Tissue and bone regeneration/engineering
Dr. Gorka Orive
Associate Professor in Pharmacy at the University of the Basque Country, Spain
Seminar Date: March 18th, 2019
Time: 12:30pm- 1:30pm
Attendees: Faculty of College of Medicine and College of Dentistry
Tissue engineering involves an interplay of cells, biomaterials and active proteins and drugs to heal and regenerate a wide range of tissues. This approach is particularly important for treating large bone defects (critical size) that fail to heal by themselves. In fact, although most fractures will heal fully, a small but notable proportion do not. These severe cases, known as non-union bone fractures, can cause long-term disability and pain, and often require surgery to rectify. Around 5–10% of bone fractures fail to heal. As the populations of developed countries age, the incidence of fractures, including non-union bone fractures is increasing. Several reports address that only in the United States, from the 8 million fractures are reported each year, around 400.000 of these fractures will fail to heal. In my seminar, I will discuss about several approaches we are now conducting to address this unmet medical need. First, the use of 3D scaffolds based on natural polymers such as alginate and gelatin which provide exciting properties for protein and cell delivery. Second, the fabrication of multi-functional, self-healing and cybernetic 3D scaffolds loaded with nanoclays and third, the application of biological therapies. This last approach is providing a accessible and autologous new tool for the stimulation and acceleration of soft-tissue and bone healing.
Presenter: Dr. Gorka Orive - guest speaker from Spain
Dr. Gorka holds a bachelor's degree in pharmacy and a PhD from the University of the Basque Country (Vitoria, Spain). He is an Associate Professor in Pharmacy at the University of the Basque Country. His main research lines include the micro and nanoencapsulation of drugs, cell therapy,biomaterials, prevention and treatment of CNS neurodegenerative diseases and translational regenerative medicine using scaffolds for bone regeneration and plasma rich in growth factors.