US Patent Application Number: 15935155. TITLE OF THE INVENTION: Discovery of NOVEL First-In-Class HETEROCYCLIC SYSTEMS for the treatment of Multidrug Resistant Superbugs. Filed on March 2018. RAM confirmation Number: 032618INTEFSW10523900. EFS ID: 32151250. Inventors: Dr. Taleb AlTel; Dr Vunnam Srinivasulu; Dr. Farah ElMarzooq; Dr Rafat El-Awady.
Summary of the Invention: The present disclosure relates to novel imidazole fused polycyclic systems, methods for their use, and processes for their preparation. The compounds of the present disclosure are particularly useful against a variety of bacteria, including multidrug resistant strains of Staphylococcus aureus, S. saprophyticus, S. haemolyticus, and S. epidermidis.
US Patent Application Number: 15935120; TITLE OF THE INVENTION: Discovery of NOVEL First-In-Class HETEROCYCLIC SYSTEMS for the treatment of Cancer. Filed in March 2018. RAM confirmation Number: 032618INTEFSW10050600 EFS ID: 32150635. Inventors: Dr. Taleb AlTel; Dr Rafat El-Awady; Dr Vunnam Srinivasulu; Dr Cijo George Vazhappilly; Dr Hany Omar.
Summary of the Invention: This disclosure relates to novel antitumor agents, pharmaceutically acceptable salts thereof, as well as processes of manufacture, and medicaments containing such compounds. The presently disclosed compounds have anticancer activity, which results in reduction of tumor cell proliferation, induction of apoptosis, as well as DNA damage. This present disclosure also concerns the use of the disclosed compounds in relation to the enzymes thioredoxin reductase, transketolase, cytosol aminopeptidase, glutathione reductase, inositol-3-phosphate synthase, and transferrin receptor activities in addition to regulation of these enzymes.
US Patent Application Number: 62/711,401. TITLE OF THE INVENTION: Discovery of Novel First-In-Class Nature-Inspired Compounds targeting the mitochondrial function and pharmaceutical composition thereof as novel treatment for cancer immunotherapy. Filed May 2018. Inventors: Dr. Taleb AlTel; Dr Vunnam Srinivasulu; Dr. Saleh Ibrahim; Dr. Paul Schilf.
Summary of the Invention:This invention relates to novel antitumor agents and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel constrained cyclic frameworks as defined in the specifications of general formulas and medicaments containing such compounds. This invention also concerns the use of such compounds to modulate the cellular mitochondrial functions by measuring the ATP content, the mitochondrial membrane potential and the cellular redox potential as well as their toxicities and effects on T and B cells.
Research Groups Recent Publications:
Srinivasulu, V., Schilf, P., Ibrahim, S., Khanfar, M., Sieburth, S., Omar, H., Sebastian, A, AlQawasmeh, R., O’Connor, M., Al-Tel, T.H.Nature Communications
Drug Design and Discovery
Design, synthesis, in vitro anticancer evaluation, kinase inhibitory effects, and pharmacokinetic profile of new 1,3,4-triarylpyrazole derivatives possessing terminal sulfonamide moiety
Abdel-Maksoud, M.S., El-Gamal, M., Gamal El-Din, M.M., Oh, C.H.Journal of Enzyme Inhibition and Medicinal ChemistryMultidirectional desymmetrization of pluripotent building block en route to diastereoselective synthesis of complex nature-inspired scaffolds
2018Hamza, A., Heeba, G., Elwy, H., Murali, C., El-Awady, R., Amin, A.Scientific Reports
2018Pathological significance of lipoprotein(a) in aortic valve stenosis
Yu, B., Khan, K., Hamid, Q., Mardini, A., Siddique, A., Aguilar-Gonzalez, L.P., Makhoul, G., Alaws, H., Genest, J., Thanassoulis, G., Cecere, R., Schwertani, A.
Wang, W., Qu, X., Dang, X., Shang, D., Yang, L., Li, Y., Xu, D., Martin, J.G., Hamid, Q., Liu, J., Chang, Y.Clinical and Experimental Allergy
Increased autophagy-related 5 gene expression is associated with collagen expression in the airways of refractory asthmaticsPoon, A., Choy, D., Chouiali, F., Ramakrishnan, R., Mahboub, B., Audusseau, S., Mogas, A., Harris, J.M., Arron, J.R., Laprise, C., Hamid, Q.
Frontiers in Immunology
Iron BiologyElevated Levels of Estrogen Suppress Hepcidin Synthesis and Enhance Serum Iron Availability in Premenopausal WomenBajbouj, K., Shafarin, J., Allam, H., Madkour, M., Awadallah, S., El-Serafy, A., Sandeep, D., Hamad, M.Experimental and Clinical Endocrinology and Diabetes2018
Estrogen-induced disruption of intracellular iron metabolism leads to oxidative stress, membrane damage, and cell cycle arrest in MCF-7 cells
Bajbouj, K., Shafarin, J., Abdalla, M.Y., Ahmad, I.M., Hamad, M.
Environment and Cancer ResearchEffect of oral isotretinoin on the nucleo-cytoplasmic distribution of FoxO1 and FoxO3 proteins in sebaceous glands of patients with acne vulgarisAgamia, N., Hussein, O., Abdelmaksoud, R., Abdalla, D., Talaat, I.,c, Zaki, E., El Tawdy, A., Melnik, B.Experimental Dermatology2018
The role of p53-microRNA 200-Moesin axis in invasion and drug resistance of breast cancer cells
Alam, F., Mezhal, F., El Hasasna, H., Nair, V., Aravind, S., Saber Ayad, M., El-Serafi, A., Abdel-Rahman, W.
Wound Healing & Oral DiagnosisBiomechanical and radiological assessment of immediate implants for alveolar ridge preservationAl Qabbani, A., Al Kawas, S., Enezei, H., Razak, N. Al Bayatti, S., Samsudin, A., Hamid, S.Dental Research Journal2018
Autologous bone marrow concentrates and concentrated growth factors accelerate bone regeneration after enucleation of mandibular pathologic lesions
Talaat, W.M., Ghoneim, M.M., Salah, O., Adly, O.A.
Journal of Craniofacial Surgery
Dental BiomaterialsOptimization of scanning electron microscope technique for amniotic membrane investigation: A preliminary studyAl Shehadat, S., Gorduysus, M.O., Hamid, S., Abdullah, N., Samsudin, A., Ahmad, A.European Journal of Dentistry2018Long-term microwaving of denture base materials: effects on dimensional, color and translucency stabilityPolychronakis, N., Polyzois, G., Lagouvardos, P., Andreopoulos, A., Ngo, H.C.Journal of applied oral science : revista FOB2018
Hydrophilicity, viscoelastic, and physicochemical properties variations in dental bone grafting substitutes
Trajkovski, B., Jaunich, M., Müller, W.-D., Beuer, F., Zafiropoulos, G.-G., Houshmand, A.
Nutrition and Food Research
In vitro investigation of health-promoting benefits of fermented camel sausage by novel probiotic Lactobacillus plantarum: A comparative study with beef sausagesThe mother-infant study cohort (misc): Methodology, challenges, and baseline characteristicsRadwan, H., Hashim, M., Obaid, R.S., Hasan, H., Naja, F., Ghazal, H., Mohamed, H., Rizk, R., Hilali, M., Rayess, R., Izzaldin, G.PLoS ONE2018
Ayyash, M., Liu, S.-Q., Al Mheiri, A., Aldhaheri, M., Raeisi, B., Al-Nabulsi, A., Osaili, T., Olaimat, A.
Dietary Supplement Intake and Associated Factors Among Gym Users in a University CommunityAttlee, A., Haider, A., Hassan, A., Alzamil, N., Hashim, M., Obaid, R.Journal of Dietary Supplements2018 Research priorities for specialized nursing practice in the United Arab EmiratesAl-Yateem, N., Al-Tamimi, M., Brenner, M., Altawil, H., Ahmad, A., Brownie, S.
International Nursing Review
Fruit and vegetable intake among Emirati adolescents: A mixed methods study
Makansi, N., Allison, P., Awad, M., Bedos, C.
Eastern Mediterranean Health Journal
Improving Health Care Delivery and Medicines UseAssessment of treatment-related problems and associated factors among hospitalized patients in the United Arab Emirates: a retrospective studyHussein, R.N., Ibrahim, O.M.Journal of Pharmaceutical Health Services Research2018
Pharmacist views and pharmacy capacity to deliver professional services in the United Arab Emirates
Alzubaidi, H., Saidawi, W., Mc Namara, K.
International Journal of Clinical Pharmacy
Diabetes and Metabolic SyndromeRORB and RORC associate with human islet dysfunction and inhibit insulin secretion in INS-1 cells
Jalal Taneera, Abdul khader Mohammed, Sara Dhaiban, Mawieh Hamad, Rashmi B. Prasad, Nabil Sulaiman, and Albert Salehi
The FTO rs9939609 “A” allele is associated with impaired fasting glucose and insulin resistance in Emirati population
Saber-Ayad, M., Manzoor, S., El Serafi, A., Mahmoud, I., Hammoudeh, S., Rani, A., Abusnana, S., Sulaiman, N.
Relationship of salivary adipocytokines, diet quality, physical activity, and nutrition status in adult Emirati females in United Arab Emirates
Attlee, A., Hasan, H., AlQattan, A., Sarhan, N., Alshammari, R., Ali, S., Nabil, M., Alattrash, A., Raigangar, V., Madkour, M.d,, Unnikannan, H., Awadallah, S.
Diabetes and Metabolic Syndrome: Clinical Research and Reviews2019
Mussa, B., Hamoudi, R., Abusnana, S.
Oral Biofilms in Health and Disease Oral Candida carriage among cigarette- and waterpipe-smokers, and electronic cigarette usersMokeem, S., Abduljabbar, T., Al-Kheraif, A., Alasqah, M., Michelogiannakis, D., Samaranayake, L., Javed, F.Oral Diseases2019
Long-term microwaving of denture base materials: effects on dimensional, color and translucency stability
Polychronakis, N., Polyzois, G., Lagouvardos, P., Andreopoulos, A., Ngo, H.
Journal of applied oral science : revista FOB2018
Infectious Disease and Anti-Infective TherapyNovel betulin derivative is responsible for the anticancer folk use of Ziziphus spina-christi from the hot environmental habitat of UAESoliman, S., Hamoda, A., El-Shorbagi, A., El-Keblawy, A.Journal of Ethnopharmacology2019
Drought tolerance during germination depends on light and temperature of incubation in Salsola imbricata, a desert shrub of Arabian desertsElnaggar, A., El-Keblawy, A., Mosa, K.A, Soliman, S.Flora: Morphology, Distribution, Functional Ecology of Plants2018 Prevalence of Cryptosporidium spp. among asymptomatic healthy expatriate workers in Sharjah, United Arab Emirates
ElBakri, A., Mogane, L., Ezzedine, S., Potgieter, N., Bessong, P., AbuOdeh, R., Samie, A.
African Journal of Infectious Diseases
Bioinformatics and Functional Genomics Using antibody directed phototherapy to target oesophageal adenocarcinoma with heterogeneous HER2 expressionPye, H., Butt, M.A., Funnell, L., Reinert, H.W., Puccio, I., Khan, S., Saouros, S., Marklew, J., Stamati, I., Qurashi, M., Haidry, , Sehgal, V., Oukrif, D., Gandy, M., Whitaker, H., Rodriguez-Justo, M., Novelli, M.e, Hamoudi, R., Yahioglu, G., Deonarain, M.P., Lovat, L.B.Oncotarget2018
Immunohistochemical assessment of Survivin and Bcl3 expression as potential biomarkers for NF-κB activation in the Barrett metaplasia–dysplasia–adenocarcinoma sequence
Puccio, I., Khan, S., Butt, A., Graham, D., Sehgal, V., Patel, D., Novelli, M., Lovat, L.B., Rodriguez-Justo, M., Hamoudi, R.
International Journal of Experimental Pathology
Prognostic significance of circulating microRNA-21 expression in esophageal, pancreatic and colorectal cancers; a systematic review and meta-analysis
International Journal of Surgery
Gene Editing & TherapyCotargeting BCL-2 and PI3K induces BAX-dependent mitochondrial apoptosis in AML cellsRahmani, M., Nkwocha, J., Hawkins, E., Pei, X., Parker, R.E., Kmieciak, M., Leverson, J.D., Sampath, D., Ferreira-Gonzalez, A., Grant, S.Cancer Research2018
The clinical burden of allergic rhinitis in five Middle Eastern countries: Results of the SNAPSHOT program
Al-Digheari, A., Mahboub, B., Tarraf, H., Yucel, T., Annesi-Maesano, I., Doble, A., Lahlou, A., Tariq, L., Aziz, F., El Hasnaoui, A.
Allergy, Asthma and Clinical Immunology
Immuno-OncologyIncidence of bladder cancer in Benghazi, Libya over the past three decadesSaheb Sharif-Askari, N., Bendardaf, R., Saheb Sharif-Askari, F., El Tabbal, A.M., El Ayan, M.A.Scientific Reports2018Innate lymphoid cells (ILCs) as mediators of inflammation, release of cytokines and lytic moleculesElemam, N.M., Hannawi, S., Maghazachi, A.A.Toxins2017