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Goals and Objectives

Group Research Goals and Objectives


The long-term goals of the Gene Editing & Therapy research group are to advance biomedical research at the University of Sharjah and to develop the infrastructure and the expertise for future clinical applications involving highly promising and fast-growing gene-editing technologies. To this end, we propose 5 objectives:

 

  1. Develop CRISPR-Cas9-based platform to allow with high accuracy and effectiveness:
    • The identification of novel therapeutic target genes in various types of cancer using genome-wide screen with sgRNA libraries.
    • The development of novel therapeutic approaches by targeting the products of identified genes.

  2. Employ CRISPR system to correct, modify, or delete aberrant genes to address their functional roles in various human diseases including cancer, diabetes, cardiovascular or respiratory diseases, among others.

  3. Identifying key signaling networks of cell growth metabolism and pathogenesis that are perturbed in diseases such as cancer, diabetes, cardiovascular or respiratory diseases.

  4. Developing new methodology to deliver gene-editing molecules into different tissues to precisely target and correct genetic defects using ultrasound-targeted microbubble and photodynamic targeted technologies.

  5. Develop the infrastructure for gene therapy that provides support for various research groups at the Research Institute of Medical & Health Sciences (RIMHS) and allow the RIMHS to acquire the knowledge and the expertise in such highly advanced gene editing technology that would serve as a basis for future clinical applications.