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Master of Science in Molecular Medicine and Translational Research

College
College of Medicine
Department
Medicine
Level
Masters
Study System
Courses and Research Project
Total Credit Hours
48 Cr.Hrs
Duration
2-4 Years
Intake
Fall & Spring
Location
Sharjah Main Campus
Language
English
Study Mode
Full Time and Part Time

Master of Science in Molecular Medicine and Translational Research

Introduction

The College of Medicine, while consolidating its undergraduate innovative educational programs, initiated post- graduate programs offering Master and Ph.D. degrees in Molecular Medicine and Translational Research. The program started in 2011.

An agreement has been signed by His Highness, Sheikh Sultan Bin Muhammad Al Qassimi, with Lubeck University in Germany to support postgraduate training and research in laboratories. An important aspect of the agreement with Lubeck University is to establish joint supervision of the postgraduate programs in Molecular Medicine and Translational Research.

The Master and PhD programs will be the cornerstone of the Sharjah Institute for medical research at the University of Sharjah.


Program Objectives

MISSION

  1. To educate future researchers through innovative teaching practices and opportunities.
  2. To allow significant graduate student participation in cutting-edge research.
  3. To provide an environment that fosters intellectual growth and professional development in the field of Molecular Medicine.
  4. To encourage students to publish high impact papers


PROGRAM OUTCOMES

Upon completion of the Master program graduates will be able to:
1. Discuss the basis of molecular medicine
2. Integrate basic theories with translational application
3. Analyze the basis of human genomes and its relevance to diseases affecting the society
4. Appraise immunological aspects of diseases and how to translate the knowledge from the immune system into therapeutic applications
5. Perform and execute experimental research independently
6. implement the values and ethics of doing research
7. Use communication and presentation skills for presentation in international conferences
8. Analyze and assimilate information from biomedical literature related to translational medicine
 

Program Structure & Requirements

Master of Science in Molecular Medicine and Translational Research is a course-based (non-thesis) program emphasising the graduation research project. The program consists of 13 major compulsory courses (12 courses of 3 Credit hours each and a Research Project, which is 6 Credit hours). Additionally, students are required to complete two elective courses of 3 Credit hours each. The total credit hours of the program are 48 Credit hours.     

 

Duration and Graduation Requirements

The MS program consists of 15 courses: 3 credits each except for research project which has 6 credits (Total 48 credits). Students are required to complete all obligatory courses in M1 (Total of 24 credits), and all obligatory and one selected Elective course per semester in M2 (Total of 24 credits).​

 

Strategy of Learning and Teaching:

A combination of didactic and interactive lectures, group discussion, projects, case studies, literature review, self-directed Learning, problem-solving, written homework assignments, practical and laboratory-based sessions, presentation-based learning, site visits and discussion.

Course Description

0900701            Biology and genetics of cancer cells            3

This course is an essential base to supply graduate students with thorough understanding of cancer biology and genetics. The course will start by an overview of the morphology and general pathological characteristics of cancer then it focuses on topics related to cellular oncogenes and tumor suppressor genes. The two main paradigms: pRb and p53 and their roles in cell cycle clock and apoptosis, respectively, will be detailed. The course also discusses maintenance of genomic integrity and its role in multistep tumorigenesis. The course is concluded by providing solutions for the effective control of this overwhelming disease.

0900702  Gene Expression     3

This course offers a comprehensive look into the regulatory elements of gene expression including transcription factors and transcriptional control, the aspects of epigenetics such as chromatin remodeling and DNA imprinting; post-transcriptional control and genetic regulation of various diseases.

0900703  Biomedical Genomics            3

This course presents an overview of Biomedical Genomics and Genetics and current potential applications in Biology and medicine, including identification of gene defects and the use of genetic tools for the diagnosis and treatment of disease.

0900704  Modern techniques in Molecular Biology I          3

An introduction to the basic laboratory techniques in molecular biology with an emphasis on recombinant DNA (molecular cloning), DNA electrophoresis and quantification, Protein electrophoresis, PCR, mammalian tissue culture and scientific writing.

0900705  Selected topics in cell biology                3

This course will focus on deep understanding of the cell compartments. Topics covered include structure of lipids bilayer, membrane proteins, membrane transport of small molecules,  active membrane transport, ion channels, cell compartments, transport of molecules between cell compartments, intracellular vesicular traffic, principles of cell communication, dynamic structure of cytoskeletal filaments and their regulation, abnormalities in genetic material that lead to cancer, the effects of carcinogens on cells, cell cycle control programmed cell death and regulation of the immune system. Importantly, related diseases for each topic will be highlighted during the course. Some laboratory techniques will be covered but not in details due to time limitation. 

0900706  Introduction to Biotechnology              3

This course focuses on the use of biological systems in medicine, industry and agriculture; food and drug production; industrial application of genetic engineering. Lectures will underlie the principles and application of recombinant DNA technology in industrial, agricultural, pharmaceutical, and biomedical fields. Lecture will also include the fermentation systems for commercial production of useful products and their purification.

0900707  Bioinformatics Networks       3

This is a hands-on course that introduces the students to Bioinformatics, which uses computer databases to store, retrieve and assist in understanding biological information. Genome-scale sequencing projects have led to an explosion of genetic sequences available for automated analysis. These gene sequences are the codes, which direct the production of proteins that in turn regulate all life processes. The student will be shown how these sequences can lead to a much fuller understanding of many biological processes allowing pharmaceutical and biotechnology companies to determine for example new drug targets or to predict if particular drugs are applicable to all patients. Students will be introduced to the basic concepts behind Bioinformatics and Computational Biology tools. Hands-on sessions will familiarize students with the details and use of the most commonly used online tools and resources. The course will cover, among other topics, the use of NCBI's Entrez, BLAST, ClustalW, Pfam, phylogenetics, and dot mapping.

0900708  Modern techniques in Molecular Biology II         3

This course provides insight into basic laboratory techniques with practical applications of each technique under the supervision of a faculty member. In this course, students will gain experience in advanced molecular biology techniques including, immunoprecipitation, in situ hybridization, flow cytometry, pulse-field gel electrophoresis.

00900709                Selected topics in immunology             3

This course is intended to give students insight into selected topics in immunology for students who have prior knowledge of basic immunology.  There will be two one-hour lectures, in addition to a one-hour tutorial, every week addressing specific areas such as the genes and proteins involved in immune recognition for the immune response, cell adhesion molecules and their role in regulating cell-cell interaction, migration and homing, intracellular signaling mechanisms, the mechanisms by which the immune system learns "self" from "non-self".  In addition, cytokines and chemokines, and the interaction between tumors and the immune response, and current immunotherapies will all be presented.  Topics will be selected each semester this course is taught depending on factors such as research activity of faculty members, and current trends in immunology.

 

0900710  Advanced topics in Human Molecular Genetics   3

This course presents an overview of the central dogma of molecular biology introducing the student to the structures of DNA, RNA and proteins and the relationship between them in human molecular genetics. This course also covers the types of genetic variants and chromosomal abnormalities, and detail pathogenesis of common monogenetic diseases. In addition, it will touch on regulatory elements of gene expression including transcription factors and transcriptional control and basics of epigenetics.

The course will then introduce the student to the genetic mapping of Mendelian and complex diseases. The student will analyze and assess the use of linkage and association studies in mapping polygenic disease loci. The course will then introduces the student to advanced topics in cancer genetics and immune genetics followed by the use of multi OMICs techniques and methods used in molecular medicine for diagnostics, mechanistic and therapeutic studies focusing on genomics (DNA), transcriptomics (RNA) and proteomics (Protein). .

0900711  Selected topics in molecular biology     3

This course will focus on selected advanced topics of relevance to Molecular medicine and translational research. The course is an excellent opportunity to address advanced topics and principle of techniques not covered in other courses. The course contents are continuously updated to cover the rapidly developing field.  Current topics include but not limited to: Stem Cell research, Pharmacogenetics, CRISPR gene editing technology, Tumor Angiogenesis, Cancer Metastasis, Pancreatic islets: structure, hormones and transplantation, Identification of novel genes for T2D in pancreatic islets.

0900712  Monoclonal antibodies          3

This course will focus on the methods used to develop monoclonal antibodies and on their use in medicine. Topics include: hybridoma cell production, purification of monoclonal antibodies, recombinant antibodies for cancer treatment and chimeric antibodies generation. 

0900713  Selected topics in cancer biology          3

This course aims at providing a comprehensive overview of diverse aspects of tumorigenesis and various therapeutic strategies with emphasis on targeted therapy and precision medicine. We will discuss various perturbations of key cell signaling pathways that lead to resistance to programmed cell death and uncontrolled cell growth of cancer cells. These include Receptor tyrosine kinases (RTKs), Ras/Raf/MEK/ERK, PI3K/AKT/mTOR among others. We will also discuss the success and challenges of targeting these pathways for cancer therapy. A particular emphasis will be placed on patients' response and development of resistance to targeted therapies. In addition, we will explore the impact of the recent application of advanced technological tools such as OMICS and CRISPR system in cancer diagnosis, identification of valuable targets and biomarkers to inform therapy and predict for drug resistance.

0900715  Cell communication and signaling        3

This course aims to enhance the understanding of cellular communication, in particular, the fundamental principles of relaying extracellular information into cell resulting in gene expression program. Moreover, emphasis has been placed on the signaling paradigm in cell growth and differentiation, development, immune response, and cell stress, as well as insights into molecular basis of diseases.

0900716  Programmed cell death in cancer therapy            3

This course will focus on the regulated process of programmed cell death.  Topics include: the biochemical events leading to cell death, apoptosis, autophagy, anoikis and detailed studies on the basic concepts and pathways of programmed cell death and their impact on cancer therapy.

0900717  Animal models in molecular biology and therapeutics        3

The course will consider how experimental models can contribute to curing human diseases. We will discuss how different experimental models have contributed to our growing understanding of the molecular basis of human diseases such as cancer, diabetes, obesity, atherosclerosis, multiple sclerosis or arthritis. Applications of these models for addressing mechanistic questions and testing potential therapeutic options will be presented. The ethics and welfare implications of animal model use and confounders in experimental results will also be dealt with.

0900718  Research Project     3

The research project course aims to provide the students with thorough knowledge of research design and methodology and to train the student in required skills to set a research question, set achievable objectives, formulate a problem, critically reviewing scientific literature, write a study plan with proper methodology and estimate a time frame for the proposed project. Afterward, the students will embark on conducting laboratory research under the supervision of a faculty member.



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