The idea that estrogen exerts –at least some of- its biological effects through manipulating iron homeostasis lends itself to further investigating the paradoxical effects of estrogen in the pathogenesis (and treatment) of various disease states. Current work in the lab is mainly concerned with the overall role of estrogen in iron homeostasis at the systemic level. Furthermore, the capacity of estrogen to deplete intracellular iron and hence deprive cells of iron as a cofactor in various metabolic process is under investigation. The role of estrogen in stem cell development and differentiation, that is, development of mesenchymal stem cells in the osteogenic and adipogenic lineages, is being currently investigated. Future work will address the role of estrogen in intracellular iron homeostasis as it pertains to cancer pathogenesis and treatment, host susceptibility to infection and autoimmunity.