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Current Projects & Future Directions

Current Projects & Future Directions

1.Analyze the influence of exposure to common environmental toxins on normal mammary, colonic or skin epithelial cells and isogenic breast or colon cancer cells harboring common molecular alterations.

2.Analyze the role of epithelial to mesenchymal transition in colon and breast carcinogenesis and identify novel mediators of this phenomenon.

3.Role of p53 & microRNA in apoptosis, epithelial to mesenchymal transition and chemo-resistance.

4.Carcinogenic mechanisms and predisposition to familial and Eastern subsets of colon cancer. This involves international collaboration with Finland and Egypt.

It is widely acknowledged that our environment is becoming increasingly contaminated with man-made chemicals. Mammals, as well as lower organisms, are vulnerable to exposure to these agents through a variety of different sources and routes and there are concerns that they may be having a detrimental effect on ecological and population health.

Endocrine disruptors (EDs) have been described as exogenous agents that interfere with the production, release, transport, metabolism, binding, action or elimination of the natural ligands responsible for maintaining homeostasis and

regulating body development. Many different EDs are present in the various compartments of the environment (air, water and land) and in foods (of plant and animal origin). They may originate from food packaging, combustion products, plant health treatments, detergents and the chemical industry in general.

Children obesity is a colossal concern as it  predisposes to various health problems,  which are linked later with adult morbidity  and mortality. Previously, the child obesity  prevention programs were mainly focusing on promoting the physical exercise and  cutting down calories, while it has been

proposed recently that endocrine disrupters  such as Phthalate and BPA have a

significant role in the drastic increment of  child obesity incidence. Various studies have proved the relation between the levels of urinary phthalates and BPAs to children obesity; however, more validation is required by relating the active forms levels in the serum with the child obesity.

Significant Research publications: (Publication related to the environmental pollution/ protective effects of antioxidants) Mostafa,R.M.; Serafi ,A. and Shafie,A.(2015): The stolen dreams, endocrine disrupting chemical and childhood obesity , Med. Res. Chron., 2 (5), 564-571

Mostafa,R.M., Moustafa,Y.M.,  Al Kusayer,G.; Moustafa, K.M. (2013): Antioxidant effect of Garlic (Allium Sativum) and Black Seeds (Nigella Sativa) in healthy postmenopausal women , Sage open Medicine, (1) 2050312113517501, doi:10.1177/2050312113517501  .

Abdel-Rahman,W.A.,  Moustafa,Y.M.,  Ahmed,B.O.and  Mostafa,R.M (2012) . Endocrine disruptors and breast cancer risk – time to consider the environment" . Asian Pacific Journal for Cancer Prevention) , 13 (12), 5937-5946.

Mostafa ,RM , Moustafa ,YM & Mirghani, Z.(2012) : Thymoquinone alone or in combination with phenobarbital reduces the seizure score and improves the oxidative burden in pentylenetetrazole-kindled rats , Oxidants and Antioxidants in Medical Science. Oxid Antioxid Med Sci 1(3):185-192

Mostafa RM, Moustafa,Y. (2012): Oxidants and antioxidants balance modulation by Nigella Sativa Seeds consumption in Healthy postmenopausal. Maturitas , Volume 71, Pages S79

Mostafa RM.Dilemma of Women’s Passive smoking Ann Thorac Med. 2011 Apr;6(2):55-6.

Mostafa ,R.M . Male rats sex hormones status after exposure to 50 Hz, 10 mTesla mangetic field. Fertility and Sterility.90 (Suppl.1) S185 , 2008.

 Ahmed, R.Y., Abdulqawi,K.; Mostafa RM. , Abo El Azm, T. and  Al Inany,H (2008): . Fetal and neonatal responses following maternal exposure to mobile phones. Saudi Medical Journal, 29 (2):218-223.

Mostafa,RM., Mirghani, Z.; Moustafa ,K.M. , , Moustafa ,Y.M.,  and  El Hefnawi, M.H.( 2007)  New Chapter in old story : endocrine disruptors and male reproductive system  Journal of Medical Sciences Research, 1 (2): 33-42 .

Mostafa RM,  Moustafa,YM, , Fadel MA. And ,Shafik,A. (2006) Sex hormone status in male rats after exposure to 50HZ, 5 mTesla Magnetic Field.. Archives of Andrology, Sept –oct 52(5):363-9  .

Fadel,M.Ali, Wael,S.,Mostafa, R.M. (2003): Effect of 50Hz, 0.2 m T magnetic fields on RBC properties and heart functions of albino rats. Bioelectromagnetics, Volume 24, ( 8):535-545 .

Gabry, K.E., Chrousos, G.P., Rice, K.C., Mostafa, RM., Sternberg, E., Aegrao, A.B., Webster, E.L., McCann, S.M. and Gold, P.W. (2002):  Marked suppresion of gastric ulcerogenesis and intestinal resposes to stress by a novel class of drugs. Molecular Psychiatry , Volume 7, Issue 5.

Mostafa, RM., Mostafa, Y.M. and  Ennaceur, A. (2002): Effect of exposure to extremely low-frequency magnetic field of 2 G intensity on memory and corticosterone level in rats.  Journal of Physiology and Behavior 76 (589-595) .

 Moustafa,Y., Mostafa,RM. , Belacy ,A., Abou El Ela ,S. and Fadel,M.A. (2001): Effect of acute exposure to radiofrequency fields of cellular phones on plasma lipid peroxide and antioxidant activites in human erythrocytes. Journal of pharmaceutical and biomedical analysis 26 (605-608).

Dr. Ayssar Nahlé


 

Contact detail: Department of Chemistry, College of Sciences, University of Sharjah, Sharjah, P.O.Box: 27272, United Arab Emirates

Tel:  +971-6-505 3812

Fax: +971-6-505 3820

       +971-6-505 0757

Mobile: +971-50-4855830

Office location: Building M7 - Room 211

Email: anahle@sharjah.ac.ae


Awards/Grants Received by Group members 1) “Rafic Hariri Foundation” scholarship for Ph.D. Degree.

2)Recipient of “Best Published Scientific Paper” Award in the area of Basic and Applied Sciences during the 4th Annual Scientific Research Forum at the University of Sharjah, organized by the “College of Graduate Studies & Research”, University of Sharjah. (May 7-8, 2008) for the paper entitled: “Electrochemical Studies of the Effect of Trans-4-Hydroxy-4’-Stilbazole on Corrosion Inhibition of Mild Steel in HCl Solution”.

Ayssar Nahlé, Ideisan Abu-Abdoun, and Ibrahim Abdel-Rahman

Anti-Corrosion Methods and Materials, Vol. 54 No. 4, 2007, Emerald Group Publishing Limited, England, UK, ISSN: 0003-5599.

Honored by His Highness Sheikh Dr. Sultan bin Mohammed Al Qassemi, Member of the Supreme Council, Ruler of Sharjah, and Supreme President of the University of Sharjah.

3)Recipient of “Best Published Scientific Paper” Award in the area of Basic and Applied Sciences during the 5th Annual Scientific Research Forum at the University of Sharjah, organized by the “College of Graduate Studies & Research”, University of Sharjah. (April 29, 2009) for the paper entitled: “Inhibition of Carbon Steel Corrosion by 4-vinyl-benzyl triphenyl phosphonium chloride in HCl Solution”.

Ayssar Nahlé, Ideisan Abu-Abdoun, and Ibrahim Abdel-Rahman

Anti-Corrosion Methods and Materials, Vol. 55 No. 4, 2008, Emerald Group Publishing Limited, England, UK, ISSN: 0003-5599.

Honored by His Highness Sheikh Dr. Sultan bin Mohammed Al Qassemi, Member of the Supreme Council, Ruler of Sharjah, and Supreme President of the University of Sharjah.

4)Winner of the “Annual Incentives Award for distinguished Faculty Members (2009-2010)” in the Area of “University & Community Services”, during the 6th Annual Scientific Research Forum at the University of Sharjah, organized by the “College of Graduate Studies & Research”, University of Sharjah (April 26, 2010).

Honored by His Highness Sheikh Dr. Sultan bin Mohammed Al Qassemi, Member of the Supreme Council, Ruler of Sharjah, and Supreme President of the University of Sharjah.

5)Winner of the “Award for distinguished Faculty Members (2012-2013)” in “Academia”, during the Annual College of Sciences Meeting, University of Sharjah (May 30, 2013).

Honored by Professor Hamid M. Al-Naimiy, Dean of the College of Sciences, and Vice-Chancellor for Academic Affairs, University of Sharjah.

6)Recipient of an Award for participating as a judge in the "2014 Think Science Judging Panel". (May 27, 2014).

Honored by His Highness Sheikh Abdullah bin Zayed Al Nahyan, Minister of Foreign Affairs & Chairman of Emirates Foundation for Youth Development. Zayed University, Abu Dhabi.

Current Projects & Future Directions -  Green and synthesized corrosion inhibitors for corrosion of metals in aggressive acidic media.

Significant/Recent Research publications (Total 34):

34)  "Corrosion Inhibition of 1-Vinylimidazole-3-phenacyl hexafluoroantimonate Salt on Mild Steel in HCl Solution"

                Ayssar Nahlé, Ideisan Abu-Abdoun, and Ibrahim Abdel-Rahman.

                International Journal Corrosion and Scale Inhibition, 4(3) (2015), 255–268.

                doi: 10.17675/2305-6894-2015-4-3-255-268


33)  “UAE Rhazya Stricta Decne Extract as a Corrosion Inhibitor for Mild Steel in HCl Solution”.

Ayssar Nahlé, Ibrahim Almaidoor, and Ibrahim Abdel-Rahman.

Anti-Corrosion Methods and Materials, 61(4) (2014), 261-266.

                               
32)  “Corrosion Inhibition of Mild Steel by P,P’-Bis (triphenylphosphonio) methyl benzophenone dibromide in HCl Solution”.

                Ayssar Nahlé, Maysoon Al-Khayat, Ideisan Abu-Abdoun, and Ibrahim Abdel-Rahman.

                Anti-Corrosion Methods and Materials,60(1) (2013), 20-27.

 
31) “Inhibition of Mild Steel Corrosion by 3-Benzoylmethyl benzimidazolium hexafluoroantimonate in Acidic Solution”.

Ayssar Nahlé, Ideisan Abu-Abdoun, and Ibrahim Abdel-Rahman.

International Journal of Corrosion.Volume 2012, Article ID 246013, 10 pages. doi:10.1155/2012/246013.


30) “Effect of Temperature on the Corrosion Inhibition of Trans-4-Hydroxy-4-Stilbazole on Mild Steel in HCl Solution”.

           Ayssar Nahlé, Ideisan Abu-Abdoun, and Ibrahim Abdel-Rahman.

            International Journal of Corrosion.Volume 2012, Article ID 380329, 7 pages. doi:10.1155/2012/380329.


29) “Inhibition Efficiency of Two Bipyrazole Derivatives on Steel Corrosion in Hydrochloric Acid Media”.

           K. Tebbji, A. Aouniti, A. Attayibat, B. Hammouti, H. Oudda, M. Benkaddour, S. Radi, and A. Nahlé.

           Indian Journal of Chemical Technology (IJCT). Volume 18(3) (May 2011), 244-253.

 
28) “UAE Neem Extract as a Corrosion Inhibitor for Carbon Steel in HCl Solution”.

                Ayssar Nahlé, Ideisan Abu-Abdoun, Ibrahim Abdel-Rahman, and Maysoon Al-Khayat.

               International Journal of Corrosion. Volume 2010, Article ID 460154, 9 pages. doi:10.1155/2010/460154.


27) “Inhibition of Carbon Steel Corrosion by 4-vinyl-benzyl triphenyl phosphonium chloride in HCl Solution”.

             Ayssar Nahlé, Ideisan Abu-Abdoun, and Ibrahim Abdel-Rahman.

              Anti-Corrosion Methods and Materials. 55(4) (2008), 217-224.


26)“Electrochemical Studies of the Effect of Trans-4-Hydroxy-4’-Stilbazole on Corrosion Inhibition of Mild Steel in HCl Solution”.

                Ayssar Nahlé, Ideisan Abu-Abdoun, and Ibrahim Abdel-Rahman.

                Anti-Corrosion Methods and Materials, 54(4) (2007), 244-248.



25) “Corrosion Inhibition of (Anthraquinone-2-ylmethyl) Triphenyl Phosphonium Bromide on Mild Steel in HCl Solution”. 
 Ayssar Nahlé, Ideisan Abu-Abdoun, and Ibrahim Abdel-Rahman.

Bulletin of Electrochemistry, 23 (2007), 201-209.​