Department of Pharmacy Practice and Pharmacotherapeutics
  • Prof. Raafat Abd El-Gawad El-Gharib El-Awady
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  • Academic RankProfessor
  • Tel:+(971) 6 5057409
  • Fax:+(971) 6 5585812
  • Specialization:Pharmacology
  • Research Interests:Mechanisms of resistance to anticancer drugs, Regulation of DNA repair and cell cycle after anticancer drugs, Testing and biological characterization of potential anticancer agents

EducationBachelor of Pharmaceutical Sciences (Mai 1990) College of Pharmacy, Zagazig University, Egypt Master in Pharmaceutical Sciences/ Pharmacology (June 1996) Subject: “Chemosensitivity of certain tumour cell lines to topoisomerase inhibitors as determined by graded-field gel electrophoresis “ College of Pharmacy, Cairo University, Egypt PhD in Pharmacology (July 2000) Subject: “Concept of DNA double-strand breaks induction and repair for radiosensitivity of human tumour cells”. Cairo/Hamburg University (channel system)PhD

Employment HistoryJuly 2013, Professor of Pharmacology, National Cancer Institute, Cairo University, Egypt Associate Professor of Pharmacology, College of Pharmacy, Sharjah University, United Arab Emirates Aug 2006 – Aug 2008 Associate Professor of Pharmacology, College of Pharmacy, King Khalid University, Kingdom Saudi Arabia October 2005 – July 2006 Sep 2002-Sep 2005 Postdoc fellow, Experimental Oncology Department, School of Medicine, Hamburg University, Germany Jan 2000- Aug 2002 Assistant Professor of Pharmacology and experimental Oncology, Cancer Biology Department, National Cancer Institute, Cairo University, Egypt Jun 1997-Oct. 1999 Ph.D. fellow, Department of Experimental Oncology, School of Medicine, Hamburg University, Germany 1996-2000 Lecturer of pharmacology, Cancer Biology Department, National Cancer Institute, Cairo University 1992-1996 Demonstrator of pharmacology, Cairo University.

Professional ActivitiesSep 2012 – Present Chairman of the Department of Pharmacy Practice & Pharmacotherapeutics, College of Pharmacy, University of Sharjah, UAE Sep 2008 – Present Coordinator of Pharmacology and Clinical Drug Monitoring Unit, National Cancer Institute, Cairo University, Cairo, Egypt

Professional Memberships- Member of the German DNA Repair Network. - Member in the Emirates Medical Association - International Scholarly research network Genetics Journal, Editor - International Journal of Medicine and medical sciences, Editor - Journal of costal life medicine, Editor - World Journal Surgical Oncology, reviewer - Carcinogenesis Journal, reviewer - International Journal of Oncology, reviewer - Saudi Medical Journal, reviewer

Selected Research ProjectsRaafat El-Awady, Zimmermann, farman Matloob and Taleb Al-Tel ”Effect of tumour secretome before and after chemotherapy on the morphology and function of cardiac and skeletal muscles” financially supported by AlJalila foundation, UAE , 2014 Taleb Al-Tel, Raafat El-Awady “Novel approaches toward the discovery of drugs for the treatment of diabetes, obesity and cancer” financially supported by the National Research Foundation, UAE , 2010 Raafat El-Awady, Amer Al-Homssi, Mohammed Taysser, Mousa Sohail. Breast cancer epigenetics and pharmacotherapy. Boehringer Ingelheim Pharmaceutical company, One year. Raafat El-Awady, Zainab Al-Rubayi, Ward Saidaawi, Ahmed Monther. Leptin as target for cancer chemotherapy. Boehringer Ingelheim Pharmaceutical company, One year. Taleb Al-Tel, Raafat El-Awady, Basel Al-RamadiTargeted Salem Chouib. Cancer Drug Design: Selective Targeting of HDACs Using Diversity Oriented Organic Synthesis and In Silico Aided Drug Design Strategies. TerryFox foundation, three years.

Selected Publications1. Semreen MH, El-Awady R, Abu-Odeh R, Saber M, Al-Qawasmeh RA, Chouaib S, Al-Tel TH, Voelter W. Tandem Multicomponent Reactions Toward the Design and Synthesis of Novel Antibacterial and Cytotoxic Motifs. Curr Med Chem. 2013;20(11):1445-59. 2. E. M. Saleh*, R. A. El-awady*, N. Anis. Predictive markers for the outcome of 5-fluorouracil in cancer cells: Constant field gel electrophoresis as a tool for prediction of response to 5-fluorouracil-based chemotherapy. Oncol Lett. 2013 Jan;5(1):321-327 3. Saleh EM, El-Awady RA, Anis N, El-Sharkawy N. Induction and repair of DNA double-strand breaks using constant-field gel electrophoresis and apoptosis as predictive markers for sensitivity of cancer cells to cisplatin. Biomed Pharmacother. 2012 Oct;66(7):554-62. 4. Ekram M. Saleh*, Raafat A. El-awady*, Nadia A. Eissa, Wael M. Abdel-Rahman. Antagonism between curcumin and the topoisomerase II inhibitor etoposide: a study of DNA damage, death pathways and cell cycle regulation. Cancer Biology &Therapy, Cancer Biol Ther. 2012 Sep 1;13(11):1058-71. 5. Al-Tel TH, Semreen MH, Al-Qawasmeh RA, Schmidt MF, El-Awadi R, Ardah M, Zaarour R, Rao SN, El-Agnaf O. Design, Synthesis, and Qualitative Structure-Activity Evaluations of Novel β-Secretase Inhibitors as Potential Alzheimer's Drug Leads.J Med Chem. 2011 Dec 22;54(24):8373-85. Epub 2011 Nov 16. 6. El-Awady RA, Saleh EM, Ezz M, Elsayed AM. Interaction of celecoxib with different anti-cancer drugs is antagonistic in breast but not in other cancer cells. Toxicol Appl Pharmacol. 2011 Sep 15;255(3):271-86 7. Saleh EM and El-Awady RA. Expression of RAD51, BRCA1 and p53 does not correlate with cellular radiosensitivity of normal human fibroblasts. Ir J Med Sci. 2011 Sep;180(3):715-20 8. Raafat A. El-Awady, Ekram M. Saleh and Jochen Dahm-Daphi. Targeting DNA double-strand breaks repair: is it the right way for sensitizing cells to 5-FU. Anticancer Drugs 2010 Mar; 21(3):277-87. 9. Saleh EM, El-Awady RA, Abdel Alim MA, Abdel Wahab AH. Altered expression of proliferation-inducing and proliferation-inhibiting genes might contribute to acquired doxorubicin resistance in breast cancer cells. Cell Biochem Biophys. 2009;55(2):95-105. 10. Raafat A. El-Awady, Mahmoud Ali, Ekram M. Saleh, and Fayek M. Ghaleb. Apoptosis is the most efficient death-pathway in tumour cells after topoisomerase II inhibition. Saudi Medical Journal. (2008); 29(4): 477-483 11. Leonie Schulte-Uentrop*, Raafat A. El-Awady*, Henning Willers, Jochen Dahm-Daphi1. Distinct roles of XRCC4 and Ku80 in non-homologous endjoining of enzyme- and radiation-induced DNA double-strand breaks. Nucleic Acids Research, 2008, Vol. 36, No. 8 2561–2569 12. R.A. EL-Awady, M. Mahmoud, E.M. Saleh, M. Lotayef, H. Abd El-Baki, J.Dahm-Daphi and E. Dikomey. No correlation between radiosensitivity or dsb repair capacity of normal fibroblasts and acute normal tissue reaction after radiotherapy of breast cancer patients., INT.J.RADIAT.BIOL., 2005, 81(7):501-508. 13. Jochen Dahm-Daphi, Petra Hubbe, Fruzsina Horvath, Raafat A. EL-Awady, Katie E. Bouffard, Simon N. Powell and Henning Willers. Non-homologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53. Oncogene., 2005, 24: 1663-1672.

Awards RecognitionsAnnual Incentive Award of University of Sharjah for outstanding faculty in the field of research 2013/2014 Annual Incentive Award of University of Sharjah for outstanding faculty in the field of research 2010/2011 Sharjah Islamic Bank award for the best research paper 2009/2010 Post-doc scholarship in School of Medicine, Hamburg University 2002-2005 Cairo University Award for the best PhD thesis 2001 DAAD PhD scholarship (Hamburg University/Germany) 1996 - 1999

Teaching PhilosophyOver the past 15 years I have had the opportunity to construct, coordinate and sustain numerous basic and clinical pharmacology syllabi in different universities at both under- and postgraduate levels. It is from this history that I have drawn my own teaching philosophy. My teaching philosophy is that teaching is a two-way process. Both students and teacher should come to the classroom with high expectations of each other and put in their best efforts. This means that students should be engaged in the lecture and the teacher's role is to guide, providing access to information rather than acting as the primary source of information. I see the instructor, students, and the selected course material all playing pivotal roles in the success of any class. In all programs, I focus on three issues; communication, critical thinking and application of evidence-based pharmacotherapy. I facilitate oral communication through presentations, topic discussions, and pharmacotherapeutic care plan discussions- and written communication through journal clubs, and formal drug information questions. I model and ask learners to think about their thought processes regarding common occurrences in practice I always try to make my students to realize their full potential and expect a lot from themselves. This can be achieved through creating a stimulating atmosphere allowing the student's natural curiosity to direct their learning. Another side that I strongly believe in as a very important part of the teacher’s job is to promote the learner’s respect for all things and all people. To assist the learners keeping their passion and motivation at the top, I must keep my knowledge always updated, growing and developed. I always seek out educational and research opportunities that directly apply to my areas of practice: both educational and administrative Finally, I view research as an extension of my teaching. It serves to educate students and to reinforce my personal commitment to learning. Likewise, I am deeply dedicated to increasing my own understanding of the subject matter I teach. I design my research projects to have particular relevance to my courses, and I continually look for ways to push my own knowledge base, which is essential for teaching such an evolving discipline. I will absolutely continue my habit of gaining and incorporating research experience into my pharmacology courses, which I value equally to information acquired from published reports and scholarly articles.