Medicinal chemistry IB

Introduction

This course is concerned with the theory and practice of the preparation of some of the active ingredients in pharmaceutical preparation and classical and instrumental methods for the separation, identification and quantitative analysis of chemical substances. Satisfactory completion of this course affords students a working knowledge of analytical instrumentation typically employed in pharmaceutical and biochemical research laboratories. It also provides students with an appreciation of the relative strengths and limitations of different instrumental-based analysis methods.

Equipment and Instruments

• UV-VIS Spectrophotometer
• GC-MSMS
• GC-FID and GC-ECD
• HPLC-UV
• Analytical Balances
• Hot Plates and Stirrers
• Rotatory Evaporators and Vacuum Pumps
• Polarimeters
• Distillation Apparatuses
• Melting Point Apparatuses
• Water Baths
• Ultrasonic Bath
• Ovens 

Experiments

• Methyl Salicilate Preparation
• Drugs Mixture Separation Using TLC
• Determination of  Paracetamol Concentration Using Spectrophotometer
• Separation of Caffeine and Paracetamol Mixture Using HPLC
• Separation and Identification of Hydrocarbon Mixture Using GC-FID and GC-MSMS

Tests and Services

• Development and Validation of Analytical Methods for Analysis of Active Ingredients
• Related Substances Analysis
• Routine Quality Control of Pharmaceutical Products