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Dr.Hany A. Omar Vice Dean of College Of Pharmacy Academic RankAssociate Professor

Specialization:

  • Molecular Pharmacology and Therapeutics

Research Interests:

  • Molecular mechanisms of anticancer drugs, Treatment of hepatocellular carcinoma, Molecular pharmacology as a basis for cardiovascular drugs development, Oxidative stress and antioxidants implication in the pathophysiology of clinical disorders

Contact

- Ph.D (Molecular Pharmacology) Ohio State University, Columbus, Ohio, USA 2010. - M.Sc (Pharmacology and Toxicology) Faculty of Pharmacy, Cairo University, Egypt 2005 - Bachelor of Science (Pharmacy) Faculty of Pharmacy, Cairo University, Egypt 1998.
- 2013-Current College of Pharmacy, University of Sharjah, Sharjah, UAE - 2012-2013 College of Pharmacy, Taif University, Taif, KSA - 2010-2012 Faculty of Pharmacy, Beni-Suef University, Egypt. - 2006-2010 College of Pharmacy, Ohio State University, Ohio, USA - 1999- 2005 Faculty of Pharmacy, Cairo University, Beni-Suef campus, Egypt.
- Member of editorial boards and program committees of many international journals - Member of the Research Ethics Committee Of the University of Sharjah - Member of the College of Pharmacy University of Sharjah Scientific Committee.
- American Association for Cancer Research (AACR) - European Association for Cancer Research (EACR). - The American Association of Pharmaceutical Scientists. - American Society Clinical Pharmacology Therapeutics. - American Society for Biochemistry and Molecular Biology.
- PI for Research grant from Al-Jalila Foundation UAE for 249,000 AED for two years; Project title “OSU-2S Combinatorial Approach, the Next Level in Tackling Cancer Cell Survival” 2014 - PI for Research grant from Boehringer Ingelheim pharmaceutical company for 34,700 AED; Project title “Pre-clinical investigation of novel metformin derivatives as energy restriction mimetic anticancer agents” 2014 - PI for Research grant from Taif University Vice-Presidency for Graduate Studies and Research for 107,000 SR; Project title “The Ability of Novel Energy Restriction Mimetic Agents to target Colorectal Cancer” 2013 - Co-PI for Research grant from Taif University Vice-Presidency for Graduate Studies and Research for 86,000 SR; Project title “Design, Synthesis and Biological Evaluation of Novel Cyclooxygenase-II Inhibitors for the Treatment of Colorectal Cancer” 2013
- Hany A. Omar, Aaron M. Sargeant, Jing-Ru Weng, Dasheng Wang, Samuel K. Kulp, Tushar Patel, and Ching-Shih Chen. Targeting of the Akt-NF-кB Signaling Network by OSU-A9, a Novel Indole-3-Carbinol Derivative, in a Mouse Model of Hepatocellular Carcinoma. Molecular Pharmacology, 2009 Nov;76(5):957-68. - Jing-Ru Weng, Chen-Hsun Tsai, Hany A. Omar, Aaron M. Sargeant, Dasheng Wang, Samuel K. Kulp, Charles L. Shapiro, and Ching-Shih Chen. OSU-A9, a Potent Indole-3-Carbinol Derivative, Suppresses Breast Tumor Growth by Targeting the Akt-NF-κB Pathway and Stress Response Signaling. Carcinogenesis, 2009 Oct;30(10):1702-9. - Jing-Ru Weng, Li-Yuan Bai, Hany A. Omar, Aaron Sargeant , Ching-Tung Yeh, Yuan-Yin Chen, Ming-Hsui Tsai, Chang-Fang Chiu. A novel indole-3-carbinol derivative inhibits growth of human oral squamous cell carcinoma in vitro. Oral Oncology, 2010 Oct; 46(10): 748-754. - Li-Yuan Bai, Hany A. Omar, Chang-Fang Chiu, Zeng-Pang Chi, Jing-Ru Weng. Antitumor effects of (S)-HDAC42, a phenylbutyrate-derived histone deacetylase inhibitor, in multiple myeloma cells. Cancer Chemotherapy and Pharmacology, 2010 Aug;68(2):489-96. - Jing-Ru Weng, Hany A. Omar, Samuel K. Kulp, and Ching-Shih Chen. Pharmacological Exploitation of Indole-3-Carbinol to Develop Potent Antitumor Agents. Mini-Reviews in Medicinal Chemistry, 2010 May;10(5):398-404. - Hany A. Omar, Lisa Berman-Booty, Samuel K. Kulp, and Ching-Shih Chen. Energy Restriction as an Antitumor Target. Future Oncology, 2010 Nov; 6(11), 1675–1679. - Hany A. Omar, Yihui Ma, Jui-Hsiang Hung, Chih-Chien Chou, Lisa D. Berman-Booty, Dasheng Wang, Takayuki Kogure, Tushar Patel, Natarajan Muthusamy, John C. Byrd, Samuel K. Kulp and Ching-Shih Chen. Antitumor Effects of OSU-2S, a Non-immunosuppressive Analogue of FTY720, in Hepatocellular Carcinoma. Hepatology, 2011 Jun;53(6):1943-58. - Hany A. Omar, Lisa Berman-Booty and Weng JR. Energy restriction: stepping stones towards cancer therapy. Future Oncology, 2012 Dec;8(12):1503-1506. - Hany A. Omar, El-Shaimaa A. Arafa, Jing-Ru Weng. Sensitization of Hepatocellular Carcinoma Cells to TRAIL by a Novel Aκt/NF-kappaB Signaling Inhibitor. Clinical Cancer Research, 2012;18 (10 Suppl). - Ahmed O.H. El-Nezhawy, Ayman R. Biuomy, Fatma S. Hassan, Ayman K. Ismaiel and Hany A. Omar. Design, synthesis and pharmacological evaluation of omeprazole-like agents with anti-inflammatory activity. Bioorganic & Medicinal Chemistry, 2013 Apr 1;21(7):1661-1670. - Mohamed A. Abdelgawad, Heba A. H. Elshemy, Khaled R. A. Abdellatif and Hany A. Omar. Synthesis of novel substituted 4H-chromenes and their antioxidant screening. Journal of Chemical and Pharmaceutical Research, 2013, 5(1):387-394. - Hany A. Omar, Samir A. Salama, El-Shaimaa A. Arafa and Jing-Ru Weng. Antitumor Effects of Energy Restriction-Mimetic Agents: Thiazolidinediones. Biological Chemistry, 2013; 394(7): 865–870. - Mohamed A. Abdelgawad, Amany Belal, Hany A. Omar, Lamees Hegazy and Mostafa E. Rateb. Synthesis, Anti-Breast Cancer Activity and Molecular Modeling of Some Benzothiazole and Benzoxazole Derivatives. Archiv der Pharmazie Chemistry in Life Sci. 2013, 346(7), 534–541. - Khaled R. A. Abdellatif a, Amany Belal, Hany A. Omar. Design, synthesis and biological evaluation of novel triaryl (Z)-olefins as tamoxifen analogues. Bioorganic & Medicinal Chemistry Letters, 2013 Sep 1;23(17):4960-4963 - Hany A. Omar, El-Shaimaa A. Arafa, Samir A. Salama and Jing-Ru Weng. OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting Akt-NF-κB and MAPK signaling pathways. Toxicology and Applied Pharmacology, 2013 Nov 1;272(3):616-24. - Samir A. Salama, Hany A. Omar, Ibrahim A. Maghrabi, Mohammed S. AlSaeed and Adel E. EL-Tarras. Iron supplementation at high altitude causes oxidative injury and inflammation in lung tissues of rats. Toxicology and Applied Pharmacology, 2014 Jan 1;274(1):1-6. - Samir A. Salama, Hany H. Arab, Hany A. Omar and Robert M. Snapka. Nicotine mediates hypochlorous Acid-induced nuclear protein damage in Mammalian cells. Inflammation, 2014 Jun;37(3):785-92. - El-Shaimaa A. Arafa, Ahmed H. Abdelazeem, Hany H. Arab and Hany A. Omar. OSU-CG5, a Novel Energy Restriction Mimetic Agent Inhibits Colorectal Cancer Cells. Acta Pharmacologica Sinica, 2014 Mar; 35(3):394-400. - Kuan-Han Lee, Wen-Yueh Ho, Shu-Jing Wu, Hany A. Omar, Po-Jui Huang, Clay C. C. Wang and Jui-Hsiang Hung. Modulation of cyclins, p53 and MAPK signaling in breast cancer cell lines by 4-(3,4,5-trimethoxyphenoxy)benzoic acid. International Journal of Molecular Sciences, 2014, 15(1), 743-757 - Hany A. Omar, El-Shaimaa A. Arafa, A. Maghrabi and Jing-Ru Weng. Sensitization of Hepatocellular Carcinoma Cells to Apo2L/TRAIL by a Novel Akt/NF-kB Signaling Inhibitor. Basic & Clinical Pharmacology & Toxicology, 2014 Jun;114(6):464-71 - Hany H. Arab, Samir A. Salama, Ahmed H. Eid, Hany A. Omar, El-Shaimaa A. Arafa and Ibrahim A. Maghrabi. Camel’s milk ameliorates TNBS-induced colitis in rats via down-regulation of inflammatory cytokines and oxidative stress. Food and Chemical Toxicology, April, 2014, 69C:294-302. - Ahmed O. H. El-Nezhawy, Ibrahim A. Maghrabi, Khaled. M. Mohamed and Hany A. Omar. Cymbopogon proximus Extract Decreases L-NAME-Induced Hypertension in Rats. International Journal of Pharmaceutical Sciences Review and Research, July 2014; 27(1): 66-69. - Ahmed H. Abdelazeem, Shaimaa A. Abdelatef, Mohammed T. El-Saadi, Hany A. Omar, Shabana I. Khan, Christopher R. McCurdy and Samir M. El-Moghazy. Novel Pyrazolopyrimidine Derivatives Targeting COXs and iNOS enzymes; Design, Synthesis and Biological Evaluation as Potential Anti-inflammatory Agents. European Journal of Pharmaceutical Sciences, Oct 2014, 62, 197–211 - Khaled R. A. Abdellatif, Heba A. H. Elshemy, Samir A. Salama, and Hany A. Omar. Synthesis, characterization and biological evaluation of novel 4’-fluoro-2’-hydroxy-chalcone derivatives as antioxidant, anti-inflammatory and analgesic agents. Journal of Enzyme Inhibition and Medicinal Chemistry, Sep 2014 8:1-8, doi: 10.3109/14756366.2014.949255 - Hany A. Omar, Mai F. Tolba and Maha M. Saber-Ayad. Potential Targets of Energy Restriction Mimetic Agents in Cancer Cells. Future Oncology, 2014 Dec;10(16): 2547-2550. - Ahmed H. Abdelazeem, Ahmed M. Gouda, Hany A. Omar, Mai F. Tolba. Design, Synthesis and Biological Evaluation of Novel Diphenylthiazole-Based Cyclooxygenase Inhibitors as Potential Anticancer Agents. Bioorganic Chemistry, Dec 2014, 57, 132–141 - Mai F.Tolba, Hany A. Omar, Samar S. Azab, Amani E. Khalifa, Ashraf B. Abdel-Naim, Sherif Z. Abdel-Rahman. Caffeic acid phenethyl ester: A review of its antioxidant, antimicrobial activities, protective effects against ischemia reperfusion injury and drug adverse reactions. Critical Reviews in Food Science and Nutrition, November 2014 doi:10.1080/10408398.2013.821967 - Mai A. Elhemely, Hany A. Omar, Afaf A. Ain-Shoka, Hekma A. Abd El-Latif, Amira M. Abo-youssef, Gamal A. El Sherbiny. Rosuvastatin and ellagic acid protect against isoproterenol-induced myocardial infarction in hyperlipidemic rats. Beni-Suef University Journal of Basic and Applied Sciences, Dec 2014, 3 (4), 239–246 - Mustafa A. AbdEllraheim, Amira M. AboYoussef, Hany A. Omar, Hekma A. AbdEllatif. Angiotensin inhibitors potentiate the hypoglycemic and antioxidant effects of gliclazide in rats. International Journal of Pharmaceutical Sciences Review and Research, March 2015, 31 (1) 14-847
- Ph.D: Candidate: Amany Abd-Elkhalek A. Azouz; Title: “Novel strategy for cytoprotection of transplanted kidneys”. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Egypt - M.Sc: Candidate: Mustafa Ahmed Abdel-Raheim; Title: “Pharmacological study of the possible interactions between antidiabetic drugs and some angiotensin inhibitors in streptozotocin-induced diabetic rats”. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Egypt - M.Sc: Candidate: Sayed Mizar Metwally Mizar. Title: “Pharmacological study of the possible protective effect of B-blockers and Statins in experimentally-induced liver injury”. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Egypt
- 2012: The winner of 31,000 LE Scientific Publication Award for the best published research article with an impact factor of 11.981 (Hepatology, 2011) from Misr El Kheir Foundation - 2011: The winner of 35,000 LE grant for a research proposal from Beni-Suef University Research Centre, Projects Funding and Support Unit, October 2011. - 2011: The best PhD thesis, Beni-Suef University, Egypt, April 2011. - 2011: Egyptian Students Association in North America (ESANA) Best Research Award. ESANA-GA annual meeting, January 2011 in Washington, D.C., USA. - 2010: The National Institutes of Health (NIH) travel award to the fifth annual NIH National Graduate Student Research Festival, October 25-26, 2010 in Bethesda, Maryland, USA. - 2009: American Association of Cancer Research (AACR) award to support professional development as an early-career investigator-in-training waiving Associate membership dues for two years, 2010-2011.
Bringing exercises and simulations into the classroom is essential since, for most students, what they learn only comes to life when they start using it In the field of pharmacology; students enjoy applying what they learn in real life by integrating the class knowledge to the hospital or pharmacy training. I used to guide my students how to use the available resources to discover new medications by gathering existing knowledge from comprehensive sources, prioritizing it, designing set of experiments and eventually publishing work and seeking the best applications.
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