The history of wound care spans from prehistory to modern medicine. As wounds naturally heal by themselves, regardless of whether recovery from the scar or recovery from lost body tissue, hunter-gatherers would have noticed several factors and certain herbal remedies would speed up or assist the process. The treatment of acute and chronic wounds is an ancient area of specialization in medical practice, with a long and eventful clinical history that traces its origins to ancient Egypt and Greece. The Ebers Papyrus, circa 1500 BC, details the use of lint, animal grease, and honey as topical treatments for wounds. In ancient history this was followed by the realization of the necessity of hygiene and the halting of bleeding, where wound dressing techniques and surgery developed. Eventually the germ theory of disease also assisted in improving wound care. Oral and craniofacial wound healing is a very interesting and challenging area of dental science. Researching into the basic biological processes of inflammation, re epithelialization and angiogenesis often create more questions than answers and invites a cluster of multidisciplinary team involving biochemist, pharmacist, pathologist, dentists, surgeons, nurses as well as researchers in oral medicine and biology to search for evidence in wound healing mechanism and its management. The fundamental concept under investigation is “how does bone and soft tissue heals naturally following an injury” and the knowledge gain can be applied in solving the whole range of dental issues that include dento-facial defects, TMJ derangement, dental implants, periodontal regeneration, and pulp healing. Salivary diagnostics has evolved into a sophisticated science, and serves as a subset of the larger field of molecular diagnostics, now recognized as a central player in a wide variety of biomedical basic and clinical areas. Molecular diagnostics feeds into a wide range of disciplines including drug development, personalized medicine (pharmacogenomics) and plays a major role in discovery of biomarkers for the diagnosis of oral and systemic diseases. This is especially true since most of the biomarkers present in blood and urine can also be detected in a sample of saliva.