TIRF

Research Goals and Objectives

Our group focus encompasses tissue injury and repair related to pathogenesis and therapeutics of multiple origins from molecular and cellular levels to its clinical impact.

Our objectives are:

1. To define the biomarkers of diseases involving tissue repair and remodeling e.g. myocardial infarction, bronchial asthma.

2.  Determine early vascular changes in diabetes mellitus and metabolic syndrome patients to detect cardiovascular injuries in its earlier stage using non-invasive diagnostic tests and biomedical markers. 

3.  To evaluate the influence of gene polymorphism and tissue microenvironment on tissue remodeling, neoplasia and response to medications.

4.  Describing 3D scaffold free models of related tissue types for tissue regeneration as well as drug testing.

5.  Explore the potential beneficial effects of vitamin D and antioxidants in reversing and repairing the vascular injuries.

6.  Examine the immunological reactions mounting after environmental insults or genetic modifications

7.   Establish animal models representing human cardiovascular disease and obstructive airway diseases.

 Research Team

Prof. Qutayba Hamid : Dean of the College of Medicine

Dr. Ahmed El-Serafy, Assistant Professor , Basic Medical Sciences Dep.

Dr. Adel Al-Moseilhy, Associate Professor, Basic Medical Sciences Dep.

Dr. Maha Saber, Associate Professor,  Clinical Sciences Dep.

Dr. Samerin Ahmed, Assistant Professor, Basic Medical Sciences Dep.

Dr. Bashair Moussa, Assistant Professor, Basic Medical Sciences Dep.

Dr. Maha Gumei, Assistant Professor, Clinical Sciences Dep.

Prof. Mohamed Al-Hajjaj, Professor,  Clinical Sciences Dep.

Prof. Azzam Magazachi, Professor, Clinical Sciences Dep.

Lines of Research

1.  Bronchial Asthma in the community of Sharjah; incidence, provocative factors and molecular background.

2.  Cardiovascular disease, in association with early endothelial damage and associated biomarkers.

3.  Genetic polymorphism and its association with the response to treatment.

4.  Exploring the readiness of the important factors in tissue repair in the local community, such as vitamin D and antioxidants.

5.  The effect of genetic predisposition and tissue microenvironment versus environmental challenges in muscle injury.

6.  Investigate the role of immune system during inflammation.

Publications

Prof. Hamid

1.  R. Halwani, J. Al Abri, J.G. Martin, Q. Hamid.  CC and CXC chemokines induce airway smooth muscle proliferation and survival.  J. Immunol. 186: 4156-4163, 2011.

2.  R. Halwani, S. Al-Muhsen, H. Al-Jahdali, Q. Hamid. Role of TGF-(beta) in airway remodeling in asthma.  Am. J. Respir. Cell Mol. Biol. 44: 127-133, 2011.

3.  Y. Chang, L. Al-Alwan, P.A. Risse, L. Roussel, A.J. Halayko, J.G. Martin, Q. Hamid, D.H. Eidelman.  TH17 cytokines induce human airway smooth muscle cell migration.  J. Allergy Clin. Immunol. 127: 1046-1053, 2011.

4.   R. Olivenstein, Q. Hamid.  Asthma in the elderly: Their time is right now.  Clin. Exp. Allergy 41: 457-458, 2011.

5.   R. Olivenstein, H. Al Jahdali, N. Alkhamis, R. Halwani, S. Al-Muhsen, Q. Hamid.  Challenges in the management of severe asthma: Role of current and future therapies.  Curr. Pharm Des. 17: 703-711, 2011.

6.   C. McCusker, Q. Hamid.  Managing asthma during pregnancy: What information do we need to optimize care?  Am. J. Respir. Care Med. 183: 687-688, 2011.

7.  Y. Chang, J. Nadigel, N. Boulais, J. Bourbeau, F. Maltais, D.H. Eidelman, Q. Hamid.  CD8 positive T cells express IL-17 in patients with chronic obstructive pulmonary diseases.  Respir. Res. 12: 43, 2011.

8.   L. Roussel, S. Robins, A. Schachter, J. Berube, Q. Hamid, S. Rousseau.  Steroids and extracellular signal-regulated kinase ½ activity suppress activating transcription factor 3 expression in patients with severe asthma.  J. Allergy Clin. Immunol. 2011 127: 1632-40.

9.   S. Robins, L. Roussel, A. Schachter, P.A. Risse, A.K. Mogas, R. Olivenstein, J.G. Martin, Q. Hamid, S. Rousseau.  Steroid-insensitive ERK ½-activity drives CXCL8 synthesis and neutrophilia by airway smooth muscle.  Am J. Respir. Cell Mol. Biol. 45: 984-990, 2011.

10.  R.J. Kimoff, Q. Hamid, M. Divangahi, S. Hussain, W. Bao, N. Naor, R.J. Payne,  A. Ariyarajah, K. Mulrain, B.J. Petrof.  Increased upper airway cytokines and oxidative stress in severe obstructive sleep apnea.  Eur. Respir. J. 38: 89-97, 2011.

11.  S. Al-Muhsen, J.R. Johnson, Q. Hamid.  Remodeling in asthma.  J. Allergy Clin. Immunol. 128: 451-462, 2011.

12.  E.M. Schauberger, S.L. Ewart, S.H. Arshad, M. Huebner, W. Karmaus, J.W. Holloway, K.H. Friderici, J.T. Ziegler, H. Zhang, M.J. Rose-Zerilli, S.J. Barton, S.T. Holgate, J.R. Kilpatrick, S. Lajoie-Kadoch, I.T. Harley, Q. Hamid,  R.J. Kurukulaaratchy, M.A. Seibold, P.C. Avila, W. Rodriquez-Cintron, J.R. Rodriguez-Santana, D. Hu, C. Gignoux, I. Romieu, S.J. London, E.G. Burchard, C.D. Langefeld, M. Wills-Karp.  Identification of ATPAF1 as a novel candidate gene for athma in children.  J. Allergy Clin Immunol. 128: 753-760, 2011.

13.  J. Nadigel, D. Prefontaine, C.J. Baglole, F. Maltais, J. Bourbeau, D.H. Eidelman, Q. Hamid.  Cigarette-smoke increases TLR4 and TLR9 expresion and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease.  Respir. Res. 12: 149, 2011.

14.  A. Vazquez-Tello, R. Halwani, R. Li, J. Nadigel, A. Bar-Or, B.D. Mazer, S. Al-Muhsen, Q. Hamid.  IL-17A and IL-17F expression in B lymphocytes.  Int’l Archives Allergy Immunol. 157: 406-416, 2012.

15.  A. Bener, M.S. Ehlayel, M.K. Tulic, Q. Hamid.  Vitamin D deficiency as a strong predictor of asthma in children.  Int'l Arch Allergy Immunol. 157: 168-175, 2012.

16.  A.H. Poon, F. Chouiali, S.M. Tse, A.A. Litonjua, S.N. Hussain, C.J. Baglole, D.H. Eidelman, R. Olivenstein, J.G. Martin, S.T. Weiss, Q. Hamid, C. Laprise.  Genetic and histologic evidence for autophagy in asthma pathogenesis.  J. Allergy Clin Immunol. 129: 569-571, 2012.

17.  P. Joubert, S. Lajoie-Kadoch, V. Wellemans, S. Letuve, M.K. Tulic, A.J. Halayko, Q. Hamid.  Expression and regulation of CCL15 by human airway smooth muscle cells.  Clin. Exp. Allergy 42: 85-94, 2012.

18.  J.R. Johnson, Q. Hamid.  Appraising the small airways in asthma.  Curr. Opin. Pulm. Med. 18: 23- 28, 2012.

19.  N. Hirota, P.A. Risse, M. Novali, T. McGovern, L. Al-Alwan, S. McCuaig, D. Proud, P. Hayden, Q. Hamid, J.G. Martin.  Histamine may induce airway remodeling through release of epidermal growth factor receptor ligands from bronchial epithelial cells.  FASEB J. 26: 1704-1716, 2012.

20.  A.M. Byrne, E. Goleva, F. Chouiali, M.H. Kaplan, Q. Hamid, D.Y. Leung.  Induction of GITRL expression in human keratinocytes by Th2 cytokines and TNF-: Implication for atopic dermatitis. Clin. Exp. Allergy 42: 550-559, 2012.

21.   A. Poon, D. Eidelman, C. Laprise, Q. Hamid.  ATG5, autophagy and lung function in asthma.  Autophagy 8:694-695, 2012.

22.   A.H. Poon, D.H.Eidelman, J.G. Martin, C. Laprise, Q. Hamid.  Pathogenesis of severe asthma.  Clin. Exp. Allergy 42: 625-637, 2012.

23.   A.H. Poon, Q. Hamid.  Personalized medicine for asthma: Are we there yet?  Ann. Thorac. Med. 7: 55-60, 2012.

24.   A.J. Wardlaw, R.E. O'Hehir, C.J. Corrigan, Q.A. Hamid.  Special issue on severe asthma. Clin. Exp. Allergy 42: 611, 2012.

25.   A.H. Poon, L. Gong, C. Brasch-Andersen, A.A. Litonjua, B.A. Raby, Q. Hamid, C. Laprise, S.T. Weiss, R.B. Altman, T.E. Klein.  Very important pharmacogene summary for VDR.  Pharmacogenet Genomics 22: 758-763, 2012.

26.  L.A. Alwan, Y. Chang, C.J. Baglole, P.A. Risse, A.J. Halayko, J.G. Martin, D.H. Eidelman, Q. Hamid.  Autocrine-regulated airway smooth muscle cell migration is dependent on IL-17-induced   growth-related oncogenes.  J. Allergy Clin. Immunol.  130: 977-985, 2012.

27.  Q. Hamid.  Pathogenesis of small airways in asthma.  Respiration 84: 4-11, 2012.

28.  M. Contoli, M. Kraft, Q. Hamid, J. Bousquet, K.F. Rabe, L.M. Fabbri, A. Papi.  Do small airway abnormalities characterize asthma phenotypes?  In search of proof.  Clin. Exp. Allergy 42:1150-1160, 2012.

29.  G. Jia, R.W. Erickson, D.F. Choy, S. Mosesova, L.C. Wu, O.D. Solberg, A. Shikotra, R. Carter, S. Audusseau, Q. Hamid, P. Bradding, J.V. Fahy, P.G. Woodruff, J.M. Harris, J.R. Arron;.   Bronchoscopic exploratory research study of biomarkers in corticosteroid-refractory asthma (BOBCAT) study group. Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J. Allergy Clin. Immunol.  130: 647-654, 2012.

30.  Al Al-Khayyat, M. Al-Anazi, A. Warsy, A. Vazquez-Tello, A.M. Alamri, R. Halwani, A. Alangari, A. Al-Frayh, Q. Hamid, S. Al-Muhsen.  T1 and T2 ADAM33 single nucleotide polymorphisms and the risk of childhood asthma in a Saudi Arabian population: A pilot study.  Ann Saudi Med. 32: 479-486, 2012.

31.  Y. Chang, L. Al-Alwan, P.A. Risse, A.J. Halayko, J.G. Martin, C.J. Baglole, D.H. Eidelman, Q. Hamid.  Th17-associated cytokines promote human airway smooth muscle cell proliferation. FASEB J. 26: 5152-5160, 2012.

32.  A.H. Poon, Q. Hamid.  Asthma endotypes: The right direction towards personlized medicine for asthma.  Expert Rev. Clin. Immunol. 8: 595-596, 2012.

33.    I.P. Lewkowich, S. Lajoie, S.L. Stoffers, Y. Suzuki, P.K. Richgels, K. Dienger, A.A. Sproles, H. Yagita, Q. Hamid, M. Wills-Karp. PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production.  Mucosal Immunol. 6: 728-739, 2013.

34.   A. Vazquez-Tello, R. Halwani, Q. Hamid, S. Al-Muhsen.  Glucocorticoid receptor-beta up-regulation and steroid resistance induction by IL-17 and IL-23 cytokine stimulation in peripheral mononuclear cells. J.  Clin. Immunol. 33: 466-478, 2013.

35.  R. Halwani, A. Vazquez-Tello, Y. Sumi, M.A. Pureza, A. Bahammam, H. Al-Jahdali, A. Soussi-Gounni, B. Mahboub, S. Al-Muhsen, Q. Hamid. Eosinophils induce airway smooth muscle proliferation. J. Clin. Immunol. 33: 594-604, 2013.

36.  T.Y. Lin, A.H. Poon, Q. Hamid.  Athma phenotypes and endotypes.  Curr. Opin. Pulm. Med. 19: 18-23, 2013.

37.   R. Halwani, S. Al-Muhsen, Q. Hamid.  T helper 17 cells in airway diseases: From laboratory bench to bedside.  Chest 143: 494-501, 2013.

38.    S. Al-Muhsen, S. Letuve, A. Vazquez-Tello, M.A. Pureza, H. Al-Jahdali, A.S. Bahammam, Q. Hamid, R. Halwani.  Th17 cytokines induce pro-fibrotic cytokines release from human eosinophils.  Respir. Res. 14: 34, 2013.

39.   J. Nadigel, S. Audusseau, C.J. Baglole, D.H. Eidelman, Q. Hamid.  IL-8 production in response to cigarette smoke is decreased in epithelial cells from COPD patients.  Pulm. Pharmacol. Ther. 26: 596-602, 2013. 

40.   S. Kyoh, N. Venkatesan, A.H. Poon, M. Nishioka, T.Y. Lin, C.J. Baglole, D.H. Eidelman, Q. Hamid.  Are leukocytes in asthmatic patients aging faster?  A study of telomere length and disease severity.  J. Allergy Clin. Immunol. 132: 480-482, 2013.

41.  A.H. Poon, B. Mahboub, Q. Hamid.  Vitamin D deficiency and severe asthma.  Pharmacol. Ther. 140: 148-155, 2013.

42.    L.A. Al-Alwan, Y. Chang, A. Mogas, A.J. Halayko, C.J. Baglole, J.G. Martin, S. Rousseau, D.H. Eidelman, Q. Hamid.  Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration.  J. Immunol. 191: 2731-2741, 2013.

43.   T.Y. Lin, N. Venkatesan, B. Mahboub, Q. Hamid.  Involvement of lymphocytes in asthma and allergic diseases: A genetic point of view.  Curr. Opin. Allergy Clin. Immunol. 13: 500-506, 2013.

44.   F. Lavigne,  B.J. Petrof,  J.R. Johnson,  P. Lavigne,  N. Binothman,  G.O. Kassissia,  M. Al Samri, C. Giordano, N. Dubé, D. Hercz, A. Benedetti, Q. Hamid.   Effect of topical corticosteroids on allergic airway inflammation and disease severity in obstructive sleep apnoea.  Clin. Exp. Allergy 43: 1124-33, 2013.

45.  W.C. Tan, J. Bourbeau, P. Hernandez, K.R. Chapman, R. Cowie, M. Fitzgerald A. Shawn et al; CanCOLD Collaborative Research Group.  Bronchodilator responsiveness and reported respiratory symptoms in an adult population.  PloS One 8: e58932, 2013.

46.  M. Zago, J.A. Sheridan, P. Nair, A. Rico de Souza,  I.E.Gallouzi, S. Rousseau, S. Di Marco, Q. Hamid, D.H. Eidelman, C.J. Baglole.  Aryl Hydrocarbon receptor-dependent retention of nuclear HuR suppresses cigarette smoke-induced cyclooxygenase-2 expression independent of DNA-binding.  PLoS One  8:e74953, 2013.

47.  J.R. Johnson, M. Nishioka, J. Chakir, P.A. Risse, I. Almaghlouth, A.N. Bazarbashi, S. S. Plante, J.G. Martin,D. Eidelman, Q. Hamid. IL-22 contributes to TGF-β1-mediated epithelial-mesenchymal transition in asthmatic bronchial epithelial cells.  Respir Res. 14: 118, 2013.

48.  Y. Chang, L. Al-Alwan, S. Audusseau, Chouiali F, Carlevaro-Fita J, Iwakura Y, Baglole CJ, Eidelman DH, Hamid Q.  Genetic deletion of IL-17A reduces cigarette smoke-induced inflammation and alveolar type II cell apoptosis.  Am. J. Physiol. Lung Cell. Mol. Physiol. 306: L132-143, 2014.

49.  J.R. Arron, D.F. Choy, M. Laviolette, S.G. Kelsen, A. Hatab, R. Leigh, N.C. Thomson, E.R. Bleecker, R. Olivenstein, P.C. Avila, N.J. Jarjour, M. Castro, G.M. Gauvreau, J.T. Good, J.N. Kline, A. Mansur, I. Mayers, L.G. Heaney, Q. Hamid, J.M. Harris. Disconnect between sputum neutrophils and other measures of airway inflammation in asthma.  Eur. Respir. J. 43: 627-629, 2014.  

50.   E.Y. Bissonnette, A.M. Madore, J. Chakir, M. Laviolette, L.P. Boulet LP, Q. Hamid, C.Bergeron, K. Maghni, C. Laprise.  Fibroblast growth factor-2 is a sputum remodeling biomarker of severe asthma. J. Asthma 51: 119-126, 2014.

51.   K.F. Chung, S.E. Wenzel, J.L. Brozek, A. Bush, M. Castro, P.J. Sterk, I.M. Adcock, E.D. Bateman, E.H. Bel, E.R. Bleecker, L.P. Boulet, C. Brightling, P. Chanez, S.E. Dahlen, R. Djukanovic, U. Frey, M. Gaga, P. Gibson, Q. Hamid, N.N. Jarjour, T. Mauad,  R.L. Sorkness, W.G. Teague.  International ERS/ATS guidelines on definition, evaluation  and treatment of severe asthma.  Eur. Respir. J. 43: 343-373, 2014.

52.   M. Zago, A. Rico de Souza, E. Hecht, S. Rousseaux, Q. Hamid, D.H. Eidelman, C.J. Baglole.  The NF-kB family member RelB regulates microRNA miR-146a to suppress cigarette smoke-induced COX-2 protein expression in lung fibroblasts.  Toxicol. Lett.  226: 107-116, 2014.

53.   W.C. Tan, J. Bourbeau, D. O'Donnell, S. Aaron, F. Maltais, D. Marciniuk, P. Hernandez, R. Cowie, K. Chapman, A. Sonia Buist, M.J. Fitzgerald et al; CanCOLD Collaborative Research Group.  Quality assurance of spirometry in a population-based study-predictors of good outcome in spirometry testing. COPD 11: 143-151, 2014.

54.   A.R. de Souza, M. Zago, D.H. Eidelman, Q. Hamid, C.J. Baglole.  Aryl hydrocarbon receptor (AhR) attenuation of subchronic cigarette smoke-induced pulmonary neutrophilia is associated with retention of nuclear RelB and suppression of intercellular adhesion molecule (lCAM-1).  Toxicol. Sci. 140: 204-223, 2014.

55.  S. Lajoie, I. Lewkowich, N.S. Herman, A. Sproles, J.T. Pesce, T.A. Wynn, M.J. Grusby, Q. Hamid, M. Wills-Karp.  IL-21 receptor signaling partially mediates Th2-mediated allergic airway responses.  Clin. Exp. Allergy 44: 976-985, 2014.

 56.   L.A. Al-Alwan, Y. Chang, S. Rousseau, J.G. Martin, D.H. Eidelman, Q. Hamid.  CXCL1 inhibits airway smooth muscle cell migration through the Decoy receptor Duffy antigen receptor for chemokines.  J. Immunol. 193: 1416-1426, 2014.

57.   W.C. Tan,  J. Bourbeau,  P. Hernandez,  K.R. Chapman, R. Cowie, J.J. FitzGerald, D.D. Marciniuk, F. Maltais , A.S. Buist, D.E. O'Donnell, et al.  CanCOLD Collaborative Research Group. Exacerbation-like respiratory symptoms in individuals without chronic obstructive pulmonary disease: Results from a population-based study.  Thorax 69: 709-717, 2014.

58.   A. Yáñez,  S-H. Cho,  J.B. Soriano, L.J. Rosenwasser, G.J. Rodrigo, K.F. Rabe, S. Peters, A. Niimi, D.K. Bedford, R. Katial, F.C. Hoyte, L.M. Fabbri, J.C. Celedón, G. W. Canonica, P. Busse,  L-P. Boulet, C.E. Baena-Cagnani,  Q. Hamid, C. Bachert, R. Pawankar, S.T. Holgate. Erratum: Asthma in the elderly: What we know and what we have yet to know.  World Allergy Org. J. 7: 16, 2014.

59.  E. Hecht, M. Zago, M. Sarill, A. Rico de Souza, A. Gomez, J. Matthews, Q. Hamid, D.H. Eidelman C.J. Baglole.  Aryl hydrocarbon receptor-dependent regulation of miR-196a expression controls lung fibroblast apoptosis but not proliferation.  Toxicol. Appl. Pharmacol. S0041, 2014.

60.  A. Bener, M.S. Ehlayel, H.Z. Bener, Q. Hamid.  The impact of Vitamin D deficiency on asthma, allergic rhinitis and wheezing in children: An emerging public health problem.  J.               Family Community Med. 21: 154-161, 2014.

61. T.Y. Lin, N. Venkatesan, M. Nishioka, S. Kyoh, L. Al-Alwan, C.J. Baglole, D.H. Eidelman,    M.S. Ludwig, Q. Hamid.  Monocyte-derived fibrocytes induce an inflammatory phenotype            in airway smooth muscle cells.  Clin. Exp. Allergy  44: 1347-1360, 2014.

62.  Y. Chang, L. Al-Alwan, S. Al Shakfa, S. Audusseau, A. Mogas, F. Chouiali, P. Nair, C.J. Baglole, Q. Hamid, D.H. Eidelman.  Upregulation of IL-17A/F from human lung tissue       explants with cigarette smoke   exposure implications for COPD.  Respir. Res. 15: 145,         2014.

63. G. Scadding, C. Brock, F. Chouiali, Q. Hamid. Laryngeal inflammation in the sudden infant death syndrome. Curr Pediatr Rev. 10:309-13, 2014.

64.  R. Halwani, R. Al-Kufaidy, A. Vazquez-Tello, M. Pureza, A. BaHammam , H. Al-Jahdali, S. Alnassar , Q. Hamid, S. Al-Muhsen. IL-17 Enhances Chemotaxis of Primary Human B Cells during Asthma. PLoS One. 10 (12):e114604, 2014.

65.  Y. Chang, L. Al-Alwan, S. Alshakfa, S. Audusseau, A. Mogas, F. Chouiali, P. Nair, C. Baglole, Q. Hamid, D. Eidelman. Upregulation of IL-17A/F from human lung tissue explants with cigarette smoke exposure: implications for COPD. Respir Res. 27:145, 2014.

66.  C. Corrigan, Q. Hamid, R. O'Hehir, A. Wardlaw. Farewell. Clin Exp Allergy. 45(12):1721-2, 2015.

67.  M. Sarill, M. Zago, J. Sheridan, P. Nair, J. Matthews, A. Gomez, L. Roussel, S. Rousseau, Q. Hamid, D. Eidelman, C. Baglole. The aryl hydrocarbon receptor suppresses cigarette-smoke-induced oxidative stress in association with dioxin response element (DRE)-independent regulation of sulfiredoxin 1. Free Radic Biol Med. 25: 342-357, 2015.

68.  N. Venkatesan, P. Lavigne, F. Lavigne, Q. Hamid. Effects of Fluticasone Furoate on Clinical and Immunological Outcomes (IL-17) for Patients With Nasal Polyposis Naive to Steroid Treatment. Ann Otol Rhinol Laryngol. 24. pii: 0003489415606449

69.  M. Miller, A. Beppu, P. Rosenthal, A. Pham, S. Das , M. Karta , D. Song, C. Vuong, T. Doherty, M. Croft, B. Zuraw, X. Zhang, X. Gao, S. Aceves, F. Chouiali, Q. Hamid, D. Broide. Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M. J Immunol. 195:3546-56, 2015.

70.  M. Nishioka, N. Venkatesan, K. Dessalle, A. Mogas, S. Kyoh, T. Lin , P. Nair, C. Baglole, D. Eidelman, M. Ludwig, Q. Hamid. Fibroblast-epithelial cell interactions drive epithelial-mesenchymal transition differently in cells from normal and COPD patients. Respir Res. 18:72, 2015.

71. W. Tan, D. Sin, J. Bourbeau, P. Hernandez, K. Chapman, R. Cowie, J. FitzGerald, D. Marciniuk, F. Maltais, A. Buist, J. Road, J. Hogg, M. Kirby, H. Coxson, C. Hague, J. Leipsic, D. O'Donnell, S. Aaron, CanCOLD Collaborative Research Group. Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study. Thorax. 70:822-9, 2015.

72.  J. Sheridan, M. Zago, P. Nair, P. Li, J. Bourbeau, W. Tan , Q. Hamid, D. Eidelman, A. Benedetti, C. Baglole. Decreased expression of the NF-κB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression. Respir Res. 6;16:54, 2015.

73.  Q. Hamid, C. Wang, J. Snyder, S. Williams, Y. Liu, W. Sun. Maskless fabrication of cell-laden microfluidic chips with localized surface functionalization for the co-culture of cancer cells. Biofabrication.  7:015012, 2015.

Dr. El-Serafi

1.   Mostafa Hassan and Ahmed T. El-Serafi (2015). Personalized Treatment: The Future of Medicine. A Perspective on the Preconditioning for Stem Cell Transplantation. Editorial in MOJ Cell Science and Report 2: 00032.

2.   Randa M. Mstafa, Ahmed T. El-Serafi and Ayman Shafei (2015). The Stolen Dreams, Endocrine Disrupting Chemicals and Childhood Obesity. Review article in Medico Research Chronicles 2: 564-571.

3.   Raafat A.El-Awady, Fatema Herzi, Hala Al-Tunaiji, Ekram M. Saleh, Abdel-Hady A. Abdel-Wahab, Amer Al Homssi, Mousa Suhail, Ahmed El-Serafi and Taleb Al-Tel (2015). Epigenetics and miRNA as predictive markers and targets for lung cancer chemotherapy. Cancer Biology and Therapy 7: 1056--1070.

4.  Hatem Sallam, Ahmed T. El Serafi, Elisabeth Filipski, Ylva Tereliusd, Francis Lévi and Moustapha Hassan (2015). The effect of circadian rhythm on pharmacokinetics and metabolism of the Cdk inhibitor, roscovitine. International Chronobiology 32: 608-614.

5.  Ahmed El-Serafi, Sara Osama, Hussein El-Zalat, Ibrahim Mohey EL-Deen (2015). Dysregulation of the Male Sex Hormones in Chronic Hepatitis C Patients. Andrologia (available on line).

6.  Shymaa Maher, Eman Kolieb, Nagwan A Sabik, Dalia Abd-Elhalim, Ahmed T El-Serafi and Yasser El-Wazir (2015). Comparison of the Osteogenic Differentiation Potential of Mesenchymal Cells Isolated from Human Bone Marrow, Umbilical Cord Blood and Placenta Derived Stem Cells. Beni-Suef University Journal of Basic and Applied Sciences 4: 80-85.

7.   Taher I. El Serafi, Mohamed M. Awad, Loaa A. Tag Eldeen, Ahmed T. EL Serafi, Marwa Husin (2013). Effect of interleukin-6 and insulin resistance on early virological response of Egyptian chronic hepatitis C patients to combined pegylated interferon plus ribavirin therapy. Egyptian Liver Journal 3: 21-27.

8.  Gehan H. Ibrahim, Fawzy A. Khalil, Taghrid B. El-Abaseri, Fadia M. Attia and Ahmed T. El-Serafi (2013). Impact of Interleukin- 28b Gene Polymorphism (Rs12979860) on Egyptian Patients Infected with Hepatitis C Virus Genotype-4. Eastern Mediterranean Health Journal 19 S2: S98-S104 .

9.   Emad F. Ismail, Amany El-Kazaz, Ahmed T. El-Serafi, May Ibrahim (2012). Role of Insulin Like Growth Factor-1 and Insulin Like Growth Factor Binding Protein-3 in Patients of Coronary Artery Disease Attending Suez Canal University Hospital.  Bulletin of Egyptian Society for Physiological Sciences 32: 293- 308.

10.  Ahmed T. El-Serafi , David I. Wilson, Helmtrud I. Roach and Richard O.C. Oreffo (2011). Developmental Plasticity of Human Fetal Femur-derived Cells in Pellet Culture: Self-assembly of an Osteoid Shell around a Cellular/cartilaginous Core. European Cells and Materials 21: 558-567.

11.  Ahmed T. El-Serafi, Richard O.C. Oreffo and Helmtrud I. Roach (2011). Epigenetic Modifiers Influence Lineage Commitment of Human Bone Marrow Stromal Cells: Differential Effects of 5-Aza-Deoxycytidine and Trichostatin A. Differentiation 81: 35-41.

12.  Taher I. El Serafi, Loaa A. Tag Eldeen, Mohamed M. Awad, Ahmed T. EL Serafi, Marwa Husin (2011). Effect of Interleukin-6 and Insulin Resistance on Hepatic fibrosis in chronic hepatitis C patients. Journal of Medical Molecular Biotechnology.

Dr. Elmoselhi

1. Mohamed Eladl,  Mohamed.S Shehata, Adel Elmoselhi (2016), Early Echocardiography experience assists in improving and retaining knowledge of Cardiac Anatomy and Physiology for medical students , (in preparation)

2. Adel Elmoselhi, Harvey Sparks, Phil Van Lente, Gregory Fink, Kerry Polizzi and Dianne Wagner (2015) “Enhanced medical student understanding of basic ECG concepts using hands-on laboratory experience”  (in preparation)

3. Adel Elmoselhi (2012) “Clinically-oriented laboratory illuminates challenging respiratory concepts to the pre-clinical medical students”, Medical Teacher 34(3):258; 2012

Dr. Moussa

1.  Mussa, B.M. Schuaman, M. Jomma, Y. Abusnana S. (2016) Investigation of hypertension and obesity in Emirati patients with type 2 diabetes (accepted, Journal of Diabetes and Metabolism, 7:1)

2.  Mussa, B.M. & Verberne,A.J.M (2013). The dorsal motor nucleus of the vagus and regulation of pancreatic secretory function. Experimental Physiology, 98(1):25-37.

3.  Mussa, B.M., Sartor, D.M. & Verberne, A.J.M. (2011). Effects of nitric oxide synthase blockade on dorsal vagal stimulation-induced pancreatic insulin secretion.  Brain Research, 1394, 62-70.

Dr. Guimei

1. “The role of hepatic progenitor cells, bone morphogenic protein (BMP) and Gremlin in the pathogenesis of hepatocellular carcinoma on top of chronic HCV.”N. Baddour, M. Guimei, Y. Taher, D. ElKaffash, L. Abdou. Journal of Hepatology 2011 vol. 54 | S363–S534

2. “Gremlin in the pathogenesis of hepatocellular carcinoma in chronic hepatitis C: an immunohistochemical and PCR study of human liver biopsies.” Maha Guimei, Nahed Baddour, Dalal El Kaffash, Laila Abdou, Yousry Taher. BMC Research Notes 2012, 5:390

Dr. Ahmed


Ahmed, SB . and Prigent, SA. (2014). A nuclear export signal and oxidative stress regulate ShcD subcellular localisation: A potential role for ShcD in the nucleus. Cell Signal: 26, 32-40

Prof. Al-Hajaj

1.  Al-Kassimi FA, Abba AA, Al-Hajjaj MS, Alhamad EH, Raddaoui E, Shaikh SA. Asthma Masquerading as Chronic Obstructive Pulmonary Disease: A Study of Smokers Fulfilling the GOLD Definition of Chronic Obstructive Pulmonary Disease.  Respiration. 2011; 82(1):19-27.

2.  Al Ghobain M, Al-Hajjaj MS, Wali SO. Prevalence of chronic obstructive pulmonary disease among smokers attending primary healthcare clinics in Saudi Arabia. Ann Saudi Med. 2011 Mar-Apr; 31(2):129-33.

3.  Al-Hajjaj MS. Difficult-to-treat asthma, is it really difficult?. Ann Thorac Med 2011;6:1-2

4.  Al Ghobain MO, Al Moamary MS, Al Shehri SN, Al-Hajjaj MS. Prevalence and characteristics of cigarette smoking among 16 to 18 years old boys and girls in Saudi Arabia. Ann Thorac Med. 2011 Jul; 6(3):137-40.

5.  Al-Moamary MS, Al-Hajjaj MS, Tamim HM, Al-Ghobain MO, Al-Qahtani HA, Al-Kassimi FA. The reliability of an Arabic translation of the chronic obstructive pulmonary disease assessment test. Saudi Med J. 2011 Oct; 32(10):1028-33.

6. Bazzi MD, Sultan MA, Al Tassan N, Alanazi M, Al-Amri A, Al-Hajjaj MS, Al-Muhsen S, Alba-Concepcion K, Warsy A. Interleukin 17A and F and asthma in Saudi Arabia: gene polymorphisms and protein levels. J Investig Allergol Clin Immunol. 2011; 21(7):551-5.

7.  Al Moamary MS, Al Ghobain MA, Al Shehri SN, Alfayez AI, Gasmelseed AY, Al-Hajjaj MS. The prevalence and characteristics of water-pipe smoking among high school students in Saudi Arabia. J Infect Public Health. 2012 Apr; 5(2):159-68. 

8.  Al Ghobain MO, Al-Hajjaj MS, Al Moamary MS. Asthma prevalence among 16- to 18-year-old adolescents in Saudi Arabia using the ISAAC questionnaire. BMC Public Health. 2012 Mar 26; 12(1):239.

9.  Alhamad EH, Al-Kassimi FA, Alboukai AA, Raddaoui E, Al-Hajjaj MS, Hajjar W, Shaik SA. Comparison of three groups of patients with usual interstitial pneumonia. Respir Med. 2012 Aug 4.

10. Al-Kassimi FA, Alhamad EH, Al-Hajjaj MS,Abba AA, Raddaoui E, Shaikh SA. Abrupt withdrawal of inhaled corticosteroids does not result in spirometric deterioration in chronic obstructive pulmonary disease: Effect of phenotyping? Ann Thorac Med 2012; 7:238-42.

11.  Al-Moamary MS, Alhaider SA, Al-Hajjaj MS, Al-Ghobain MO, Idrees MM, Zeitouni MO, Al-Harbi AS, Al Dabbagh MM, Al-Matar H, Alorainy HS. The Saudi initiative for asthma - 2012 update: Guidelines for the diagnosis and management of asthma in adults and children. Ann Thorac Med 2012;7:175-204

12.  Al Moamary MS, Al Ghobain MO, Al Shehri SN, Gasmelseed AY, Al-Hajjaj MS. Predicting tobacco use among high school students by using the global youth tobacco survey in Riyadh, Saudi Arabia. Ann Thorac Med 2012; 7:122-9

13. Bazzi MD, Sultan MA, Al Tassan N, Alanazi M, Al-Amri A, Al-Hajjaj MS, Al-Muhsen S, Alba-Concepcion K, Warsy A. Interleukin(IL)-17A and IL-17F and asthma in Saudi Arabia: mRNA transcript levels and gene polymorphisms. Afr.J. Biotechnol Vo. 12(23)pp 3615-3621, 5 June 2013

14.  Al Ghobain MO, Alhamad EH, Alorainy HS, Hazmi M, Al Moamary MS,   Al-Hajjaj MS, Idress MM, Al-Jahdali HH, Zeitouni MO.   Spirometric reference values for healthy nonsmoking Saudi adults. Clin Respir J. 2014 Jan;8(1):72-8

15.  Al Otair HA, Al-Boukai AA, Ibrahim GF, Al Shaikh MK, Mayet AY, Al-Hajjaj MS. Outcome of pulmonary embolism and clinico-radiological predictors of mortality: Experience from a university hospital in Saudi Arabia. Ann Thorac Med, 2014; 9:18-22.

16. Al Moamary MS, Alorainy H, Al-Hajjaj MS. Pulmonary rehabilitation: A regional perspective evidenced-based review. Ann Thorac Med. 2014 Jan; 9(1):3-7.

17. Al-Muhsen S, Vazquez-Tello A, Alzaabi A, Al-Hajjaj MS, Al-Jahdali HH, Halwani R. IL-4 receptor alpha single-nucleotide polymorphisms rs1805010 and rs1801275 are associated with increased risk of asthma in a Saudi Arabian population. Ann Thorac Med 2014;9:81-6

18.  Khan JH, Lababidi HM, Al-Moamary MS, Zeitouni MO, AL-Jahdali HH, Al-Amoudi OS, Wali SO, Idrees MM, Al-Shimemri AA, Al Ghobain MO, Alorainy HS, Al-Hajjaj MS. The Saudi guidelines for the diagnosis and management of COPD. Ann Thorac Med 2014;9:55-76

19. Al-Hameed F, Al-Dorzi HM, Shamy A, Qadi A, Bakhsh E, Aboelnazar E, Abdelaal M, AlKhuwaitir T, Al-Moamary MS, Al-Hajjaj MS, Brozek J, Schunemann H, Mustafa R, Falavigna M. The Saudi clinical practice guideline for the diagnosis of the first deep venous thrombosis of the lower extremity. Ann Thorac Med 2015;10:3-15

20. Al Ghobain MO, Al Hajjaj MS, Lababidi H, Alorainy HS. The prevalence of Chronic Obstructive Pulmonary Disease (COPD) in Saudi Arabia (BOLD study). Int J Tuberc Lung Dis. 2015 Oct; 19(10):1252-7.

Prof. Azzam Maghazazhi

1.    Vego H, Sand KL, Høglund RA, Fallang LE, Gundersen G, Holmøy T, Maghazachi AA. Monomethyl fumarate augments NK cell lysis of tumor cells through degranulation and the upregulation of NKp46 and CD107a. Cell Mol Immunol. 13: 57-64, 2016

2.    Al-Jaderi Z, Maghazachi AA. Vitamin D3 and monomethyl fumarate enhance natural killer cell lysis of dendritic cells and ameliorate the clinical score in mice suffering from experimental autoimmune encephalomyelitis (EAE). Toxins 7, 4730-4744, 2015

3.    Rolin J, Maghazachi AA. Chemokine receptors and inflammatory lipids. Implications for atherosclerosis. J. Leukoc. Biol. 95: 575-585, 2014.

4.    Al-Jaderi Z, Maghazachi AA. Effects of Vitamin D3, Calcipotriol and FTY720 on the expression of surface molecules and cytolytic activities of human natural killer cells and dendritic cells. Toxins. 5: 1932-1947, 2013.

5.    Høglund R, Harbo HF, Holmøy T, Maghazachi AA. A one year follow-up study of natural killer and dendritic cells activities in multiple sclerosis patients receiving glatiramer acetate. PLoS One 8(4): e62237, 2013.

6.    Rolin J, Al-Jaderi Z, Maghazachi AA. Oxidized lipids and lysophosphatidylcholine induce the chemotaxis and intracellular calcium influx in natural killer cells. Immunobiology 218: 875-883, 2013.

7.    Pandya A, Høglund RA, Holmøy T, Harbo HF, Norgauer J, Maghazachi AA. Identification of human NK17/NK1 cells. PLoS One 6(10):e26780, 2011.

8.    Maghazachi AA. Role of chemokines in the biology of natural killer cells. Curr. Topics Microbiol. Immunol. 341: 37-58, 2010.

9.    Rolin J, Sand KL, Knudsen E, Maghazachi AA. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release.  Cancer Immunol. Immnuother. 59: 575-586, 2010.

10.  Sand KL, Rolin J, Knudsen E, Al-Falahi Y, Maghazachi AA. Modulation of natural killer cell cytotoxicity and cytokine release by the drug glatiramer acetate. Cell. Mol. Life Sci. 66: 1446-1456, 2009.

11.  Al-Falahi Y, Sand  KL, Knudsen  E, Damaj  BB, Rolin  J,  Maghazachi AA. Splenic natural killer cell activity in two models of experimental neurodegenerative diseases. J. Cell. Mol. Med 13: 2693-2703, 2009.

12.  Damaj BB, Bacerra C, Esber HJ, Wen Y, Maghazachi AA. Functional expression of histamine H4 receptor in human natural killer cells, monocytes, and dendritic cells. J. Immunol. 179: 7907-7915, 2007.

13.  Oz-Arslan D, Rüscher W, Myrtek D, Ziemer M, Jin Y, Damaj BB, Sorichter S, Idzko M,  Norgauer J,  Maghazachi AA. IL-6 and IL-8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids. J. Leukoc. Biol. 80: 287-97, 2006.       

14.  Jin Y, Damaj B, Maghazachi AA. Human resting CD16-, CD16+ and IL-2-, IL-12, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor. Eur. J. Immunol. 35: 2699-2708, 2005.

15.  Maghazachi AA. Insights into seven and single transmembrane spanning domain receptors and their signaling pathways in human natural killer cells. Pharmacol. Rev.  57: 339-357, 2005.

16.  Maghazachi AA: G protein-coupled receptors in natural killer cells. J. Leukoc. Biol. 74: 16-24, 2003.

17.  Jin Y, Knudsen E, Wang L, Bryceson Y, Damaj B, Gessani S, Maghazachi   AA: Sphingosine 1-phosphate is a novel inhibitor of T cell proliferation. Blood   101: 4909-4915, 2003.

18.  Kveberg L, Bryceson Y, Inngjerdingen M, Rolstad B, Maghazachi AA: Sphingosine 1 phosphate induces the chemotaxis of natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases. Eur. J. Immunol.   32: 1856-1864, 2002.

19.  Inngjerdingen M, Torgersen KM, Maghazachi AA: Lck is required for stromal-derived factor (CXCL12)-induced lymphoid cell chemotaxis. Blood 99: 4318- 4325, 2002.

20.  Inngjerdingen M, Damaj B, Maghazachi AA: Expression and regulation of chemokine receptors in human natural killer cells. Blood 97: 367-375, 2001.

 

 

 



Group Collaborators

Local Collaborators

a. Dr. Mohamed Saleh Alhajjaj

b. Dr. Bassam Hassan Mahboub

c. Dr. Ashraf Al Zaabi; Zayed military hospital

d. Dr. Mohamed Seif; UHS

e. Dr. Salah Abu Senana; Rashid center of Diabetes and research;

f. Dr. Fatma Al-Hashimi; Dubai Cord Blood Research Center;

g. Dr. Mohamed Hassanein; Dubai Hospital

h. Prof. Sherif Karam, Dr. Sahar Mohsin; United Arab Emirates University

International Collaborators

a. Prof. David Eidelman; McGill University, Canada.

b. Prof. James Martin; McGill University, Canada.

c. Dr. Carolyn Baglole; McGill University, Canada

d. Dr. Rabie Halwani; King Saud University, KSA.

e. Prof. Wahib Mahana; Université Paris-sud, France.

f. Dr. Sandra Gessani; Instituto Superiore di Sanita, Rome, Italy.

g. Prof. Adel Schwertani, Montreal General Hospital, Canada

h. Prof. Moustapha Hassan; Karoliniska Institute, Sweden

i. Prof. Ton Rabelink; Leiden University Medical Centre

j. Prof. Imed Gallouzi; McGill University