It is now recognized that 65% of all human infections are caused by biofilms, which are defined as functional communities of organisms attached to an abiotic or a biotic surface and encased in an extracellular matrix. The eco-biology of biofilms, formerly called dental plaque in the case of oral biofilms, is yet to be fully explored. Hence the goal of the group will be to investigate the structure, function and physiology of oral plaque biofilms in health and disease. The major goals of the proposed group are to investigate the two main non-communicable diseases (NCDs) of the human kind, caries and periodontal (gum) disease caused by plaque biofilms as well as to study how bacteria and yeast species co-exist within these biofilms (i.e. inter-kingdom interactions).