TIRF

Research Goals and Objectives
Our group focus encompasses tissue injury and repair related to pathogenesis and therapeutics of multiple origins from molecular and cellular levels to its clinical impact.

Our objectives are:
1. To define the biomarkers of diseases involving tissue repair and remodeling e.g. myocardial infarction, bronchial asthma.
2.  Determine early vascular changes in diabetes mellitus and metabolic syndrome patients to detect cardiovascular injuries in its earlier stage using non-invasive diagnostic tests and biomedical markers. 
3.  To evaluate the influence of gene polymorphism and tissue microenvironment on tissue remodeling, neoplasia and response to medications.
4.  Describing 3D scaffold free models of related tissue types for tissue regeneration as well as drug testing.
5.  Explore the potential beneficial effects of vitamin D and antioxidants in reversing and repairing the vascular injuries.
6.  Examine the immunological reactions mounting after environmental insults or genetic modifications
7.   Establish animal models representing human cardiovascular disease and obstructive airway diseases.

 Research Team
Prof. Qutayba Hamid : Dean of the College of Medicine
Dr. Ahmed El-Serafy, Assistant Professor , Basic Medical Sciences Dep.
Dr. Adel Al-Moseilhy, Associate Professor, Basic Medical Sciences Dep.
Dr. Maha Saber, Associate Professor,  Clinical Sciences Dep.
Dr. Samerin Ahmed, Assistant Professor, Basic Medical Sciences Dep.
Dr. Bashair Moussa, Assistant Professor, Basic Medical Sciences Dep.
Dr. Maha Gumei, Assistant Professor, Clinical Sciences Dep.
Prof. Mohamed Al-Hajjaj, Professor,  Clinical Sciences Dep.
Prof. Azzam Magazachi, Professor, Clinical Sciences Dep.

Lines of Research
1.  Bronchial Asthma in the community of Sharjah; incidence, provocative factors and molecular background.
2.  Cardiovascular disease, in association with early endothelial damage and associated biomarkers.
3.  Genetic polymorphism and its association with the response to treatment.
4.  Exploring the readiness of the important factors in tissue repair in the local community, such as vitamin D and antioxidants.
5.  The effect of genetic predisposition and tissue microenvironment versus environmental challenges in muscle injury.
6.  Investigate the role of immune system during inflammation.

Publications

Rolin J Maghazachi AAChemokine receptors and inflammatory lipids. Implications for atherosclerosis.Journal of Leukocyte Biology201495575-585

Rolin J

Vego H Maghazachi AA

Oxidized lipids and lysophosphatidylcholine induce the chemotaxis, up-regulate the expression of CCR9 and CXCR4 and abrogate the release of IL-6 in human monocytesToxins (Basel)201462840-2856

Høglund RA Maghazachi AA

Multiple sclerosis and the role of immune cell

 

 

World Journal of Experimental Medicine2014427-37


 

Al-Jaderi  Z Maghazachi AAVitamin D3 and monomethyl fumarate enhance natural killer cell lysis of dendritic cells and ameliorate the clinical score in mice suffering from experimental autoimmune encephalomyelitis (EAE).Toxins (Basel)201574730-4744

Vego H

Sand KL Høglund RA Fallang LE Gundersen G Holmøy T

Maghazachi AA

Monomethyl fumarate augments NK cell lysis of tumor cells through degranulation and the upregulation of NKp46 and CD107a.Cellular & Molecular Immunology20161357-64
Dash NR Maghazachi AABCG Vaccine – Beginning of its EndMOJ Immunololgy20163DOI: 10.15406/moji.2016.03.00085,
Dash NR Maghazachi AADengue Vaccine an Optimistic BeginningMOJ Immunololgy20164DOI: 10.15406/moji.2016.04.00112

Guimei MM

Barqawi HJ Dash NR Maghazachi AA

Sepsis- The Dilemma ContinuesMOJ Immunology20164DOI: 10.15406/moji.2016.04.00125

Al-Jaderi  Z Maghazachi AA

 

Utilization of dimethyl fumarate and related molecules for treatment of multiple sclerosis, cancer, and other diseasesFrontiers in Immunology20167278. DOI: 10.3389/fimmu.2016.00278 eCollection 201
Maghazachi AA Al-Jaderi  Z Sand KLGlatiramer acetate, dimethyl fumarate and monomethyl fumarate up-regulate the expression of CCR10 on the surface of natural killer cells and enhance their chemotaxis and cytotoxicity.Frontiers in Immunology20167437. eCollection 2016
Elemam N Hannawi S Maghazachi AAInnate lymphoid cells: Is there a fourth subset?Frontiers in Immunology2017In PressIn Press


 

Group Collaborators
Local Collaborators
a. Dr. Mohamed Saleh Alhajjaj
b. Dr. Bassam Hassan Mahboub
c. Dr. Ashraf Al Zaabi; Zayed military hospital
d. Dr. Mohamed Seif; UHS
e. Dr. Salah Abu Senana; Rashid center of Diabetes and research;
f. Dr. Fatma Al-Hashimi; Dubai Cord Blood Research Center;
g. Dr. Mohamed Hassanein; Dubai Hospital
h. Prof. Sherif Karam, Dr. Sahar Mohsin; United Arab Emirates University

International Collaborators
a. Prof. David Eidelman; McGill University, Canada.
b. Prof. James Martin; McGill University, Canada.
c. Dr. Carolyn Baglole; McGill University, Canada
d. Dr. Rabie Halwani; King Saud University, KSA.
e. Prof. Wahib Mahana; Université Paris-sud, France.
f. Dr. Sandra Gessani; Instituto Superiore di Sanita, Rome, Italy.
g. Prof. Adel Schwertani, Montreal General Hospital, Canada
h. Prof. Moustapha Hassan; Karoliniska Institute, Sweden
i. Prof. Ton Rabelink; Leiden University Medical Centre
j. Prof. Imed Gallouzi; McGill University