Deciphering the mechanism of breast cancer using interdisciplinary systems medicine approaches
Dr. Rifat Hamoudi
College of Medicine and Sharjah Institute for Medical Research, University of Sharjah,UAE
The Bioinformatics and Functional Genomics group, is a new group that links researchers between RHIMS and RISE to carry out interdisciplinary research. As the name suggests, the group focusses on the acquisition and processing of data related to various chronic complex diseases using systems medicine approach and validation of the finding using translational research and functional genomics approaches.
This seminar will focus on the work done so far on understanding the molecular heterogeneity of breast cancer using transcriptomic data generated through Next Generation Sequencing from patients’ clinical biopsies. The seminar will discuss the optimization of the NGS assay for clinical biopsies as well as the bioinformatics and mathematical tools developed to analyse the resulting data generating patterns of biomarkers that can explain the mechanism of breast cancer.
Data showing how the biomarkers found can be used in translational research will be presented and functional validation of the biomarkers using breast cancer cell lines will be present. Finally, novel results obtained from single cell methodology developed in RHIMS will be presented.
Throughout the seminar, the role of interdisciplinary approach to tackle the complex problem will be highlighted.