مجموعة أبحاث تعديل الجينات والعلاج الجيني

الرسالة والأهداف

مجموعة أبحاث تعديل الجينات والعلاج الجيني

المنشورات

2018

1. Rahmani M, Nkwocha J, Hawkins E, Pei X, Parker RE, Kmieciak M, Leverson JD, Sampath D, Ferreira-Gonzalez A, Grant S. Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells. Cancer Res. 2018 Jun 1;78(11):3075-3086.

2. Gupte M, Tumuluru S, Sui JY, Singh AP, Umbarkar P, Parikh SS, Ahmad F, Zhang Q, Force T, Lal H. Cardiomyocyte-specific deletion of GSK-3β leads to cardiac dysfunction in a diet induced obesity model. Int J Cardiol. 2018 May 15;259:145-152.

3. Shifaa M. Abdin, Dana M. Zaher, El-Shaimaa A. Arafa and Hany A. Omar*. Tackling the cancer resistance by immunotherapy: Updated clinical impact and safety of PD-1/PD-L1 inhibitors. Cancers, 2018, 10(2), 32; doi: 10.3390/cancers10020032.

4. Mai F. Tolba and Hany A. Omar*, Immunotherapy, an evolving approach for the management of triple negative breast cancer: converting non-responders to responders. Critical Reviews in Oncology/Hematology, 2018, doi: 10.1016/j.critrevonc.2018.01.005.

5. Abdel-Nasser El-Shorbagi, Mohamed El-Naggar, Hamadeh Tarazi, Sachin Chaudhary, Hajjaj Abdu-Allah, Fatema Hersi, Hany A. Omar. Bis-(5-substituted-2-thiono-1,3,5-thiadiazinan-3-yl) butane as a scaffold of anti-proliferative activity, blended by a multicomponent process. Medicinal Chemistry Research, 2018, doi: 10.1007/s00044-018-2133-9.

6. Hamza AA, Heeba GH, Elwy HM, Murali C, El-Awady R, Amin A. Molecular characterization of the grape seeds extract's effect against chemically induced liver cancer: In vivo and in vitro analyses. Sci Rep. 2018 Jan 19;8(1):1270.

7. Srinivasulu V, Sieburth SM, El-Awady R, Kariem NM, Tarazi H, O'Connor MJ, Al-Tel TH. Post-Ugi Cascade Transformations for Accessing Diverse Chromenopyrrole Collections. Org Lett. 2018 Jan 12. doi: 10.1021/acs.orglett.7b03986

8. Khan FM, Saleh E, Alawadhi H, Harati R, Zimmermann WH, El-Awady R. Inhibition of exosome release by ketotifen enhances sensitivity of cancer cells to doxorubicin. Cancer Biol Ther. 2018 Jan 2;19(1):25-33.

2017

9. Nguyen T, Parker R, Hawkins E, Yazbeck Y, Kolluri A, Kmieciak M, Rahmani M, Grant S. Synergistic interactions between PLK1 and HDAC inhibitors in non-Hodgkin's lymphoma cells occur in vitro and in vivo and proceed through multiple mechanisms. Oncotarget, 2017;8(19):31478-31493

10. Tlili A, Fahd Al Mutery A, Mahfood M, Kamal Eddine Ahmad Mohamed W, Bajou K. Identification of a novel frameshift mutation in the ILDR1 gene in a UAE family, mutations review and phenotype genotype correlation. PLoS One. 2017 Sep 25;12(9):e0185281.

11. Gupta M, Lal H Ahmad F, Sawyer DB, Hill MF. Chronic Neuregulin-1? Treatment Mitigates the Progression of Post-Myocardial Infarction Heart Failure in the Setting of Type 1 Diabetes Mellitus by Suppressing Myocardial Apoptosis, Fibrosis and Key Oxidant-Producing Enzymes. J Card Fail. 2017: S1071-9164(17)31159-4.

12. Hany A. Omar, Dana M. Zaher, Vunnam Srinivasulu, Fatema Hersi, Hamadeh Tarazi, Taleb H. Al-Tel. Design, synthesis and biological evaluation of new pyrrolidine carboxamide analogues as potential chemotherapeutic agents for hepatocellular carcinoma. European Journal of Medicinal Chemistry, 2017 Oct 20; 139:804-814. doi: 10.1016/j.ejmech.2017.08.054.

13. Ahmed M. Gouda, Ahmed H. Abdelazeem, Hany A. Omar, Ashraf N. Abdalla, Mohammed A.S. Abourehab, Hamed I. Ali. Pyrrolizines: design, synthesis, anticancer evaluation and investigation of the potential mechanism of action. Bioorganic & Medicinal Chemistry 2017 Oct 15;25(20):5637-5651.

14. Hany H. Arab, Samir A. Salama, Tamer M. Abdelghany, Hany A. Omar, El-Shaimaa A. Arafa, El- Ibrahim A. Maghrabi. Camel milk attenuates rheumatoid arthritis via inhibition of mitogen activated protein kinase pathway. Cellular Physiology and Biochemistry, 2017 Sep 20;43(2):540-552.

15. Ahmed H. Abdelazeem, Mohammed T. El-Saadi, Eman G. Said, Bahaa G.M. Youssif, Hany A. Omar, Samir M. El-Moghazy. Novel Diphenylthiazole Derivatives with Multi-Target Mechanism: Synthesis, Docking study, Anticancer and Anti-Inflammatory Activities. Bioorganic Chemistry, 2017 Sep 12;75:127-138.

16. Mohamed A. Abdelgawad, Rania B. Bakr, Hany A. Omar. Design, synthesis and biological evaluation of some novel benzothiazole/ benzoxazole and/ or benzimidazole derivatives incorporating a pyrazole scaffold as antiproliferative agents. Bioorganic Chemistry, 2017 Jul 15;74:82-90.

17. Mai F. Tolba, Ahmed T. El-Serafi, Hany A. Omar*. Caffeic acid phenethyl ester protects against glucocorticoid-induced osteoporosis in vivo: Impact on oxidative stress and RANKL/OPG signals. Toxicology and Applied Pharmacology, June 2017 324: 26-35.

18. Khaled R. A. Abdellatif, Eman K. A. Abdelall, Mohamed A. Abdelgawad, Dina M. E. Amin, Hany A. Omar. Design, synthesis and biological evaluation of new 4-(4-substituted-anilino) quinoline derivatives as anticancer agents. Medicinal Chemistry Research, May 2017 26 (5): 929-939.

19. Ahmed H. Abdelazeema, Mohammed T. El-Saadi, Asmaa G. Safi El-Din, Hany A. Omar and Samir M. El-Moghazy. Design, Synthesis and Analgesic/Anti-inflammatory Evaluation of Novel Diarylthiazole and Diarylimidazole Derivatives Towards Selective COX-1 Inhibitors with Better Gastric Profile. Bioorganic & Medicinal Chemistry 2017 Jan 15;25(2):665-676.

20. The Role of Eukaryotic and Prokaryotic ABC Transporter Family in Failure of Chemotherapy. El-Awady R, Saleh E, Hashim A, Soliman N, Dallah A, Elrasheed A, Elakraa G.Front Pharmacol. 2017 Jan 10;7:535. doi: 10.3389/fphar.2016.00535. eCollection 2016. Review.

2016

21. Zhou L, Chen S, Zhang Y, Kmieciak M, Leng Y, Li L, Lin H, Rizzo AK, Dumur IC, Ferreira-Gonzalez A, Rahmani M, Povirk L, Chalasani S, Berger J.A, Dai Y, Grant S. The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR. Blood. 2016 May 5;127(18):2219-30.

22. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, …Rahmani M, ...Zughaier SM. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222.

23. Toor AA, Toor AA, Rahmani M, Manjili MH. On the organization of human T-cell receptor loci: log-periodic distribution of T-cell receptor gene segments. J R Soc Interface 2016;13(114):20150911.

24. Sperlazza J, Rahmani M, Beckta J, Aust M, Hawkins E, Wang SZ, Zu Zhu S, Podder S, Dumur C, Archer K, Grant S, Ginder GD. Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formation. Blood. 2015;126(12):1462-72

25. Zhou J*, Ahmad F*, Lal H, Force T. Response by Zhou et al to Letter Regarding Article, "Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy". Invited commentary Circ Res. 2016;119:e29-e30 *Equal first author

26. Zhou J*, Ahmad F*, Parikh S, Hoffman NE, Rajan S, Verma VK, Song J, Yuan A, Shanmughapriya S, Guo Y, Gao E, Koch W, Woodgett JR, Madesh M, Kishore R, Lal H, Force T. Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy. Circ Res 2016: 118;1208-1222. *Equal first author

27. Jui-Hsiang Hung, Chia-Yun Chen, Hany A. Omar, Kuo-Yuan Huang, Che-Chia Tsao, Chien-Chih, Chiu, Yi-Ling Chen, Po-Han Chen, Yen-Ni Teng. Reactive oxygen species mediate terbufos-induced apoptosis in mouse testicular cell lines via the modulation of cell cycle and pro-apoptotic proteins. Environmental Toxicology, 2016 Dec;31(12):1888-1898 Link

28. Hany A. Omar*, Mai F. Tolba, Jui-Hsiang Hung, Taleb H. AlTel. OSU-2S/sorafenib synergistic antitumor combination against hepatocellular carcinoma: The role of PKCδ/p53. Frontiers in Pharmacology 2016 Nov 30;7:463 Link

29. Mai F.Tolba, Hany A. Omar, Samar S. Azab, Amani E. Khalifa, Ashraf B. Abdel-Naim, Sherif Z. Abdel-Rahman. Caffeic acid phenethyl ester: A review of its antioxidant, antimicrobial activities, protective effects against ischemia reperfusion injury and drug adverse reactions. Critical Reviews in Food Science and Nutrition, 2016 Oct 2;56(13):2183-90. Link

30. Ahmed Abdelazeem, Yasser Mohamed, Ahmed Gouda, Hany Omar, Majed Al Robaian. Novel Thymohydroquinone Derivatives as Potential Anticancer Agents: Design, Synthesis and Biological Screening. Australian Journal of Chemistry, 2016 Jun, 69, 1277–1284 Link

31. Khaled R. Abdellatif, Phoebe F. Lamie, Hany A. Omar. 3-Methyl-2-phenyl-1-substituted-indole derivatives as indomethacin analogs: design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents. Journal of Enzyme Inhibition and Medicinal Chemistry, 2016 Apr;31(2):318-24. Link

32. Hany A. Omar, Wafaa R. Mohamed, Hany H. Arab, El-Shaimaa A. Arafa. Tangeretin alleviates cisplatin-induced acute hepatic injury in rats: Targeting MAPKs and apoptosis. PLoS ONE, 2016 Mar 31;11(3):e0151649 Link

33. In-silico screening for DNA-dependent protein kinase (DNA-PK) inhibitors: Combined homology modeling, docking, molecular dynamic study followed by biological investigation. Tarazi H, Saleh E, El-Awady R. Biomed Pharmacother. 2016 Oct;83:693-703.

34. Design and synthesis of novel 5-aminosalicylate (5-ASA)-4-thiazolinone hybrid derivatives with promising antiproliferative activity. Abdu-Allah HH, Abdel-Moty SG, El-Awady R, El-Shorbagi AN. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1647-50.

35. Chronic obstructive pulmonary disease in Middle East and UAE: AnUnrecognized Underestimated Epidemic: Ashraf Al Zaabi, Bassam H Mahboub,Mayank G Vats, Mohammed Nizam Iqbal, Deepa Vats, Journal of Lung, Pulmonary &Respiratory Research, Volume 3 Issue 4‐2016

36. Obesity and Sleep‐Related Breathing Disorders in Middle East and UAE: Vats MG, Mahboub BH, Al Hariri H, Al Zaabi A, Vats D. Can Respir J. 2016;2016:9673054.

37. Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations: Mahboub B, Alzaabi A, Iqbal MN, Salhi H, Lahlou A, Tariq L, El Hasnaoui A. Int J Chron Obstruct Pulmon Dis. 2016 Feb 5;11:273‐

38. Real life management of community‐acquired Pneumonia in adults in the Gulf region and comparison with practice guidelines: a prospective study: Mahboub B, Al Zaabi A, Al Ali OM, Ahmed R, Niederman MS, El‐Bishbishi R. BMC Pulm Med. 2015 Sep 30;15:112.

39. Prevalence and triggers of allergic rhinitis in the United Arab Emirates. Mahboub B, Al‐Hammadi S, Prakash VP, Sulaiman N, Blaiss MS, Redha AA, Vats DM. World Allergy Organ J. 2014 Aug 1;7(1):19.

2015

40. Rahmani M, Aust MM, Hawkins E, Parker RE, Ross M, Kmieciak M, Reshko LB, Rizzo KA, Dumur CI, Ferreira-Gonzalez A, Grant S. Co-administration of the mTORC1/TORC2 inhibitor INK128 and the Bcl-2/Bcl-xL antagonist ABT-737 kills human myeloid leukemia cells through Mcl-1 down-regulation and AKT inactivation. Haematologica. 2015;100(12):1553-63.

41. Herkenne S, Paques C, Nivelles O, Lion M, Bajou K, Pollenus T, Fontaine M, Carmeliet P, Martial JA, Nguyen NQ, Struman I. The interaction of uPAR with VEGFR2 promotes VEGF-induced angiogenesis. Sci Signal. 2015 Nov 17;8(403):ra117.

42. Lal H, Ahmad F, Woodgett JR, Force T. The GSK-3 family as a therapeutic target for myocardial diseases. Circ Res. 2015 Jan 2;116(1):138-149. Invited Review

43. Hany A. Omar, Wafaa R. Mohamed, El-Shaimaa A. Arafa, Basim A. Shehata, Gamal A. El Sherbiny, Hany H. Arab, Abdel Nasser. A. M. Elgendy. Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its antitumor activity. Pharmacological Reports, 2015. Sep;68(2): 349–56

44. Samir A. Salama, Mohammad S. Al-Harbi, Mohamed S. Abdel-Bakky, Hany A. Omar. Glutamyl cysteine dipeptide suppresses ferritin expression and alleviates liver injury in iron-overload rat model. Biochimie, June 2015. 115, 203-211.

45. Kuan-Han Lee*, Hany A. Omar*, Shu-Jing Wu, Pin-Shern Chen, Yu-Chung Chen, Yen-Ni Teng, Hung-Chang Huang, Clay C. C. Wang and Jui-Hsiang Hung. The effect of reactive oxygen species produced by 6-shogaol on cell cycle progression and cell death-associated signaling pathways in human hepatoma cells. European Journal of Pharmacology, June 2015, 762(5) 449–458. Link (*Equal contribution)

46. Hany H. Arab, Samir A. Salama, Hany A. Omar, El-Shaimaa A. Arafa and Ibrahim A. Maghrabi. Diosmin protects against ethanol-induced gastric injury in rats: Novel anti-ulcer actions. PLoS ONE, March, 2015, 30;10(3):e0122417.

47. Khaled R. A. Abdellatif, Heba A. H. Elshemy, Samir A. Salama, and Hany A. Omar. Synthesis, characterization and biological evaluation of novel 4'-fluoro-2'-hydroxy-chalcone derivatives as antioxidant, anti-inflammatory and analgesic agents. Journal of Enzyme Inhibition and Medicinal Chemistry, June 2015; 30(3):484-91.

48. Modulation of DNA damage response and induction of apoptosis mediates synergism between doxorubicin and a new imidazopyridine derivative in breast and lung cancer cells. El-Awady RA, Semreen MH, Saber-Ayad MM, Cyprian F, Menon V, Al-Tel TH. DNA Repair (Amst). 2016 Jan;37:1-11.

49. Epigenetics and miRNA as predictive markers and targets for lung cancer chemotherapy. El-Awady RA, Hersi F, Al-Tunaiji H, Saleh EM, Abdel-Wahab AH, Al Homssi A, Suhail M, El-Serafi A, Al-Tel T. Cancer Biol Ther. 2015;16(7):1056-70.

2014

50. Rahmani M, Aust MM, Benson EC, Wallace L, Friedberg J, Grant S. PI3K/mTOR inhibition markedly potentiates HDAC inhibitor activity in NHL cells through BIM- and MCL-1-dependent mechanisms in vitro and in vivo. Clin Cancer Res. 2014;20(18):4849-60.

51. Vachhani P, Bose P, Rahmani M, Grant S. Rational combination of dual PI3K/mTOR blockade and Bcl-2/-xL inhibition in AML. Physiol Genomics. 2014;46(13):448-56.

52. Cazanave C.S, Wang X, Zho H, Rahmani M, Grant S, Durrant E.D, Klaassen D.C, Yamamoto M and Sanyal J.A. Degradation of Keap1 Activates BH3-only Proteins Bim and PUMA During Hepatocyte Lipoapoptosis. Cell Death and Differentiation. 2014;21(8):1303-12.

53. Bajou K, Herkenne S, Thijssen VL, D'Amico S, Nguyen NQ, Bouché A, Tabruyn S, Srahna M, Carabin JY, Nivelles O, Paques C, Cornelissen I, Lion M, Noel A, Gils A, Vinckier S, Declerck PJ, Griffioen AW, Dewerchin M, Martial JA, Carmeliet P, Struman I. PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin. Nat Med. 2014 Jul;20(7):741-7.

54. 4- Amand,M., Erpicum,C., Bajou,K., Cerignoli,F., Blacher,S., Martin,M., Dequiedt,F., Drion,P., Singh,P., Tinatin,Z., Vandereyken,M., Musumeci,L., Mustelin,T., Moutschen,M., Gilles,C., Noel,A. and Rahmouni,S. DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase. Molecular cancer, 2014, 13, 1-08

55. Ahmad F, Lal H, Zhou J, Vagnozzi RJ, Yu JE, Shang X, Woodgett JR, Gao E, Force T. Cardiomyocyte specific deletion of Gsk3a mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure. J Am Col Cardiol 2014;64(7):696-706

56. Lal H*, Ahmad F*, Zhou J, Yu JE, Vagnozzi RJ, Guo Y, Yu D, Tsai JE, Woodgett JR, Gao E, Force T. Cardiac fibroblast GSK-3β regulates ventricular remodeling and dysfunction in ischemic heart. Circulation 2014;130(5)419-30. *Equal first author (Faculty of 1000 rating:**)

57. Lal H, Ahmad F, Parikh S, Force T. TNNI3K, a novel cardiac-specific kinase, emerging as a molecular target for the treatment of cardiac disease. Circulation J 2014 Jun 25;78(7):1514-9. Invited Review

58. Ahmad F*, Oyen F, Jan R, Budde U, Schneppenheim R, Saxena R. Germline de novo mutations and linkage markers versus DNA sequencing for carrier detection in von Willebrand disease. Haemophilia 2014 Jul;20(4):e311-7 *Corresponding author

59. Ahmed H. Abdelazeem, Ahmed M. Gouda, Hany A. Omar, Mai F. Tolba. Design, Synthesis and Biological Evaluation of Novel Diphenylthiazole-Based Cyclooxygenase Inhibitors as Potential Anticancer Agents. Bioorganic Chemistry, Dec 2014, 57, 132–141.

60. Hany A. Omar, Mai F. Tolba and Maha M. Saber-Ayad. Potential Targets of Energy Restriction Mimetic Agents in Cancer Cells. Future Oncology, 2014 Dec;10(16): 2547-2550.

61. Ahmed H. Abdelazeem, Shaimaa A. Abdelatef, Mohammed T. El-Saadi, Hany A. Omar, Shabana I. Khan, Christopher R. McCurdy and Samir M. El-Moghazy. Novel Pyrazolopyrimidine Derivatives Targeting COXs and iNOS enzymes; Design, Synthesis and Biological Evaluation as Potential Anti-inflammatory Agents. European Journal of Pharmaceutical Sciences, Oct 2014, 62, 197–211.

62. Hany H. Arab, Samir A. Salama, Ahmed H. Eid, Hany A. Omar, El-Shaimaa A. Arafa and Ibrahim A. Maghrabi. Camel's milk ameliorates TNBS-induced colitis in rats via down-regulation of inflammatory cytokines and oxidative stress. Food and Chemical Toxicology, April, 2014, 69C:294-302.

63. Hany A. Omar, El-Shaimaa A. Arafa, A. Maghrabi and Jing-Ru Weng. Sensitization of Hepatocellular Carcinoma Cells to Apo2L/TRAIL by a Novel Akt/NF-kB Signaling Inhibitor. Basic & Clinical Pharmacology & Toxicology, 2014 Jun;114(6):464-71.

64. Kuan-Han Lee, Wen-Yueh Ho, Shu-Jing Wu, Hany A. Omar, Po-Jui Huang, Clay C. C. Wang and Jui-Hsiang Hung. Modulation of cyclins, p53 and MAPK signaling in breast cancer cell lines by 4-(3,4,5-trimethoxyphenoxy)benzoic acid. International Journal of Molecular Sciences, 2014, 15(1), 743-757.

65. Samir A. Salama, Hany A. Omar, Ibrahim A. Maghrabi, Mohammed S. AlSaeed and Adel E. EL-Tarras. Iron supplementation at high altitude causes oxidative injury and inflammation in lung tissues of rats. Toxicology and Applied Pharmacology, 2014 Jan 1;274(1):1-6.

66. El-Shaimaa A. Arafa, Ahmed H. Abdelazeem, Hany H. Arab and Hany A. Omar. OSU-CG5, a Novel Energy Restriction Mimetic Agent Inhibits Colorectal Cancer Cells. Acta Pharmacologica Sinica, 2014 Mar; 35(3):394-400.

67. Samir A. Salama, Hany H. Arab, Hany A. Omar and Robert M. Snapka. Nicotine mediates hypochlorous Acid-induced nuclear protein damage in Mammalian cells. Inflammation, 2014 Jun;37(3):785-92.

Book chapter

1. Mohamed Rahmani and Steven Grant. PI3K/AKT/mTOR Pathway. Ed. Ashkan Emadi, Judith E. Karp. Acute Leukemia. An Illustrated Guide to Diagnosis and Treatment. New York: Demos Medical Publishing, 2017, page 67. Print.

Conferences Abstracts:

2. Nguyen T, Parker R, Hawkins E, Holkova B, Yazbeck V, Kolluri A, Kmieciak M, Rahmani M, Grant S. Synergistic interactions between PLK1 and HDAC inhibitors in non-Hodgkin's lymphoma cells occur in vitro and in vivo and proceed through multiple mechanisms. AACR annual meeting 2017, Washington DC.

3. Rahmani M, Aust1 MM, Hawkins E, Parker RE, Reshko L, Ross M, Kmieciak M, Rizzo KA, Dumur CI, Ferreira-Gonzalez A and Grant S. Co-Administration of the mTORC1/TORC2 Inhibitor INK128 and the Bcl-2/Bcl-Xl Antagonist ABT-737 Kills Human Myeloid Leukemia Cells through Mcl-1 Down-Regulation and AKT Inactivation. ASH annual meeting 2015, Orlando.

4. Rahmani M, Mayo M, Grant S. E2F1 potentiates proteasome inhibition-mediated cell death in leukemia cells through induction of Noxa. AACR Annual Meeting 2014, San Diego.

5. Bajou, K. Targeting Plasminogen Activator Inhibitor-1 using 16K fragment of human prolactin.International Conference on Advances in Biotechnology, July, 10-12, 2017, Dubai, United Arab Emirate.

6. Bajou, K. Anti-angiogenic function of 16K Prolactin requires Plasminogen Activator Inhibitor-1 expression. 4th Biotechnology Word congress, February 15th -18th, 2016, Sharjah, United Arab Emirate.

7. Bajou, K. Plasminogen activator inhibitor-1 between bench and clinic. 1st Annual UAE Biotechnology Students' Research & Innovation Conference, Dec. 15th & 16th, 2015, Sharjah, United Arab Emirate.

8. Gupta M, Tumuluru S, Singh AP, Umbarkar P, Zhang Q, Ahmad F, Parikh P, Force T, Lal H, Cardiomyocyte-specific Conditional Deletion of GSK-3β Leads to Cardiac Dysfunction in a High Fat Diet Induced Obesity Model. Circ Res 2017; in press

9. Gupta M, Lal H Ahmad F, Sawyer DB, Hill MF. Chronic Neuregulin-1β Treatment Mitigates the Progression of Post-myocardial Infarction Heart Failure in the Setting of Type 1 Diabetes Mellitus. Circ Res 2017; in press

10. Ahmad F, Lal H, Verma VK, Woodgett JR, Force T. Cardiomyocyte GSK-3a Signaling Exacerbate Pressure Overload-induced Dilated Cardiomyopathy and Heart Failure. Circ Res 2016:;119:A69

11. Lal H, Ahmad F, Verma VK, Tumuluru S, Parikh S, Zhang Q, Force T. Cardiomyocyte-specific Conditional Deletion of GSK-3β Leads to Global Metabolic Defects and Cardiac Dysfunction in a HFD Induced Obesity Model. Circ Res 2016;119:A75

12. Verma VK, Ahmad F, Zhang Q, Force T, Lal H. Cardiac fibroblast-specific deletion of GSK-3α alleviate from cardiac dysfunction and fibrotic remodeling in ischemic heart. Circ Res 2016:2016;119:A280

13. Hany A. Omar. Mai F. Tolba, Jui-Hsiang Hung, Taleb H. AlTel. Mechanistic insights into the significance of sorafenib and OSU-2S combination for the treatment of hepatocellular carcinoma. The 9th Dubai International Conference for Medical Sciences, Dubai, UAE 14-16 December 2016.

14. Basma Ahmed, Nadia Malahfji, Salma Fouz and Hany A. Omar. C-pulse Heart Assist System. Dubai International Pharmaceuticals and Technologies (DUPHAT) 7-9, March, 2017.

15. Mai F. Tolba and Hany A. Omar; Insights into the anti-prostate cancer activity of pterostilbene. AACR Special Conference on Translational Control of Cancer: A New Frontier in Cancer Biology and Therapy; October 27-30, 2016; San Francisco, CA, USACancer Research 77 (6 Supplement), B45-B45 doi: 10.1158/1538-7445

16. Hany A. Omar; Mai F. Tolba; Jui-Hsiang Hung; Taleb H. AlTel. Talking liver cancer by a novel combination between OSU-2S and sorafenib. Experimental Biology Chicago, IL, USA, April 22 – 26, 2017. The FASEB Journal, April 2017, 31 (1 Supplement), 671.1-671.1

17. MF Tolba, Hany A. Omar, AM Noreddin; The impact of catechol estrogen metabolism on the proliferation rate and Docetaxel (DOC) resistance in hormone-responsive cancers. 2017 AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC, USA. Cancer Research 77 (13 Supplement), 4174-4174 doi:10.1158/1538-7445.AM2017-4174