Human Disease Biomarkers Discovery Research Group

Biomarkers are biomolecules that are associated with or inform about physiological processes, diseases, and so on. There is an urgent need to identify novel biomarkers that are first and foremost informative about a specific disease (or a set of diseases) and the majority of them are applicable to the target population. Proteomics and metabolomics methodologies are now the foundation of fundamental and translational biomedical research all over the world. The use of proteomics and metabolomics in the search for disease biomarkers, on the other hand, will continue to advance drug development and personalized therapy in the future. A panel of novel protein/metabolite sensitive biomarkers will undoubtedly be a valuable bio-molecular resource for effectively monitoring drug treatment and accurately assessing the efficacy of new drugs/therapies (including the nature inspired compound library available at the Sharjah Institute for Medical Research (RIMHS)). 

1. The main goal of this group is to thoroughly identify proteins/metabolites that result from alterations in biological processes associated with non-communicable diseases but also against important infectious diseases such as COVID-19
2. Contribute to a better understanding of the underlying mechanisms of diseases through the application of large-scale proteomics and metabolomics.
3. Optimization of large-scale data analysis and downstream computational, bioinformatics analysis and machine learning.
4. Consistently verification and translational of identified disease biomarkers through the application of MS-based quantitative measurements.
5. Developed qualified biomarkers warranty approved by the FDA
6. Identify new targets for drugs against non-communicable diseases but also against important infectious diseases such as COVID-19
7. Utilize qualified biomarker(s) to develop and test therapeutic agents against Human diseases
8. Development of immunochemistry/colorimetric products for a rapid detection of the qualified biomarkers

1. Cancer Biomarkers -early diagnosis and treatment follow up
2. Novel biomarkers for early detection of Diabetes in the Emirati population
3. Biomarkers of Infectious diseases -Covid-19, Tuberculosis and Candida
4. Search for biomarkers of neuropathological disorders and treatment follow up