US Patent Application Number: 15935155. TITLE OF THE INVENTION: Discovery of NOVEL First-In-Class HETEROCYCLIC SYSTEMS for the treatment of Multidrug Resistant Superbugs. Filed on March 2018. RAM confirmation Number: 032618INTEFSW10523900. EFS ID: 32151250. Inventors: Dr. Taleb AlTel; Dr Vunnam Srinivasulu; Dr. Farah ElMarzooq; Dr Rafat El-Awady.
Summary of the Invention: The present disclosure relates to novel imidazole fused polycyclic systems, methods for their use, and processes for their preparation. The compounds of the present disclosure are particularly useful against a variety of bacteria, including multidrug resistant strains of Staphylococcus aureus, S. saprophyticus, S. haemolyticus, and S. epidermidis.
US Patent Application Number: 15935120; TITLE OF THE INVENTION: Discovery of NOVEL First-In-Class HETEROCYCLIC SYSTEMS for the treatment of Cancer. Filed in March 2018. RAM confirmation Number: 032618INTEFSW10050600 EFS ID: 32150635. Inventors: Dr. Taleb AlTel; Dr Rafat El-Awady; Dr Vunnam Srinivasulu; Dr Cijo George Vazhappilly; Dr Hany Omar.
Summary of the Invention: This disclosure relates to novel antitumor agents, pharmaceutically acceptable salts thereof, as well as processes of manufacture, and medicaments containing such compounds. The presently disclosed compounds have anticancer activity, which results in reduction of tumor cell proliferation, induction of apoptosis, as well as DNA damage. This present disclosure also concerns the use of the disclosed compounds in relation to the enzymes thioredoxin reductase, transketolase, cytosol aminopeptidase, glutathione reductase, inositol-3-phosphate synthase, and transferrin receptor activities in addition to regulation of these enzymes.
US Patent Application Number: 62/711,401. TITLE OF THE INVENTION: Discovery of Novel First-In-Class Nature-Inspired Compounds targeting the mitochondrial function and pharmaceutical composition thereof as novel treatment for cancer immunotherapy. Filed May 2018. Inventors: Dr. Taleb AlTel; Dr Vunnam Srinivasulu; Dr. Saleh Ibrahim; Dr. Paul Schilf.
Summary of the Invention:This invention relates to novel antitumor agents and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel constrained cyclic frameworks as defined in the specifications of general formulas and medicaments containing such compounds. This invention also concerns the use of such compounds to modulate the cellular mitochondrial functions by measuring the ATP content, the mitochondrial membrane potential and the cellular redox potential as well as their toxicities and effects on T and B cells.
المنشورات الحديثة للمجموعات البحثية:
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2018Hamza, A., Heeba, G., Elwy, H., Murali, C., El-Awady, R., Amin, A.Scientific Reports
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Ayyash, M., Liu, S.-Q., Al Mheiri, A., Aldhaheri, M., Raeisi, B., Al-Nabulsi, A., Osaili, T., Olaimat, A.
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