First 1000 days of life: evidence from the USM Pregnancy Cohort Study

SIMR meeting room 20 NOV 20164 PM

First 1000 days of life: evidence from the USM Pregnancy Cohort Study

Hamid Jan B. Jan Mohamed

Nutrition and Dietetics Program, School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan.

The first 1000 days of life concept originated from research findings of several birth and

pregnancy cohort studies around the world. However, the pioneer of this concept was the

late Professor Barker who suggested the Developmental Origins of Health and Disease

hypothesis (DOHaD) based on his findings from old birth records in the United Kingdom.

The DOHaD concept describes how during early life (from conception till early childhood),

the unhealthy maternal diet, poor maternal health status and the polluted environment

during pregnancy trigger changes in fetal development that leads to long term detrimental

effect by modulating risks of non-communicable disease across the life course. Poor dietary

intake and exposure of polluted environment during early childhood also contributes

to non-communicable disease development in later life. However, the DOHaD concept

was not tested in the local population. Hence, upon discussion with DOHaD experts, a

local pregnancy cohort was initiated and named as the USM Pregnancy Cohort Study.

The background and design of this cohort will be presented. Findings that indicated the

association of maternal environment based on the aspects of prenatal dietary intake and

nicotine exposure with birth outcomes will be discussed.


Assoc Professor Dr Hamid Jan works as a lecturer at the Nutrition and Dietetics Programme, University of Sains Malaysia (USM) since year 2007. He joined this institution immediately after completing his PhD (Nutrition) at King's College London, United Kingdom. He holds a Masters Degree in Nutrition from UKM and Bachelor Degree in Nutrition and Community Health from UPM. He received extensive training on laboratory skills from the Diploma in Medical Laboratory Technology Course at USM.

The diversity of his education background contributed towards the creation of several interesting research related to nutrition and disease in Malaysia. Dr Hamid Jan initiated the first birth cohort in Malaysia named the USM Pregnancy Cohort Study which started in year 2009. This cohort was aimed at investigating the role of maternal nutrition, oxidative stress and adipokines in the development of obesity and diabetes. Preliminary findings of this study are available in several local and international journals.

In addition to teaching undergraduate students, Dr Hamid has successfully graduated 1 PhD and 7 Master (MSc) students and currently supervising 8 PhD and 3 MSc students on various research topics. Dr Hamid also works closely with the Ministry of Health Malaysia by being committee member of the Technical Working Group for Nutrition Guidelines and other consultative activities.


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