Overview
Goals and Objectives
Our Team
Publications
Collaborations
Lines of Research
Awards
Projects
Overview
Our broader aim is to investigate the molecular perturbations involved in CVDs such as hypertension, vascular dysfunction, atherosclerosis, thrombosis, and ischemia- and hypertension-induced cardiac remodeling and heart failure. Moreover, considering several structural and functional similarities in cardiac and skeletal muscles, CVR group is additionally focusing on investigating the potential molecular mechanisms causing the coupling of cardiac and skeletal muscle dysfunction. We will meet our aims with the following specific objectives:
- Identify genes and genetic defects and, delineate the underlying molecular mechanisms to enhance our understanding of CVDs including various types of cardiomyopathies, thrombotic and vascular disorders including endothelial dysfunction, familial hypercholesterolemia and inherited bleeding disorders.
- Perform detailed phenotypic and molecular characterization of patients with major CVDs.
- Establish potential circulating biomarkers for early risk assessment and treatment of CVDs.
- Identify and characterize the novel drug targets employing in vitro and in vivo mouse models.
- Delineate the molecular mechanisms causing coupling of cardiac and skeletal muscle dysfunction and, evaluate the effects of microgravity on cardiovascular remodeling.
- Screen the small molecule inhibitors to design better therapies against CVDs.
- Investigate the immunopharmacological interventions related to renal and cardiovascular disorders.
Research Publications
No Record Found
- Section on Cardiovascular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA
- Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada
- College of Sport Sciences and Physical Activity, King Saud University, Riyadh, Saudi Arabia
- Faculty of Medicine, Department of Cardiology, Mansoura University, Egypt
- Niigata University Graduate School of Medical and Dental Sciences, Japan
- Mohammed Bin Rashid University, Dubai, UAE
- Simon Fraser University, Canada
List of institutions and organizations collaborating with us to achieve our research and community goal:
Cardiovascular research group has adapted a multi-pronged approach, including both the in-vitro and in-vivo models to meet our research aims. We employ gain- and loss-of-function models to better understand the pathomechanisms of cardiovascular and muscular disorders. Our research primarily focuses on investigating the mechanisms of ischemic heart diseases- and pressure overload -induced cardiac remodelling and dysfunction, hypertension, vascular dysfunction, thrombosis and atherosclerosis. Moreover, our group is engaged to investigate the causes of muscular and associated cardiovascular defects in a mouse model of space flight or prolonged bedrest. Cardiovascular research group has well-established cardiac and skeletal muscle cell lines, which are being used to thoroughly investigate the molecular and genetic changes dictating various diseases. Small molecular inhibitors screening, in in-vitro and ex-vivo models in an attempt to design potential novel therapies to minimize or reverse the cardiovascular disease, is an important goal of our group.
Below are the awards and recognitions received by our members, reflecting their excellence and academic achievements:
- American Heart Association (AHA), Paul Dudley White International Scholar Award, in the Basic Cardiovascular Sciences Scientific Sessions 2024 to Dr. Adel Elmoselhi
