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Research

Priority lines of research

The group is working incoherent manner to focus on the following lines of research:

  • Identify mutations involved in human monogenetic disorders. The group has access to the Sanger sequencer to carry out routine DNA sequencing.
  • Find the differentially expressed genes and microRNAs during the differentiation of mesenchymal and dental pulp stem cells into neural and adipocytes lineages
  • Sequencing of transcriptomics by NGS (next-generation sequencing) to find differential genes and microRNAs expressions during the differentiation of mesenchymal and dental pulp stem cells into neural and adipocytes lineages.
  • Whole exome sequencing  to unravel the mutations in the affected individuals
  • Find different and enhanced protocols and different factors to enhance the differentiation of mesenchymal and dental pulp stem cells towards neural and adipocytes lineages.

 

  • Main Research Areas

Health Biotechnology, Genetic of monogenic diseases, genetic biomarkers, Bioinformatics, Hereditary Hearing Loss diseases, Pyridoxine-dependant epilepsies, Human molecular genetics, Molecular diagnostics. Tumor Angiogenesis and metastasis. Stem cells. Animal Biotechnology. Biochemistry and Cell biology.


  • Research Projects

 

  • Title of Project: Identification of Genetic and Molecular Basis of hearing loss in two UAE affected families.

Funding: Sheikh Hamdan bin Rashid Al Maktoum Award for medical sciences

Investigator: Dr. Abdelaziz Tlili

 

  • Title of Project: Identification of genetic factors responsible for hearing impairment in 10 patients living in the UAE.

Funding: University of Sharjah

Investigator: Dr. Abdelaziz Tlili

 

  • Title of Project: Identification of a new gene responsible for distichiasis in a large UAE family.

Funding: University of Sharjah

Investigator: Dr. Abdelaziz Tlili

 

  • Title of Project: Study of two splice site variants detected in two UAE families with hearing loss.

Funding: University of Sharjah

Investigator: Dr. Abdelaziz Tlili

 

  • Title of Project: Development of Copper-Silver Nanoparticles decorated Silicon Nanowires/TiO2 nanocomposite for highly sensitive and fast detection of Corona Virous (COVID19).

Funding: University of Sharjah

Investigators: Dr. Mounir Kaidi, Dr. Abdelaziz Tlili et al.,

 

  • Title of Project: Genetic mutations of GJB2 and mitochondrial 12SrRNA in nonsyndromic hearing loss in UAE

Funding: University of Sharjah

Investigator: Dr. Abdelaziz Tlili

 

  • Title of Project: The roles of microRNAs and IGF-1 in the enhanced differentiation of human dental pulp stem cells into neural progenitor-like cells in the presence of bFGF and EGF factors

Funding: University of Sharjah

Investigator: Amir Ali Khan

 

  • Title of Project: The role IGF-1 in the enhanced differentiation of MSCs into neural progenitor-like cells in the presence of  bFGF and EGF.   

Funding: University of Sharjah

Investigator: Amir Ali Khan

 

  • Title of project: Fabrication and characterization of magnetic-plasmonic Hybrid nanoclusters for photo and megnetothermal therapy for cancer cells

Funding: University of Sharjah

Investigators: Hafsa Khurshid, Amir Ali Khan et. al

 

  • Title of project: Transcriptomics Analysis of the Adipocytes Differentiated from the Human Mesenchymal Stem Cells

Funding: University of Sharjah and Sandooq Al Watan

Investigators: Muhammad Nasir Khan and Amir Ali Khan

 

  • Title of the project: Role of the Epigenetic Modifiers 5-aza-deoxycytidine and suberoylanilide hydroxamic acid in the Differentiation of Dental Pulp into Neural Lineages

Funding: University of Sharjah and Sandooq Al Watan

Investigator: Amir Ali Khan

 

  • Title of the project: The characteristics of the dental pulp stem cells growth in 3D Cell Culture

Funding: University of Sharjah

Investigator: Amir Ali Khan

 

  • Title of the project: Identification of novel single nucleotide polymorphisms (SNPs) of CYP3A5 in healthy Emirati population.

Funding: University of Sharjah

Investigator: Abdullah Al Mutery