Clinical Sciences Our People Detail

Education

2011 - Ph.D. Department of Pathology, University of Cambridge, United Kingdom. Dissertation: "Molecular Pathogenesis of MALT Lymphoma" 2000 - M.Sc. Department of Computer Science, Birkbeck College, University of London. Dissertation: “Automation of workflow within laboratory using novel Web-based Client/Server Information Management Software” 1994 - M.Sc. Department of Electrical and Electronic Engineering, City University, University of London. Dissertation: "Development of brain imaging software for functional brain imaging using MRI, PET and Neuroelectromagnetic data" 1992 - M.Sc. Biochemistry Department, King’s College, University of London. Dissertation: "Sequencing and expression of mouse testis-specific cDNA clones mapping to the t-complex using pGEX-2T GST fusion vector” 1991 - PGD Department of Computing, Metropolitan University. Dissertation: "Development of Medical Expert System for diagnosing diseases”

Employment History

Feb 2017 – Present: Associate Professor in Molecular, Cellular and Computational Medicine. College of Medicine, University of Sharjah, Sharjah, UAE. Oct 2013 – Jan 2017: Associate Professor in Molecular and Computational Pathology. Division of Surgery and Interventional Science, Wing 2.4, The Cruciform Building, University College London, England. 2011 – 2013: Assistant Professor & Head of Research and Development in next generation molecular pathology. Department of Pathology, Rockefeller Building, University College London, England. 2003 – 2011: Leukaemia & Lymphoma Research Fellow. Department Pathology, University of Cambridge, England. 2001 – 2011 : Senior Bioinformatician. Department of Histopathology, University College London, England. 2001 – 2003 : Research Fellow in Lymphoma. Department of Histopathology, University College London, England. 1995 – 2001 : Cancer Gene Cloning Centre Manager & Higher Scientific Officer. Haddow Labs, Institute of Cancer Research, Sutton, England. 1995 – 2001 : Engineer and bioinformatics support. Haddow Laboratories, Institute of Cancer Research, Sutton, England. 1999 – 2016 : Assistant professor (part time) in Computer Science. Open University, 1-11 Hawley Crescent, Camden Town, London, England.

Professional Activities

Medical scientist: pathology, immunology, genetics, bioinformatics, biochemistry, haematology and microbiology Electronic engineer: PCB and VLSI design, instrument design Software engineer: software development using waterfall life cycle model. Languages: C/C++, Perl, Python, JAVA, Ruby, R, SQL, Visual BASIC, Javascript, PHP and Assembly language

Professional Memberships

) Chartered Scientist (CSci): BMS/109/011887 2) Fellow of the Higher Education Academy (FHEA): PR101635 3) Fellow of the Institute of Biomedical Sciences (FIBMS): Fellowship No. 375850 4) European Engineer (Eur Ing) status: Membership No. 26479 5) Chartered Engineer (C.Eng) status: Membership No. 531617 6) Member of the British Computer Society (MBCS): Membership No. 08532810 7) Chartered Biologist (C. Biol) status: Membership No. 003014663 8) Member of the Institute of Biology (MBiol): Membership No. 003014663 9) Graduate Member of the Institute of Physics and Engineering in Medicine (IPEM) : Membership No. 8882

Selected Research Projects

Deciphering the molecular mechanism of disease including cancer, autoimmune and pathogen driven diseases using integrative multi-OMICs screening Development of novel bioinformatics algorithms for transriptomic, genomic and epigenetic analysis Mathematical modelling of transcriptomic data to identify therapeutic targets of disease Diagnostic and prognostic biomarker discovery of Breast cancer Immune response from Photodynamic Therapy and Photochemical Internalization treatments for Prostate cancer Characterization of Sonodynamic Therapy for pancreatic cancer Image registration from multi-modalities (MRI, PET, CT and MFT) Software development for medical system integration Software development for Natural Language Processing Software development for interactive lectures to support student learning and education

Selected Publications

Sultan AA, Jerjes W, Berg K, Høgset A, Mosse CA, Hamoudi R, Hamdoon Z, Simeon C, Carnell D, Forster M, Hopper C. (2016) Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial. Lancet Oncology, 17:1217-1229. Libertini E, Heath SC, Hamoudi RA, Gut M, Ziller MJ, Herrero J, Czyz A, Ruotti V, Stunnenberg HG, Frontini M, Ouwehand WH, Meissner A, Gut IG, Beck S. (2016) Saturation analysis for whole-genome bisulfite sequencing data. Nature Biotechnology, doi: 10.1038/nbt.3524 Libertini E, Heath SC, Hamoudi RA, Gut M, Ziller MJ, Czyz A, Ruotti V, Stunnenberg HG, Frontini M, Ouwehand WH, Meissner A, Gut IG, Beck S. (2016) Information recovery from low coverage whole-genome bisulfite sequencing. Nature Communications, doi: 10.1038/ncomms11306 McEwan C, Kamila S, Owen J, Nesbitt H, Callan B, Borden M, Nomikou N, Hamoudi RA, Taylor MA, Stride E, McHale AP, Callan JF. (2016) Combined sonodynamic and antimetabolite therapy for the improved treatment of pancreatic cancer using oxygen loaded microbubbles as a delivery vehicle. Biomaterials, 80:20-32 Rifat Hamoudi, Joshua Kapp, Sevgi Umur and Michael Gandy. (2015) Variations in pre-analytical FFPE sample processing and bioinformatics: challenges for next generation molecular diagnostic testing in clinical pathology. Clinical Laboratory International, 16-18 Hamoudi RA, Watkins AJ, Zeng N, Yan Q, Huang Y, Liu H, Zhang J, Braggio E, Fonseca R, de Leval L, Isaacson PG, Wotherspoon A, McPhail ED, Dogan A, Du MQ. (2012) An integrated genomic and expression analysis of 7q deletion in splenic marginal zone lymphoma. PLoS One, 7, 9, e44997 Rosebeck, S., Madden, L., Jin, X., Gu, S., Apel, I. J., Appert, A., Hamoudi, R. A., Noels, H., Sagaert, X., Van Loo, P., Baens, M., Du, M. Q., Lucas, P. C., McAllister-Lucas, L. M. (2011) Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. Science, 331, 468-472 Hamoudi, R. A., Appert, A., Ye, H., Ruskone-Fourmestraux, A., Streubel, B., Chott, A., Raderer, M., Gong, L., Wlodarska, I., Wolf-Peeters, C., Maclennan, K. A., de Leval, L., Isaacson, P. G., Du, M. Q. (2010). "Differential expression of NF-kappaB target genes in MALT lymphoma with and without chromosome translocation: insights into molecular mechanism", Leukemia, vol. 24, no. 8, pp. 1487-1497

Theses and Projects Supervision

PhD projects 1) The genetic characterisation of splenic lymphoma with villous lymphocytes. Institute of Cancer Research, University of London (2002) 2) Prognostic molecular markers for cervical intraepithelial neoplasia. University College London (2004) 3) FOXP1 Abnormalities in Lymphoma. University of Cambridge (2009) 4) Aetiology and molecular genetics of ocular adnexal and pulmonary MALT lymphomas. University of Cambridge (2009) 5) Molecular Characterization of Splenic Marginal Zone Lymphoma. University of Cambridge (2011) 6) Light-based therapies in Prostate Cancer treatment. University College London (2016) MSc projects 1) Bioconjugated Quantum Dots for Imaging the NFκB Inflammatory Pathway in Cancer. University College London (2014) 2) Role of clinicopathological implications and Human Papilloma Virus sub-typing in Oro-pharyngeal Cancers. University College London (2015) 3) Development of a matrix-based system for the isolation of metastatic circulating tumour cells. University College London (2015) 4) Molecular characterisation of FFPE pancreatic tumours treated with 5-Fluorouracil and Sonodynamic Therapy using whole transcriptome analysis. University College London (2016) 5) Molecular characterisation of HER2 heterogeneity in breast cancer using whole transcriptomic analysis. University College London (2016) 6) Mathematical Modelling of Cellular Processes Using Gene Expression Data. University College London (2016)

Patents

Detecting of oesophageal cancer biomarkers from saliva

Awards Recognitions

2015 Institute of Biomedical Sciences Research award 2014 - Wellcome Trust Institutional Strategic Support Fund - Investing in Excellent Researchers Award 1994 – School of Engineering best M.Sc. project 1991 – School of Computing Overall Prize

Services

Member, College of Medicine Research Committee, UoS Member, At risk students Committee, UoS Lead of Cell and Molecular Pathology Committee for Computational Medicine & Pathology, NCRI, England

Teaching Philosophy

I believe that all humans including professors continuously learn throughout their lifespan. My goal as an educator is to encourage, enhance and focus such learning experience through problem-based learning and the development of software to implement interactive FLIP lectures that can detect the student’s pace and level of knowledge and move through different levels using Artificial Intelligence algorithms. Having taught both engineering, computer science and medical subjects I tend to structure my lectures so they adhere to a syllabus and tend to motivate the students through asking questions and introducing topics of discussion in the classroom. This will not only enhance the learning but can introduce novel ideas or angles on the taught subject. I believe that a successful educator must possess the following qualities: kindness, patience, the ability to clearly explain and express their ideas, respond to students' queries, and be available during working hours. Finally my teaching philosophy is to ensure that students learn the facts to enhance their knowledge but also to teach them how to use those facts to nurture and develop new ideas which can advance the field taught and their future career and hopefully encourage them in their learning journey to stay on in academia and study for postgraduate degree

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