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Publications

2017
1) Tarazi, H,  Odeh, R.A.,  Al-Qawasmeh, R.,  Yousef, I.A.,  Voelter, W.,  Al-Tel, T.H.   Design,ynthesis and SAR analysis of potent BACE1 inhibitors: Possible lead drug candidates for Alzheimer's disease. European Journal of Medicinal Chemistry. Volume 125, 5 January 2017, Pages 1213-1224 Link
2) Abdelazeem, A.H., El-Saadi, M.T.,  Safi El-Din, A.G.,  Omar, H.A.,  El-Moghazy, S.M.   Design, synthesis and analgesic/anti-inflammatory evaluation of novel
diarylthiazole and diarylimidazole derivatives towards selective COX-1 inhibitors with better gastric profile. Bioorganic and Medicinal Chemistry, Volume 25, Issue 2, 15 January 2017, Pages 665-676 Link
3) Mohammed I. El-Gamal,  Khan, M.A.,  Tarazi, H.,  Abdel-Maksoud, M.S.,  Gamal El-Din, M.M.,  Yoo, K.H.,  Oh, C.-H.   Design and synthesis of new RAF kinase-inhibiting antiproliferative quinoline derivatives. Part 2: Diarylurea derivatives European Journal of Medicinal Chemistry, Volume 127, 15 February 2017, Pages 413-423 Link
4) El-Awady R, Saleh E, Hashim A, Soliman N, Dallah A, Elrasheed A, Elakraa G. The Role of Eukaryotic and Prokaryotic ABC Transporter Family in Failure of Chemotherapy. Front Pharmacol. 2017 Jan 10;7:535. doi: 10.3389/fphar.2016.00535 Link
5) Mohammad Ashrafuddin Khan, Mohammed I. El-Gamal, and Chang-Hyun Oh; Advanced melanoma: A progressive review of V600E-B-RAF kinase and drugs inhibiting it. Mini-Reviews in Medicinal Chemistry, 2017, 17(4): 351-365 Link
6) Mohammed I. El-Gamal, Mohammed S. Abdel-Maksoud, Mahmoud M. Gamal El-Din, Ji-Sun Shin, Kyung-Tae Lee, Kyung Ho Yoo, and Chang-Hyun Oh; "Synthesis, in vitro antiproliferative and antiinflammatory activities, and kinase inhibitory effects of new 1,3,4-triarylpyrazole derivatives". Anti-Cancer Agents in Medicinal Chemistry 2017, 17:75-84 Link
7) Mohammed I. El-Gamal, and Hanan S. Anbar. Recent advances of pyrrolopyridine derivatives: a patent and literature review. Expert Opinion of Therapeutic Patents, Jan 2017 in press Link
8) A modular CuI-L-Proline catalyzed one-pot route for the rapid access of constrained and privileged hetero-atom-linked medium-sized ring systems Vunnam Srinivasulu, Kim D. Janda, Imad A. Abu-Yousef, Matthew John O'Connor, Taleb H. Al-Tel; Tetrahedron, DOI: 10.1016/j.tet.2017.02.061
 9) AlTel, Taleb, Intramolecular Diaza-Diels-Alder Protocol: A Novel Diastereoselective and Modular One-Step Synthesis of Constrained Polycyclic Frameworks; Chemistry- A European Journal: http://onlinelibrary.wiley.com/doi/10.1002/chem.201605231/full
10) . Hamadeh Tarazi, Raed Abu Odeh, Raed Al-Qawasmeh, Imad Abu Yousef, Wolfgang Voelter, Taleb H. Al-Tel; Design, synthesis and SAR analysis of potent BACE1 inhibitors: Possible lead drug candidates for Alzheimer's disease; European Journal of Medicinal Chemistry, Volume 125, 5 January 2017, Pages 1213-1224
2016
1) Silva AN, Coffa J, Menon V, Hewitt LC, Das K, Miyagi Y, Bottomley D, Slaney H, Aoyama T, Mueller W, Arai T, Tan IB, Deng N, Chan XB, Tan P, Tsuburaya A, Sakamaki K, Hayden JD, Yoshikawa T, Zondervan I, Savola S, Grabsch HI. Frequent Coamplification of Receptor Tyrosine Kinase and Downstream Signaling Genes in Japanese Primary Gastric Cancer and Conversion in Matched Lymph Node Metastasis. Annals Surgery 2016 Oct 24 Link  
2) Mai F.Tolba, Hany A. Omar, Samar S. Azab, Amani E. Khalifa, Ashraf B. Abdel-Naim, Sherif Z. Abdel-Rahman. Caffeic acid phenethyl ester: A review of its antioxidant, antimicrobial activities, protective effects against ischemia reperfusion injury and drug adverse reactions. Critical Reviews in Food Science and Nutrition, 2016 Oct 2;56(13):2183-90 Link
3) Hany A. Omar, Mai F. Tolba, Jui-Hsiang Hung, Taleb H. AlTel. OSU-2S/sorafenib synergistic antitumor combination against hepatocellular carcinoma: The role of PKCδ/p53. Frontiers in Pharmacology. 2016 10.3389/fphar.2016.00463
4) Mahmoud M. Gamal El-Din, Mohammed I. El-Gamal, Mohammed S. Abdel-Maksoud, Kyung Ho Yoo, and Chang-Hyun Oh; "Design, synthesis, broad-spectrum antiproliferative activity, and kinase inhibitory effect of triarylpyrazole derivatives possessing arylamides or arylureas moieties". European Journal of Medicinal Chemistry 2016, 119, 122-131 Link
5) Mahmoud M. Gamal El-Din, Mohammed I. El-Gamal, Mohammed S. Abdel-Maksoud, Kyung Ho Yoo, Daejin Baek, Jungseung Choi, Huiseong Lee, and Chang-Hyun Oh; "Design, synthesis, and in vitro antiproliferative and kinase inhibitory effects of pyrimidinylpyrazole derivatives terminating with arylsulfonamido or cyclic sulfamide substituents". Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, 31:111-122 Link
6) Khaled R. Abdellatif, Phoebe F. Lamie, Hany A. Omar. 3-Methyl-2-phenyl-1-substituted-indole derivatives as indomethacin analogs: design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents. Journal of Enzyme Inhibition and Medicinal Chemistry, 2016 Apr;31(2):318-24 Link
7) Mohammad Ashrafuddin Khan, Mohammed I. El-Gamal, Hamadeh Tarazi, Hong Seok Choi, and Chang-Hyun Oh; "Design and synthesis of a new series of highly potent RAF kinase-inhibiting triarylpyrazole derivatives possessing antiproliferative activity against melanoma". Future Medicinal Chemistry 2016, 8(18):2197-2211 Link
8) Hany A. Omar, Wafaa R. Mohamed, Hany H. Arab, El-Shaimaa A. Arafa. Tangeretin alleviates cisplatin-induced acute hepatic injury in rats: Targeting MAPKs and apoptosis. PLoS ONE, 2016 Mar 31;11(3):e0151649 Link
9) Mohammed I. El-Gamal, Mohammad H. Semreen, Paul A. Foster, and Barry V.L. Potter; "Design, synthesis, and biological evaluation of new arylamide derivatives possessing sulfonate or sulfamate moieties as steroid sulfatase enzyme inhibitors". Bioorganic & Medicinal Chemistry 2016, 24(12), 2762-2767 Link  
10) Ahmed H. Abdelazeema, Mohammed T. El-Saadi, Asmaa G. Safi El-Din, Hany A. Omar and Samir M. El-Moghazy. Design, Synthesis and Analgesic/Anti-inflammatory Evaluation of Novel Diarylthiazole and Diarylimidazole Derivatives Towards Selective COX-1 Inhibitors with Better Gastric Profile. Bioorganic & Medicinal Chemistry 2016  doi.org/10.1016/j.bmc.2016.11.037 Link   
11) El-Awady RA, Semreen MH, Saber-Ayad MM, Cyprian F, Menon V, Al-Tel TH. Modulation of DNA damage response and induction of apoptosis mediates synergism between doxorubicin and a new imidazopyridine derivative in breast and lung cancer cells. DNA repair (Amst) 37(2016):1-11 Link
12) Marwa E. Sayour , Rania M. Abd El Salam , Mohamed F. Elyamany, Abeer M. El Sayed ,  Raafat A. El-Awady. Combination of paracetamol and the glutathione depleting agent buthionine sulfoximine show differential effect on liver cancer cells and normal hepatocytes. Pharmacology & Pharmacy (2016) 7, 443-458 Link
13) Abdu-Allah HH, Abdel-Moty SG , El-Awady R, El-Shorbagi AA. Design and synthesis of novel 5-aminosalicylate (5-ASA)–4-thiazolinone hybrid derivatives with promising antiproliferative activity. Bioorganic & Medicinal Chemistry Letters 26 (2016) 1647–1650 Link
14) Hamadeh Tarazi, Ekram Saleh, Raafat El-Awady. In-silico screening for DNA-dependent protein kinase (DNA-PK) inhibitors: Combined homology modeling, docking, molecular dynamic study followed by biological investigation. Biomedicine & Pharmacotherapy 83 (2016) 693–703 Link
15) Mohammed I. El-Gamal, Woo-Seok Lee, Ji-Sun Shin, Chang-Hyun Oh, Kyung-Tae Lee, Jungseung Choi, Nohsun Myoung, and Daejin Baek; "Synthesis of new tricyclic and tetracyclic fused coumarin sulfonate derivatives, and their inhibitory effects on LPS-induced nitric oxide and PGE2 productions in RAW 264.7 macrophages: Part 2". Archiv der Pharmazie, 2016, 349(11), 853-863 Link
16) Al-Qawasmeh RA1, Huthail BB, Sinnokrot MO, Semreen MH, Odeh RA, Abu-Zarga MH, Tarazi H, Yousef IA, Al-Tel TH. Design, Synthesis and qualitative structure activity relationship evaluations of quinoline-based bisarylimidazoles as antibacterial motifs. Med Chem. 2016;12(6):563-73 Link
17) Mohammed S. Abdel-Maksoud, Mohammed I. El-Gamal, Mahmoud M. Gamal El-Din,  Seong-Shin Kwak, Hyun-Il Kim, and Chang-Hyun Oh, "Broad-spectrum antiproliferative activity of a series of 6-(4-fluorophenyl)-5-(2-substituted pyrimidin-4-yl)imidazo[2,1-b]thiazole derivatives". Medicinal Chemistry Research 2016, 25(5), 824-833 Link
18) Ahmed Abdelazeem, Yasser Mohamed, Ahmed Gouda, Hany Omar, Majed Al Robaian. Novel Thymohydroquinone Derivatives as Potential Anticancer Agents: Design, Synthesis and Biological Screening. Australian Journal of Chemistry   June, 2016 DOI.org/10.1071/CH16102 Link
19) Mohammed I. El-Gamal, Daejin Baek, and Chang-Hyun Oh; "A New Series of Cycloalkane-fused Coumarin Sulfonates: Synthesis and In Vitro Antiproliferative Screening" Bull. Korean Chemical Soc. 2016, 37(2), 184-191 Link
2015
1) Hany H. Arab, Samir A. Salama, Hany A. Omar, El-Shaimaa A. Arafa and Ibrahim A. Maghrabi. Diosmin protects against ethanol-induced gastric injury in rats: Novel anti-ulcer actions. PLoS ONE, March, 2015, 30;10(3):e0122417 Link      
2) Samir A. Salama, Mohammad S. Al-Harbi, Mohamed S. Abdel-Bakky, Hany A. Omar. Glutamyl cysteine dipeptide suppresses ferritin expression and alleviates liver injury in iron-overload rat model. Biochimie, June 2015. 115, 203-211 Link         
3) El-Awady RA, Hersi F, Al-Tunaiji H, Saleh EM, Abdel-Wahab AH, Al Homssi A, Suhail M, El-Serafi A, Al-Tel T. Epigenetics and miRNA as predictive markers and targets for lung cancer chemotherapy. Cancer Biol Ther. 2015;16(7):1056-70 Link      
4) Jui-Hsiang Hung, Chia-Yun Chen, Hany A. Omar, Kuo-Yuan Huang, Che-Chia Tsao, Chien-Chih, Chiu, Yi-Ling Chen, Po-Han Chen, Yen-Ni Teng. Reactive oxygen species mediate terbufos-induced apoptosis in mouse testicular cell lines via the modulation of cell cycle and pro-apoptotic proteins. Environmental Toxicology, September 2015 DOI: 10.1002/tox.22190   Link      
5) Kuan-Han Lee*, Hany A. Omar*, Shu-Jing Wu, Pin-Shern Chen, Yu-Chung Chen, Yen-Ni Teng, Hung-Chang Huang, Clay C. C. Wang and Jui-Hsiang Hung. The effect of reactive oxygen species produced by 6-shogaol on cell cycle progression and cell death-associated signaling pathways in human hepatoma cells. European Journal of Pharmacology, June 2015, 762(5) 449–458 Link      
6) Hany A. Omar, Wafaa R. Mohamed, El-Shaimaa A. Arafa, Basim A. Shehata, Gamal A. El Sherbiny, Hany H. Arab, Abdel Nasser. A. M. Elgendy. Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its antitumor activity. Pharmacological Reports, 2015.  Sep;68(2): 349–56 Link      
7) Nidal Jaradat, Fatima Hussen, Anas Al Ali, Hasan Alniss, Maram Dweikat. J. Mater. Phytoconstituents, Free Radical Scavenging Potential, Total Phenols and Total Flavonoids Assessments for Violet Horned Poppy from Jerusalem Mountains. Environ. Sci. 2015, 6(10): 2958-2966 Link      
8) Mahmoud M. Gamal El-Din, Mohammed I. El-Gamal, Mohammed S. Abdel-Maksoud, Kyung Ho Yoo, and Chang-Hyun Oh; "Synthesis and in vitro antiproliferative activity of new 1,3,4-oxadiazole derivatives possessing sulfonamide moiety". Eur. J. Med. Chem. 2015, 90, 45-52. Link
9) Link
10)     Mohammed S. Abdel-Maksoud, Mi-Ryeong Kim, Mohammed I. El-Gamal, Mahmoud M. Gamal El-Din, Jinsung Tae, Hong Seok Choi, Kyung-Tae Lee, Kyung Ho Yoo, and Chang-Hyun Oh; "Design, synthesis, in vitro antiproliferative evaluation, and kinase inhibitory effects of a new series of imidazo[2,1-b]thiazole derivatives", Eur. J. Med. Chem. 2015, 95, 453-463. Link
2014
1. Ahmed H. Abdelazeem, Ahmed M. Gouda, Hany A. Omar, Mai F. Tolba. Design, Synthesis and Biological Evaluation of Novel Diphenylthiazole-Based Cyclooxygenase Inhibitors as Potential Anticancer Agents. Bioorganic Chemistry, Dec 2014, 57, 132–141. Link
2. Hany A. Omar, Mai F. Tolba and Maha M. Saber-Ayad. Potential Targets of Energy Restriction Mimetic Agents in Cancer Cells. Future Oncology, 2014 Dec;10(16): 2547-2550. Link
3. Ahmed H. Abdelazeem, Shaimaa A. Abdelatef, Mohammed T. El-Saadi, Hany A. Omar, Shabana I. Khan, Christopher R. McCurdy and Samir M. El-Moghazy. Novel Pyrazolopyrimidine Derivatives Targeting COXs and iNOS enzymes; Design, Synthesis and Biological Evaluation as Potential Anti-inflammatory Agents. European Journal of Pharmaceutical Sciences, Oct 2014, 62, 197–211. Link
4. Hany H. Arab, Samir A. Salama, Ahmed H. Eid, Hany A. Omar, El-Shaimaa A. Arafa and Ibrahim A. Maghrabi. Camel's milk ameliorates TNBS-induced colitis in rats via down-regulation of inflammatory cytokines and oxidative stress. Food and Chemical Toxicology, April, 2014, 69C:294-302. Link
5.Hany A. Omar, El-Shaimaa A. Arafa, A. Maghrabi and Jing-Ru Weng. Sensitization of Hepatocellular Carcinoma Cells to Apo2L/TRAIL by a Novel Akt/NF-kB Signaling Inhibitor. Basic & Clinical Pharmacology & Toxicology, 2014 Jun;114(6):464-71.  Link  
6. Kuan-Han Lee, Wen-Yueh Ho, Shu-Jing Wu, Hany A. Omar, Po-Jui Huang, Clay C. C. Wang and Jui-Hsiang Hung. Modulation of cyclins, p53 and MAPK signaling in breast cancer cell lines by 4-(3,4,5-trimethoxyphenoxy)benzoic acid. International Journal of Molecular Sciences, 2014, 15(1), 743-757.  Link
7. Samir A. Salama, Hany A. Omar, Ibrahim A. Maghrabi, Mohammed S. AlSaeed and Adel E. EL-Tarras. Iron supplementation at high altitude causes oxidative injury and inflammation in lung tissues of rats. Toxicology and Applied Pharmacology, 2014 Jan 1;274(1):1-6. Link  
8. El-Shaimaa A. Arafa, Ahmed H. Abdelazeem, Hany H. Arab and Hany A. Omar. OSU-CG5, a Novel Energy Restriction Mimetic Agent Inhibits Colorectal Cancer Cells. Acta Pharmacologica Sinica,   2014 Mar; 35(3):394-400. Link  
9. Samir A. Salama, Hany H. Arab, Hany A. Omar and Robert M. Snapka. Nicotine mediates hypochlorous Acid-induced nuclear protein damage in Mammalian cells. Inflammation, 2014 Jun;37(3):785-92. Link  
10. Hasan Y. Alniss, Stephanie A. T. Dillon, Nahoum G. Anthony, Abedawn I. Khalaf, Simon P. MacKay, Colin J. Suckling and John A. Parkinson. Molecular recognition of DNA by thiazotropsin class analogues through the DNA minor groove. European Journal of Chemical Biology, 2014 Jul; 15(13):1978-90. Link
11. Mohammed I. El-Gamal, and Chang-Hyun Oh; "Diarylureas and diarylamides with pyrrolo[2,3-d]pyrimidine scaffold as broad-spectrum anticancer agents". Chem. Pharm. Bull. 2014, 62(1), 25-34. Link
12. Alaa A. Hassan, Tarek M. Bebair, and Mohammed I. El-Gamal; "Synthesis of pyrazolylthiazole and pyrazolyl-1,2,4-triazepine derivatives". J. Chem. Res. 2014, 38(1), 27-31. Link
13. Hyeon-Lok Jang, Mohammed I. El-Gamal, Hye-Eun Choi, Ho-Yeong Choi, Kyung-Tae Lee, and Chang-Hyun Oh; "Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE2 productions in RAW 264.7 macrophages". Bioorg. Med. Chem. Lett. 2014, 24(2), 571-575. Link
14. Mohammed I. El-Gamal, Mohammed S. Abdel-Maksoud, Mahmoud M. Gamal El-Din, Daejin Baek, Kyung Ho Yoo, and Chang-Hyun Oh; "Cell-based biological evaluation of a new bisamide FMS kinase inhibitor possessing pyrrolo[3,2-c]pyridine scaffold". Arch. Pharm. 2014, 347(9), 635-641. Link
15. Mohammad Ashrafuddin Khan, Mohammed I. El-Gamal, Mohammed S. Abdel-Maksoud, Mahmoud M. Gamal El-Din, Kyung Ho Yoo, and Chang-Hyun Oh; "Broad-spectrum antiproliferative activity of diarylureas and diarylamides possessing pyrrolo[3,2-c]pyridine scaffold". Journal of Pharmacy and Pharmacology 2014, 2, 157-169. Link
16. Mohammed I. El-Gamal, and Chang-Hyun Oh; "Synthesis, in vitro antiproliferative activity, and in silico studies of fused tricyclic coumarin sulfonate derivatives". Eur. J. Med. Chem. 2014, 84, 68-76. Link
17. Mohammed I. El-Gamal, Mohammad Ashrafuddin Khan, Mohammed S. Abdel-Maksoud, Mahmoud M. Gamal El-Din, and Chang-Hyun Oh; "A new series of diarylamides possessing quinoline nucleus: Synthesis, in vitro anticancer activities, and kinase inhibitory effect". Eur. J. Med. Chem. 2014, 87, 484-492. Link 
18. Subash Chandra Sahoo, Naba K. Nath, Lidong Zhang, Mohammad H. Semreen, Taleb H. Al-Tel and Panče Naumov, Actuation based on thermo/photosalient effect: a biogenic smart hybrid driven by light and heat, RSC Adv., 2014,4, 7640-7647.