Pharmaceutics 1B

Introduction

This course supports theory taught by applying some experimental work to determine biopharmaceutical and pharmacokinetic aspects of drug products.

Dissolution experiments are done to determine the kinetics of drug release from different formulations. Students run experiments to determine the effect of diluents and lubricants, and the effect of different mediums and humidity in tablet and capsule formulation on drug dissolution.

Equipment and Instruments

• UV Spectrophotometer
• Analytical Balance
• Desicator
• Hot Plate and Stirrers
• Beakers, Measuring Cylinders, Funnel and Conical Flasks
• Thermometer
• Filter Papers
• Pipette
• Test Tubes

Experiments

• Mathematical Calculations
• Rates and Orders of Reactions
• Dissolution of Salicylic Acid
• Formulation Factors Affecting Drug Dissolution* Effect of Diluents on Drug Dissolution and Effect of Lubricants on Drug Dissolution
• Effect of Different Mediums on the Dissolution of Capsules
• Effect of Different Humidity on the Dissolution of Capsules
• One Compartment Intravenous Model
• One Compartment Model with Extravascular Dose
• Calculation of PK Parameters From Urinary Data
• Two Compartment Model with Intravenous Dose
• Calculation of Pharmacokinetic Parameters using WinNonlin Software