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براءات الإختراع و المنشورات الحديثة

براءات الإختراع:

US Patent Application Number: 15935155. TITLE OF THE INVENTION: Discovery of NOVEL First-In-Class HETEROCYCLIC SYSTEMS for the treatment of Multidrug Resistant Superbugs. Filed on March 2018. RAM confirmation Number: 032618INTEFSW10523900. EFS ID: 32151250. Inventors: Dr. Taleb AlTel; Dr Vunnam Srinivasulu; Dr. Farah ElMarzooq; Dr Rafat El-Awady.

Summary of the Invention: The present disclosure relates to novel imidazole fused polycyclic systems, methods for their use, and processes for their preparation. The compounds of the present disclosure are particularly useful against a variety of bacteria, including multidrug resistant strains of Staphylococcus aureus, S. saprophyticus, S. haemolyticus, and S. epidermidis.

US Patent Application Number15935120; TITLE OF THE INVENTION: Discovery of NOVEL First-In-Class HETEROCYCLIC SYSTEMS for the treatment of Cancer. Filed in March 2018. RAM confirmation Number: 032618INTEFSW10050600 EFS ID:  32150635. Inventors: Dr. Taleb AlTel; Dr Rafat El-Awady; Dr Vunnam Srinivasulu; Dr Cijo George Vazhappilly; Dr Hany Omar.

Summary of the Invention: This disclosure relates to novel antitumor agents, pharmaceutically acceptable salts thereof, as well as processes of manufacture, and medicaments containing such compounds. The presently disclosed compounds have anticancer activity, which results in reduction of tumor cell proliferation, induction of apoptosis, as well as DNA damage. This present disclosure also concerns the use of the disclosed compounds in relation to the enzymes thioredoxin reductase, transketolase, cytosol aminopeptidase, glutathione reductase, inositol-3-phosphate synthase, and transferrin receptor activities in addition to regulation of these enzymes.

US Patent Application Number: 62/711,401. TITLE OF THE INVENTION: Discovery of Novel First-In-Class Nature-Inspired Compounds targeting the mitochondrial function and pharmaceutical composition thereof as novel treatment for cancer immunotherapy. Filed May 2018Inventors: Dr. Taleb AlTel; Dr Vunnam Srinivasulu; Dr. Saleh Ibrahim; Dr. Paul Schilf.

Summary of the Invention:This invention relates to novel antitumor agents and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel constrained cyclic frameworks as defined in the specifications of general formulas and medicaments containing such compounds. This invention also concerns the use of such compounds to modulate the cellular mitochondrial functions by measuring the ATP content, the mitochondrial membrane potential and the cellular redox potential as well as their toxicities and effects on T and B cells.

المنشورات الحديثة للمجموعات البحثية:

Drug Design and Discovery

Design, synthesis, in vitro anticancer evaluation, kinase inhibitory effects, and pharmacokinetic profile of new 1,3,4-triarylpyrazole derivatives possessing terminal sulfonamide moiety
Abdel-Maksoud, M.S.,  El-Gamal, M.,  Gamal El-Din, M.M.,  Oh, C.H.
Journal of Enzyme Inhibition and Medicinal Chemistry
One-Pot Synthesis of Diverse Collections of Benzoxazepine and Indolopyrazine Fused to Heterocyclic Systems
Vunnam Srinivasulu, Ihsan Shehadehو Monther A. Khanfar, Omar G. Malik, Hamadeh Tarazi, Imad A. Abu-Yousef, Anusha Sebastian, Nabil Baniowda, Matthew John O’Connor, and Taleb H. Al-Tel
The Journal of Organic Chemistry
Multidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds
Srinivasulu, V.,  Schilf, P.,  Ibrahim, S.,  Khanfar, M.,  Sieburth, S.,  Omar, H.,  Sebastian, A,  AlQawasmeh, R.,  O’Connor, M.,  Al-Tel, T.H.
Nature Communications
Hamza, A.,  Heeba, G.,  Elwy, H.,  Murali, C.,  El-Awady, R.,  Amin, A.
Scientific Reports

Tissue Injury and Repair

Pathological significance of lipoprotein(a) in aortic valve stenosis
Yu, B.,  Khan, K.,  Hamid, Q.,  Mardini, A.,  Siddique, A.,  Aguilar-Gonzalez, L.P.,  Makhoul, G.,  Alaws, H.,  Genest, J.,  Thanassoulis, G.,  Cecere, R.,  Schwertani, A.
Differential expression of TGFβ isoforms in breast cancer highlights different roles during breast cancer progression
Hachim, M.Y.,  Hachim, I.Y.,  Dai, M.,  Ali, S.,  Lebrun, J.
Tumor Biology
Wang, W.,  Qu, X.,  Dang, X.,  Shang, D.,  Yang, L.,  Li, Y.,  Xu, D.,  Martin, J.G.,  Hamid, Q.,  Liu, J.,  Chang, Y.
Clinical and Experimental Allergy
Increased autophagy-related 5 gene expression is associated with collagen expression in the airways of refractory asthmatics
Poon, A.,  Choy, D.,  Chouiali, F.,  Ramakrishnan, R.,  Mahboub, B.,  Audusseau, S.,  Mogas, A.,  Harris, J.M.,  Arron, J.R.,  Laprise, C.,  Hamid, Q.
Frontiers in Immunology

Iron Biology

Elevated Levels of Estrogen Suppress Hepcidin Synthesis and Enhance Serum Iron Availability in Premenopausal Women
Bajbouj, K.,  Shafarin, J.,  Allam, H.,  Madkour, M.,  Awadallah, S.,  El-Serafy, A.,  Sandeep, D.,  Hamad, M.
Experimental and Clinical Endocrinology and Diabetes
Estrogen-induced disruption of intracellular iron metabolism leads to oxidative stress, membrane damage, and cell cycle arrest in MCF-7 cells
Bajbouj, K.,  Shafarin, J., Abdalla, M.Y.,  Ahmad, I.M., Hamad, M.
Tumor Biology

Environment and Cancer Research

Impact of diurnal intermittent fasting during Ramadan on inflammatory and oxidative stress markers in healthy people: Systematic review and meta-analysis
Faris, M.A.-I.E.,  Jahrami, H.A.,  Obaideen, A.A.,  Madkour, M.I.
Journal of Nutrition and Intermediary Metabolism

Effect of oral isotretinoin on the nucleo-cytoplasmic distribution of FoxO1 and FoxO3 proteins in sebaceous glands of patients with acne vulgaris
Agamia, N.,  Hussein, O.,  Abdelmaksoud, R.,  Abdalla, D.,  Talaat, I.,c,  Zaki, E.,  El Tawdy, A.,  Melnik, B.
Experimental Dermatology
The role of p53-microRNA 200-Moesin axis in invasion and drug resistance of breast cancer cells
Alam, F.,  Mezhal, F.,  El Hasasna, H.,  Nair, V.,  Aravind, S.,  Saber Ayad, M.,  El-Serafi, A.,  Abdel-Rahman, W.
Tumor Biology

Wound Healing & Oral Diagnosis

Biomechanical and radiological assessment of immediate implants for alveolar ridge preservation
Al Qabbani, A.,  Al Kawas, S.,  Enezei, H.,  Razak, N.  Al Bayatti, S.,  Samsudin, A.,  Hamid, S.
Dental Research Journal
Bone texture fractal dimension analysis of ultrasound-treated bone around implant site: A double-blind clinical trial
Abdulhameed, E.,  Al-Rawi, N.,  Uthman, A.,  Samsudin, A.
International Journal of Dentistry
Autologous bone marrow concentrates and concentrated growth factors accelerate bone regeneration after enucleation of mandibular pathologic lesions
Talaat, W.M.,  Ghoneim, M.M.,  Salah, O.,  Adly, O.A.
Journal of Craniofacial Surgery

Dental Biomaterials

Optimization of scanning electron microscope technique for amniotic membrane investigation: A preliminary study
Al Shehadat, S.,  Gorduysus, M.O.,  Hamid, S.,  Abdullah, N.,  Samsudin, A.,  Ahmad, A.
European Journal of Dentistry
Long-term microwaving of denture base materials: effects on dimensional, color and translucency stability
Polychronakis, N.,  Polyzois, G.,  Lagouvardos, P.,  Andreopoulos, A.,  Ngo, H.C.
Journal of applied oral science : revista FOB
Hydrophilicity, viscoelastic, and physicochemical properties variations in dental bone grafting substitutes
Trajkovski, B.,  Jaunich, M.,  Müller, W.-D.,  Beuer, F.,  Zafiropoulos, G.-G.,  Houshmand, A.

Nutrition and Food Research

Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations
José Villar, Michelle Fernandes, Manorama Purwar, Eleonora Staines-Urias, Paola Di Nicola, Leila Cheikh Ismail, [....] Stephen Kennedy 
Nature Communications

In vitro investigation of health-promoting benefits of fermented camel sausage by novel probiotic Lactobacillus plantarum: A comparative study with beef sausages
Ayyash, M.,  Liu, S.-Q.,  Al Mheiri, A.,  Aldhaheri, M.,  Raeisi, B.,  Al-Nabulsi, A.,  Osaili, T.,  Olaimat, A.
The mother-infant study cohort (misc): Methodology, challenges, and baseline characteristics
Radwan, H.,  Hashim, M.,  Obaid, R.S.,  Hasan, H.,  Naja, F.,  Ghazal, H.,  Mohamed, H.,  Rizk, R.,  Hilali, M.,  Rayess, R.,  Izzaldin, G.
Dietary Supplement Intake and Associated Factors Among Gym Users in a University Community
Attlee, A.,  Haider, A.,  Hassan, A., Alzamil, N.,  Hashim, M.,  Obaid, R.
Journal of Dietary Supplements

Health Promotion Research Group

Association between quality of sleep and health-related quality of life in persons with diabetes mellitus type 2
Bani-issa, W.,  Al-Shujairi, A.,  Patrick, L.
Journal of Clinical Nursing
Research priorities for specialized nursing practice in the United Arab Emirates
Al-Yateem, N.,  Al-Tamimi, M.,  Brenner, M.,  Altawil, H.,  Ahmad, A.,  Brownie, S.
International Nursing Review
Fruit and vegetable intake among Emirati adolescents: A mixed methods study
Makansi, N.,  Allison, P.,  Awad, M.,  Bedos, C.
Eastern Mediterranean Health Journal

Improving Health Care Delivery and Medicines Use

Assessment of treatment-related problems and associated factors among hospitalized patients in the United Arab Emirates: a retrospective study
Hussein, R.N.,  Ibrahim, O.M.
Journal of Pharmaceutical Health Services Research
Pharmacist views and pharmacy capacity to deliver professional services in the United Arab Emirates
Alzubaidi, H.,  Saidawi, W.,  Mc Namara, K.
International Journal of Clinical Pharmacy

Diabetes and Metabolic Syndrome

RORB and RORC associate with human islet dysfunction and inhibit insulin secretion in INS-1 cells
Jalal Taneera, Abdul khader Mohammed, Sara Dhaiban, Mawieh Hamad, Rashmi B. Prasad, Nabil Sulaiman, and Albert Salehi

The FTO rs9939609 “A” allele is associated with impaired fasting glucose and insulin resistance in Emirati population
Saber-Ayad, M.,  Manzoor, S.,  El Serafi, A.,  Mahmoud, I.,  Hammoudeh, S.,  Rani, A.,  Abusnana, S.,  Sulaiman, N.
Relationship of salivary adipocytokines, diet quality, physical activity, and nutrition status in adult Emirati females in United Arab Emirates
Attlee, A.,  Hasan, H.,  AlQattan, A.,  Sarhan, N.,  Alshammari, R.,  Ali, S.,  Nabil, M.,  Alattrash, A.,  Raigangar, V.,  Madkour, M.d,,  Unnikannan, H.,  Awadallah, S.
Diabetes and Metabolic Syndrome: Clinical Research and Reviews


Oral Biofilms in Health and Disease 

Oral Candida carriage among cigarette- and waterpipe-smokers, and electronic cigarette users
Mokeem, S.,  Abduljabbar, T.,  Al-Kheraif, A.,  Alasqah, M.,  Michelogiannakis, D.,  Samaranayake, L.,  Javed, F.
Oral Diseases
Long-term microwaving of denture base materials: effects on dimensional, color and translucency stability
Polychronakis, N.,  Polyzois, G.,  Lagouvardos, P.,  Andreopoulos, A.,  Ngo, H.
Journal of applied oral science : revista FOB

Cariogenic microbiome and microbiota of the early primary dentition: A contemporary overview
Fakhruddin, K.,  Ngo, H.,  Samaranayake, L.
Oral Diseases

Infectious Disease and Anti-Infective Therapy

Novel betulin derivative is responsible for the anticancer folk use of Ziziphus spina-christi from the hot environmental habitat of UAE
Soliman, S.,  Hamoda, A.,  El-Shorbagi, A.,  El-Keblawy, A.
Journal of Ethnopharmacology
Drought tolerance during germination depends on light and temperature of incubation in Salsola imbricata, a desert shrub of Arabian deserts
Elnaggar, A.,  El-Keblawy, A.,  Mosa, K.A,  Soliman, S.
Flora: Morphology, Distribution, Functional Ecology of Plants
Prevalence of Cryptosporidium spp. among asymptomatic healthy expatriate workers in Sharjah, United Arab Emirates
ElBakri, A.,  Mogane, L.,  Ezzedine, S.,  Potgieter, N.,  Bessong, P.,  AbuOdeh, R.,  Samie, A.
African Journal of Infectious Diseases

Bioinformatics and Functional Genomics 

Using antibody directed phototherapy to target oesophageal adenocarcinoma with heterogeneous HER2 expression
Pye, H.,  Butt, M.A.,  Funnell, L.,  Reinert, H.W.,  Puccio, I.,  Khan, S.,  Saouros, S.,  Marklew, J.,  Stamati, I.,  Qurashi, M.,  Haidry, ,  Sehgal, V.,  Oukrif, D.,  Gandy, M.,  Whitaker, H.,  Rodriguez-Justo, M.,  Novelli, M.e, Hamoudi, R.,  Yahioglu, G.,  Deonarain, M.P.,  Lovat, L.B.
Immunohistochemical assessment of Survivin and Bcl3 expression as potential biomarkers for NF-κB activation in the Barrett metaplasia–dysplasia–adenocarcinoma sequence
Puccio, I.,  Khan, S.,  Butt, A.,  Graham, D.,  Sehgal, V.,  Patel, D.,  Novelli, M.,  Lovat, L.B.,  Rodriguez-Justo, M.,  Hamoudi, R.
International Journal of Experimental Pathology
Prognostic significance of circulating microRNA-21 expression in esophageal, pancreatic and colorectal cancers; a systematic review and meta-analysis
Guraya, S.
International Journal of Surgery

Gene Editing & Therapy

Cotargeting BCL-2 and PI3K induces BAX-dependent mitochondrial apoptosis in AML cells
Rahmani, M.,  Nkwocha, J.,  Hawkins, E.,  Pei, X.,  Parker, R.E.,  Kmieciak, M.,  Leverson, J.D.,  Sampath, D.,  Ferreira-Gonzalez, A.,  Grant, S.
Cancer Research
The clinical burden of allergic rhinitis in five Middle Eastern countries: Results of the SNAPSHOT program
Al-Digheari, A.,  Mahboub, B.,  Tarraf, H.,  Yucel, T.,  Annesi-Maesano, I.,  Doble, A.,  Lahlou, A.,  Tariq, L.,  Aziz, F.,  El Hasnaoui, A.
Allergy, Asthma and Clinical Immunology


Incidence of bladder cancer in Benghazi, Libya over the past three decades
Saheb Sharif-Askari, N.,  Bendardaf, R.,  Saheb Sharif-Askari, F.,  El Tabbal, A.M.,  El Ayan, M.A.
Scientific Reports
Innate lymphoid cells (ILCs) as mediators of inflammation, release of cytokines and lytic molecules
Elemam, N.M.,  Hannawi, S.,  Maghazachi, A.A.


إحصائيات منشورات معهد الشارقة لبحوث الطب و العلوم الصحية 2015-2018