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Environment and Cancer Research

Overview & Subject Areas:

The recent increments of cancer incidence can not only be explained by genetic factors.  A mounting body of evidence supports the role of environmental exposures in cancer development and progression. Group members are involved in a wide range of projects centered on this concept. The objectives of ongoing and future work includes but not limited to the following:

1. Analyze the influence of exposure to common environmental toxins on normal mammary, colonic or skin epithelial cells and isogenic breast or colon cancer cells harboring common molecular alterations.

2. Analyze the role of epithelial to mesenchymal transition in colon and breast carcinogenesis and identify novel mediators of this phenomenon.

3. A recent identified protein ShcD was shown to play a role in melanoma cell invasion. It is of particular interest to study the level of ShcD expression in the melanocytes and melanoma cells exposed to different doses of UV, adding to that, we would like to explore the role of ShcD expression in protecting the melanoma cells form the UV mediated DNA damage, which might provide the melanoma with more survival signal.

4. To better characterize current and future population exposure levels to common health hazards particularly electromagnetic fields and Bisphenol A.

5.To better understand the link between Metabolic Syndrome and colon cancer serum predictor factors.

6.To characterize the molecular changes Associated with the Dietary Chemoprevention of Camel Milk (Camelus dromedarius), and lentils against Azoxymethane-Induced Colorectal Cancer in Fischer 344 Rat Model.

1- Name: Dr.Wael M. Abdel-Rahman Hassan PI           


 

Contact detail: University of Sharjah, College of Health Sciences, MLS, P.O. Box 27272, Sharjah, UAE
Tel 971 6 5057556  Fax  971 6 5057515  email whassan@sharjah.ac.ae