Social and Economic Development 2013-2014, (50,000 USD) •University of Strathclyde Research Scholarship (2007-2010)-PhD. in Pharmacy and Biomedical Sciences, University of Strathclyde. UK. • Said Foundation Scholarship (2006-2007) - MSc. in Pharmaceutical Analysis, University of Strathclyde.
• Chairperson of class schedule and examination committee at the College of Pharmacy (Fall 2018-Present). This committee is responsible for the preparation of the teaching schedules the arrangement of midterm and final exams. • Evaluation of research articles and grants in the field of medicinal chemistry
From my teaching experience, I have realized that a good instructor has to follow two guiding principles: passion and empathy. All teaching methodologies are derived from these two principles and cannot be effective without either of them. If the instructors love what they do and bring passion to their teaching, this will be reflected on the students, who will definitely appreciate it and reciprocate with increased levels of their own enthusiasm. On the other hand, understanding the students’ needs, struggles, & cognitive pattern will enable the instructor to deal with students more effectively and thus improve the students’ performance & learning outcomes. I believe that good teacher should have abilities to prepare and organize well, teach adaptively, and to nurture critical thinking.
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